{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:30:38Z","timestamp":1787614238325,"version":"build-2736575974"},"reference-count":131,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"am","delay-in-days":321,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000057","name":"NIH National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM121334"],"award-info":[{"award-number":["P20GM121334"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007688","name":"American University of Beirut","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016263","name":"American University of Beirut University Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019603","name":"Faculty of Medicine, American University of Beirut","doi-asserted-by":"publisher","award":["MPP \\u2013 320145"],"award-info":[{"award-number":["MPP \\u2013 320145"]}],"id":[{"id":"10.13039\/100019603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019603","name":"Faculty of Medicine, American University of Beirut","doi-asserted-by":"publisher","award":["URB \\u2013 104524"],"award-info":[{"award-number":["URB \\u2013 104524"]}],"id":[{"id":"10.13039\/100019603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019603","name":"Faculty of Medicine, American University of Beirut","doi-asserted-by":"publisher","award":["URB \\u2013 104115"],"award-info":[{"award-number":["URB \\u2013 104115"]}],"id":[{"id":"10.13039\/100019603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019603","name":"Faculty of Medicine, American University of Beirut","doi-asserted-by":"publisher","award":["URB \\u2013 104262"],"award-info":[{"award-number":["URB \\u2013 104262"]}],"id":[{"id":"10.13039\/100019603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019603","name":"Faculty of Medicine, American University of Beirut","doi-asserted-by":"publisher","award":["URB \\u2013 103949"],"award-info":[{"award-number":["URB \\u2013 103949"]}],"id":[{"id":"10.13039\/100019603","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ejphar.2025.177356","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T19:34:08Z","timestamp":1738870448000},"page":"177356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Hepatokines and their role in cardiohepatic interactions in heart failure"],"prefix":"10.1016","volume":"992","author":[{"given":"Wael A.","family":"Shouman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Najmeddine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilas","family":"Sinno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Dib Nehme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Ghawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna A.","family":"Ziade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Altara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghadir","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W.","family":"Booz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4451-804X","authenticated-orcid":false,"given":"Fouad A.","family":"Zouein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.177356_bib1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/0968-0004(90)90037-C","article-title":"An intriguing member of the lipocalin protein family: alpha 1-microglobulin","volume":"15","author":"Akerstr\u00f6m","year":"1990","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejphar.2025.177356_bib2","doi-asserted-by":"crossref","first-page":"8318","DOI":"10.3390\/ijms23158318","article-title":"Adropin's role in energy homeostasis and metabolic disorders","volume":"23","author":"Ali","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177356_bib3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.31083\/j.rcm2303091","article-title":"Cardiovascular events after liver transplantation: MACE hurts","volume":"23","author":"Altieri","year":"2022","journal-title":"Rev. Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2025.177356_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11010-013-1660-4","article-title":"Expression of adropin in rat brain, cerebellum, kidneys, heart, liver, and pancreas in streptozotocin-induced diabetes","volume":"380","author":"Aydin","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2025.177356_bib5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11906-023-01242-8","article-title":"Mechanisms linking metabolic-associated fatty liver disease (MAFLD) to cardiovascular disease","volume":"25","author":"Badmus","year":"2023","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.ejphar.2025.177356_bib6","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1111\/bph.14383","article-title":"A long-acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non-alcoholic steatohepatitis partly through an FGF21-adiponectin-IL17A pathway","volume":"175","author":"Bao","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177356_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/metabo13060757","article-title":"Metabolic-associated fatty liver disease and insulin resistance: a review of complex interlinks","volume":"13","author":"Barber","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.ejphar.2025.177356_bib8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2025.177356_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12020516","article-title":"Cardiac hepatopathy: new perspectives on old problems through a prism of endogenous metabolic regulations by hepatokines","volume":"12","author":"Berezin","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejphar.2025.177356_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11020457","article-title":"The impact of SGLT2 inhibitor dapagliflozin on adropin serum levels in men and women with type 2 diabetes mellitus and chronic heart failure","volume":"11","author":"Berezin","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2025.177356_bib11","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.3390\/diagnostics14161728","article-title":"Adropin