{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:15:40Z","timestamp":1785762940587,"version":"3.56.0"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170445"],"award-info":[{"award-number":["82170445"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ejphar.2024.177141","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T11:53:40Z","timestamp":1732017220000},"page":"177141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Novel applications of metformin in the treatment of septic myocardial injury based on metabolomics and network pharmacology"],"prefix":"10.1016","volume":"986","author":[{"given":"Xingyu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaohong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ejphar.2024.177141_bib1","first-page":"234","article-title":"Cardioprotective effect of metformin against doxorubicin cardiotoxicity in rats","volume":"16","author":"Argun","year":"2016","journal-title":"Anatol. J. Cardiol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177141_bib2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13054-021-03862-5","article-title":"Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review","volume":"26","author":"Barichello","year":"2022","journal-title":"Crit. Care"},{"issue":"7","key":"10.1016\/j.ejphar.2024.177141_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159381","article-title":"Metformin prevents nigrostriatal dopamine degeneration independent of AMPK activation in dopamine neurons","volume":"11","author":"Bayliss","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2024.177141_bib4","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3389\/fendo.2019.00851","article-title":"Editorial: metformin: beyond diabetes","volume":"10","author":"Bost","year":"2019","journal-title":"Front. Endocrinol."},{"issue":"3\u20134","key":"10.1016\/j.ejphar.2024.177141_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.drudis.2011.09.019","article-title":"Retrospective clinical analysis for drug rescue: for new indications or stratified patient groups","volume":"17","author":"Cavalla","year":"2012","journal-title":"Drug Discov. Today"},{"issue":"12","key":"10.1016\/j.ejphar.2024.177141_bib6","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1111\/jcmm.12871","article-title":"Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K\/Akt\/mTOR pathway in vitro and in vivo","volume":"21","author":"Chen","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2024.177141_bib7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mce.2016.11.011","article-title":"Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms","volume":"440","author":"Chen","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.ejphar.2024.177141_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/SHK.0000000000001383","article-title":"Integrin \u03b23 modulates TLR4-mediated inflammation by regulation of CD14 expression in macrophages in septic condition","volume":"53","author":"Chen","year":"2020","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.ejphar.2024.177141_bib9","doi-asserted-by":"crossref","first-page":"9676","DOI":"10.1038\/s41598-024-59400-0","article-title":"Integrative analysis of metabolomics and transcriptomics to uncover biomarkers in sepsis","volume":"14","author":"Chen","year":"2024","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.ejphar.2024.177141_bib10","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1080\/03007995.2017.1284052","article-title":"Antidiabetic agents and cardiovascular outcomes in patients with heart diseases","volume":"33","author":"Cheng","year":"2017","journal-title":"Curr. Med. Res. Opin."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177141_bib11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/sj.bjp.0707344","article-title":"Acute actions and novel targets of matrix metalloproteinases in the heart and vasculature","volume":"152","author":"Chow","year":"2007","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.ejphar.2024.177141_bib12","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/sj.bjp.0705997","article-title":"Platelet-leukocyte aggregation induced by PAR agonists: regulation by nitric oxide and matrix metalloproteinases","volume":"143","author":"Chung","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177141_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155325","article-title":"Gramine improves sepsis-induced myocardial dysfunction by binding to NF-\u03baB p105 and inhibiting its ubiquitination","volume":"125","author":"Dao","year":"2024","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.ejphar.2024.177141_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058371","article-title":"\u03b1-Lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia\/reperfusion injury through activation of PI3K\/Akt\/Nrf2 pathway","volume":"8","author":"Deng","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.ejphar.2024.177141_bib15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1055\/a-1322-7478","article-title":"Short-term effects of metformin on cardiac and peripheral blood cells following cecal ligation and puncture-induced sepsis","volume":"71","author":"Didari","year":"2021","journal-title":"Drug Res."