{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:08:58Z","timestamp":1778648938608,"version":"3.51.4"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100023238","name":"Mennonite Central Committee","doi-asserted-by":"publisher","award":["2.72 \\u00B1 0.89 \\u03BCg\/mL"],"award-info":[{"award-number":["2.72 \\u00B1 0.89 \\u03BCg\/mL"]}],"id":[{"id":"10.13039\/100023238","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["2211-C"],"award-info":[{"award-number":["2211-C"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20OC0065767"],"award-info":[{"award-number":["NNF20OC0065767"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003010","name":"Ege University","doi-asserted-by":"publisher","award":["TDK-2021-22681"],"award-info":[{"award-number":["TDK-2021-22681"]}],"id":[{"id":"10.13039\/501100003010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ejphar.2025.177619","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T02:47:17Z","timestamp":1744339637000},"page":"177619","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Osthole improves erectile function by increasing endogenous H2S production"],"prefix":"10.1016","volume":"997","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-4068","authenticated-orcid":false,"given":"Elif","family":"Alan-Albayrak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7852-992X","authenticated-orcid":false,"given":"Est\u00e9fano","family":"Pinilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-694X","authenticated-orcid":false,"given":"Simon","family":"Comerma-Steffensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin","family":"Erac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunay","family":"Yetik-Anacak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-7666","authenticated-orcid":false,"given":"Ulf","family":"Simonsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4814-9245","authenticated-orcid":false,"given":"Gulnur","family":"Sevin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.177619_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/and.14604","article-title":"Relaxation mechanisms of chloroform root extracts of Prangos heyniae and Prangos uechtritzii on mouse corpus cavernosum","author":"Alan","year":"2022","journal-title":"Andrologia e14604"},{"key":"10.1016\/j.ejphar.2025.177619_bib2","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/sj.bjp.0705293","article-title":"Calcium dobesilate potentiates endothelium-derived hyperpolarizing factor-mediated relaxation of human penile resistance arteries","volume":"139","author":"Angulo","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177619_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.niox.2017.08.005","article-title":"The interaction of L-cysteine\/H2S pathway and muscarinic acetylcholine receptors (mAChRs) in mouse corpus cavernosum","volume":"70","author":"Aydinoglu","year":"2017","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.ejphar.2025.177619_bib4","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/1440-1681.12554","article-title":"Characterization of relaxant mechanism of H2S in mouse corpus cavernosum","volume":"43","author":"Aydinoglu","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2025.177619_bib5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.niox.2014.12.004","article-title":"Role of cGMP in hydrogen sulfide signaling","volume":"46","author":"Bibli","year":"2015","journal-title":"Nitric Oxide - Biol. Chem."},{"key":"10.1016\/j.ejphar.2025.177619_bib6","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1002\/j.1939-4640.2003.tb02743.x","article-title":"Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease","volume":"24","author":"Bivalacqua","year":"2003","journal-title":"J. Androl."},{"key":"10.1016\/j.ejphar.2025.177619_bib7","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0022-5347(05)67613-6","article-title":"Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue in vitro","volume":"163","author":"Chen","year":"2000","journal-title":"J. Urol."},{"key":"10.1016\/j.ejphar.2025.177619_bib8","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.taap.2011.08.005","article-title":"Reduction of isoprenaline-induced myocardial TGF-\u03b21 expression and fibrosis in osthole-treated mice","volume":"256","author":"Chen","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177619_bib9","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1055\/s-2001-12013","article-title":"Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum","volume":"67","author":"Chiou","year":"2001","journal-title":"Planta Med."},{"key":"10.1016\/j.ejphar.2025.177619_bib10","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1111\/bph.16362","article-title":"A novel reuptake inhibitor, IP2015, induces erection by increasing central dopamine and peripheral nitric oxide release","volume":"181","author":"Comerma-Steffensen","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177619_bib11","first-page":"113","article-title":"Erectile dysfunction. Physician assist","volume":"3","author":"Dougherty","year":"2018","journal-title":"Clin"},{"key":"10.1016\/j.ejphar.2025.177619_bib12","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ejphar.2025.177619_bib13","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3390\/antiox12051023","article-title":"Osthole prevents heart damage induced by diet-induced metabolic syndrome: role of fructokinase (KHK)","volume":"12","author":"Garc\u00eda-Arroyo","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejphar.2025.177619_bib14","doi-asserted-by":"crossref","first-page":"H7","DOI":"10.1016\/S1520-765X(02)90046-5","article-title":"Phosphodiesterase type 5 inhibition in erectile dysfunction: an overview","volume":"4","author":"Giuliano","year":"2002","journal-title":"Eur. Heart J. Suppl."