predicts asymptomatic heart failure in patients with type 2 diabetes mellitus independent of the levels of natriuretic peptides","volume":"14","author":"Berezina","year":"2024","journal-title":"Diagnostics"},{"key":"10.1016\/j.ejphar.2025.177356_bib12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/hep.510270106","article-title":"Q-T interval prolongation in cirrhosis: prevalence, relationship with severity, and etiology of the disease and possible pathogenetic factors","volume":"27","author":"Bernardi","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2025.177356_bib13","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.2169\/internalmedicine.46.0059","article-title":"Hypoxic hepatopathy: pathophysiology and prognosis","volume":"46","author":"Birrer","year":"2007","journal-title":"Intern. Med."},{"key":"10.1016\/j.ejphar.2025.177356_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9101407","article-title":"Role of adropin in cardiometabolic disorders: from pathophysiological mechanisms to therapeutic target","volume":"9","author":"Bozic","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2025.177356_bib15","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3181\/00379727-143-37399","article-title":"Effect of dietary selenium level on Se binding to rat plasma proteins","volume":"143","author":"Burk","year":"1973","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.ejphar.2025.177356_bib16","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1126\/science.abn0910","article-title":"Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure","volume":"377","author":"Cao","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2025.177356_bib17","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s12072-014-9531-y","article-title":"Cirrhotic cardiomyopathy: review of pathophysiology and treatment","volume":"8","author":"Chayanupatkul","year":"2014","journal-title":"Hepatol Int"},{"key":"10.1016\/j.ejphar.2025.177356_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.945287","article-title":"The structure, biosynthesis, and biological roles of fetuin-A: a review","volume":"10","author":"Chekol Abebe","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2025.177356_bib19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bbrc.2020.06.093","article-title":"Trimethylamine N-oxide impairs perfusion recovery after hindlimb ischemia","volume":"530","author":"Chen","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2025.177356_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.362","article-title":"Adropin deficiency worsens HFD-induced metabolic defects","volume":"8","author":"Chen","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2025.177356_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101068","article-title":"Adropin protects against liver injury in nonalcoholic steatohepatitis via the Nrf2 mediated antioxidant capacity","volume":"21","author":"Chen","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2025.177356_bib22","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/S0002-9149(03)00370-9","article-title":"Liver dysfunction and heart failure","volume":"91","author":"Cogger","year":"2003","journal-title":"Am. J. Cardiol."},{"issue":"Pt 2","key":"10.1016\/j.ejphar.2025.177356_bib23","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1042\/bj2920485","article-title":"Human inter-alpha-inhibitor family in inflammation: simultaneous synthesis of positive and negative acute-phase proteins","volume":"292","author":"Daveau","year":"1993","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2025.177356_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052639","article-title":"Adipokines, myokines, and hepatokines: crosstalk and metabolic repercussions","volume":"22","author":"de Oliveira Dos Santos","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177356_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/bj20030676","article-title":"Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A","volume":"376","author":"Denecke","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2025.177356_bib26","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s10741-022-10282-2","article-title":"Right ventricular failure in left heart disease: from pathophysiology to clinical manifestations and prognosis","volume":"28","author":"Dini","year":"2023","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.ejphar.2025.177356_bib27","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/TP.0b013e31825f0f97","article-title":"Diastolic dysfunction in patients with end-stage liver disease is associated with development of heart failure early after liver transplantation","volume":"94","author":"Dowsley","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.ejphar.2025.177356_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jchf.2015.09.015","article-title":"Assessing the risk of progression from asymptomatic left ventricular dysfunction to overt heart failure: a systematic overview and meta-analysis","volume":"4","author":"Echouffo-Tcheugui","year":"2016","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.ejphar.2025.177356_bib29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12933-018-0728-6","article-title":"Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007-2017","volume":"17","author":"Einarson","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.ejphar.2025.177356_bib30","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1016\/S0021-9258(17)40934-3","article-title":"Human alpha1-microglobulin. Purification procedure, chemical and physiochemical properties","volume":"252","author":"Ekstr\u00f6m","year":"1977","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2025.177356_bib31","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0006-291X(75)80388-3","article-title":"A