},{"issue":"5","key":"10.1016\/j.ejphar.2024.177141_bib16","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nm.3787","article-title":"Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats","volume":"21","author":"Duca","year":"2015","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.ejphar.2024.177141_bib17","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and Python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"issue":"11","key":"10.1016\/j.ejphar.2024.177141_bib19","doi-asserted-by":"crossref","first-page":"e1063","DOI":"10.1097\/CCM.0000000000005337","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"49","author":"Evans","year":"2021","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ejphar.2024.177141_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2020.05.016","article-title":"Metformin protects against ischaemic myocardial injury by alleviating autophagy-ROS-NLRP3-mediated inflammatory response in macrophages","volume":"145","author":"Fei","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"6","key":"10.1016\/j.ejphar.2024.177141_bib21","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.cmet.2014.09.018","article-title":"Metformin: from mechanisms of action to therapies","volume":"20","author":"Foretz","year":"2014","journal-title":"Cell Metabol."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177141_bib22","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCOUTCOMES.117.004040","article-title":"Myocardial injury in patients with sepsis and its association with long-term outcome","volume":"11","author":"Frencken","year":"2018","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"1","key":"10.1016\/j.ejphar.2024.177141_bib23","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s10753-018-0894-4","article-title":"NLRP3\/Caspase-1 pathway-induced pyroptosis mediated cognitive deficits in a mouse model of sepsis-associated encephalopathy","volume":"42","author":"Fu","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2024.177141_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-immunol-071719-094903","article-title":"Mast cells in inflammation and disease: recent progress and ongoing concerns","volume":"38","author":"Galli","year":"2020","journal-title":"Annu. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.ejphar.2024.177141_bib25","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1007\/BF00404340","article-title":"Effect of metformin on insulin-stimulated glucose transport in isolated skeletal muscle obtained from patients with NIDDM","volume":"37","author":"Galuska","year":"1994","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.ejphar.2024.177141_bib26","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/FJC.0000000000001463","article-title":"Metformin alleviates sepsis-associated myocardial injury by enhancing AMP-activated protein kinase\/mammalian target of rapamycin signaling pathway-mediated autophagy","volume":"82","author":"Gao","year":"2023","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"10","key":"10.1016\/j.ejphar.2024.177141_bib27","doi-asserted-by":"crossref","first-page":"9767","DOI":"10.1007\/s11033-022-07468-0","article-title":"Interplay between PI3K\/AKT pathway and heart disorders","volume":"49","author":"Ghafouri-Fard","year":"2022","journal-title":"Mol. Biol. Rep."},{"issue":"3","key":"10.1016\/j.ejphar.2024.177141_bib28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1161\/CIRCRESAHA.108.190918","article-title":"Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure","volume":"104","author":"Gundewar","year":"2009","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.ejphar.2024.177141_bib29","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.1021\/acs.est.1c02471","article-title":"Exposure to GenX and its novel analogs disrupts hepatic bile acid metabolism in male mice","volume":"56","author":"Guo","year":"2022","journal-title":"Environ. Sci. Technol."},{"issue":"6","key":"10.1016\/j.ejphar.2024.177141_bib30","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.cmet.2011.11.007","article-title":"Identifying novel transcriptional components controlling energy metabolism","volume":"14","author":"Gupta","year":"2011","journal-title":"Cell Metabol."},{"issue":"6","key":"10.1016\/j.ejphar.2024.177141_bib31","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41569-020-00492-2","article-title":"Pathophysiology of sepsis-induced cardiomyopathy","volume":"18","author":"Hollenberg","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"issue":"12","key":"10.1016\/j.ejphar.2024.177141_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083922","article-title":"Combining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for network pharmacology","volume":"8","author":"Hsin","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.ejphar.2024.177141_bib33","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","article-title":"FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation","volume":"21","author":"Hu","year":"2020","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.ejphar.2024.177141_bib34","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.2337\/diabetes.49.12.2063","article-title":"Mechanism by which