{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:39:26Z","timestamp":1787315966279,"version":"build-2736575974"},"reference-count":188,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016286","name":"Urmia University of Medical Sciences","doi-asserted-by":"publisher","award":["12444"],"award-info":[{"award-number":["12444"]}],"id":[{"id":"10.13039\/501100016286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016286","name":"Urmia University of Medical Sciences","doi-asserted-by":"publisher","award":["12478"],"award-info":[{"award-number":["12478"]}],"id":[{"id":"10.13039\/501100016286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.ejphar.2025.177726","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T12:49:21Z","timestamp":1746794961000},"page":"177726","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Menstrual blood and endometrial mesenchymal stem\/stromal cells: A frontier in regenerative medicine and cancer therapy"],"prefix":"10.1016","volume":"1000","author":[{"given":"Maryam","family":"Rahnama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Ghasemzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Latifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Kheradmand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba Abbasi","family":"Koukia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khan","family":"Sharun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8661-5046","authenticated-orcid":false,"given":"Ali","family":"Golchin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.177726_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-022-02938-5","article-title":"Chronic obstructive pulmonary disease and asthma: mesenchymal stem cells and their extracellular vesicles as potential therapeutic tools","volume":"13","author":"Abbaszadeh","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib2","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/GCO.0000000000000702","article-title":"Endometrial stem cells: origin, biological function, and therapeutic applications for reproductive disorders","volume":"33","author":"Abuwala","year":"2021","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.ejphar.2025.177726_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.943003","article-title":"Immobilization of modular peptides on graphene cocktail for differentiation of human mesenchymal stem cells to hepatic-like cells","volume":"10","author":"Adibi-Motlagh","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.ejphar.2025.177726_bib4","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1039\/C6TB00152A","article-title":"Graphene scaffolds in progressive nanotechnology\/stem cell-based tissue engineering of the nervous system","volume":"4","author":"Akhavan","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ejphar.2025.177726_bib5","doi-asserted-by":"crossref","first-page":"8017","DOI":"10.1016\/j.biomaterials.2012.07.040","article-title":"Size-dependent genotoxicity of graphene nanoplatelets in human stem cells","volume":"33","author":"Akhavan","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejphar.2025.177726_bib6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.carbon.2013.03.010","article-title":"Graphene nanogrids for selective and fast osteogenic differentiation of human mesenchymal stem cells","volume":"59","author":"Akhavan","year":"2013","journal-title":"Carbon N. Y."},{"issue":"27","key":"10.1016\/j.ejphar.2025.177726_bib7","first-page":"1","article-title":"Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting","volume":"271","author":"Al-Azab","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.ejphar.2025.177726_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-015-0013-5","article-title":"Characterization of menstrual stem cells: angiogenic effect, migration and hematopoietic stem cell support in comparison with bone marrow mesenchymal stem cells","volume":"6","author":"Alcayaga-Miranda","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-015-0192-0","article-title":"Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis","volume":"6","author":"Alcayaga-Miranda","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1031331","article-title":"Safety and efficacy of clinical-grade, cryopreserved menstrual blood mesenchymal stromal cells in experimental acute respiratory distress syndrome","volume":"11","author":"Alcayaga-Miranda","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2025.177726_bib11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1631\/jzus.B1200062","article-title":"Human adult stem cells from menstrual blood and endometrial tissue","volume":"13","author":"Allickson","year":"2012","journal-title":"J. Zhejiang Univ."},{"key":"10.1016\/j.ejphar.2025.177726_bib12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1876893801103010004","article-title":"Recent studies assessing the proliferative capability of a novel adult stem cell identified in menstrual blood","volume":"3","author":"Allickson","year":"2011","journal-title":"Open Stem Cell J."},{"key":"10.1016\/j.ejphar.2025.177726_bib13","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41417-019-0110-1","article-title":"Enhanced antitumor efficacy of an oncolytic adenovirus armed with an EGFR-Targeted BiTE using menstrual blood-derived mesenchymal stem cells as carriers","volume":"27","author":"Barlab\u00e9","year":"2020","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3389\/fcell.2020.00497","article-title":"Endometrial and menstrual blood mesenchymal stem\/stromal cells: biological properties and clinical application","volume":"8","author":"Bozorgmehr","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2025.177726_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00497","article-title":"Endometrial and menstrual blood mesenchymal stem\/stromal cells: biological properties and clinical application","volume":"8","author":"Bozorgmehr","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2025.177726_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00497","article-title":"Endometrial and menstrual blood mesenchymal stem\/stromal cells: biological properties and clinical application","volume":"8","author":"Bozorgmehr","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2025.177726_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/srep37019","article-title":"Human endometrial mesenchymal stem cells exhibit intrinsic anti-tumor properties on human epithelial ovarian cancer cells","volume":"6","author":"Bu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.177726_bib18","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1002\/stem.3070","article-title":"Myometrial cells stimulate self-renewal of endometrial mesenchymal stem-like cells through WNT5A\/\u03b2-catenin signaling","volume":"37","author":"Cao","year":"2019","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2025.177726_bib19","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1095\/biolreprod.103.024109","article-title":"Clonogenicity of human endometrial epithelial and stromal cells","volume":"70","author":"Chan","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ejphar.2025.177726_bib20","doi-asserted-by":"crossref","first-page":"368","DOI":"10.4252\/wjsc.v12.i5.368","article-title":"Safety of menstrual blood-derived stromal cell transplantation in treatment of intrauterine adhesion","volume":"12","author":"Chang","year":"2020","journal-title":"World J. Stem Cell."