{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:23:59Z","timestamp":1780917839462,"version":"3.54.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0909000"],"award-info":[{"award-number":["2020YFA0909000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2024ZZ 2056"],"award-info":[{"award-number":["2024ZZ 2056"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82127807"],"award-info":[{"award-number":["82127807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003142"],"award-info":[{"award-number":["82003142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015377","name":"Shanghai Key Laboratory of Molecular Imaging","doi-asserted-by":"publisher","award":["18DZ2260400"],"award-info":[{"award-number":["18DZ2260400"]}],"id":[{"id":"10.13039\/501100015377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ejphar.2025.177839","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T11:36:15Z","timestamp":1750332975000},"page":"177839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Baicalein suppresses the malignant progression of acute myeloid leukemia via ROS-dependent metabolic reprogramming: Mechanisms of differentiation induction and ferroptosis activation"],"prefix":"10.1016","volume":"1002","author":[{"given":"Meishi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6015-2426","authenticated-orcid":false,"given":"Yuhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangle","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.177839_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115787","article-title":"The warburg effect explained: integration of enhanced glycolysis with heterogeneous mitochondria to promote cancer cell proliferation","volume":"24","author":"Alberghina","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177839_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.133550","article-title":"Exploration of binding mechanism of triclosan towards cancer markers using molecular docking and molecular dynamics","volume":"293","author":"Bhardwaj","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.ejphar.2025.177839_bib3","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.3390\/ijms24054732","article-title":"Stompor-gor\u0105cy promising role of the Scutellaria baicalensis root hydroxyflavone-baicalein in the prevention and treatment of human diseases","volume":"24","author":"Chmiel","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177839_bib4","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s41419-022-05213-w","article-title":"FOXD1 facilitates pancreatic cancer cell proliferation, invasion, and metastasis by regulating GLUT1-mediated aerobic glycolysis","volume":"13","author":"Cai","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2025.177839_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.577","article-title":"Baicalein resensitizes tamoxifen-resistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxia-inducible factor-1\u03b1","volume":"11","author":"Chen","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.ejphar.2025.177839_bib6","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0140-6736(23)00108-3","article-title":"Acute myeloid leukaemia","volume":"401","author":"DiNardo","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2025.177839_bib7","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.tips.2024.03.005","article-title":"AML treatment: conventional chemotherapy and emerging novel agents","volume":"45","author":"Forsberg","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2025.177839_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231710037","article-title":"Revisited metabolic control and reprogramming cancers by means of the warburg effect in tumor cells","volume":"23","author":"Fukushi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177839_bib9","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.cmet.2022.08.002","article-title":"Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of I\u03baB\u03b1","volume":"34","author":"Guo","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejphar.2025.177839_bib10","article-title":"Mitochondria and the permeability transition pore in cancer metabolic reprogramming","volume":"88","author":"Guo","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177839_bib11","first-page":"47","article-title":"Cancer incidence and mortality in China, 2022","volume":"4","author":"Han","year":"2024","journal-title":"J Natl Cancer Cent."},{"key":"10.1016\/j.ejphar.2025.177839_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2024.109286","article-title":"In silico exploration of phytochemicals as inhibitors for acute myeloid leukemia by targeting LIN28A gene: a cheminformatics study","volume":"183","author":"Hassan","year":"2024","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.ejphar.2025.177839_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12020279","article-title":"Synergistic differential DNA demethylation activity of danshensu (Salvia miltiorrhiza) associated with different probiotics in nonalcoholic fatty liver disease","volume":"12","author":"Hassan","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2025.177839_bib14","doi-asserted-by":"crossref","first-page":"6568","DOI":"10.3390\/ijms23126568","article-title":"Arsenic trioxide and venetoclax synergize against AML progenitors by ROS induction and inhibition of Nrf2 activation","volume":"23","author":"Hoang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177839_bib15","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2025.177839_bib16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.ejphar.2025.177839_bib17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40880-018-0288-x","article-title":"Amino acid transporter SLC7A11\/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer","volume":"38","author":"Koppula","year":"2018","journal-title":"Cancer Commun."