{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:11:08Z","timestamp":1772802668793,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.ejphar.2024.177216","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:28:45Z","timestamp":1734568125000},"page":"177216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Sodium valproate reverses aortic hypercontractility in acute myocardial infarction in rabbits"],"prefix":"10.1016","volume":"988","author":[{"given":"S.","family":"Guerra-Ojeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0932-7870","authenticated-orcid":false,"given":"A.","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Belmonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Marchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Genov\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.J.","family":"Arias-Mutis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6630-0493","authenticated-orcid":false,"given":"M.","family":"Aldasoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Vila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2968-3349","authenticated-orcid":false,"given":"E.","family":"Serna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7695-2898","authenticated-orcid":false,"given":"M.D.","family":"Mauricio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2024.177216_bib1","first-page":"91","article-title":"Update on angiotensin AT2 receptors","volume":"26","author":"Carey","year":"2017","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.ejphar.2024.177216_bib2","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1038\/ijo.2017.166","article-title":"Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDAC1\/angiotensin II axis","volume":"41","author":"Choi","year":"2017","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.ejphar.2024.177216_bib3","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1007\/s12272-020-01297-0","article-title":"Therapeutic effects of histone deacetylase inhibitors on heart disease","volume":"43","author":"Chun","year":"2020","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.ejphar.2024.177216_bib4","doi-asserted-by":"crossref","first-page":"858","DOI":"10.7150\/ijbs.67724","article-title":"Propionate alleviates myocardial ischemia-reperfusion injury aggravated by Angiotensin II dependent on caveolin-1\/ACE2 axis through GPR41","volume":"18","author":"Deng","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ejphar.2024.177216_bib5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1517\/14728222.8.3.191","article-title":"The endothelin system and its role in acute myocardial infarction","volume":"8","author":"Doggrell","year":"2004","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejphar.2024.177216_bib6","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1042\/CS20201099","article-title":"Renin-angiotensin system overactivation in perivascular adipose tissue contributes to vascular dysfunction in heart failure","volume":"134","author":"Fontes","year":"2020","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.ejphar.2024.177216_bib7","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of Physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2024.177216_bib8","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.3390\/ani10091576","article-title":"Development and long-term follow-up of an experimental model of myocardial infarction in rabbits","volume":"10","author":"Genov\u00e9s","year":"2020","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.ejphar.2024.177216_bib9","series-title":"Pharmacology of Neurotransmitter Release, Handbook of Experimental Pharmacology","first-page":"261","article-title":"Presynaptic metabotropic receptors for acetylcholine and adrenaline\/noradrenaline","author":"Gilsbach","year":"2008"},{"key":"10.1016\/j.ejphar.2024.177216_bib10","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/ejhf.1858","article-title":"Epidemiology of heart failure","volume":"22","author":"Groenewegen","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.ejphar.2024.177216_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176475","article-title":"Sodium valproate treatment reverses endothelial dysfunction in aorta from rabbits with acute myocardial infarction","volume":"970","author":"Guerra-Ojeda","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177216_bib12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0031-6997(24)01495-9","article-title":"Vascular adrenoceptors: an update","volume":"53","author":"Guimar\u00e3es","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2024.177216_bib13","doi-asserted-by":"crossref","DOI":"10.1177\/03000605231202573","article-title":"Mechanism of heart failure after myocardial infarction","volume":"51","author":"Jiang","year":"2023","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.ejphar.2024.177216_bib14","doi-asserted-by":"crossref","first-page":"727","DOI":"10.33549\/physiolres.934110","article-title":"Histone deacetylase inhibition has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy","volume":"68","author":"Jung","year":"2019","journal-title":"Physiol. Res."},{"key":"10.1016\/j.ejphar.2024.177216_bib15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.lfs.2014.01.060","article-title":"Ventricular tachyarrhythmias during acute myocardial infarction: the role of endothelin-1","volume":"118","author":"Kolettis","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2024.177216_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.healun.2019.07.007","article-title":"Endothelin-1, cardiac morphology, and heart failure: the MESA Angiogenesis Study","volume":"39","author":"Leary","year":"2020","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.ejphar.2024.177216_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117062","article-title":"Endothelin receptors in the brain modulate autonomic responses and arrhythmogenesis during acute myocardial infarction in rats","volume":"239","author":"Lekkas","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2024.177216_bib18","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.3906\/sag-1704-142","article-title":"Effects of valproic acid on sympathetic activity and left ventricularmyocardial remodelling in rats during pressure overload","volume":"47","author":"Liu","year":"2017","journal-title":"Turk. J. Med. Sci."