},{"key":"10.1016\/j.ejphar.2025.177619_bib15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1743-6109.2011.02508.x","article-title":"Characterization of the vasculature supplying the genital tissues in female rats","volume":"9","author":"Hannan","year":"2012","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.ejphar.2025.177619_bib16","doi-asserted-by":"crossref","first-page":"H1231","DOI":"10.1152\/ajpheart.00237.2019","article-title":"Hydrogen sulfide regulation of renal and mesenteric blood flow","volume":"317","author":"Haushalter","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2025.177619_bib17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1124\/jpet.115.227017","article-title":"Involvement of potassium channels and calcium-independent mechanisms in hydrogen sulfide-induced relaxation of rat mesenteric small arteries","volume":"356","author":"Hedegaard","year":"2016","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2025.177619_bib18","first-page":"492","article-title":"Vasorelaxant effect of osthole on isolated thoracic aortic rings in rats","volume":"39","author":"Huang","year":"2019","journal-title":"J. Tradit. Chinese Med. = Chung i tsa chih ying wen pan"},{"key":"10.1016\/j.ejphar.2025.177619_bib19","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2010.03.038","article-title":"Osthole improves chronic cerebral hypoperfusion induced cognitive deficits and neuronal damage in hippocampus","volume":"636","author":"Ji","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177619_bib20","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1177\/1535370217732325","article-title":"Hydrogen sulfide ameliorated L-NAME-induced hypertensive heart disease by the Akt\/eNOS\/NO pathway","volume":"242","author":"Jin","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.ejphar.2025.177619_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4934592","article-title":"Osthole protects against acute lung injury by suppressing NF-\u03ba B-dependent inflammation","volume":"2018","author":"Jin","year":"2018","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.ejphar.2025.177619_bib22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejps.2012.11.001","article-title":"Hydrogen sulfide increases nitric oxide production with calcium-dependent activation of endothelial nitric oxide synthase in endothelial cells","volume":"48","author":"Kida","year":"2013","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejphar.2025.177619_bib23","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1073\/pnas.1321871111","article-title":"Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent","volume":"111","author":"King","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2025.177619_bib24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0014-2999(92)90576-P","article-title":"Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens","volume":"219","author":"Ko","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177619_bib25","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1161\/CIRCULATIONAHA.112.000855","article-title":"H2S protects against pressure overload induced heart failure via upregulation of endothelial nitric oxide synthase (eNOS)","volume":"127","author":"Kondo","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2025.177619_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172675","article-title":"L-cysteine\/hydrogen sulfide pathway induces cGMP-dependent relaxation of corpus cavernosum and penile arteries from patients with erectile dysfunction and improves arterial vasodilation induced by PDE5 inhibition","volume":"863","author":"La Fuente","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177619_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173370","article-title":"Erectile dysfunction is associated with defective L-cysteine\/hydrogen sulfide pathway in human corpus cavernosum and penile arteries","volume":"884","author":"La Fuente","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177619_bib28","doi-asserted-by":"crossref","first-page":"12874","DOI":"10.1021\/jf2036559","article-title":"Osthole enhances glucose uptake through activation of AMP-Activated protein kinase in skeletal muscle cells","volume":"59","author":"Lee","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2025.177619_bib29","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1111\/j.1743-6109.2008.01168.x","article-title":"Erectile dysfunction in diabetes mellitus","volume":"6","author":"Malavige","year":"2009","journal-title":"J. Sex. Med."},{"key":"10.1016\/j.ejphar.2025.177619_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/sj.ijir.3900526","article-title":"Pre-penile arteries are dominant in the regulation of penile vascular resistance in the rat","volume":"12","author":"Manabe","year":"2000","journal-title":"Int. J. Impot. Res."},{"key":"10.1016\/j.ejphar.2025.177619_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-4939-9528-8_9","article-title":"Simultaneous measurements of tension and free H2S in mesenteric arteries","author":"Nielsen","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2025.177619_bib32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/MNH.0b013e32835021bd","article-title":"New insights into hypertension-associated erectile dysfunction","volume":"21","author":"Nunes","year":"2012","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.ejphar.2025.177619_bib33","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jep.2007.01.028","article-title":"Effects of osthol on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats","volume":"112","author":"Ogawa","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2025.177619_bib34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.freeradbiomed.2006.03.021","article-title":"Hydrogen sulfide inhibits nitric oxide production and nuclear factor-\u03baB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide","volume":"41","author":"Oh","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2025.177619_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106834","article-title":"Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE-\/- mice corpus cavernosum microcirculation","volume":"194","author":"Olivencia","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2025.177619_bib36","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1080\/10715762.2018.1431626","article-title":"Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C2C12 mouse myotubes","volume":"52","author":"Parsanathan","year":"2018","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.ejphar.2025.177619_bib37","article-title":"Plasma free H2S levels are elevated in patients with cardiovascular disease","volume":"2","author":"Peter","year":"2013","journal-title":"J. Am. Hear. Assoc. Cardiovasc. Cerebrovasc. Dis."