{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:12:45Z","timestamp":1778879565269,"version":"3.51.4"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Wuxi Medical Innovation Team Project","award":["CXTD202401"],"award-info":[{"award-number":["CXTD202401"]}]},{"name":"Wuxi \"Light of Taihu Lake\" Science and Technology Tacking (Basic research) Project","award":["K20241011"],"award-info":[{"award-number":["K20241011"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400455"],"award-info":[{"award-number":["82400455"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Province Financial Pair Assistance for the Construction of Regional Medical Centre Project","award":["DHLCYJ202502"],"award-info":[{"award-number":["DHLCYJ202502"]}]},{"name":"Wuxi Municipal Health Commission Scientific Research Fund Youth Project","award":["Q202234"],"award-info":[{"award-number":["Q202234"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ejphar.2025.177807","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T02:44:59Z","timestamp":1749005099000},"page":"177807","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Morin ameliorates coronary artery relaxation by activating TRPV4-eNOS-NO signalling in high-salt diet-fed rats"],"prefix":"10.1016","volume":"1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4480-8012","authenticated-orcid":false,"given":"Xiaodong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhixuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifei","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runfeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.177807_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25105333","article-title":"Potential role and mechanism of mulberry extract in immune modulation: focus on chemical compositions, mechanistic insights, and extraction techniques","volume":"25","author":"Abbas","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177807_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19092605","article-title":"Role of nitric oxide in the cardiovascular and renal systems","volume":"19","author":"Ahmad","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177807_bib3","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1161\/HYPERTENSIONAHA.123.21887","article-title":"Dissociation of hypertension and renal damage after cessation of high-salt diet in dahl rats","volume":"81","author":"Arkhipov","year":"2024","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.177807_bib4","first-page":"18174","article-title":"Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone","volume":"109","author":"Bagher","year":"2012","journal-title":"Proc."},{"key":"10.1016\/j.ejphar.2025.177807_bib5","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.brainresbull.2018.03.006","article-title":"Involvement of GABAergic, BDNF and Nox-2 mechanisms in the prevention and reversal of ketamine-induced schizophrenia-like behavior by morin in mice","volume":"139","author":"Ben-Azu","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2025.177807_bib6","doi-asserted-by":"crossref","first-page":"H634","DOI":"10.1152\/ajpheart.00717.2011","article-title":"Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling","volume":"302","author":"Bubolz","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2025.177807_bib7","doi-asserted-by":"crossref","first-page":"H854","DOI":"10.1152\/ajpheart.00282.2017","article-title":"Muscle contraction induced arterial shear stress increases endothelial nitric oxide synthase phosphorylation in humans","volume":"313","author":"Casey","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2025.177807_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/bs.ctm.2020.01.007","article-title":"Endothelial TRPV4 channels and vasodilator reactivity","volume":"85","author":"Chen","year":"2020","journal-title":"Curr. Top. Membr."},{"key":"10.1016\/j.ejphar.2025.177807_bib9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/MCA.0000000000000603","article-title":"The association of chronic air pollutants with coronary artery spasm, vasospastic angina, and endothelial dysfunction","volume":"29","author":"Choi","year":"2018","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.ejphar.2025.177807_bib10","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ccc.2019.12.009","article-title":"Nitric oxide and endothelial dysfunction","volume":"36","author":"Cyr","year":"2020","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.ejphar.2025.177807_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.569914","article-title":"L-Arginine-Nitric oxide-asymmetric dimethylarginine pathway and the coronary circulation: translation of basic science results to clinical practice","volume":"11","author":"Cziraki","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177807_bib12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/21224","article-title":"Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation","volume":"399","author":"Dimmeler","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2025.177807_bib13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s11906-010-0118-2","article-title":"Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets","volume":"12","author":"Feletou","year":"2010","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.ejphar.2025.177807_bib14","doi-asserted-by":"crossref","first-page":"968","DOI":"10.3389\/fphar.2018.00968","article-title":"Inflammasome-independent NALP3 contributes to high-salt induced endothelial dysfunction","volume":"9","author":"Fu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177807_bib15","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016773","article-title":"Genetically predicted midlife blood pressure and coronary artery disease risk: mendelian randomization analysis","volume":"9","author":"Gill","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ejphar.2025.177807_bib16","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.jacc.2019.11.055","article-title":"Salt reduction to prevent hypertension and cardiovascular disease: JACC State-of-the-Art review","volume":"75","author":"He","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2025.177807_bib17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4196\/kjpp.2021.25.3.177","article-title":"Morin alleviates fructose-induced metabolic syndrome in rats via ameliorating oxidative stress, inflammatory and fibrotic markers","volume":"25","author":"Heeba","year":"2021","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177807_bib18","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1017\/S0007114513003693","article-title":"Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients","volume":"111","author":"Horn","year":"2014","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ejphar.2025.177807_bib19","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1001\/jama.2018.13467","article-title":"Association of clinical and social factors with excess hypertension risk in black compared with white US adults","volume":"320","author":"Howard","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2025.177807_bib20","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.15420\/ecr.2019.20","article-title":"Coronary artery spasm: the interplay between endothelial dysfunction and vascular smooth muscle cell hyperreactivity","volume":"15","author":"Hubert","year":"2020","journal-title":"Eur. Cardiol."