metformin reduces glucose production in type 2 diabetes","volume":"49","author":"Hundal","year":"2000","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.ejphar.2024.177141_bib35","first-page":"405","article-title":"Macrophage activation with pantethine and pantetheine-4'-phosphate","volume":"55","author":"Iida","year":"1985","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"10.1016\/j.ejphar.2024.177141_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.967397","article-title":"Analysis of metabolic disturbances attributable to sepsis-induced myocardial dysfunction using metabolomics and transcriptomics techniques","volume":"9","author":"Jia","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ejphar.2024.177141_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109847","article-title":"NSC228155 alleviates septic cardiomyopathy via protecting mitochondria and inhibiting inflammation","volume":"116","author":"Jiang","year":"2023","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ejphar.2024.177141_bib38","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40560-016-0148-1","article-title":"Sepsis-induced myocardial dysfunction: pathophysiology and management","volume":"4","author":"Kakihana","year":"2016","journal-title":"J. Intensive Care"},{"issue":"10","key":"10.1016\/j.ejphar.2024.177141_bib39","first-page":"3113","article-title":"Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma","volume":"7","author":"Kallakury","year":"2001","journal-title":"Clin. Cancer Res."},{"issue":"11","key":"10.1016\/j.ejphar.2024.177141_bib40","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.amjcard.2004.02.028","article-title":"Relation of metformin treatment to clinical events in diabetic patients undergoing percutaneous intervention","volume":"93","author":"Kao","year":"2004","journal-title":"Am. J. Cardiol."},{"issue":"9","key":"10.1016\/j.ejphar.2024.177141_bib41","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1055\/s-0030-1255033","article-title":"Metformin attenuates production of nitric oxide in response to lipopolysaccharide by inhibiting MyD88-independent pathway","volume":"42","author":"Kato","year":"2010","journal-title":"Horm. Metab. Res."},{"issue":"2","key":"10.1016\/j.ejphar.2024.177141_bib42","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/prot.20149","article-title":"Comparative evaluation of eight docking tools for docking and virtual screening accuracy","volume":"57","author":"Kellenberger","year":"2004","journal-title":"Proteins"},{"issue":"6","key":"10.1016\/j.ejphar.2024.177141_bib43","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin","volume":"346","author":"Knowler","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2024.177141_bib44","article-title":"BATMAN-TCM 2.0: an enhanced integrative database for known and predicted interactions between traditional Chinese medicine ingredients and target proteins","author":"Kong","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.ejphar.2024.177141_bib45","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1055\/s-0038-1641750","article-title":"Apolipoprotein M protects lipopolysaccharide-treated mice from death and organ injury","volume":"118","author":"Kurano","year":"2018","journal-title":"Thromb. Haemostasis"},{"issue":"5","key":"10.1016\/j.ejphar.2024.177141_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196478","article-title":"Role of matrix metalloproteinases 2 and 9, toll-like receptor 4 and platelet-leukocyte aggregate formation in sepsis-associated thrombocytopenia","volume":"13","author":"Larkin","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.ejphar.2024.177141_bib47","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3724\/SP.J.1009.2013.00110","article-title":"Traditional Chinese medicine network pharmacology: theory, methodology and application","volume":"11","author":"Li","year":"2013","journal-title":"Chin. J. Nat. Med."},{"issue":"3","key":"10.1016\/j.ejphar.2024.177141_bib48","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaa079","article-title":"Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study","volume":"22","author":"Li","year":"2021","journal-title":"Briefings Bioinf."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177141_bib49","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13054-019-2346-4","article-title":"Association of preadmission metformin use and mortality in patients with sepsis and diabetes mellitus: a systematic review and meta-analysis of cohort studies","volume":"23","author":"Liang","year":"2019","journal-title":"Crit. Care"},{"key":"10.1016\/j.ejphar.2024.177141_bib50","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.intimp.2017.04.002","article-title":"Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK","volume":"47","author":"Liu","year":"2017","journal-title":"Int. Immunopharm."},{"issue":"6","key":"10.1016\/j.ejphar.2024.177141_bib51","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1289\/ehp.6028","article-title":"The comparative toxicogenomics database (CTD)","volume":"111","author":"Mattingly","year":"2003","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.ejphar.2024.177141_bib52","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/physrev.1997.77.4.1033","article-title":"Mast cells","volume":"77","author":"Metcalfe","year":"1997","journal-title":"Physiol. Rev."