},{"key":"10.1016\/j.ejphar.2025.177619_bib38","first-page":"141","article-title":"Antispasmodic effect of osthole and Prangos ferulacea extract on rat uterus smooth muscle motility","volume":"7","author":"Sadraei","year":"2012","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.ejphar.2025.177619_bib39","first-page":"137","article-title":"Antispasmodic effects of Prangos ferulacea acetone extract and its main component osthole on ileum contraction","volume":"8","author":"Sadraei","year":"2013","journal-title":"Res. Pharm. Sci."},{"key":"10.1016\/j.ejphar.2025.177619_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114823","article-title":"Comparative evaluation of relaxant effects of three prangos species on mouse corpus cavernosum: chemical characterization and the relaxant mechanisms of action of P. pabularia and (+)-oxypeucedanin","volume":"284","author":"Sevin","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177619_bib41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.5812\/jjnpp.63764","article-title":"Safety assessment of osthole isolated from prangos ferulacea: acute and subchronic toxicities and modulation of cytochrome P450","volume":"12","author":"Shokoohinia","year":"2017","journal-title":"Jundishapur J. Nat. Pharm. Prod."},{"key":"10.1016\/j.ejphar.2025.177619_bib42","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/aps.2017.71","article-title":"Osthole pretreatment alleviates TNBS-Induced colitis in mice via both cAMP\/PKA-dependent and independent pathways","volume":"38","author":"Sun","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2025.177619_bib43","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/BF00169838","article-title":"The relaxant action of osthole isolated from Angelica pubescens in guinea-pig trachea","volume":"349","author":"Teng","year":"1994","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.ejphar.2025.177619_bib44","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.intimp.2018.10.031","article-title":"Osthole alleviates oxidized low-density lipoprotein-induced vascular endothelial injury through suppression of transforming growth factor-\u03b21\/Smad pathway","volume":"65","author":"Wang","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2025.177619_bib45","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainresbull.2020.01.017","article-title":"Osthole relieves diabetics cardiac autonomic neuropathy associated with P2X3 receptor in ratstellate ganglia","volume":"157","author":"Wu","year":"2020","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2025.177619_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6043038","article-title":"Hydrogen sulfide and cellular redox homeostasis","author":"Xie","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejphar.2025.177619_bib47","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s11064-016-2082-y","article-title":"Osthole protects bone marrow-derived neural stem cells from oxidative damage through PI3K\/Akt-1 pathway","volume":"42","author":"Yan","year":"2017","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2025.177619_bib48","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejphar.2012.11.056","article-title":"Osthole relaxes pulmonary arteries through endothelial phosphatidylinositol 3-kinase\/Akt-eNOS-NO signaling pathway in rats","volume":"699","author":"Yao","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177619_bib49","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.phrs.2016.08.015","article-title":"Hydrogen sulfide compensates nitric oxide deficiency in Murine corpus cavernosum","volume":"113","author":"Yetik-Anacak","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2025.177619_bib50","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/bph.12700","article-title":"Gas what: NO is not the only answer to sexual function","volume":"172","author":"Yetik-Anacak","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177619_bib51","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1007\/s11064-009-0006-9","article-title":"Hydrogen sulfide attenuates neuronal injury induced by vascular dementia via inhibiting apoptosis in rats","volume":"34","author":"Zhang","year":"2009","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2025.177619_bib52","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1139\/y03-077","article-title":"Modulation of endogenous production of H2S in rat tissues","volume":"81","author":"Zhao","year":"2003","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177619_bib53","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.ejphar.2025.177619_bib54","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s11745-012-3710-1","article-title":"Reduction of rat cardiac hypertrophy by osthol is related to regulation of cardiac oxidative stress and lipid metabolism","volume":"47","author":"Zhou","year":"2012","journal-title":"Lipids"},{"key":"10.1016\/j.ejphar.2025.177619_bib55","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.aca.2007.12.029","article-title":"Determination of osthole in rat plasma by high-performance liquid chromatograph using cloud-point extraction","volume":"608","author":"Zhou","year":"2008","journal-title":"Anal. Chim. Acta"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925003735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925003735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:13:36Z","timestamp":1778645616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925003735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":55,"alternative-id":["S0014299925003735"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177619","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Osthole improves erectile function by increasing endogenous H2S production","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177619","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177619"}}