{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:21:34Z","timestamp":1783437694820,"version":"3.54.6"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.ejphar.2024.177173","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T17:39:39Z","timestamp":1733247579000},"page":"177173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Oxymatrine relieves non-alcoholic fatty liver disease by promoting sirtuin 1\/adenosine 5\u2018-monophosphate-activated protein kinase pathway and peroxisome proliferator activated receptor alpha-mediated hepatic fatty acid oxidation"],"prefix":"10.1016","volume":"987","author":[{"given":"Yijun","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaofeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaolin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.177173_bib1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s12263-015-0495-x","article-title":"Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice","volume":"10","author":"Ann","year":"2015","journal-title":"Genes Nutr"},{"key":"10.1016\/j.ejphar.2024.177173_bib2","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jnutbio.2010.01.005","article-title":"Liver fatty acid-binding protein and obesity","volume":"21","author":"Atshaves","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.ejphar.2024.177173_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101725","article-title":"Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism","volume":"72","author":"Chalhoub","year":"2023","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.ejphar.2024.177173_bib4","article-title":"Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism","volume":"8","author":"Chen","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2024.177173_bib5","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s00394-020-02362-6","article-title":"Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10\/AMPK signaling pathway in ApoE(-\/-) mice","volume":"60","author":"Chen","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.ejphar.2024.177173_bib6","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1681\/ASN.2017070802","article-title":"Impairment of PPAR\u03b1 and the fatty acid oxidation pathway aggravates renal fibrosis during aging","volume":"29","author":"Chung","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ejphar.2024.177173_bib7","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3389\/fphar.2020.00858","article-title":"Untargeted metabolomic analysis of the effects and mechanism of nuciferine treatment on rats with nonalcoholic fatty liver disease","volume":"11","author":"Cui","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177173_bib8","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ejphar.2018.11.007","article-title":"Oxymatrine prevents the development of monocrotaline-induced pulmonary hypertension via regulation of the N(G), N(G)-dimethyl-L-arginine metabolism pathways in rats","volume":"842","author":"Dai","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177173_bib9","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.apsb.2022.04.003","article-title":"Targeting macrophagic 17\u03b2-HSD7 by fenretinide for the treatment of nonalcoholic fatty liver disease","volume":"13","author":"Dong","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejphar.2024.177173_bib10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3390\/ph15040465","article-title":"Effects of a short-term lipopolysaccharides challenge on mouse brain and liver peroxisomal antioxidant and \u03b2-oxidative functions: protective action of argan oil","volume":"15","author":"Essadek","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejphar.2024.177173_bib11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jhep.2015.02.019","article-title":"PPAR\u03b1 gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis","volume":"63","author":"Francque","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejphar.2024.177173_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/6603522","article-title":"Rhinacanthin C ameliorates insulin resistance and lipid accumulation in NAFLD mice via the AMPK\/SIRT1 and SREBP-1c\/FAS\/ACC signaling pathways","volume":"2023","author":"Gong","year":"2023","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.ejphar.2024.177173_bib13","doi-asserted-by":"crossref","first-page":"13929","DOI":"10.1021\/acs.jafc.9b05632","article-title":"\u03b3-Mangostin ameliorates free fatty acid-induced lipid accumulation via the SIRT1\/LKB1\/AMPK pathway in HepG2 and L02 cells","volume":"67","author":"Gu","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2024.177173_bib14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12906-023-03903-2","article-title":"Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3\/Caspase-1\/IL-1\u03b2 signaling pathway","volume":"23","author":"Guan","year":"2023","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.ejphar.2024.177173_bib15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1055\/s-0033-1360369","article-title":"Protective effects of oxymatrine on experimental diabetic nephropathy","volume":"80","author":"Guo","year":"2014","journal-title":"Planta Med."},{"key":"10.1016\/j.ejphar.2024.177173_bib16","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.phymed.2014.02.007","article-title":"Hypoglycemic and hypolipidemic effects of oxymatrine in high-fat diet and streptozotocin-induced diabetic rats","volume":"21","author":"Guo","year":"2014","journal-title":"Phytomedicine : International Journal Of Phytotherapy And Phytopharmacology"},{"key":"10.1016\/j.ejphar.2024.177173_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.961998","article-title":"Effect of different sweeteners on the quality, fatty acid and volatile flavor compounds of braised pork","volume":"9","author":"He","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ejphar.2024.177173_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2023.105565","article-title":"Oxymatrine: a current overview of its health benefits","volume":"168","author":"Huan","year":"2023","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ejphar.2024.177173_bib19","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12955-021-01778-w","article-title":"Health-related