{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:27:02Z","timestamp":1785209222403,"version":"3.55.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["2787076"],"award-info":[{"award-number":["2787076"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.ejphar.2025.177274","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T12:42:45Z","timestamp":1737463365000},"page":"177274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Memantine and amantadine KLVFF peptide conjugates: Synthesis, structure determination, amyloid-\u03b2 interaction and effects on recognition memory in mice"],"prefix":"10.1016","volume":"990","author":[{"given":"Eleonora","family":"Bocchieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Zimbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1729-3159","authenticated-orcid":false,"given":"Maria Laura","family":"Giuffrida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1241-3246","authenticated-orcid":false,"given":"Giuseppe","family":"Di Natale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-7517","authenticated-orcid":false,"given":"Giuseppina","family":"Sabatino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8305-081X","authenticated-orcid":false,"given":"Graziella","family":"Vecchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7328-3492","authenticated-orcid":false,"given":"Giuseppe","family":"Pappalardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4648-391X","authenticated-orcid":false,"given":"Santina","family":"Chiechio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.177274_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118020","article-title":"The role of CREB and BDNF in neurobiology and treatment of Alzheimer's disease","volume":"257","author":"Amidfar","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.177274_bib2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejphar.2018.03.023","article-title":"The role of memantine in the treatment of major depressive disorder: clinical efficacy and mechanisms of action","volume":"827","author":"Amidfar","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177274_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1517\/14728222.7.1.101","article-title":"CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects","volume":"7","author":"Barco","year":"2003","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.ejphar.2025.177274_bib4","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1038\/s41386-019-0430-8","article-title":"A randomized trial of an NMDA receptor antagonist for reversing corticosteroid effects on the human hippocampus","volume":"44","author":"Brown","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2025.177274_bib5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejphar.2008.05.014","article-title":"Memantine prevents the cognitive impairment induced by 3,4-methylenedioxymethamphetamine in rats","volume":"589","author":"Camarasa","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177274_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11356-021-16871-2","article-title":"Cyclodextrin applications in pharmacy, biology, medicine, and environment","volume":"29","author":"Crini","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ejphar.2025.177274_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109002","article-title":"Exogenous A\u03b21-42 monomers improve synaptic and cognitive function in Alzheimer's disease model mice","volume":"209","author":"Duan","year":"2022","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2025.177274_bib8","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1056\/NEJMoa1812840","article-title":"Randomized trial of verubecestat for prodromal Alzheimer's disease","volume":"380","author":"Egan","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2025.177274_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data","volume":"31","author":"Ennaceur","year":"1988","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2025.177274_bib10","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1523\/JNEUROSCI.0367-19.2019","article-title":"CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons","volume":"40","author":"Esvald","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2025.177274_bib11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jalz.2011.09.224","article-title":"Safety and biomarker effects of solanezumab in patients with Alzheimer's disease","volume":"8","author":"Farlow","year":"2012","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ejphar.2025.177274_bib12","doi-asserted-by":"crossref","first-page":"29525","DOI":"10.1074\/jbc.271.47.29525","article-title":"A strategy for designing inhibitors of beta-amyloid toxicity","volume":"271","author":"Ghanta","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2025.177274_bib13","doi-asserted-by":"crossref","first-page":"10582","DOI":"10.1523\/JNEUROSCI.1736-09.2009","article-title":"Beta-amyloid monomers are neuroprotective","volume":"29","author":"Giuffrida","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2025.177274_bib14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3389\/fncel.2015.00297","article-title":"Monomeric \u00df-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons","volume":"9","author":"Giuffrida","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ejphar.2025.177274_bib15","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13024-020-00391-7","article-title":"Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease","volume":"15","author":"Guo","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejphar.2025.177274_bib16","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/JCP.0000000000001115","article-title":"Adjunctive memantine treatment of schizophrenia: a double-blind, randomized placebo-controlled study","volume":"39","author":"Hassanpour","year":"2019","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2025.177274_bib17","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/0022-2836(92)90835-8","article-title":"Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides","volume":"228","author":"Hilbich","year":"1992","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejphar.2025.177274_bib18","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1056\/NEJMoa1705971","article-title":"Trial of solanezumab for mild dementia due to Alzheimer's disease","volume":"378","author":"Honig","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2025.177274_bib19","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s10495-009-0370-6","article-title":"An involvement of BDNF and PI3-K\/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons","volume":"14","author":"Jantas","year":"2009","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejphar.2025.177274_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101496","article-title":"Past, present and future of therapeutic strategies against amyloid-\u03b2 peptides in Alzheimer's disease: a systematic review","volume":"72","author":"Jeremic","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ejphar.2025.177274_bib21","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00894-021-04968-x","article-title":"Destabilization of the Alzheimer's amyloid-\u03b2 peptide by a proline-rich \u03b2-sheet breaker peptide: a molecular dynamics simulation