},{"key":"10.1016\/j.ejphar.2025.177726_bib21","doi-asserted-by":"crossref","first-page":"368","DOI":"10.4252\/wjsc.v12.i5.368","article-title":"Safety of menstrual blood-derived stromal cell transplantation in treatment of intrauterine adhesion","volume":"12","author":"Chang","year":"2020","journal-title":"World J. Stem Cell."},{"key":"10.1016\/j.ejphar.2025.177726_bib22","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1111\/jgh.15493","article-title":"Menstrual blood\u2010derived mesenchymal stem cells attenuate inflammation and improve the mortality of acute liver failure combining with A2AR agonist in mice","volume":"36","author":"Chen","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2025.177726_bib23","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.eng.2020.02.006","article-title":"Clinical study of mesenchymal stem cell treatment for acute respiratory distress syndrome induced by epidemic influenza A (H7N9) infection: a hint for COVID-19 treatment","volume":"6","author":"Chen","year":"2020","journal-title":"Engineering"},{"key":"10.1016\/j.ejphar.2025.177726_bib24","doi-asserted-by":"crossref","DOI":"10.1007\/s43032-024-01458-2","article-title":"A novel method to repair thin endometrium and restore fertility based on menstruation-derived stem cell","author":"Chen","year":"2024","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-019-1503-7","article-title":"Menstrual blood-derived stem cells: toward therapeutic mechanisms, novel strategies, and future perspectives in the treatment of diseases","author":"Chen","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-018-1105-9","article-title":"The multi-functional roles of menstrual blood-derived stem cells in regenerative medicine","volume":"10","author":"Chen","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib27","volume":"vols. 1\u201315","author":"Chen","year":"2021"},{"key":"10.1016\/j.ejphar.2025.177726_bib28","doi-asserted-by":"crossref","DOI":"10.1177\/09636897221086971","article-title":"Nonfreezing low temperature maintains the viability of menstrual blood\u2013derived endometrial stem cells under oxygen\u2013glucose deprivation through the sustained release of autophagy-produced energy","volume":"31","author":"Chen","year":"2022","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ejphar.2025.177726_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-020-01926-x","article-title":"Human menstrual blood-derived stem cells mitigate bleomycin-induced pulmonary fibrosis through anti-apoptosis and anti-inflammatory effects","volume":"11","author":"Chen","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4794827","article-title":"Characteristics of human endometrium-derived mesenchymal stem cells and their tropism to endometriosis","author":"Cheng","year":"2017","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.ejphar.2025.177726_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25021025","article-title":"The concept behind the suitability of menstrual blood-derived stem cells for the management of vaginal atrophy among BRCA mutation carriers after RRSO","author":"Cordeiro","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib32","first-page":"1","article-title":"Endometrial stem\/progenitor cells\u2013their role in endometrial repair and regeneration","volume":"3","author":"Cousins","year":"2021","journal-title":"Front. Reprod. Health"},{"key":"10.1016\/j.ejphar.2025.177726_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2018.00464","article-title":"The reparative abilities of menstrual stem cells modulate the wound matrix signals and improve cutaneous regeneration","volume":"9","author":"Cuenca","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejphar.2025.177726_bib34","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1091\/mbc.e06-09-0872","article-title":"Menstrual blood-derived cells confer human dystrophin expression in the murine model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation","volume":"18","author":"Cui","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ejphar.2025.177726_bib35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tice.2018.09.010","article-title":"A feasible method for the isolation of mesenchymal stem cells from menstrual blood and their exosomes","volume":"55","author":"Dalirfardouei","year":"2018","journal-title":"Tissue Cell"},{"key":"10.1016\/j.ejphar.2025.177726_bib36","doi-asserted-by":"crossref","first-page":"6554","DOI":"10.1038\/s41598-018-24919-6","article-title":"Endometrial mesenchymal stem\/stromal cells modulate the macrophage response to implanted polyamide\/gelatin composite mesh in immunocompromised and immunocompetent mice","volume":"8","author":"Darzi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.177726_bib37","doi-asserted-by":"crossref","first-page":"303","DOI":"10.18295\/squmj.12.2022.066","article-title":"Expression of DKK1 in endometrial endometrioid carcinoma and its correlation with Wnt\/\u03b2-catenin signalling pathway","volume":"23","author":"Das","year":"2023","journal-title":"Sultan Qaboos Univ. Med. J."},{"key":"10.1016\/j.ejphar.2025.177726_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212177","article-title":"IFN-gamma and TNF-alpha as a priming strategy to enhance the immunomodulatory capacity of secretomes from menstrual blood-derived stromal cells","volume":"22","author":"de Pedro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s10020-023-00646-1","article-title":"Menstrual blood-derived stromal cells: insights into their secretome in acute hypoxia conditions","volume":"29","author":"de Pedro","year":"2023","journal-title":"Mol. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib40","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3390\/biomedicines10051117","article-title":"Intrapericardial administration of secretomes from menstrual blood-derived mesenchymal stromal cells: effects on immune-related genes in a porcine model of myocardial infarction","volume":"10","author":"de Pedro","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2025.177726_bib41","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ejphar.2025.177726_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/jpm11060466","article-title":"Generation of therapeutically potent spheroids from human endometrial mesenchymal stem\/stromal cells","volume":"11","author":"Domnina","year":"2021","journal-title":"J. Personalized Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/stmcls\/sxac091","article-title":"HGF secreted by menstrual blood-derived endometrial stem cells ameliorates non-alcoholic fatty liver disease through downregulation of hepatic Rnf186","volume":"41","author":"Du","year":"2023","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2025.177726_bib44","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1007\/s12035-016-9828-z","article-title":"Inhibitor of PI3K\/Akt signaling pathway small molecule promotes motor neuron differentiation of human endometrial stem cells cultured on electrospun biocomposite polycaprolactone\/collagen scaffolds","volume":"54","author":"Ebrahimi-Barough","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2025.177726_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/btpr.3374","article-title":"Application of mesenchymal stem cells in regenerative medicine: a new approach in modern medical science","volume":"39","author":"Ebrahimi","year":"2023","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.ejphar.2025.177726_bib46","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.actbio.2014.10.043","article-title":"Temporal changes in the biomechanical properties of endometrial mesenchymal stem cell seeded scaffolds in a rat model","volume":"13","author":"Edwards","year":"2015","journal-title":"Acta Biomater."