{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:56:15Z","timestamp":1787586975974,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010227","name":"Nanjing Health Bureau Medical Science and Technology Development Foundation","doi-asserted-by":"publisher","award":["YKK22101"],"award-info":[{"award-number":["YKK22101"]}],"id":[{"id":"10.13039\/501100010227","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010227","name":"Nanjing Health Bureau Medical Science and Technology Development Foundation","doi-asserted-by":"publisher","award":["YKK23114"],"award-info":[{"award-number":["YKK23114"]}],"id":[{"id":"10.13039\/501100010227","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ejphar.2025.177483","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T11:32:02Z","timestamp":1741260722000},"page":"177483","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["NADPH oxidase 2 inhibitor GSK2795039 prevents against cardiac remodeling after MI through reducing oxidative stress and mitochondrial dysfunction"],"prefix":"10.1016","volume":"997","author":[{"given":"Yun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meili","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peina","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7110-6722","authenticated-orcid":false,"given":"Yifei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4169-4980","authenticated-orcid":false,"given":"Qiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.177483_bib1","first-page":"686","article-title":"Diaphragm abnormalities in patients with end-stage heart failure: nadph oxidase upregulation and protein oxidation","volume":"7","author":"Ahn","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejphar.2025.177483_bib2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev.arplant.55.031903.141701","article-title":"Reactive oxygen species: metabolism, oxidative stress, and signal transduction","volume":"55","author":"Apel","year":"2004","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.ejphar.2025.177483_bib3","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10557-020-06977-z","article-title":"Berberine attenuates cardiac hypertrophy through inhibition of mTOR signaling pathway","volume":"34","author":"Chen","year":"2020","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.ejphar.2025.177483_bib4","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1089\/ars.2019.7915","article-title":"The NADPH oxidase family and its inhibitors","volume":"33","author":"Chocry","year":"2020","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2025.177483_bib5","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.4103\/1673-5374.303036","article-title":"P2X7 receptor activation aggravates NADPH oxidase 2-induced oxidative stress after intracerebral hemorrhage","volume":"16","author":"Deng","year":"2021","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.ejphar.2025.177483_bib6","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/1873-3468.13995","article-title":"Mitochondrial disorders of the oxphos system","volume":"595","author":"Fernandez-Vizarra","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ejphar.2025.177483_bib7","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1089\/ars.2014.6202","article-title":"Discovery of Gsk2795039, a novel small molecule nadph oxidase 2 inhibitor","volume":"23","author":"Hirano","year":"2015","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2025.177483_bib8","first-page":"124","article-title":"Reactive oxygen species - sources, functions","volume":"48","author":"Jakubczyk","year":"2020","journal-title":"Oxidative Damage. Pol Merkur Lekarski"},{"key":"10.1016\/j.ejphar.2025.177483_bib9","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.15420\/cfr.2023.03","article-title":"Epidemiology, clinical characteristics and cause-specific outcomes in heart failure with preserved ejection fraction","volume":"9","author":"Kapelios","year":"2023","journal-title":"Card. Fail. Rev."},{"key":"10.1016\/j.ejphar.2025.177483_bib10","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1080\/07391102.2018.1552896","article-title":"Aerobic respiration: proof of concept for the oxygen-centric murburn perspective","volume":"37","author":"Manoj","year":"2019","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.ejphar.2025.177483_bib11","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1001\/jama.2020.10262","article-title":"Heart failure with reduced ejection fraction: a review","volume":"324","author":"Murphy","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2025.177483_bib12","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/hrt.2005.068270","article-title":"Oxidative stress and redox signalling in cardiac hypertrophy and heart failure","volume":"93","author":"Seddon","year":"2007","journal-title":"Heart"},{"key":"10.1016\/j.ejphar.2025.177483_bib13","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/HYPERTENSIONAHA.107.101980","article-title":"Involvement of Nox2 nadph oxidase in adverse cardiac remodeling after myocardial infarction","volume":"51","author":"Sirker","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.177483_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00441-016-2431-9","article-title":"Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration","volume":"365","author":"Talman","year":"2016","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ejphar.2025.177483_bib15","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.cardiores.2006.04.015","article-title":"Redox signaling in angiogenesis: role of nadph oxidase","volume":"71","author":"Ushio-Fukai","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2025.177483_bib16","doi-asserted-by":"crossref","first-page":"890","DOI":"10.3390\/antiox10060890","article-title":"Nadph oxidases (nox): an overview from discovery, molecular mechanisms to physiology and pathology","volume":"10","author":"Vermot","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejphar.2025.177483_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113121","article-title":"Low-dose dexamethasone in combination with luteolin improves myocardial infarction recovery by activating the antioxidative response","volume":"151","author":"Wang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2025.177483_bib18","article-title":"Tracheal epithelial cell-exosome-derived mir-21-5p inhibits alveolar macrophage pyroptosis to resist pulmonary bacterial infection through Pik3cd-autophagy pathway","volume":"336","author":"Wang","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.177483_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102763","article-title":"NOX2 inhibition stabilizes vulnerable plaques by enhancing macrophage efferocytosis via MertK\/PI3K\/AKT pathway","volume":"64","author":"Wang","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2025.177483_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.toxlet.2024.05.001","article-title":"Matrine induces cardiotoxicity by promoting ferroptosis through the Nrf2 antioxidant system in H9c2 cells","volume":"397","author":"Wang","year":"2024","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.ejphar.2025.177483_bib21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jacbts.2016.11.009","article-title":"Metabolic origins of heart failure","volume":"2","author":"Wende","year":"2017","journal-title":"JACC Basic Transl Sci."},{"key":"10.1016\/j.ejphar.2025.177483_bib22","first-page":"266","article-title":"Ivabradine promotes angiogenesis and reduces cardiac hypertrophy in mice with myocardial infarction","volume":"20","author":"Wu","year":"2018","journal-title":"Anatol. J. Cardiol."},{"key":"10.1016\/j.ejphar.2025.177483_bib23","doi-asserted-by":"crossref","first-page":"10189","DOI":"10.1111\/jcmm.15630","article-title":"Zinc finger protein 91 loss induces cardiac hypertrophy through adenosine A1 receptor down-regulation under pressure overload status","volume":"24","author":"Wu","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2025.177483_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116412","article-title":"GSK2795039 prevents RIP1-RIP3-MLKL-mediated cardiomyocyte necroptosis in doxorubicin-induced heart failure through inhibition of NADPH oxidase-derived oxidative stress","volume":"463","author":"Zhang","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177483_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176351","article-title":"NADPH oxidase 2 inhibitor GSK2795039 prevents doxorubicin-induced cardiac atrophy by attenuating cardiac sympathetic nerve terminal abnormalities and myocyte autophagy","volume":"967","author":"Zhao","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177483_bib26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s00395-022-00939-2","article-title":"Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model","volume":"117","author":"Zhou","year":"2022","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2025.177483_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.113912","article-title":"Glycyrrhizin attenuates myocardial ischemia reperfusion injury by suppressing Inflammation, oxidative stress, and ferroptosis via the HMGB1-TLR4-GPX4 pathway","volume":"435","author":"Zhu","year":"2024","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2025.177483_bib28","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","article-title":"Mitochondrial membrane potential","volume":"552","author":"Zorova","year":"2018","journal-title":"Anal. Biochem."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925002377?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925002377?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:32:08Z","timestamp":1762144328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925002377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":28,"alternative-id":["S0014299925002377"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177483","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NADPH oxidase 2 inhibitor GSK2795039 prevents against cardiac remodeling after MI through reducing oxidative stress and mitochondrial dysfunction","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177483","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177483"}}