quality of life in Chinese population with non-alcoholic fatty liver disease: a national multicenter survey","volume":"19","author":"Huang","year":"2021","journal-title":"Health Qual. Life Outcome"},{"key":"10.1016\/j.ejphar.2024.177173_bib20","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/bcpt.13549","article-title":"The effect of acetylsalicylic acid and pentoxifylline in Guinea pigs with non-alcoholic steatohepatitis","volume":"128","author":"Ipsen","year":"2021","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2024.177173_bib21","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.bbadis.2018.06.023","article-title":"Animal models of NAFLD from a hepatologist's point of view","volume":"1865","author":"Jahn","year":"2019","journal-title":"Biochimica et biophysica acta. Molecular basis of disease"},{"key":"10.1016\/j.ejphar.2024.177173_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsz121","article-title":"Sleep duration and fragmentation in relation to leukocyte DNA methylation in adolescents","volume":"42","author":"Jansen","year":"2019","journal-title":"Sleep"},{"key":"10.1016\/j.ejphar.2024.177173_bib23","doi-asserted-by":"crossref","first-page":"5091","DOI":"10.1080\/21655979.2022.2036902","article-title":"Liraglutide inhibits receptor for advanced glycation end products (RAGE)\/reduced form of nicotinamide-adenine dinucleotide phosphate (NAPDH) signaling to ameliorate non-alcoholic fatty liver disease (NAFLD) in vivo and vitro","volume":"13","author":"Ji","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.ejphar.2024.177173_bib24","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3390\/antiox11030552","article-title":"Hydroxy selenomethionine alleviates hepatic lipid metabolism disorder of pigs induced by dietary oxidative stress via relieving the endoplasmic reticulum stress","volume":"11","author":"Jing","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejphar.2024.177173_bib25","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.70472","article-title":"Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA","volume":"10","author":"Lee","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.ejphar.2024.177173_bib26","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.2147\/DMSO.S428864","article-title":"Oxymatrine alleviates high-fat-high-fructose-induced fatty liver in rats: understanding the molecular mechanism through an untargeted metabonomics study","volume":"16","author":"Li","year":"2023","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.ejphar.2024.177173_bib27","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1007\/s12035-023-03364-1","article-title":"Neuroprotective effects of oxymatrine via triggering autophagy and inhibiting apoptosis following spinal cord injury in rats","volume":"60","author":"Li","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2024.177173_bib28","doi-asserted-by":"crossref","first-page":"12792","DOI":"10.18632\/oncotarget.12478","article-title":"Protective effects of oxymatrine against arsenic trioxide-induced liver injury","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2024.177173_bib29","article-title":"Effect of octreotide on hepatic steatosis in diet-induced obesity in rats","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2024.177173_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155285","article-title":"Formononetin promotes fatty acid \u03b2-oxidation to treat non-alcoholic steatohepatitis through SIRT1\/PGC-1\u03b1\/PPAR\u03b1 pathway","volume":"124","author":"Liao","year":"2024","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"},{"key":"10.1016\/j.ejphar.2024.177173_bib31","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3390\/cells8050447","article-title":"Protective effects of licochalcone A ameliorates obesity and non-alcoholic fatty liver disease via promotion of the sirt-1\/AMPK pathway in mice fed a high-fat diet","volume":"8","author":"Liou","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2024.177173_bib32","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13578-020-00477-1","article-title":"Phloretin ameliorates hepatic steatosis through regulation of lipogenesis and Sirt1\/AMPK signaling in obese mice","volume":"10","author":"Liou","year":"2020","journal-title":"Cell Biosci."},{"key":"10.1016\/j.ejphar.2024.177173_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109948","article-title":"Rhynchophylline relieves nonalcoholic fatty liver disease by activating lipase and increasing energy metabolism","volume":"117","author":"Liu","year":"2023","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.ejphar.2024.177173_bib34","article-title":"High-concentration metformin reduces oxidative stress injury and inhibits the growth and migration of clear cell renal cell carcinoma","volume":"2022","author":"Liu","year":"2022","journal-title":"Comput. Math. Methods Med."},{"key":"10.1016\/j.ejphar.2024.177173_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12906-022-03697-9","article-title":"Salvia-Nelumbinis naturalis improves lipid metabolism of NAFLD by regulating the SIRT1\/AMPK signaling pathway","volume":"22","author":"Liu","year":"2022","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.ejphar.2024.177173_bib36","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/bcpt.12608","article-title":"Oxymatrine induces liver injury through JNK signalling pathway mediated by TNF-\u03b1 in vivo","volume":"119","author":"Lu","year":"2016","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2024.177173_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12030595","article-title":"Swietenine alleviates nonalcoholic fatty liver disease in diabetic mice via lipogenesis inhibition and antioxidant mechanisms","volume":"12","author":"Mak","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejphar.2024.177173_bib38","doi-asserted-by":"crossref","first-page":"C4","DOI":"10.1152\/ajpcell.00296.2011","article-title":"A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells","volume":"303","author":"Nelson","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ejphar.2024.177173_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113436","article-title":"Lactobacillus sakei MJM60958 as a potential probiotic alleviated