urinary and plasma alpha1-glycoprotein of low molecular weight: isolation and some properties","volume":"65","author":"Ekstr\u00f6m","year":"1975","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2025.177356_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/cells9030567","article-title":"Relationship between heart disease and liver disease: a two-way street","volume":"9","author":"El Hadi","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2025.177356_bib33","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1136\/heartjnl-2021-320131","article-title":"Prevalence, incidence and survival of heart failure: a systematic review","volume":"108","author":"Emmons-Bell","year":"2022","journal-title":"Heart"},{"key":"10.1016\/j.ejphar.2025.177356_bib34","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1111\/bph.12475","article-title":"Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy","volume":"171","author":"Fillmore","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177356_bib35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-physiol-021115-105339","article-title":"Understanding the physiology of FGF21","volume":"78","author":"Fisher","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2025.177356_bib36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/molehr\/gaw068","article-title":"Down-regulation of the liver-derived plasma protein fetuin-B mediates reversible female infertility","volume":"23","author":"Floehr","year":"2017","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.ejphar.2025.177356_bib37","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/ajcn\/84.4.762","article-title":"Selenium and coronary heart disease: a meta-analysis","volume":"84","author":"Flores-Mateo","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ejphar.2025.177356_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21249420","article-title":"Congestive hepatopathy","volume":"21","author":"Fortea","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177356_bib39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4254\/wjh.v6.i1.41","article-title":"Hepato-cardiac disorders","volume":"6","author":"Fouad","year":"2014","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.ejphar.2025.177356_bib40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1741-7015-11-117","article-title":"Immunity, atherosclerosis and cardiovascular disease","volume":"11","author":"Frosteg\u00e5rd","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.ejphar.2025.177356_bib41","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/oby.2012.31","article-title":"Adropin deficiency is associated with increased adiposity and insulin resistance","volume":"20","author":"Ganesh Kumar","year":"2012","journal-title":"Obesity"},{"key":"10.1016\/j.ejphar.2025.177356_bib42","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.2337\/db14-0388","article-title":"Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin","volume":"63","author":"Gao","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.ejphar.2025.177356_bib43","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.molmet.2015.01.005","article-title":"Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance","volume":"4","author":"Gao","year":"2015","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.ejphar.2025.177356_bib44","doi-asserted-by":"crossref","DOI":"10.1530\/EC-23-0172","article-title":"Evaluation of the correlation between Fetuin-B levels and essential hypertension: a cross-sectional study","volume":"12","author":"Gao","year":"2023","journal-title":"Endocrine Connections"},{"key":"10.1016\/j.ejphar.2025.177356_bib45","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/ncpgasthep0498","article-title":"Therapy insight: cirrhotic cardiomyopathy","volume":"3","author":"Gaskari","year":"2006","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2025.177356_bib46","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S1089-3261(02)00056-9","article-title":"The liver in heart failure","volume":"6","author":"Giallourakis","year":"2002","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.ejphar.2025.177356_bib47","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1007\/s11695-019-03998-y","article-title":"Serum irisin, adropin, and preptin in obese patients 6 Months after bariatric surgery","volume":"29","author":"Gl\u00fcck","year":"2019","journal-title":"Obes. Surg."},{"key":"10.1016\/j.ejphar.2025.177356_bib48","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.jpeds.2013.05.040","article-title":"Circulating adropin concentrations in pediatric obstructive sleep apnea: potential relevance to endothelial function","volume":"163","author":"Gozal","year":"2013","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ejphar.2025.177356_bib49","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jplph.2005.12.007","article-title":"Lipocalins - a family portrait","volume":"163","author":"Grzyb","year":"2006","journal-title":"J. Plant Physiol."