},{"issue":"119495","key":"10.1016\/j.ejphar.2025.177726_bib47","article-title":"Composite mesh design for delivery of autologous mesenchymal stem cells influences mesh integration, exposure and biocompatibility in an ovine model of pelvic organ prolapse","volume":"225","author":"Emmerson","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejphar.2025.177726_bib48","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4252\/wjsc.v8.i5.202","article-title":"Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse","volume":"8","author":"Emmerson","year":"2016","journal-title":"World J. Stem Cell."},{"key":"10.1016\/j.ejphar.2025.177726_bib49","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s13534-018-0084-1","article-title":"Promotion of excisional wound repair by a menstrual blood-derived stem cell-seeded decellularized human amniotic membrane","volume":"8","author":"Farzamfar","year":"2018","journal-title":"Biomed. Eng. Lett."},{"key":"10.1016\/j.ejphar.2025.177726_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-022-02771-w","article-title":"Safety and efficacy study of allogeneic human menstrual blood stromal cells secretome to treat severe COVID-19 patients: clinical trial phase I & II","volume":"13","author":"Fathi-Kazerooni","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib51","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s12015-018-9867-0","article-title":"Human menstrual blood-derived stromal cells promote recovery of premature ovarian insufficiency via regulating the ECM-dependent FAK\/AKT signaling","volume":"15","author":"Feng","year":"2019","journal-title":"Stem cell Rev. Rep."},{"key":"10.1016\/j.ejphar.2025.177726_bib52","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.reprotox.2022.03.012","article-title":"Menstrual blood-derived endometrial stem cells ameliorate the viability of ovarian granulosa cells injured by cisplatin through activating autophagy","volume":"110","author":"Fu","year":"2022","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.ejphar.2025.177726_bib53","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11010-014-2109-0","article-title":"Gene expression profiling of endometrium versus bone marrow-derived mesenchymal stem cells: upregulation of cytokine genes","volume":"395","author":"Gaafar","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2025.177726_bib54","first-page":"10","article-title":"Non-gynaecological applications of menstrual-derived stem cells: a systematic review","volume":"14","author":"Galea","year":"2021","journal-title":"Avicenna J. Med. Biotechnol. (AJMB)"},{"key":"10.1016\/j.ejphar.2025.177726_bib55","first-page":"1","article-title":"A new source of stem cells : mesenchymal stem cells from menstrual blood","volume":"4","author":"Gallicchio","year":"2020","journal-title":"J. Med. - Clin. Res. Rev."},{"key":"10.1016\/j.ejphar.2025.177726_bib56","first-page":"137","article-title":"Endometrial stem\/progenitor cells: the first 10 years","volume":"22","author":"Gargett","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ejphar.2025.177726_bib57","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1095\/biolreprod.108.075226","article-title":"Isolation and culture of epithelial progenitors and mesenchymal stem cells from human endometrium","volume":"80","author":"Gargett","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ejphar.2025.177726_bib58","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-981-16-0301-3_3","article-title":"Characteristic and regenerative potential of human endometrial stem cells and progenitors","author":"Ghamari","year":"2021","journal-title":"Stem cells from potential to promise"},{"key":"10.1016\/j.ejphar.2025.177726_bib59","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1007\/s12015-020-10036-3","article-title":"From mesenchymal stromal\/stem cells to insulin-producing cells: progress and challenges","volume":"16","author":"Ghoneim","year":"2020","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.ejphar.2025.177726_bib60","series-title":"Advances in Experimental Medicine and Biology","article-title":"Embryonic stem cells in clinical trials: current overview of developments and challenges","author":"Golchin","year":"2021"},{"key":"10.1016\/j.ejphar.2025.177726_bib61","first-page":"209","article-title":"Regenerative medicine under the control of 3D scaffolds: current state and progress of tissue scaffolds","volume":"16","author":"Golchin","year":"2020","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib62","doi-asserted-by":"crossref","DOI":"10.1007\/5584_2018_256","article-title":"Promotion of cell-based therapy: special focus on the cooperation of mesenchymal stem cell therapy and gene therapy for clinical trial studies","author":"Golchin","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejphar.2025.177726_bib63","article-title":"Regenerative medicine: injectable cell-based therapeutics and approved products","author":"Golchin","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejphar.2025.177726_bib64","doi-asserted-by":"crossref","first-page":"780","DOI":"10.14740\/jocmr3964","article-title":"Advanced therapy medicinal products challenges and perspectives in regenerative medicine","volume":"12","author":"Goula","year":"2020","journal-title":"J. Clin. Med. Res."