},{"key":"10.1016\/j.ejphar.2024.177216_bib19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12906-016-1100-6","article-title":"Asiatic acid attenuates renin-angiotensin system activation and improves vascular function in high-carbohydrate, high-fat diet fed rats","volume":"16","author":"Maneesai","year":"2016","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.ejphar.2024.177216_bib20","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1113\/JP275611","article-title":"Chronic exercise impairs nitric oxide pathway in rabbit carotid and femoral arteries","volume":"596","author":"Marchio","year":"2018","journal-title":"J Physiol"},{"key":"10.1016\/j.ejphar.2024.177216_bib21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.amjhyper.2006.06.011","article-title":"Role of Ca2+-activated K+ channels on adrenergic responses of human saphenous vein","volume":"20","author":"Mauricio","year":"2007","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ejphar.2024.177216_bib22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00395-009-0066-7","article-title":"Endothelin-B receptors and ventricular arrhythmogenesis in the rat model of acute myocardial infarction","volume":"105","author":"Oikonomidis","year":"2010","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2024.177216_bib23","doi-asserted-by":"crossref","first-page":"R32","DOI":"10.1186\/cc12532","article-title":"Acute myocardial infarction is associated with endothelial glycocalyx and cell damage and a parallel increase in circulating catecholamines","volume":"17","author":"Ostrowski","year":"2013","journal-title":"Crit. Care"},{"key":"10.1016\/j.ejphar.2024.177216_bib24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.HYP.0000158262.11935.d0","article-title":"Endothelin, angiotensin, and oxidative stress in hypertension","volume":"45","author":"Pollock","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2024.177216_bib25","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1242\/jcs.03073","article-title":"Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes","volume":"119","author":"Proven","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejphar.2024.177216_bib26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10741-019-09855-5","article-title":"The renin-angiotensin-aldosterone system: a crossroad from arterial hypertension to heart failure","volume":"25","author":"Pugliese","year":"2020","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.ejphar.2024.177216_bib27","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3390\/antiox10060931","article-title":"Oxidative stress as A mechanism for functional alterations in cardiac hypertrophy and heart failure","volume":"10","author":"Shah","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejphar.2024.177216_bib28","first-page":"213","article-title":"Adrenergic mechanism in the control of endothelial function","volume":"1","author":"Sorriento","year":"2011","journal-title":"Transl Med UniSa"},{"key":"10.1016\/j.ejphar.2024.177216_bib29","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/FJC.0b013e31821325ad","article-title":"Contribution of nitric oxide in big endothelin-1-induced cardioprotective effects on ischemia\/reperfusion injury in rat hearts","volume":"57","author":"Tawa","year":"2011","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177216_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/789071","article-title":"Endothelin-1 and norepinephrine overflow from cardiac sympathetic nerve endings in myocardial ischemia","volume":"2012","author":"Tawa","year":"2012","journal-title":"Cardiol. Res. Pract."},{"key":"10.1016\/j.ejphar.2024.177216_bib31","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1016\/0002-9343(89)90496-8","article-title":"Alpha 2-adrenoceptors and endothelium-derived relaxing factor","volume":"87","author":"Vanhoutte","year":"1989","journal-title":"Am. J. Med."},{"key":"10.1016\/j.ejphar.2024.177216_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1070973","article-title":"Post-myocardial infarction fibrosis: pathophysiology, examination, and intervention","volume":"14","author":"Yin","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2024.177216_bib33","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3892\/ijmm.2014.1931","article-title":"Natakalim improves post-infarction left ventricular remodeling by restoring the coordinated balance between endothelial function and cardiac hypertrophy","volume":"34","author":"Zhou","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2024.177216_bib34","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3390\/cells10020381","article-title":"Angiotensin II and angiotensin receptors 1 and 2-multifunctional system in cells biology, what do we know?","volume":"10","author":"Ziaja","year":"2021","journal-title":"Cells"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924009063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299924009063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T10:15:18Z","timestamp":1742033718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299924009063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":34,"alternative-id":["S0014299924009063"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177216","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sodium valproate reverses aortic hypercontractility in acute myocardial infarction in rabbits","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2024.177216","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"177216"}}