},{"key":"10.1016\/j.ejphar.2025.177839_bib18","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1038\/s41401-024-01258-z","article-title":"Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2\/STAT3\/GPX4 axis","volume":"45","author":"Lai","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2025.177839_bib19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13045-024-01527-8","article-title":"Metabolic reprogramming in the tumor microenvironment of liver cancer","volume":"17","author":"Lin","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ejphar.2025.177839_bib20","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/bph.15986","article-title":"Artesunate, a new antimalarial clinical drug, exhibits potent anti-AML activity by targeting the ROS\/bim and TFRC\/Fe2+ pathways","volume":"180","author":"Liu","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177839_bib21","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1182\/blood.2022018092","article-title":"Metabolism in acute myeloid leukemia: mechanistic insights and therapeutic targets","volume":"141","author":"Mishra","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2025.177839_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1403272","article-title":"Dual roles of CD11b+CD33+HLA-DR-\/lowCD14- myeloid-derived suppressor cells with a granulocytic morphology following allogeneic hematopoietic stem cell transplantation: from inflammation promoters to immune suppressors within 90 days","volume":"15","author":"Ni","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.177839_bib23","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3324\/haematol.2022.281233","article-title":"Characterization of therapy-related acute myeloid leukemia: increasing incidence and prognostic implications","volume":"108","author":"Nilsson","year":"2023","journal-title":"Haematologica"},{"key":"10.1016\/j.ejphar.2025.177839_bib24","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1142\/S0192415X21500245","article-title":"Baicalein inhibits gastric cancer cell proliferation and migration through a FAK interaction via AKT\/mTOR signaling","volume":"49","author":"Qiao","year":"2021","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.ejphar.2025.177839_bib25","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41423-021-00727-3","article-title":"The therapeutic implications of immunosuppressive tumor aerobic glycolysis","volume":"19","author":"Reinfeld","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.ejphar.2025.177839_bib26","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3390\/ijms24010449","article-title":"Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis","volume":"24","author":"Rochette","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177839_bib27","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/ajh.26822","article-title":"Acute myeloid leukemia: 2023 update on diagnosis, risk-stratification, and management","volume":"98","author":"Shimony","year":"2023","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.ejphar.2025.177839_bib28","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s13238-021-00846-7","article-title":"Metabolic reprogramming and epigenetic modifications on the path to cancer","volume":"13","author":"Sun","year":"2022","journal-title":"Protein Cell"},{"key":"10.1016\/j.ejphar.2025.177839_bib29","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.3390\/antiox11112108","article-title":"Metabolic syndrome programming and reprogramming: mechanistic aspects of oxidative stress","volume":"11","author":"Tain","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.ejphar.2025.177839_bib30","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.3390\/ijms22052470","article-title":"Oxidative stress and ROS-mediated signaling in leukemia: novel promising perspectives to eradicate chemoresistant cells in myeloid leukemia","volume":"22","author":"Trombetti","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.177839_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.177084","article-title":"Melittin suppresses aerobic glycolysis by regulating HSF1\/PDK3 to increase chemosensitivity of NSCLC","volume":"986","author":"Wang","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177839_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.107032","article-title":"Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: a comprehensive review with future perspectives","volume":"199","author":"Wang","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2025.177839_bib33","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-Induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ejphar.2025.177839_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12929-023-00956-w","article-title":"Role of mitochondrial alterations in human cancer progression and cancer immunity","volume":"30","author":"Wang","year":"2023","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ejphar.2025.177839_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120322","article-title":"Ubiquitination regulation of aerobic glycolysis in cancer","volume":"292","author":"Xie","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.177839_bib36","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-021-01316-8","article-title":"The cancer metabolic reprogramming and immune response","volume":"20","author":"Xia","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ejphar.2025.177839_bib37","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1038\/s41467-023-39401-9","article-title":"SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells","volume":"14","author":"Yan","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2025.177839_bib38","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13046-021-02012-7","article-title":"Metformin induces ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer","volume":"40","author":"Yang","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2025.177839_bib39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbrc.2021.05.010","article-title":"Baicalein inhibits RLS3-induced ferroptosis in melanocytes","volume":"5","author":"Yang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2025.177839_bib40","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/bib\/bbad518","article-title":"Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine","volume":"25","author":"Zhang","year":"2023","journal-title":"Briefings Bioinf."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992500593X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001429992500593X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:30:11Z","timestamp":1778877011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001429992500593X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":40,"alternative-id":["S001429992500593X"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177839","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baicalein suppresses the malignant progression of acute myeloid leukemia via ROS-dependent metabolic reprogramming: Mechanisms of differentiation induction and ferroptosis activation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177839","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"177839"}}