},{"issue":"11","key":"10.1016\/j.ejphar.2024.177141_bib53","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.phymed.2012.05.012","article-title":"Involvement of NF-\u03baB and Bcl2\/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A","volume":"19","author":"Mohan","year":"2012","journal-title":"Phytomedicine"},{"issue":"Web Server issue","key":"10.1016\/j.ejphar.2024.177141_bib54","doi-asserted-by":"crossref","first-page":"W26","DOI":"10.1093\/nar\/gku477","article-title":"SuperPred: update on drug classification and target prediction","volume":"42","author":"Nickel","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"7607","key":"10.1016\/j.ejphar.2024.177141_bib55","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/534314a","article-title":"Can you teach old drugs new tricks?","volume":"534","author":"Nosengo","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.ejphar.2024.177141_bib56","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12951-022-01457-y","article-title":"Heart-targeted amelioration of sepsis-induced myocardial dysfunction by microenvironment responsive nitric oxide nanogenerators in situ","volume":"20","author":"Ouyang","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"W1","key":"10.1016\/j.ejphar.2024.177141_bib57","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.ejphar.2024.177141_bib58","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.bcp.2012.09.025","article-title":"Metformin reduces airway inflammation and remodeling via activation of AMP-activated protein kinase","volume":"84","author":"Park","year":"2012","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177141_bib59","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd.2018.168","article-title":"Drug repurposing: progress, challenges and recommendations","volume":"18","author":"Pushpakom","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.ejphar.2024.177141_bib60","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2174\/1871530315666150316124019","article-title":"Metformin and inflammation: its potential beyond glucose-lowering effect","volume":"15","author":"Saisho","year":"2015","journal-title":"Endocr., Metab. Immune Disord.: Drug Targets"},{"issue":"19","key":"10.1016\/j.ejphar.2024.177141_bib61","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1161\/CIRCULATIONAHA.108.798561","article-title":"Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase","volume":"119","author":"Sasaki","year":"2009","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.ejphar.2024.177141_bib62","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1194\/jlr.P023309","article-title":"Targeted metabolomics for discrimination of systemic inflammatory disorders in critically ill patients","volume":"53","author":"Schmerler","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ejphar.2024.177141_bib63","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejphar.2014.05.003","article-title":"Chronic treatment with metformin suppresses toll-like receptor 4 signaling and attenuates left ventricular dysfunction following myocardial infarction","volume":"737","author":"Soraya","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177141_bib64","doi-asserted-by":"crossref","first-page":"3","DOI":"10.15171\/bi.2015.02","article-title":"Metformin attenuates myocardial remodeling and neutrophil recruitment after myocardial infarction in rat","volume":"5","author":"Soraya","year":"2015","journal-title":"Bioimpacts"},{"issue":"2","key":"10.1016\/j.ejphar.2024.177141_bib65","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"7","key":"10.1016\/j.ejphar.2024.177141_bib66","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/j.1476-5381.2010.01126.x","article-title":"Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice","volume":"162","author":"Tsoyi","year":"2011","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.ejphar.2024.177141_bib67","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.metabol.2016.06.012","article-title":"Metformin protects against infection-induced myocardial dysfunction","volume":"65","author":"Tzanavari","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.ejphar.2024.177141_bib68","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.intimp.2016.10.002","article-title":"AMPK activation by metformin inhibits local innate immune responses in the isolated rat heart by suppression of TLR 4-related pathway","volume":"40","author":"Vaez","year":"2016","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ejphar.2024.177141_bib69","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2015.12.030","article-title":"Cardioprotective effect of metformin in lipopolysaccharide-induced sepsis via suppression of toll-like receptor 4 (TLR4) in heart","volume":"772","author":"Vaez","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.ejphar.2024.177141_bib70","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1021\/acs.jctc.1c00645","article-title":"gmx_MMPBSA: a new tool to perform end-state free energy calculations with