},{"key":"10.1016\/j.ejphar.2025.177726_bib65","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1089\/scd.2018.0222","article-title":"Menstrual blood-derived stem cells as delivery vehicles for oncolytic adenovirus virotherapy for colorectal cancer","volume":"28","author":"Guo","year":"2019","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.ejphar.2025.177726_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmbts.2018.07.009","article-title":"Adult stem cells for regenerative therapy","volume":"160","author":"Gurusamy","year":"2018","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib67","article-title":"Advanced therapy medicinal products: current and future perspectives","volume":"4","author":"Hanna","year":"2016","journal-title":"J. Mark. access Heal. policy"},{"key":"10.1016\/j.ejphar.2025.177726_bib68","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1196\/annals.1429.018","article-title":"The menstrual cycle","volume":"1135","author":"Hawkins","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib69","doi-asserted-by":"crossref","first-page":"644","DOI":"10.2174\/1574888X18666230417085117","article-title":"Menstrual blood-derived mesenchymal stem cell therapy for severe COVID-19 patients","volume":"19","author":"Heidari","year":"2024","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/jpm11090840","article-title":"Endometrial SUSD2(+) mesenchymal stem\/stromal cells in tissue engineering: advances in novel cellular constructs for pelvic organ prolapse","volume":"11","author":"Hennes","year":"2021","journal-title":"J. Personalized Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib71","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1634\/stemcells.2007-0826","article-title":"Novel cardiac precursor-like cells from human menstrual blood-derived mesenchymal cells","volume":"26","author":"Hida","year":"2008","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2025.177726_bib72","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1093\/humrep\/deh424","article-title":"Roles of p38 and c-jun in the differentiation, proliferation and immortalization of normal human endometrial cells","volume":"19","author":"Hong","year":"2004","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ejphar.2025.177726_bib73","series-title":"Endometrial stem\/progenitor Cells: Properties, Origins, and Functions 10","author":"Hong","year":"2023"},{"key":"10.1016\/j.ejphar.2025.177726_bib74","first-page":"864","volume":"20","author":"Hong","year":"2024","journal-title":"Endometrial Stem Cells: Orchestrating Dynamic Regeneration of Endometrium and Their Implications in Diverse Endometrial Disorders"},{"key":"10.1016\/j.ejphar.2025.177726_bib75","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41585-023-00787-2","article-title":"Body fluid-derived stem cells \u2014 an untapped stem cell source in genitourinary regeneration","volume":"20","author":"Huang","year":"2023","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.ejphar.2025.177726_bib76","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10347","article-title":"Electrically conductive carbon\u2010based (bio)\u2010nanomaterials for cardiac tissue engineering","volume":"8","author":"Jalilinejad","year":"2023","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib77","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13287-022-02782-7","article-title":"Shining the light on clinical application of mesenchymal stem cell therapy in autoimmune diseases","volume":"13","author":"Jasim","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib78","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12712","article-title":"Immune modulation by mesenchymal stem cells","volume":"53","author":"Jiang","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ejphar.2025.177726_bib79","first-page":"2614","article-title":"Co-culture with endometrial stromal cells promotes the differentiation of menstrual blood-derived mesenchymal stem cells into endometrial epithelial cells","volume":"97","author":"Jiang","year":"2017","journal-title":"Zhonghua Yixue Zazhi"},{"key":"10.1016\/j.ejphar.2025.177726_bib80","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.291","article-title":"Application of stem cells in regeneration medicine","volume":"4","author":"Jin","year":"2023","journal-title":"MedComm"},{"key":"10.1016\/j.ejphar.2025.177726_bib81","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1016\/j.yexcr.2010.06.002","article-title":"Novel markers of mesenchymal stem cells defined by genome-wide gene expression analysis of stromal cells from different sources","volume":"316","author":"Kaltz","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2025.177726_bib82","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.3390\/cells11091464","article-title":"Interaction of neural stem cells (NSCs) and mesenchymal stem cells (MSCs) as a promising approach in brain study and nerve regeneration","volume":"11","author":"Kaminska","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2025.177726_bib83","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.3390\/ijms23084462","article-title":"Bone marrow niches of hematopoietic stem and progenitor cells","volume":"23","author":"Kandarakov","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0175986","article-title":"Niche matters: the comparison between bone marrow stem cells and endometrial stem cells and stromal fibroblasts reveal distinct migration and cytokine profiles in response to inflammatory stimulus","volume":"12","author":"Khatun","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2025.177726_bib85","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00205","article-title":"The promising potential of menstrual stem cells for antenatal diagnosis and cell therapy","volume":"5","author":"Khoury","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.177726_bib86","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1556\/oh.2008.28291","article-title":"Mesenchymal stem cells and the immune system\u2013immunosuppression without drugs","volume":"149","author":"Kiss","year":"2008","journal-title":"Orv. Hetil."},{"key":"10.1016\/j.ejphar.2025.177726_bib87","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3906\/biy-1508-56","article-title":"Comparison of enzymatic and nonenzymatic isolation methods for endometrial stem cells","volume":"40","author":"Ko\u00e7ak","year":"2016","journal-title":"Turkish J. Biol."},{"key":"10.1016\/j.ejphar.2025.177726_bib88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02526-z","article-title":"Endometrial stem\/progenitor cells and their roles in immunity, clinical application, and endometriosis","volume":"12","author":"Kong","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib89","first-page":"181","article-title":"Comparative study of the influence of EDTA and sodium heparin on long term storage of cattle DNA","volume":"17","author":"Kotikalapudi","year":"2015","journal-title":"Cell J"},{"key":"10.1016\/j.ejphar.2025.177726_bib90","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jcyt.2017.12.012","article-title":"Human endometrial stem cells: high-Yield isolation and characterization","volume":"20","author":"Kovina","year":"2018","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ejphar.2025.177726_bib91","article-title":"Therapeutic features and updated clinical trials of mesenchymal stem cell (Msc)-derived exosomes","author":"Lee","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib92","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5653\/cerm.2011.38.3.119","article-title":"Role of endometrial immune cells in implantation","volume":"38","author":"Lee","year":"2011","journal-title":"Clin. Exp. Reprod. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib93","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13287-023-03330-7","article-title":"Menstrual blood-derived endometrial stem cells alleviate neuroinflammation by modulating M1\/M2 polarization in cell and rat Parkinson's disease models","volume":"14","author":"Li","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib94","article-title":"WNT5A interacts with FZD5 and LRP5 to regulate proliferation and self-renewal of endometrial mesenchymal stem-like cells","volume":"10","author":"Li","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2025.177726_bib95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40659-024-00484-3","article-title":"Endometrial mesenchymal stromal\/stem cells improve regeneration of injured endometrium in mice","volume":"57","author":"Li","year":"2024","journal-title":"Biol. Res."},{"key":"10.1016\/j.ejphar.2025.177726_bib96","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s13287-022-02838-8","article-title":"Menstrual blood-derived mesenchymal stromal cells efficiently ameliorate experimental autoimmune encephalomyelitis by inhibiting T cell activation in mice","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib97","article-title":"Human menstrual blood-derived stem cells inhibit the proliferation of HeLa cells via TGF-\u03b21-mediated JNK\/P21 signaling pathways","volume":"2019","author":"Liu","year":"2019","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.ejphar.2025.177726_bib98","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00441-023-03831-0","article-title":"Exploration of eMSCs with HA-GEL system in repairing damaged endometrium after endometrial cancer with fertility-sparing treatment","volume":"394","author":"Liu","year":"2023","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ejphar.2025.177726_bib99","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s00018-019-03019-2","article-title":"Therapeutic potential of menstrual blood-derived endometrial stem cells in cardiac diseases","volume":"76","author":"Liu","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib100","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1111\/jcmm.13437","article-title":"Biological characteristics of human menstrual blood-derived endometrial stem cells","volume":"22","author":"Liu","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib101","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.12998\/wjcc.v9.i7.1705","article-title":"Human menstrual blood-derived stem cells as immunoregulatory therapy in COVID-19: a case report and review of the literature","volume":"9","author":"Lu","year":"2021","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.ejphar.2025.177726_bib102","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/stem.2244","article-title":"The immunosuppressive signature of menstrual blood mesenchymal stem cells entails opposite effects on experimental arthritis and graft versus host diseases","volume":"34","author":"Luz-Crawford","year":"2016","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2025.177726_bib103","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/mrd.23476","article-title":"Adult stem cells in endometrial regeneration: molecular insights and clinical applications","volume":"88","author":"Lv","year":"2021","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.ejphar.2025.177726_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-014-0344-5","article-title":"Endometrial regenerative cells as a novel cell therapy attenuate experimental colitis in mice","volume":"12","author":"Lv","year":"2014","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib105","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ogc.2012.10.002","article-title":"Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility","volume":"39","author":"Macer","year":"2012","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"10.1016\/j.ejphar.2025.177726_bib106","doi-asserted-by":"crossref","DOI":"10.1002\/btpr.3243","article-title":"Functional in vitro characterization of small extracellular vesicles isolated from menstrual blood\u2010derived mesenchymal stem\/stromal cells","volume":"38","author":"Mahdipour","year":"2022","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.ejphar.2025.177726_bib107","doi-asserted-by":"crossref","first-page":"118","DOI":"10.15283\/ijsc.2014.7.2.118","article-title":"Comparison of mesenchymal stem cell markers in multiple human adult stem cells","volume":"7","author":"Maleki","year":"2014","journal-title":"Int. J. Stem Cells"},{"key":"10.1016\/j.ejphar.2025.177726_bib108","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/nm912","article-title":"Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts","volume":"9","author":"Mangi","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib109","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1089\/jwh.2019.7745","article-title":"Menstrual blood-derived mesenchymal stem cells: women's attitudes, willingness, and barriers to donation of menstrual blood","volume":"28","author":"Manley","year":"2019","journal-title":"J. Wom. Health"},{"key":"10.1016\/j.ejphar.2025.177726_bib110","article-title":"The most commonly used cell surface markers for determining mesenchymal stromal cells in stromal vascular fraction and bone marrow autologous concentrate: a systematic review","volume":"14","author":"Maslennikov","year":"2023","journal-title":"J. Biotech Res."},{"key":"10.1016\/j.ejphar.2025.177726_bib111","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/sctm.19-0044","article-title":"Challenges in clinical development of mesenchymal stromal\/stem cells: concise review","volume":"8","author":"Mastrolia","year":"2019","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib112","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.3727\/096368911X637362","article-title":"A novel marker of human endometrial mesenchymal stem-like cells","volume":"21","author":"Masuda","year":"2012","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ejphar.2025.177726_bib113","first-page":"132","article-title":"Growth kinetics, characterization, and plasticity of human menstrual blood stem cells. Iran","volume":"41","author":"Mehrabani","year":"2016","journal-title":"J. Med. Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib114","doi-asserted-by":"crossref","first-page":"936","DOI":"10.3892\/etm.2021.10368","article-title":"Comparative study of three types of mesenchymal stem cell to differentiate into pancreatic \u03b2-like cells in vitro","volume":"22","author":"Mo","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib115","doi-asserted-by":"crossref","DOI":"10.15283\/ijsc23091","article-title":"Human endometrial regenerative cells for neurological disorders: hype or hope?","author":"Momeni","year":"2024","journal-title":"Int. J. Stem Cells"},{"key":"10.1016\/j.ejphar.2025.177726_bib116","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1158\/1535-7163.MCT-18-0431","article-title":"Enhanced antitumor efficacy of oncolytic adenovirus\u2013loaded menstrual blood\u2013derived mesenchymal stem cells in combination with peripheral blood mononuclear cells","volume":"18","author":"Moreno","year":"2019","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.ejphar.2025.177726_bib117","first-page":"1","article-title":"Human menstrual blood-derived mesenchymal stem cells as potential cell carriers for oncolytic