study","volume":"27","author":"Kanchi","year":"2021","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.ejphar.2025.177274_bib22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1756-6606-5-14","article-title":"The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB","volume":"5","author":"Kandel","year":"2012","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ejphar.2025.177274_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2475","article-title":"Default mode network connectivity and treatment response in geriatric depression","volume":"12","author":"Kilpatrick","year":"2022","journal-title":"Brain Behav"},{"key":"10.1016\/j.ejphar.2025.177274_bib24","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3233\/JAD-170424","article-title":"Memantine for Alzheimer's disease: an updated systematic review and meta-analysis","volume":"60","author":"Kishi","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ejphar.2025.177274_bib25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.schres.2014.04.037","article-title":"Potential role of the combination of galantamine and memantine to improve cognition in schizophrenia","volume":"157","author":"Koola","year":"2014","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.ejphar.2025.177274_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2024.116172","article-title":"Tackling influenza A virus by M2 ion channel blockers: Latest progress and limitations","volume":"267","author":"Kumar","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.ejphar.2025.177274_bib27","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1073\/pnas.95.11.6448","article-title":"Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins","volume":"95","author":"Lambert","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2025.177274_bib28","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.yebeh.2018.06.047","article-title":"Does memantine improve memory in subjects with focal-onset epilepsy and memory dysfunction? A randomized, double-blind, placebo-controlled trial","volume":"88","author":"Leeman-Markowski","year":"2018","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.ejphar.2025.177274_bib29","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0378-4347(87)80440-1","article-title":"Reversed-phase high-performance liquid chromatographic-radioreceptor assay of human cerebrospinal fluid neuropeptides. Maximizing recovery of picomoles of peptides and minimizing memory","volume":"422","author":"Liu","year":"1987","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.ejphar.2025.177274_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176694","article-title":"Eicosanoid signaling in neuroinflammation associated with Alzheimer's disease","volume":"976","author":"Lohitaksha","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177274_bib31","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0896-6273(02)00828-0","article-title":"Function and regulation of CREB family transcription factors in the nervous system","volume":"35","author":"Lonze","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2025.177274_bib32","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/104012371803000307","article-title":"The use of memantine in neuropsychiatric disorders: an overview","volume":"30","author":"Lu","year":"2018","journal-title":"Ann. Clin. Psychiatry"},{"key":"10.1016\/j.ejphar.2025.177274_bib33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1006\/mcne.2001.1027","article-title":"The neuroprotective agent memantine induces brain-derived neurotrophic factor and trkB receptor expression in rat brain","volume":"18","author":"Marvanov\u00e1","year":"2001","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ejphar.2025.177274_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123289","article-title":"Memantine monotherapy for Alzheimer\u2019s disease: a systematic review and meta-analysis","volume":"10","author":"Matsunaga","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2025.177274_bib65","doi-asserted-by":"crossref","first-page":"12","DOI":"10.17116\/jnevro201911908112","article-title":"Different types of cognitive rehabilitation in patients with type 2 diabetes","volume":"119","author":"Matveeva","year":"2019","journal-title":"Zh. Nevrol. Psikhiatr. Im. S S Korsakova"},{"key":"10.1016\/j.ejphar.2025.177274_bib34","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.jcis.2022.01.051","article-title":"KLVFF oligopeptide-decorated amphiphilic cyclodextrin nanomagnets for selective amyloid beta recognition and fishing","volume":"613","author":"Mazzaglia","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ejphar.2025.177274_bib35","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.3390\/ijms23052857","article-title":"Novel design of neuropeptide-based drugs with \u03b2-sheet breaking potential in amyloid-beta cascade: molecular and structural deciphers","volume":"23","author":"Mocanu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177274_bib36","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.2174\/1386207325666220428112541","article-title":"NMDA inhibitors: a potential contrivance to assist in management of Alzheimer's disease","volume":"26","author":"Painuli","year":"2023","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.ejphar.2025.177274_bib37","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41582-018-0116-6","article-title":"A critical appraisal of amyloid-\u03b2-targeting therapies for Alzheimer disease","volume":"15","author":"Panza","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejphar.2025.177274_bib38","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.neuropharm.2007.07.013","article-title":"Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system\u2014too little activation is bad, too much is even worse","volume":"53","author":"Parsons","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2025.177274_bib39","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.1523\/JNEUROSCI.4540-10.2011","article-title":"Identification of cis-elements and transcription factors regulating neuronal activity-dependent transcription of human BDNF gene","volume":"31","author":"Pruunsild","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2025.177274_bib40","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1750-1326-6-60","article-title":"Downregulation of CREB expression in Alzheimer's brain and in A\u03b2-treated rat hippocampal neurons","volume":"6","author":"Pugazhenthi","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejphar.2025.177274_bib41","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S1474-4422(21)00249-0","article-title":"Amantadine in the treatment of Parkinson's disease and other movement disorders","volume":"20","author":"Rascol","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2025.177274_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113443","article-title":"Involvement of dopamine D2 and glutamate NMDA receptors in the antidepressant-like effect of amantadine in mice","volume":"413","author":"Raupp-Barcaro","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2025.177274_bib43","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1056\/NEJMoa013128","article-title":"Memantine in moderate-to-severe Alzheimer's disease","volume":"348","author":"Reisberg","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2025.177274_bib44","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.phrs.2010.02.009","article-title":"Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: a systematic review","volume":"61","author":"Repantis","year":"2010","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2025.177274_bib45","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1016\/j.neurobiolaging.2015.04.014","article-title":"CREB expression mediates amyloid \u03b2-induced basal BDNF downregulation","volume":"36","author":"Rosa","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2025.177274_bib46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/a-0970-9310","article-title":"Acute and long-term memantine add-on treatment to risperidone improves cognitive dysfunction in patients with acute and chronic schizophrenia","volume":"53","author":"Schaefer","year":"2020","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.ejphar.2025.177274_bib47","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1001\/jama.1969.03160070046011","article-title":"Amantadine in the treatment of Parkinson's disease","volume":"208","author":"Schwab","year":"1969","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2025.177274_bib48","doi-asserted-by":"crossref","first-page":"18295","DOI":"10.1074\/jbc.271.31.18295","article-title":"Amyloid beta-protein and the genetics of Alzheimer's disease","volume":"27","author":"Selkoe","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2025.177274_bib69","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ejphar.2025.177274_bib49","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2174\/1567205019666220120112301","article-title":"Comparative efficacy and Acceptability of cholinesterase inhibitors and memantine based on dosage in patients with Vascular cognitive impairment: a network meta-analysis","volume":"19","author":"Shi","year":"2022","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.ejphar.2025.177274_bib50","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/35086072","article-title":"Alzheimer's disease and Abeta toxicity: from top to bottom","volume":"2","author":"Small","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2025.177274_bib51","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1089\/cap.2021.0010","article-title":"Neurocognitive outcomes from memantine: a pilot, double-blind, placebo-controlled trial in children with autism spectrum disorder","volume":"31","author":"Soorya","year":"2021","journal-title":"J. Child Adolesc. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2025.177274_bib52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-2999(94)90023-X","article-title":"Memantine-induced dopamine release in the prefrontal cortex and striatum of the rat\u2014a pharmacokinetic microdialysis study","volume":"262","author":"Spanagel","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177274_bib53","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/jemt.20190","article-title":"Structure and morphology of the Alzheimer's amyloid fibril","volume":"67","author":"Stromer","year":"2005","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.ejphar.2025.177274_bib54","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1001\/jama.291.3.317","article-title":"Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial","volume":"291","author":"Tariot","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2025.177274_bib55","doi-asserted-by":"crossref","first-page":"8545","DOI":"10.1074\/jbc.271.15.8545","article-title":"Arrest of beta-amyloid fibril formation by a pentapeptide ligand","volume":"271","author":"Tjernberg","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2025.177274_bib56","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.3390\/ijms21165858","article-title":"Revisiting the amyloid cascade hypothesis: from anti-A\u03b2 therapeutics to Auspicious new ways for Alzheimer's disease","volume":"21","author":"Uddin","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177274_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112432","article-title":"Amantadine exerts anxiolytic-like effect in mice: evidences for the involvement of nitrergic and GABAergic signaling pathways","volume":"380","author":"Walia","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2025.177274_bib58","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1471-4159.2006.04426.x","article-title":"A beta oligomers - a decade of discovery","volume":"101","author":"Walsh","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2025.177274_bib59","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1089\/neu.2013.2917","article-title":"Amantadine improves cognitive outcome and increases neuronal survival after fluid percussion traumatic brain injury in rats","volume":"31","author":"Wang","year":"2014","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.ejphar.2025.177274_bib60","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/gps.4109","article-title":"Memantine improves attention and episodic memory in Parkinson's disease dementia and dementia with Lewy bodies","volume":"30","author":"Wesnes","year":"2015","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.ejphar.2025.177274_bib61","article-title":"Memantine improves Attentional processes in fragile X-associated Tremor\/Ataxia Syndrome: Electrophysiological evidence from a randomized controlled trial","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.177274_bib62","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/1756285612461679","article-title":"Current and future treatments for Alzheimer's disease","volume":"6","author":"Yiannopoulou","year":"2013","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"10.1016\/j.ejphar.2025.177274_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.605330","article-title":"Amantadine Alleviates Postoperative cognitive dysfunction possibly by preserving neurotrophic factor expression and Dendritic Arborization in the Hippocampus of Old rodents","volume":"12","author":"Zhong","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ejphar.2025.177274_bib64","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jinorgbio.2016.07.011","article-title":"Effective cleavage of phosphodiester promoted by the zinc(II) and copper(II) inclusion complexes of \u03b2-cyclodextrin","volume":"163","author":"Zhou","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.ejphar.2025.177274_bib67","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.pbb.2006.08.011","article-title":"Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane","volume":"85","author":"Zoladz","year":"2006","journal-title":"Pharmacol. Biochem. Behav."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925000275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925000275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:08:12Z","timestamp":1778623692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925000275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":68,"alternative-id":["S0014299925000275"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177274","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Memantine and amantadine KLVFF peptide conjugates: Synthesis, structure determination, amyloid-\u03b2 interaction and effects on recognition memory in mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177274","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"177274"}}