GROMACS","volume":"17","author":"Vald\u00e9s-Tresanco","year":"2021","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.ejphar.2024.177141_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105781","article-title":"Protective effect of isosteviol sodium against LPS-induced multiple organ injury by regulating of glycerophospholipid metabolism and reducing macrophage-driven inflammation","volume":"172","author":"Wang","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.ejphar.2024.177141_bib72","doi-asserted-by":"crossref","first-page":"7134","DOI":"10.1080\/21655979.2022.2047256","article-title":"Clemastine protects against sepsis-induced myocardial injury in vivo and in vitro","volume":"13","author":"Wang","year":"2022","journal-title":"Bioengineered"},{"issue":"Database issue","key":"10.1016\/j.ejphar.2024.177141_bib73","doi-asserted-by":"crossref","first-page":"D668","DOI":"10.1093\/nar\/gkj067","article-title":"DrugBank: a comprehensive resource for in silico drug discovery and exploration","volume":"34","author":"Wishart","year":"2006","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.ejphar.2024.177141_bib74","first-page":"3338","article-title":"Astaxanthin suppresses lipopolysaccharide-induced myocardial injury by regulating MAPK and PI3K\/AKT\/mTOR\/GSK3\u03b2 signaling","volume":"22","author":"Xie","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.ejphar.2024.177141_bib75","doi-asserted-by":"crossref","first-page":"854","DOI":"10.14336\/AD.2018.1027","article-title":"Metabolomics coupled with transcriptomics approach deciphering age relevance in sepsis","volume":"10","author":"Xu","year":"2019","journal-title":"Aging Dis"},{"issue":"5","key":"10.1016\/j.ejphar.2024.177141_bib76","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10822-016-9915-2","article-title":"TargetNet: a web service for predicting potential drug-target interaction profiling via multi-target SAR models","volume":"30","author":"Yao","year":"2016","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.ejphar.2024.177141_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109231","article-title":"Dexmedetomidine prevents septic myocardial dysfunction in rats via activation of \u03b17nAChR and PI3K\/Akt- mediated autophagy","volume":"120","author":"Yu","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2024.177141_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1090288","article-title":"Mast cell activation mediates blood-brain barrier impairment and cognitive dysfunction in septic mice in a histamine-dependent pathway","volume":"14","author":"Yue","year":"2023","journal-title":"Front. Immunol."},{"issue":"24","key":"10.1016\/j.ejphar.2024.177141_bib79","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1093\/bioinformatics\/btz459","article-title":"AutoDock CrankPep: combining folding and docking to predict protein-peptide complexes","volume":"35","author":"Zhang","year":"2019","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.ejphar.2024.177141_bib80","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1440-1681.2010.05461.x","article-title":"Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase-endothelial nitric oxide synthase pathway in rats","volume":"38","author":"Zhang","year":"2011","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2024.177141_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155397","article-title":"Xiebai San alleviates acute lung injury by inhibiting the phosphorylation of the ERK\/Stat3 pathway and regulating multiple metabolisms","volume":"128","author":"Zhao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2024.177141_bib82","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.biopha.2016.06.036","article-title":"Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K\/AKT and NF-\u03baB related signaling","volume":"83","author":"Zhong","year":"2016","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.ejphar.2024.177141_bib83","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI13505","article-title":"Role of AMP-activated protein kinase in mechanism of metformin action","volume":"108","author":"Zhou","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.ejphar.2024.177141_bib84","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s13287-021-02325-6","article-title":"PINK1 contained in huMSC-derived exosomes prevents cardiomyocyte mitochondrial calcium overload in sepsis via recovery of mitochondrial Ca(2+) efflux","volume":"12","author":"Zhou","year":"2021","journal-title":"Stem Cell Res. Ther."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924008318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924008318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T01:10:06Z","timestamp":1733793006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924008318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":83,"alternative-id":["S0014299924008318"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177141","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel applications of metformin in the treatment of septic myocardial injury based on metabolomics and network pharmacology","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177141","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177141"}}