adenovirus","author":"Moreno","year":"2017","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.ejphar.2025.177726_bib118","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1631\/jzus.B1300081","article-title":"Menstrual blood-derived mesenchymal stem cells differentiate into functional hepatocyte-like cells","volume":"14","author":"Mou","year":"2013","journal-title":"J. Zhejiang Univ. - Sci. B"},{"key":"10.1016\/j.ejphar.2025.177726_bib119","doi-asserted-by":"crossref","DOI":"10.1098\/rsfs.2018.0089","article-title":"Mesenchymal stem cell-based bioengineered constructs: foreign body response, cross-talk with macrophages and impact of biomaterial design strategies for pelvic floor disorders","volume":"9","author":"Mukherjee","year":"2019","journal-title":"Interface Focus"},{"key":"10.1016\/j.ejphar.2025.177726_bib120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/bioengineering9030111","article-title":"Evolution of mesenchymal stem cell therapy as an advanced therapeutic medicinal product (ATMP)\u2014An Indian perspective","volume":"9","author":"Muthu","year":"2022","journal-title":"Bioengineering"},{"key":"10.1016\/j.ejphar.2025.177726_bib121","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1095\/biolreprod.114.126771","article-title":"The endometrium as a source of mesenchymal stem cells for regenerative medicine","volume":"92","author":"Mutlu","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ejphar.2025.177726_bib122","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1089\/cell.2019.0020","article-title":"Human menstrual blood stem cell-derived granulosa cells participate in ovarian follicle formation in a rat model of premature ovarian failure in vivo","volume":"21","author":"Noory","year":"2019","journal-title":"Cell. Reprogram."},{"key":"10.1016\/j.ejphar.2025.177726_bib123","doi-asserted-by":"crossref","DOI":"10.2174\/0118743722297410240529051323","article-title":"Adipose-derived stem cells antagonize fibrotic response of keloid-derived fibroblasts","volume":"18","author":"Nukui","year":"2024","journal-title":"Open Dermatol. J."},{"key":"10.1016\/j.ejphar.2025.177726_bib124","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/stem.2706","article-title":"Bone marrow stem cells do not contribute to endometrial cell lineages in chimeric mouse models","volume":"36","author":"Ong","year":"2018","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2025.177726_bib125","doi-asserted-by":"crossref","first-page":"42","DOI":"10.5653\/cerm.2011.38.1.42","article-title":"Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome","volume":"38","author":"Park","year":"2011","journal-title":"Clin. Exp. Reprod. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib126","series-title":"3D Bioprinted Endometrial Stem Cells on Melt Electrospun PCL Meshes for Pelvic Floor Application Promote Anti-inflammatory Responses in Mice","author":"Paul","year":"2019"},{"key":"10.1016\/j.ejphar.2025.177726_bib127","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1134\/S2079086422010054","article-title":"Menstrual blood-derived mesenchymal stromal cells as a resource for regenerative medicine","volume":"12","author":"Payushina","year":"2022","journal-title":"Biol. Bull. Rev."},{"key":"10.1016\/j.ejphar.2025.177726_bib128","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s12015-011-9338-3","article-title":"Human endometrial-derived mesenchymal stem cells suppress inflammation in the central nervous system of EAE mice","volume":"8","author":"Peron","year":"2012","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.ejphar.2025.177726_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.135578","article-title":"CaZnO-based nanoghosts for the detection of ssDNA, pCRISPR and recombinant SARS-CoV-2 spike antigen and targeted delivery of doxorubicin","volume":"306","author":"Rabiee","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.ejphar.2025.177726_bib130","first-page":"239","article-title":"Mesenchymal stem cells, aging and regenerative medicine","volume":"2","author":"Raggi","year":"2012","journal-title":"Muscles. Ligaments Tendons J."},{"key":"10.1016\/j.ejphar.2025.177726_bib131","first-page":"318","volume":"vol. 15","author":"Rahnama","year":"2024"},{"key":"10.1016\/j.ejphar.2025.177726_bib132","series-title":"Clinical Trials: a Scoping Review 20","article-title":"Global trends of exosomes application","author":"Rahnama","year":"2024"},{"key":"10.1016\/j.ejphar.2025.177726_bib133","first-page":"41","article-title":"Potential of mesenchymal stem cell based application in cancer","volume":"9","author":"Ramdasi","year":"2015","journal-title":"Int. J. Hematol. Stem Cell Res."},{"key":"10.1016\/j.ejphar.2025.177726_bib134","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.arcmed.2020.08.006","article-title":"Mesenchymal stem cells current clinical applications: a systematic review","volume":"52","author":"Rodr\u00edguez-Fuentes","year":"2021","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.ejphar.2025.177726_bib135","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/901821","article-title":"Isolation, characterization, and transduction of endometrial decidual tissue multipotent mesenchymal stromal\/stem cells from menstrual blood","volume":"2013","author":"Rossignoli","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejphar.2025.177726_bib136","series-title":"Possibilities and Limitations in Current Translational Stem Cell Research","article-title":"A new cell stem concept for pelvic floor disorders prevention and treatment\u2013endometrial mesenchymal stem cells","author":"Russu","year":"2022"},{"key":"10.1016\/j.ejphar.2025.177726_bib137","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.576176","article-title":"Mesenchymal stromal cells as critical contributors to tissue regeneration","volume":"8","author":"Sagaradze","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2025.177726_bib138","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7053521","article-title":"A comparative study of gene expression in menstrual blood-derived stromal cells between endometriosis and healthy women","volume":"2022","author":"Sahraei","year":"2022","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejphar.2025.177726_bib139","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103501","article-title":"Understanding menstrual blood-derived stromal\/stem cells: definition and properties. Are we rushing into their therapeutic applications?","volume":"24","author":"Sanchez-Mata","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.ejphar.2025.177726_bib140","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/humupd\/dmy028","article-title":"Uterine stem cells: from basic research to advanced cell therapies","volume":"24","author":"Santamaria","year":"2018","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ejphar.2025.177726_bib141","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111592","article-title":"Mesenchymal stem cell-based therapy for rheumatoid arthritis","volume":"22","author":"Sarsenova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115505","article-title":"Current progress in engineered and nano-engineered