},{"key":"10.1016\/j.ejphar.2025.177356_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-35194-w","article-title":"Hepatokine \u03b11-microglobulin signaling exacerbates inflammation and disturbs fibrotic repair in mouse myocardial infarction","volume":"8","author":"Hakuno","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.177356_bib51","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1073\/pnas.90.2.537","article-title":"Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA","volume":"90","author":"Hill","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2025.177356_bib52","doi-asserted-by":"crossref","DOI":"10.15412\/J.JBTW.01050301","article-title":"Elevated serum levels of adropin in patients with type 2 diabetes mellitus and its association with insulin resistance","volume":"5","author":"Hosseini","year":"2016","journal-title":"Journal of Biology and Today's World"},{"key":"10.1016\/j.ejphar.2025.177356_bib53","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1113\/expphysiol.2007.040055","article-title":"Long-term effects of type 2 diabetes mellitus on heart rhythm in the Goto-Kakizaki rat","volume":"93","author":"Howarth","year":"2008","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.ejphar.2025.177356_bib54","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3390\/molecules25030549","article-title":"Adropin as A Fat-Burning hormone with multiple functions\u2014review of a decade of research","volume":"25","author":"Jasaszwili","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2025.177356_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101138","article-title":"Hepatokines and metabolism: deciphering communication from the liver","volume":"44","author":"Jensen-Cody","year":"2021","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.ejphar.2025.177356_bib56","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.jacc.2019.06.023","article-title":"Selenoprotein P deficiency and risk of mortality and rehospitalization in acute heart failure","volume":"74","author":"Juji\u0107","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2025.177356_bib57","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.freeradbiomed.2023.07.007","article-title":"Selenoprotein P deficiency is associated with higher risk of incident heart failure","volume":"207","author":"Jujic","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2025.177356_bib58","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00424-020-02385-2","article-title":"Fetuin-B regulates vascular plaque rupture via TGF-\u03b2 receptor-mediated Smad pathway in vascular smooth muscle cells","volume":"472","author":"Jung","year":"2020","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.ejphar.2025.177356_bib59","first-page":"39","article-title":"Adropin and irisin in patients with cardiac cachexia","volume":"111","author":"Kalkan","year":"2018","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.ejphar.2025.177356_bib60","doi-asserted-by":"crossref","first-page":"7839","DOI":"10.1093\/nar\/14.20.7839","article-title":"The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin (protein HC)","volume":"14","author":"Kaumeyer","year":"1986","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2025.177356_bib61","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/AC.69.4.3036656","article-title":"Serum fetuin-A levels in patients with systolic heart failure","volume":"69","author":"Ke\u00e7eba\u015f","year":"2014","journal-title":"Acta Cardiol."},{"key":"10.1016\/j.ejphar.2025.177356_bib62","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1161\/CIRCULATIONAHA.105.563213","article-title":"Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms","volume":"113","author":"Kim","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2025.177356_bib63","doi-asserted-by":"crossref","first-page":"416","DOI":"10.4097\/kjae.2014.67.6.416","article-title":"Ventricular arrhythmia in patients with prolonged QT interval during liver transplantation: two cases report","volume":"67","author":"Kim","year":"2014","journal-title":"Korean J Anesthesiol"},{"key":"10.1016\/j.ejphar.2025.177356_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9121903","article-title":"Hepatokines and non-alcoholic fatty liver disease: linking liver pathophysiology to metabolism","volume":"9","author":"Kim","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2025.177356_bib65","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.gtc.2017.01.012","article-title":"Heart disease and the liver: pathologic evaluation","volume":"46","author":"Koehne de Gonzalez","year":"2017","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"10.1016\/j.ejphar.2025.177356_bib66","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1089\/ars.2018.7517","article-title":"Protection of kidney function with human antioxidation protein \u03b1(1)-microglobulin in a mouse (177)Lu-dotatate radiation therapy model","volume":"30","author":"Kristiansson","year":"2019","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2025.177356_bib67","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.cmet.2008.10.011","article-title":"Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism","volume":"8","author":"Kumar","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejphar.2025.177356_bib68","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.2147\/DMSO.S243755","article-title":"Promotion of adropin expression by hyperglycemia is associated with STAT3 activation in diabetic rats","volume":"13","author":"Kuo","year":"2020","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.ejphar.2025.177356_bib69","doi-asserted-by":"crossref","first-page":"85","DOI":"10.4097\/kjae.2018.71.2.85","article-title":"Cardiovascular dysfunction and liver transplantation","volume":"71","author":"Kwon","year":"2018","journal-title":"Korean J Anesthesiol"},{"key":"10.1016\/j.ejphar.2025.177356_bib70","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.transproceed.2017.03.043","article-title":"Pretransplant resting heart rate and its association with all-cause mortality in liver transplant recipients","volume":"49","author":"Kwon","year":"2017","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.ejphar.2025.177356_bib71","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: molecular pathways and physiological roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2025.177356_bib72","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s11897-014-0206-8","article-title":"Cardiohepatic syndrome: liver injury in decompensated heart failure","volume":"11","author":"Laribi","year":"2014","journal-title":"Curr. Heart Fail. Rep."