non-alcoholic fatty liver disease in mice fed a high-fat diet by modulating lipid metabolism, inflammation, and gut microbiota","volume":"23","author":"Nguyen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2024.177173_bib40","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.3748\/wjg.v29.i25.3999","article-title":"Insulin resistance and adipose tissue interactions as the cornerstone of metabolic (dysfunction)-associated fatty liver disease pathogenesis","volume":"29","author":"Pal","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2024.177173_bib41","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.2147\/JIR.S343236","article-title":"Melatonin suppresses NLRP3 inflammasome activation via TLR4\/NF-\u03baB and P2X7R signaling in high-fat diet-induced murine NASH model","volume":"15","author":"Saha","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.ejphar.2024.177173_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23330","article-title":"Oxymatrine and insulin resistance: focusing on mechanistic intricacies involve in diabetes associated cardiomyopathy via SIRT1\/AMPK and TGF-\u03b2 signaling pathway","volume":"37","author":"Seksaria","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ejphar.2024.177173_bib43","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3892\/mmr.2013.1512","article-title":"Oxymatrine ameliorates non-alcoholic fatty liver disease in rats through peroxisome proliferator-activated receptor-\u03b1 activation","volume":"8","author":"Shi","year":"2013","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2024.177173_bib44","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ejphar.2013.06.013","volume":"714","author":"Shi","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177173_bib45","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/19768354.2020.1810771","article-title":"Capsaicin suppresses liver fat accumulation in high-fat diet-induced NAFLD mice","volume":"24","author":"Shin","year":"2020","journal-title":"Anim. Cell Syst."},{"key":"10.1016\/j.ejphar.2024.177173_bib46","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cmet.2023.01.006","article-title":"The role of hepatokines in NAFLD","volume":"35","author":"Stefan","year":"2023","journal-title":"Cell Metabol."},{"key":"10.1016\/j.ejphar.2024.177173_bib47","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1590\/s0102-865020180030000002","article-title":"The role of oxymatrine in regulating TGF-\u03b21 in rats with hepatic fibrosis","volume":"33","author":"Wu","year":"2018","journal-title":"Acta Cir. Bras."},{"key":"10.1016\/j.ejphar.2024.177173_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2953502","article-title":"Exosomal MicroRNA expression profiling analysis of the effects of lycium barbarum polysaccharide on gestational diabetes mellitus mice","volume":"2020","author":"Xiao","year":"2020","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.ejphar.2024.177173_bib49","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3389\/fphar.2020.00216","article-title":"Hepatic proteomic changes and Sirt1\/AMPK signaling activation by oxymatrine treatment in rats with non-alcoholic steatosis","volume":"11","author":"Xu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177173_bib50","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1530\/JOE-15-0409","article-title":"Metformin improves hepatic IRS2\/PI3K\/Akt signaling in insulin-resistant rats of NASH and cirrhosis","volume":"229","author":"Xu","year":"2016","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ejphar.2024.177173_bib51","first-page":"1907","article-title":"Protective effects of oxymatrine against lipopolysaccharide\/D-galactosamine-induced acute liver failure through oxidative damage, via activation of Nrf2\/HO-1 and modulation of inflammatory TLR4-signaling pathways","volume":"17","author":"Xu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2024.177173_bib52","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3349\/ymj.2022.63.7.619","article-title":"Canagliflozin ameliorates nonalcoholic fatty liver disease by regulating lipid metabolism and inhibiting inflammation through induction of autophagy","volume":"63","author":"Xu","year":"2022","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.ejphar.2024.177173_bib53","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3390\/metabo12080759","article-title":"Mechanism analysis of metabolic fatty liver on largemouth bass (Micropterus salmoides) based on integrated lipidomics and proteomics","volume":"12","author":"Xue","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.ejphar.2024.177173_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118090","article-title":"Oxymatrine alleviated hepatic lipid metabolism via regulating miR-182 in non-alcoholic fatty liver disease","volume":"257","author":"Zhang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2024.177173_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155478","article-title":"Smilax China L. polysaccharide prevents HFD induced-NAFLD by regulating hepatic fat metabolism and gut microbiota","volume":"127","author":"Zhang","year":"2024","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"},{"key":"10.1016\/j.ejphar.2024.177173_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153270","article-title":"The water extract of Sophorae tonkinensis Radix et Rhizoma alleviates non-alcoholic fatty liver disease and its mechanism","volume":"77","author":"Zhao","year":"2020","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992400863X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992400863X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T17:07:11Z","timestamp":1735319231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429992400863X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":56,"alternative-id":["S001429992400863X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177173","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxymatrine relieves non-alcoholic fatty liver disease by promoting sirtuin 1\/adenosine 5\u2018-monophosphate-activated protein kinase pathway and peroxisome proliferator activated receptor alpha-mediated hepatic fatty acid oxidation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177173"}}