},{"key":"10.1016\/j.ejphar.2025.177807_bib21","doi-asserted-by":"crossref","first-page":"29074","DOI":"10.1007\/s11356-019-06091-0","article-title":"Amelioration of titanium dioxide nanoparticle reprotoxicity by the antioxidants morin and rutin","volume":"26","author":"Hussein","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ejphar.2025.177807_bib22","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.3892\/ijo.2015.2967","article-title":"The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells","volume":"46","author":"Hyun","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.ejphar.2025.177807_bib23","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1248\/bpb.27.1779","article-title":"Effects of morin on blood pressure and metabolic changes in fructose-induced hypertensive rats","volume":"27","author":"Kang","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2025.177807_bib24","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1080\/10641963.2022.2055764","article-title":"Astaxanthin attenuates cardiovascular dysfunction associated with deoxycorticosterone acetate-salt-induced hypertension in rats","volume":"44","author":"Khodir","year":"2022","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.ejphar.2025.177807_bib25","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1007\/s11064-016-1914-0","article-title":"Morin mitigates chronic constriction injury (CCI)-induced peripheral neuropathy by inhibiting oxidative stress induced PARP over-activation and neuroinflammation","volume":"41","author":"Komirishetty","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2025.177807_bib26","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1172\/JCI200314172","article-title":"Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension","volume":"111","author":"Landmesser","year":"2003","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2025.177807_bib27","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ejps.2018.12.011","article-title":"Mechanisms of poor oral bioavailability of flavonoid Morin in rats: from physicochemical to biopharmaceutical evaluations","volume":"128","author":"Li","year":"2019","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejphar.2025.177807_bib28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.lfs.2019.02.028","article-title":"Luteolin-induced coronary arterial relaxation involves activation of the myocyte voltage-gated K(+) channels and inward rectifier K(+) channels","volume":"221","author":"Li","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.177807_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110766","article-title":"TMEM16A-encoded anoctamin 1 inhibition contributes to chrysin-induced coronary relaxation","volume":"131","author":"Ma","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2025.177807_bib30","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/HYPERTENSIONAHA.116.08874","article-title":"TMEM16A contributes to endothelial dysfunction by facilitating Nox2 NADPH oxidase-derived reactive oxygen species generation in hypertension","volume":"69","author":"Ma","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.177807_bib31","doi-asserted-by":"crossref","first-page":"16812","DOI":"10.1002\/jcp.28350","article-title":"A review on coronary artery disease, its risk factors, and therapeutics","volume":"234","author":"Malakar","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2025.177807_bib32","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1111\/bph.16082","article-title":"Functional role of coupling the endothelial TRPV4 and K(Ca) 3.1 channels in regulating coronary vascular tone","volume":"180","author":"Mao","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177807_bib33","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/ATVBAHA.123.319516","article-title":"Single-Cell RNA-Seq reveals coronary heterogeneity and identifies CD133(+)TRPV4(high) endothelial subpopulation in regulating flow-induced vascular tone in mice","volume":"44","author":"Mao","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2025.177807_bib34","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1111\/bph.15755","article-title":"Endothelial TRPV4-eNOS coupling as a vital therapy target for treatment of hypertension","volume":"179","author":"Mao","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177807_bib35","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007157","article-title":"Nitric oxide-dependent feedback loop regulates transient receptor potential Vanilloid 4 (TRPV4) channel cooperativity and endothelial function in small pulmonary arteries","volume":"6","author":"Marziano","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ejphar.2025.177807_bib36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11010-011-1207-5","article-title":"Morin augments anticarcinogenic and antiproliferative efficacy against 7,12-dimethylbenz(a)-anthracene induced experimental mammary carcinogenesis","volume":"364","author":"Nandhakumar","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ejphar.2025.177807_bib37","first-page":"904","article-title":"Atorvastatin improves coronary flow and endothelial function in patients with coronary slow flow","volume":"15","author":"Niu","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejphar.2025.177807_bib38","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/cvr\/cvaa003","article-title":"ESC working group on coronary pathophysiology and microcirculation position paper on 'coronary microvascular dysfunction in cardiovascular disease'","volume":"116","author":"Padro","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2025.177807_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/nu13010270","article-title":"Mechanisms of dietary sodium-induced impairments in endothelial function and potential countermeasures","volume":"13","author":"Patik","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.ejphar.2025.177807_bib40","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1042\/CS20201441","article-title":"beta-blockade prevents coronary macro- and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat","volume":"135","author":"Pearson","year":"2021","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.ejphar.2025.177807_bib41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.vph.2016.06.005","article-title":"Apocynin reduces blood pressure and restores the proper function of vascular endothelium in