},{"key":"10.1016\/j.ejphar.2025.177356_bib73","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cca.2015.12.010","article-title":"A novel peptide adropin in cardiovascular diseases","volume":"453","author":"Li","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.ejphar.2025.177356_bib74","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1530\/JME-15-0207","article-title":"Adropin induction of lipoprotein lipase expression in tilapia hepatocytes","volume":"56","author":"Lian","year":"2016","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ejphar.2025.177356_bib75","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.2169\/internalmedicine.50.5163","article-title":"Elevated plasma levels of adropin in heart failure patients","volume":"50","author":"Lian","year":"2011","journal-title":"Intern. Med."},{"key":"10.1016\/j.ejphar.2025.177356_bib76","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1161\/CIRCULATIONAHA.115.015308","article-title":"Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice","volume":"131","author":"Lin","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2025.177356_bib77","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.cmet.2013.04.005","article-title":"Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice","volume":"17","author":"Lin","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejphar.2025.177356_bib78","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0167-4781(92)90462-9","article-title":"Rat alpha 1-microglobulin: co-expression in liver with the light chain of inter-alpha-trypsin inhibitor","volume":"1130","author":"Lindqvist","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2025.177356_bib79","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1038\/srep02767","article-title":"Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue","volume":"3","author":"Liu","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.177356_bib80","first-page":"1246","article-title":"Emerging evidence linking the liver to the cardiovascular system: liver-derived secretory factors","volume":"11","author":"Liu","year":"2023","journal-title":"J Clin Transl Hepatol"},{"key":"10.1016\/j.ejphar.2025.177356_bib81","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1161\/CIRCULATIONAHA.109.931782","article-title":"Adropin is a novel regulator of endothelial function","volume":"122","author":"Lovren","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2025.177356_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2021.119166","article-title":"An update on factor XII-driven vascular inflammation","volume":"1869","author":"Mailer","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.ejphar.2025.177356_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1997.00001.x","article-title":"The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis","volume":"244","author":"McGarry","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ejphar.2025.177356_bib84","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrendo.2017.56","article-title":"Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance","volume":"13","author":"Meex","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.ejphar.2025.177356_bib85","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/BJ20120448","article-title":"The crystal structure of human \u03b1(1)-microglobulin reveals a potential haem-binding site","volume":"445","author":"Meining","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2025.177356_bib86","doi-asserted-by":"crossref","first-page":"90","DOI":"10.5334\/gh.1177","article-title":"Total bilirubin level is associated with the risk of left atrial appendage thrombosis in patients with non-valvular atrial fibrillation","volume":"17","author":"Meng","year":"2022","journal-title":"Glob Heart"},{"key":"10.1016\/j.ejphar.2025.177356_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2022.101199","article-title":"Association of non-alcoholic fatty liver disease with in-hospital outcomes in primary heart failure hospitalizations with reduced or preserved ejection fraction","volume":"48","author":"Minhas","year":"2023","journal-title":"Curr. Probl. Cardiol."},{"key":"10.1016\/j.ejphar.2025.177356_bib88","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1093\/eurheartj\/eht246","article-title":"Interactions of the heart and the liver","volume":"34","author":"M\u00f8ller","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ejphar.2025.177356_bib89","first-page":"44","article-title":"Cardiovascular complications of cirrhosis","volume":"85","author":"M\u00f8ller","year":"2009","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.ejphar.2025.177356_bib90","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jhep.2010.02.023","article-title":"Cirrhotic cardiomyopathy","volume":"53","author":"M\u00f8ller","year":"2010","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejphar.2025.177356_bib91","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2174\/187221411799015372","article-title":"Fetuin-A: a multifunctional protein","volume":"5","author":"Mori","year":"2011","journal-title":"Recent Pat. Endocr. Metab. Immune Drug Discov."