{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:36:02Z","timestamp":1789601762388,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000138","name":"U.S. Department of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000138","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007421","name":"Li Ka Shing Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ejphar.2025.177476","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T11:31:36Z","timestamp":1741260696000},"page":"177476","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["L1CAM mimetic compound duloxetine improves cognitive impairment in 5xFAD mice and protects A\u03b21-42-damaged HT22\u00a0cells"],"prefix":"10.1016","volume":"997","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3124-668X","authenticated-orcid":false,"given":"Hanyu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1435-5457","authenticated-orcid":false,"given":"Stanley Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melitta","family":"Schachner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.177476_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbi.2016.12.018","article-title":"L1 retrotransposition alters the hippocampal genomic landscape enabling memory formation","volume":"64","author":"Bachiller","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2025.177476_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive review on Alzheimer's disease: causes and treatment","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2025.177476_bib3","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2174\/1381612053764805","article-title":"The dual transporter inhibitor duloxetine: a review of its preclinical pharmacology, pharmacokinetic profile, and clinical results in depression","volume":"11","author":"Bymaster","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejphar.2025.177476_bib4","first-page":"393","article-title":"Duloxetine attenuated morphine withdrawal syndrome in the rat","volume":"64","author":"Charkhpour","year":"2014","journal-title":"Drug Res."},{"key":"10.1016\/j.ejphar.2025.177476_bib5","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/cdd.2008.94","article-title":"Abeta40 promotes neuronal cell fate in neural progenitor cells","volume":"16","author":"Chen","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2025.177476_bib6","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.3233\/JAD-221058","article-title":"Inhibition of mGluR5\/PI3K-AKT pathway alleviates Alzheimer's disease-like pathology through the activation of autophagy in 5XFAD mice","volume":"91","author":"Chen","year":"2023","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.ejphar.2025.177476_bib7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.nbd.2013.04.014","article-title":"Adhesion molecule L1 binds to amyloid beta and reduces Alzheimer's disease pathology in mice","volume":"56","author":"Djogo","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2025.177476_bib8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1042\/BST0350231","article-title":"Physiological roles of PKB\/Akt isoforms in development and disease","volume":"35","author":"Dummler","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ejphar.2025.177476_bib9","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jpsychires.2013.02.013","article-title":"Chronic administration of duloxetine and mirtazapine downregulates proapoptotic proteins and upregulates neurotrophin gene expression in the hippocampus and cerebral cortex of mice","volume":"47","author":"Engel","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.ejphar.2025.177476_bib10","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1038\/s41401-022-00888-5","article-title":"Trilobatin rescues cognitive impairment of Alzheimer's disease by targeting HMGB1 through mediating SIRT3\/SOD2 signaling pathway","volume":"43","author":"Gao","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2025.177476_bib11","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s12640-020-00216-x","article-title":"Duloxetine-induced neural cell death and promoted neurite outgrowth in N2a cells","volume":"38","author":"Gao","year":"2020","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ejphar.2025.177476_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2019.06.010","article-title":"TREM2 acts downstream of CD33 in modulating microglial pathology in Alzheimer's disease","volume":"103","author":"Griciuc","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2025.177476_bib13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/YIC.0b013e32807fb1b2","article-title":"Duloxetine as an SNRI treatment for generalized anxiety disorder: results from a placebo and active-controlled trial","volume":"22","author":"Hartford","year":"2007","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2025.177476_bib14","doi-asserted-by":"crossref","first-page":"382","DOI":"10.2174\/1567205017666200422155323","article-title":"L1CAM beneficially inhibits histone deacetylase 2 expression under conditions of Alzheimer's disease","volume":"17","author":"Hu","year":"2020","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.ejphar.2025.177476_bib15","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41419-021-04348-6","article-title":"A fragment of cell adhesion molecule L1 reduces amyloid-beta plaques in a mouse model of Alzheimer's disease","volume":"13","author":"Hu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2025.177476_bib16","doi-asserted-by":"crossref","first-page":"6295","DOI":"10.1158\/1078-0432.CCR-18-2152","article-title":"Recent developments of novel pharmacologic therapeutics for prevention of chemotherapy-induced peripheral neuropathy","volume":"25","author":"Hu","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2025.177476_bib17","first-page":"25","article-title":"Long-lasting inhibition of 5-HT uptake of platelets in subjects treated by