mesenchymal stem cells for cancer: from mechanisms to therapy","volume":"167","author":"Shams","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2025.177726_bib143","first-page":"666","article-title":"Advancing application of mesenchymal stem cell-based bone tissue regeneration","volume":"6","author":"Shang","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ejphar.2025.177726_bib144","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1134\/S1990519X17010114","article-title":"Genetic stability of human endometrial mesenchymal stem cells assessed with morphological and molecular karyotyping","volume":"11","author":"Shilina","year":"2017","journal-title":"Cell tissue biol"},{"key":"10.1016\/j.ejphar.2025.177726_bib145","series-title":"Endometrial Stem Cells and its Potential Applications","author":"Somasundaram","year":"2016"},{"key":"10.1016\/j.ejphar.2025.177726_bib146","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tips.2020.06.009","article-title":"Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential","volume":"41","author":"Song","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib147","doi-asserted-by":"crossref","first-page":"5012","DOI":"10.1016\/j.actbio.2014.08.031","article-title":"Induction of endometrial mesenchymal stem cells into tissue-forming cells suitable for fascial repair","volume":"10","author":"Su","year":"2014","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejphar.2025.177726_bib148","series-title":"Seminars in Cell & Developmental Biology","first-page":"112","article-title":"Microglia-mediated neuroinflammation in neurodegenerative diseases","author":"Subhramanyam","year":"2019"},{"key":"10.1016\/j.ejphar.2025.177726_bib149","doi-asserted-by":"crossref","first-page":"983","DOI":"10.2217\/rme-2017-0029","article-title":"Mesenchymal endometrial stem\/stromal cells for hard tissue engineering: a review of in vitro and in vivo evidence","volume":"12","author":"Tabatabaei","year":"2017","journal-title":"Regen. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib150","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2174\/1874372201913010034","article-title":"Lessons from epithelialization: the reason behind moist wound environment","volume":"13","author":"Tan","year":"2019","journal-title":"Open Dermatol. J."},{"key":"10.1016\/j.ejphar.2025.177726_bib151","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2693","article-title":"Human endometrial stem cell isolation from endometrium and menstrual blood","volume":"8","author":"Tavakol","year":"2018","journal-title":"Bio Protoc."},{"key":"10.1016\/j.ejphar.2025.177726_bib152","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/jama.292.1.81","article-title":"Endometrial cells derived from donor stem cells in bone marrow transplant recipients","volume":"292","author":"Taylor","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2025.177726_bib153","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19103240","article-title":"Endometrial stem cell markers: current concepts and unresolved questions","author":"Tempest","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib154","doi-asserted-by":"crossref","first-page":"55","DOI":"10.21315\/mjms2023.30.2.5","article-title":"Human mesenchymal stromal cells derived from perinatal tissues: sources, characteristics and isolation methods","volume":"30","author":"Teoh","year":"2023","journal-title":"Malays. J. Med. Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib155","first-page":"118","article-title":"Regenerative therapy by endometrial mesenchymal stem cells in thin endometrium with repeated implantation failure","volume":"24","author":"Tersoglio","year":"2020","journal-title":"A novel strategy. JBRA Assist. Reprod."},{"key":"10.1016\/j.ejphar.2025.177726_bib156","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1007\/s12015-024-10696-5","article-title":"Bone regeneration with mesenchymal stem cells in scaffolds: systematic review of human clinical trials","volume":"20","author":"Theodosaki","year":"2024","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.ejphar.2025.177726_bib157","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2174\/157016107780368299","article-title":"Bone marrow stem cell therapy for myocardial angiogenesis","volume":"5","author":"Tse","year":"2007","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177726_bib158","doi-asserted-by":"crossref","first-page":"382","DOI":"10.2174\/1566523221666210917114353","article-title":"Mesenchymal stromal cells (MSCs): a promising tool for cell-based angiogenic therapy","volume":"21","author":"Ulpiano","year":"2021","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib159","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1517\/14712598.2013.826187","article-title":"Toward the use of endometrial and menstrual blood mesenchymal stem cells for cell-based therapies","volume":"13","author":"Ulrich","year":"2013","journal-title":"Expet Opin. Biol. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib160","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1093\/humrep\/deu159","article-title":"Mesenchymal stem\/stromal cells in post-menopausal endometrium","volume":"29","author":"Ulrich","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ejphar.2025.177726_bib161","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1754-1611-8-20","article-title":"Endometrial stem cells in regenerative medicine","volume":"8","author":"Verdi","year":"2014","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.ejphar.2025.177726_bib162","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4252\/wjsc.v14.i1.54","article-title":"Modified mesenchymal stem cells in cancer therapy: a smart weapon requiring upgrades for wider clinical applications","volume":"14","author":"Vicinanza","year":"2022","journal-title":"World J. Stem Cell."},{"key":"10.1016\/j.ejphar.2025.177726_bib163","doi-asserted-by":"crossref","first-page":"36","DOI":"10.7150\/ijms.21666","article-title":"Ethical and safety issues of stem cell-based therapy","volume":"15","author":"Volarevic","year":"2018","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib164","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-8722-5-19","article-title":"Clinical applications of mesenchymal stem cells","volume":"5","author":"Wang","year":"2012","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ejphar.2025.177726_bib165","article-title":"Human menstrual blood-derived mesenchymal stem cells as a cellular vehicle for malignant glioma gene therapy","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2025.177726_bib166","first-page":"1","article-title":"Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice","volume":"8","author":"Wang","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib167","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1582-4934.2010.01068.x","article-title":"Endometrial stem cell transplantation restores dopamine production in a Parkinson's disease model","volume":"15","author":"Wolff","year":"2011","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib168","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/jcmm.12433","article-title":"Endometrial