},{"key":"10.1016\/j.ejphar.2025.177356_bib92","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0304-4165(82)90318-X","article-title":"A selenocysteine-containing selenium-transport protein in rat plasma","volume":"719","author":"Motsenbocker","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2025.177356_bib93","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1053\/jhep.2003.50062","article-title":"Cardiac hepatopathy: clinical, hemodynamic, and histologic characteristics and correlations","volume":"37","author":"Myers","year":"2003","journal-title":"Hepatology"},{"issue":"Pt 2","key":"10.1016\/j.ejphar.2025.177356_bib94","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1042\/bj3500589","article-title":"Fetuin-B, a second member of the fetuin family in mammals","volume":"350","author":"Olivier","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2025.177356_bib95","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.freeradbiomed.2009.10.052","article-title":"Increased levels of cell-free hemoglobin, oxidation markers, and the antioxidative heme scavenger alpha(1)-microglobulin in preeclampsia","volume":"48","author":"Olsson","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2025.177356_bib96","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/nm.2851","article-title":"Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance","volume":"18","author":"Pal","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2025.177356_bib97","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.cmet.2018.04.002","article-title":"FGF21 prevents angiotensin II-induced hypertension and vascular dysfunction by activation of ACE2\/angiotensin-(1-7) Axis in mice","volume":"27","author":"Pan","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejphar.2025.177356_bib98","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF00262020","article-title":"Effect of insulin on growth of cultured human arterial smooth muscle cells","volume":"20","author":"Pfeifle","year":"1981","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2025.177356_bib99","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fendo.2015.00133","article-title":"FGF21 and cardiac physiopathology","volume":"6","author":"Planavila","year":"2015","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ejphar.2025.177356_bib100","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6128410","article-title":"Assessment of serum concentrations of adropin, afamin, and neudesin in children with type 1 diabetes","volume":"2019","author":"Polkowska","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejphar.2025.177356_bib101","doi-asserted-by":"crossref","first-page":"e984","DOI":"10.1161\/CIR.0000000000000973","article-title":"Obesity and cardiovascular disease: a scientific statement from the American heart association","volume":"143","author":"Powell-Wiley","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2025.177356_bib102","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.medcli.2020.06.061","article-title":"Alpha-1-microglobulin: prognostic value in chronic kidney disease","volume":"157","author":"Robles","year":"2021","journal-title":"Med. Clin."},{"key":"10.1016\/j.ejphar.2025.177356_bib103","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1053\/gast.1997.v113.pm9247479","article-title":"Paracentesis-induced circulatory dysfunction: mechanism and effect on hepatic hemodynamics in cirrhosis","volume":"113","author":"Ruiz-del-Arbol","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2025.177356_bib104","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1042\/BJ20040328","article-title":"Domain structure of bi-functional selenoprotein P","volume":"381","author":"Saito","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2025.177356_bib105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19051293","article-title":"Adropin contributes to anti-atherosclerosis by suppressing monocyte-endothelial cell adhesion and smooth muscle cell proliferation","volume":"19","author":"Sato","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177356_bib106","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1136\/hrt.13.3.273","article-title":"The liver in heart failure; relation of anatomical, functional, and circulatory changes","volume":"13","author":"Sherlock","year":"1951","journal-title":"Br. Heart J."},{"key":"10.1016\/j.ejphar.2025.177356_bib107","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00011-010-0205-5","article-title":"Anti-inflammatory actions of serine protease inhibitors containing the Kunitz domain","volume":"59","author":"Shigetomi","year":"2010","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.ejphar.2025.177356_bib108","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910713","article-title":"The impact of selenium deficiency on cardiovascular function","volume":"22","author":"Shimada","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177356_bib109","article-title":"Type 2 diabetes and causes of sudden cardiac death: a systematic review","volume":"13","author":"Singh","year":"2021","journal-title":"Cureus"},{"key":"10.1016\/j.ejphar.2025.177356_bib110","doi-asserted-by":"crossref","first-page":"4779","DOI":"10.3748\/wjg.v25.i32.4779","article-title":"Liver cirrhosis and left ventricle diastolic dysfunction: systematic review","volume":"25","author":"Stundiene","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2025.177356_bib111","doi-asserted-by":"crossref","first-page":"41254","DOI":"10.1074\/jbc.M202773200","article-title":"A comparative study on the hydroperoxide and thiol specificity of the glutathione peroxidase family and selenoprotein P","volume":"277","author":"Takebe","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2025.177356_bib112","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.024901","article-title":"Increases in hepatokine selenoprotein P levels are associated with hepatic hypoperfusion and predict adverse prognosis in patients with heart failure","volume":"11","author":"Takeishi","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ejphar.2025.177356_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabet.2020.101215","article-title":"NAFLD, and cardiovascular and cardiac diseases: factors influencing risk, prediction and treatment","volume":"47","author":"Targher","year":"2021","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.ejphar.2025.177356_bib114","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1007\/s00392-022-02023-0","article-title":"Decreases in hepatokine Fetuin-A levels are associated with hepatic hypoperfusion and predict cardiac outcomes in patients with heart failure","volume":"111","author":"Tomita","year":"2022","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.ejphar.2025.177356_bib115","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.2310\/JIM.0000000000000003","article-title":"Plasma adropin levels predict endothelial dysfunction like flow-mediated dilatation in patients with type 2 diabetes mellitus","volume":"61","author":"Topuz","year":"2013","journal-title":"J. Invest. Med."