duloxetine, a potential antidepressant","volume":"16","author":"Kasahara","year":"1996","journal-title":"Nihon Shinkei Seishin Yakurigaku Zasshi"},{"key":"10.1016\/j.ejphar.2025.177476_bib18","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1007\/s12035-015-9352-6","article-title":"Small molecule agonists of cell adhesion molecule L1 mimic L1 functions in vivo","volume":"53","author":"Kataria","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2025.177476_bib19","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1038\/s41598-021-85412-1","article-title":"Small compounds mimicking the adhesion molecule L1 improve recovery in a zebrafish demyelination model","volume":"11","author":"Kim","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.177476_bib20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejphar.2018.03.011","article-title":"Effects of pregabalin and duloxetine on neurotransmitters in the dorsal horn of the spinal cord in a rat model of fibromyalgia","volume":"827","author":"Kiso","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177476_bib21","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1038\/s41598-019-39884-x","article-title":"L1cam-mediated developmental processes of the nervous system are differentially regulated by proteolytic processing","volume":"9","author":"Linneberg","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.177476_bib22","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3233\/JAD-140792","article-title":"Cognitive and functional decline and their relationship in patients with mild Alzheimer's dementia","volume":"43","author":"Liu-Seifert","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.ejphar.2025.177476_bib23","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1111\/j.1471-4159.2004.02983.x","article-title":"Signal transduction pathways implicated in neural recognition molecule L1 triggered neuroprotection and neuritogenesis","volume":"92","author":"Loers","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2025.177476_bib24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1124\/jpet.120.265082","article-title":"Duloxetine attenuates paclitaxel-induced peripheral nerve injury by inhibiting p53-related pathways","volume":"373","author":"Lu","year":"2020","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.ejphar.2025.177476_bib25","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1517\/14656566.6.5.707","article-title":"Duloxetine: pharmacoeconomic implications of an antidepressant that alleviates painful physical symptoms","volume":"6","author":"McIntyre","year":"2005","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.ejphar.2025.177476_bib26","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/jpp\/rgaa003","article-title":"Protective effects of duloxetine against chronic immobilisation stress-induced anxiety, depression, cognitive impairment and neurodegeneration in mice","volume":"73","author":"Meejuru","year":"2021","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177476_bib27","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1111\/bph.14546","article-title":"The involvement of microglia in Alzheimer's disease: a new dog in the fight","volume":"176","author":"Moore","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177476_bib28","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/334701a0","article-title":"Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin","volume":"334","author":"Moos","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2025.177476_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115360","article-title":"The antidepressant drugs vortioxetine and duloxetine differentially and sex-dependently affect animal well-being, cognitive performance, cardiac redox status and histology in a model of osteoarthritis","volume":"166","author":"Nastic","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2025.177476_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.148960","article-title":"Systemic inflammation in Abeta(1-40)-induced Alzheimer's disease model: new translational opportunities","volume":"1837","author":"Nefodova","year":"2024","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2025.177476_bib31","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2025.177476_bib32","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1007\/s10753-023-01892-5","article-title":"Duloxetine HCl alleviates asthma symptoms by regulating PI3K\/AKT\/mTOR and Nrf2\/HO-1 signaling pathways","volume":"46","author":"Peng","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2025.177476_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105010","article-title":"Passive immunotherapies targeting Abeta and tau in Alzheimer's disease","volume":"144","author":"Plotkin","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2025.177476_bib34","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1526-4637.2005.00061.x","article-title":"A double-blind, randomized multicenter trial comparing duloxetine with placebo in the management of diabetic peripheral neuropathic pain","volume":"6","author":"Raskin","year":"2005","journal-title":"Pain Med."