stem cell transplantation in MPTP\u2010exposed primates: an alternative cell source for treatment of Parkinson's disease","volume":"19","author":"Wolff","year":"2015","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib169","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-019-1243-8","article-title":"Genome-wide DNA methylation and hydroxymethylation analysis reveal human menstrual blood-derived stem cells inhibit hepatocellular carcinoma growth through oncogenic pathway suppression via regulating 5-hmC in enhancer elements","volume":"10","author":"Wu","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib170","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3390\/ijms18040689","article-title":"Transplantation of menstrual blood-derived mesenchymal stem cells promotes the repair of lps-induced acute lung injury","volume":"18","author":"Xiang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177726_bib171","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-018-0874-5","article-title":"Treatment of experimental colitis by endometrial regenerative cells through regulation of B lymphocytes in mice","volume":"9","author":"Xu","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib172","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13287-023-03387-4","article-title":"Endometrium-derived mesenchymal stem cells suppress progression of endometrial cancer via the DKK1-Wnt\/\u03b2-catenin signaling pathway","volume":"14","author":"Xu","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib173","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2023.106386","article-title":"Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4\/MyD88\/NLRP3\/Casp1 pathway","volume":"157","author":"Xu","year":"2023","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.ejphar.2025.177726_bib174","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-018-1101-0","article-title":"Endometrial mesenchymal stem cells isolated from menstrual blood repaired epirubicin-induced damage to human ovarian granulosa cells by inhibiting the expression of Gadd45b in cell cycle pathway","volume":"10","author":"Yan","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib175","first-page":"43","article-title":"Endometrial mesenchymal stem\/stromal cell modulation of T cell proliferation","volume":"157","author":"Yang","year":"2019","journal-title":"Reproduction"},{"key":"10.1016\/j.ejphar.2025.177726_bib176","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13287-022-02734-1","article-title":"Human menstrual blood-derived stem cell transplantation suppresses liver injury in DDC-induced chronic cholestasis","volume":"13","author":"Yang","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib177","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.semcancer.2017.11.018","article-title":"The FOXO3-FOXM1 axis: a key cancer drug target and a modulator of cancer drug resistance","volume":"50","author":"Yao","year":"2018","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.ejphar.2025.177726_bib178","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s13287-023-03568-1","article-title":"The effects of intraovarian injection of autologous menstrual blood-derived mesenchymal stromal cells on pregnancy outcomes in women with poor ovarian response","volume":"14","author":"Zafardoust","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib179","first-page":"157","article-title":"Intrathecal autologous bone marrow-derived hematopoietic stem cell therapy in neurological diseases","volume":"9","author":"Zakerinia","year":"2018","journal-title":"Int. J. Organ Transplant. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib181","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13372","article-title":"Supplementation of mitochondria from endometrial mesenchymal stem cells improves oocyte quality in aged mice","volume":"56","author":"Zhang","year":"2023","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ejphar.2025.177726_bib182","doi-asserted-by":"crossref","first-page":"565","DOI":"10.21037\/atm.2020.03.218","article-title":"The clinical application of mesenchymal stem cells in liver disease: the current situation and potential future","volume":"8","author":"Zhang","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.ejphar.2025.177726_bib183","doi-asserted-by":"crossref","first-page":"8347","DOI":"10.1038\/s41598-023-35373-4","article-title":"Novel in vivo endometriotic models associated eutopic endometrium by implanting menstrual blood-derived stromal cells from patients with endometriosis","volume":"13","author":"Zhang","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.177726_bib184","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbmt.2014.09.030","article-title":"Immunomodulation effects of mesenchymal stromal cells on acute graft-versus-host disease after hematopoietic stem cell transplantation","volume":"21","author":"Zhao","year":"2015","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.ejphar.2025.177726_bib185","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fnmol.2018.00140","article-title":"Transplantation of human menstrual blood-derived mesenchymal stem cells alleviates Alzheimer's disease-like pathology in APP\/PS1 transgenic mice","volume":"11","author":"Zhao","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2025.177726_bib186","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3390\/genes9070361","article-title":"GADD45B as a prognostic and predictive biomarker in stage II colorectal cancer","volume":"9","author":"Zhao","year":"2018","journal-title":"Genes"},{"key":"10.1016\/j.ejphar.2025.177726_bib187","article-title":"The unique immunomodulatory properties of MSC-derived exosomes in organ transplantation","volume":"12","author":"Zheng","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.177726_bib188","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/1574888X14666181205120110","article-title":"Stem cells and endometrial regeneration: from basic research to clinical trial","volume":"14","author":"Zhu","year":"2019","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2025.177726_bib189","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1089\/bio.2017.0057","article-title":"The clinical applications of endometrial mesenchymal stem cells","volume":"16","author":"Zuo","year":"2018","journal-title":"Biopreserv. Biobanking"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925004807?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925004807?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:02:37Z","timestamp":1748908957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925004807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":188,"alternative-id":["S0014299925004807"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177726","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Menstrual blood and endometrial mesenchymal stem\/stromal cells: A frontier in regenerative medicine and cancer therapy","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177726","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177726"}}