},{"key":"10.1016\/j.ejphar.2025.177356_bib116","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1248\/bpb.b19-00837","article-title":"Selenoprotein P; P for plasma, prognosis, prophylaxis, and more","volume":"43","author":"Tsutsumi","year":"2020","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2025.177356_bib117","doi-asserted-by":"crossref","first-page":"429","DOI":"10.5507\/bp.2014.014","article-title":"Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure","volume":"159","author":"Vyskocilova","year":"2015","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1016\/j.ejphar.2025.177356_bib118","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s40001-022-00876-9","article-title":"Prognostic potential of liver injury in patients with dilated cardiomyopathy: a retrospective study","volume":"27","author":"Wang","year":"2022","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.ejphar.2025.177356_bib119","first-page":"1232","article-title":"Role of thrombosis in the pathogenesis of congestive hepatic fibrosis (cardiac cirrhosis)","volume":"21","author":"Wanless","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2025.177356_bib120","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1210\/er.2019-00034","article-title":"The liver as an endocrine organ-linking NAFLD and insulin resistance","volume":"40","author":"Watt","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2025.177356_bib121","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1097\/MCG.0000000000000323","article-title":"High rate of cardiac abnormalities in a postmortem analysis of patients suffering from liver cirrhosis","volume":"49","author":"Wehmeyer","year":"2015","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.ejphar.2025.177356_bib122","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nrgastro.2013.210","article-title":"Cirrhotic cardiomyopathy: pathogenesis and clinical relevance","volume":"11","author":"Wiese","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2025.177356_bib123","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.yjmcc.2020.03.002","article-title":"Upregulated hepatokine fetuin B aggravates myocardial ischemia\/reperfusion injury through inhibiting insulin signaling in diabetic mice","volume":"151","author":"Xing","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2025.177356_bib124","article-title":"Regulatory network and interplay of hepatokines, stellakines, myokines and adipokines in nonalcoholic fatty liver diseases and nonalcoholic steatohepatitis","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ejphar.2025.177356_bib125","article-title":"Fibroblast growth factor 21 in metabolic syndrome","volume":"14","author":"Yang","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ejphar.2025.177356_bib126","first-page":"1568","article-title":"Adropin- A novel biomarker of heart disease: a systematic review article","volume":"45","author":"Yosaee","year":"2016","journal-title":"Iran. J. Public Health"},{"key":"10.1016\/j.ejphar.2025.177356_bib127","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1507\/endocrj.EJ18-0060","article-title":"Serum adropin levels are decreased in Chinese type 2 diabetic patients and negatively correlated with body mass index","volume":"65","author":"Zang","year":"2018","journal-title":"Endocr. J."},{"key":"10.1016\/j.ejphar.2025.177356_bib128","article-title":"Hepatocardiac or cardiohepatic interaction: from traditional Chinese medicine to western medicine","volume":"2021","author":"Zhang","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.ejphar.2025.177356_bib129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21037\/cdt.2018.07.09","article-title":"Association between serum adropin level and coronary artery disease: a systematic review and meta-analysis","volume":"9","author":"Zheng","year":"2019","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"10.1016\/j.ejphar.2025.177356_bib130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12020-017-1387-1","article-title":"Increased serum levels of fetuin B in patients with coronary artery disease","volume":"58","author":"Zhu","year":"2017","journal-title":"Endocrine"},{"key":"10.1016\/j.ejphar.2025.177356_bib131","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s11596-019-2025-3","article-title":"Efficacy of long-term selenium supplementation in the treatment of chronic keshan disease with congestive heart failure","volume":"39","author":"Zhu","year":"2019","journal-title":"Curr Med Sci"}],"updated-by":[{"DOI":"10.1016\/j.ejphar.2026.178712","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000}},{"DOI":"10.1016\/j.ejphar.2026.178712","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T00:00:00Z","timestamp":1773532800000}}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925001098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925001098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:59:27Z","timestamp":1777402767000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925001098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":131,"alternative-id":["S0014299925001098"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177356","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatokines and their role in cardiohepatic interactions in heart failure","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177356","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177356"}}