},{"key":"10.1016\/j.ejphar.2025.177476_bib35","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1523\/JNEUROSCI.03-03-00441.1983","article-title":"Nerve growth factor-inducible large external (NILE) glycoprotein: studies of a central and peripheral neuronal marker","volume":"3","author":"Salton","year":"1983","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2025.177476_bib36","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces Abeta plaques in Alzheimer's disease","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2025.177476_bib37","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jns.2004.11.044","article-title":"The regulation of beta-secretase by cholesterol and statins in Alzheimer's disease","volume":"229\u2013230","author":"Sidera","year":"2005","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.ejphar.2025.177476_bib38","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jalz.2015.06.1893","article-title":"Phase 3 solanezumab trials: secondary outcomes in mild Alzheimer's disease patients","volume":"12","author":"Siemers","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.ejphar.2025.177476_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2004.11.013","article-title":"Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes","volume":"27","author":"Strekalova","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2025.177476_bib40","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.pbb.2007.02.010","article-title":"Effects of interleukin-1beta and lipopolysaccharide on behavior of mice in the elevated plus-maze and open field tests","volume":"86","author":"Swiergiel","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2025.177476_bib41","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.2147\/IJN.S200490","article-title":"Alzheimer's disease: pathogenesis, diagnostics, and therapeutics","volume":"14","author":"Tiwari","year":"2019","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.ejphar.2025.177476_bib42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41583-019-0240-3","article-title":"Amyloid-beta-independent regulators of tau pathology in Alzheimer disease","volume":"21","author":"van der Kant","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2025.177476_bib43","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.biopsych.2017.08.010","article-title":"Anti-Amyloid-beta monoclonal antibodies for Alzheimer's disease: pitfalls and promise","volume":"83","author":"van Dyck","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2025.177476_bib44","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejphar.2025.177476_bib45","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/nbdi.2001.0470","article-title":"Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains","volume":"9","author":"Wahrle","year":"2002","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2025.177476_bib46","article-title":"Chicoric acid ameliorated beta-amyloid pathology and enhanced expression of synaptic-function-related markers via L1CAM in Alzheimer's disease models","volume":"25","author":"Wang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177476_bib47","doi-asserted-by":"crossref","first-page":"20862","DOI":"10.18632\/aging.104104","article-title":"TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K\/AKT\/FoxO3a signaling pathway in Alzheimer's disease mice","volume":"12","author":"Wang","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.ejphar.2025.177476_bib48","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1111\/j.1742-1241.2007.01476.x","article-title":"The safety and tolerability of duloxetine in depressed elderly patients with and without medical comorbidity","volume":"61","author":"Wise","year":"2007","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.ejphar.2025.177476_bib49","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1017\/S1041610219000383","article-title":"Genome-wide RNA sequencing analysis reveals that IGF-2 attenuates memory decline, oxidative stress and amyloid plaques in an Alzheimer's disease mouse model (AD) by activating the PI3K\/AKT\/CREB signaling pathway","volume":"31","author":"Xia","year":"2019","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.ejphar.2025.177476_bib50","doi-asserted-by":"crossref","first-page":"9452","DOI":"10.7150\/thno.62376","article-title":"TNF-alpha-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG","volume":"11","author":"Xu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.ejphar.2025.177476_bib51","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0091-3057(85)90537-4","article-title":"Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing","volume":"22","author":"Yaksh","year":"1985","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2025.177476_bib52","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1021\/acs.jafc.2c02140","article-title":"7,8-Dihydroxycoumarin alleviates synaptic loss by activated PI3K-Akt-CREB-BDNF signaling in Alzheimer's disease model mice","volume":"70","author":"Yan","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2025.177476_bib53","first-page":"81","article-title":"Cell adhesion molecules of the immunoglobulin superfamily in axonal regeneration and neural repair","volume":"26","author":"Zhang","year":"2008","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.ejphar.2025.177476_bib54","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1152\/jn.1997.78.2.746","article-title":"Biphasic modulation of spinal nociceptive transmission from the medullary raphe nuclei in the rat","volume":"78","author":"Zhuo","year":"1997","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2025.177476_bib55","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.pbb.2012.09.011","article-title":"The role of the NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of duloxetine in the forced swimming test","volume":"103","author":"Zomkowski","year":"2012","journal-title":"Pharmacol. Biochem. Behav."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925002304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925002304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T08:15:56Z","timestamp":1745828156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925002304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":55,"alternative-id":["S0014299925002304"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177476","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"L1CAM mimetic compound duloxetine improves cognitive impairment in 5xFAD mice and protects A\u03b21-42-damaged HT22\u00a0cells","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177476","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177476"}}