SHR","volume":"87","author":"Perassa","year":"2016","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177807_bib42","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S2221-1691(12)60073-2","article-title":"Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study","volume":"2","author":"Prahalathan","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.ejphar.2025.177807_bib43","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.metabol.2011.12.012","article-title":"Morin attenuates blood pressure and oxidative stress in deoxycorticosterone acetate-salt hypertensive rats: a biochemical and histopathological evaluation","volume":"61","author":"Prahalathan","year":"2012","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.ejphar.2025.177807_bib44","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6374582","article-title":"Impact of a multichannel blocker in attenuating intramyocardial artery remodeling in hypertensive rats through increased nitric oxide bioavailability","volume":"2019","author":"Quintana-Villamandos","year":"2019","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejphar.2025.177807_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111511","article-title":"Morin hydrate: a comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential","volume":"138","author":"Rajput","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2025.177807_bib46","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s12265-019-09928-8","article-title":"Curcumin induces endothelium-dependent relaxation by activating endothelial TRPV4 channels","volume":"12","author":"Shao","year":"2019","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.ejphar.2025.177807_bib47","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12933-020-01000-z","article-title":"Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet","volume":"19","author":"Sukumaran","year":"2020","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.ejphar.2025.177807_bib48","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/mnfr.201500618","article-title":"Dietary polyphenol morin rescues endothelial dysfunction in a diabetic mouse model by activating the Akt\/eNOS pathway","volume":"60","author":"Taguchi","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejphar.2025.177807_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110463","article-title":"Plant polyphenols Morin and Quercetin rescue nitric oxide production in diabetic mouse aorta through distinct pathways","volume":"129","author":"Taguchi","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2025.177807_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173123","article-title":"Underlying mechanism of vasorelaxant effect exerted by 3,5,7,2',4'-pentahydroxyflavone in rats aortic ring","volume":"880","author":"Tew","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177807_bib51","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejphar.2011.06.028","article-title":"Coronary hemodynamic regulation by nitric oxide in experimental animals: recent advances","volume":"667","author":"Toda","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177807_bib52","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s11033-018-04575-9","article-title":"Role of MAPK\/NF-kappaB pathway in cardioprotective effect of Morin in isoproterenol induced myocardial injury in rats","volume":"46","author":"Verma","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ejphar.2025.177807_bib53","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s42003-022-03653-w","article-title":"mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling","volume":"5","author":"Wang","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ejphar.2025.177807_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102204","article-title":"RND3 attenuates oxidative stress and vascular remodeling in spontaneously hypertensive rat via inhibiting ROCK1 signaling","volume":"48","author":"Wu","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2025.177807_bib55","article-title":"Enhancing drug solubility through competitive adsorption on silica nanosurfaces with ultrahigh silanol densities","volume":"122","author":"Xu","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2025.177807_bib56","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1161\/CIRCRESAHA.119.316394","article-title":"Intestinal Flora modulates blood pressure by regulating the synthesis of intestinal-derived corticosterone in high salt-induced hypertension","volume":"126","author":"Yan","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.177807_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172561","article-title":"Morin induces endothelium-dependent relaxation by activating TRPV4 channels in rat mesenteric arteries","volume":"859","author":"Zhang","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177807_bib58","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0021-9150(99)00288-9","article-title":"Endothelium-dependent and -independent functions are impaired in patients with coronary heart disease","volume":"149","author":"Zhang","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ejphar.2025.177807_bib59","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/cts.12770","article-title":"Potential protective effects of the water-soluble Chinese propolis on hypertension induced by high-salt intake","volume":"13","author":"Zhou","year":"2020","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.ejphar.2025.177807_bib60","doi-asserted-by":"crossref","first-page":"10137","DOI":"10.1039\/D0FO02356F","article-title":"Puerarin induces mouse mesenteric vasodilation and ameliorates hypertension involving endothelial TRPV4 channels","volume":"11","author":"Zhou","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.ejphar.2025.177807_bib61","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1159\/000102955","article-title":"Effect of high-salt diet on vascular relaxation and oxidative stress in mesenteric resistance arteries","volume":"44","author":"Zhu","year":"2007","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.ejphar.2025.177807_bib62","doi-asserted-by":"crossref","first-page":"H575","DOI":"10.1152\/ajpheart.00331.2003","article-title":"Effect of high-salt diet on NO release and superoxide production in rat aorta","volume":"286","author":"Zhu","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925005618?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925005618?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:26:22Z","timestamp":1778876782000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925005618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":62,"alternative-id":["S0014299925005618"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177807","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Morin ameliorates coronary artery relaxation by activating TRPV4-eNOS-NO signalling in high-salt diet-fed rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177807","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177807"}}