{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:24:31Z","timestamp":1784132671497,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024J011125"],"award-info":[{"award-number":["2024J011125"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022J011067"],"award-info":[{"award-number":["2022J011067"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023J011321"],"award-info":[{"award-number":["2023J011321"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ejphar.2025.177931","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T08:38:18Z","timestamp":1752568698000},"page":"177931","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Wnt5a-AS knockdown alleviates sevoflurane-induced depression by promoting hippocampal neurogenesis and mitochondrial fusion in adolescent rats"],"prefix":"10.1016","volume":"1003","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-2964","authenticated-orcid":false,"given":"Guo-Lin","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Qing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Nan","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-3090","authenticated-orcid":false,"given":"Li-Qun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan-Fang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ejphar.2025.177931_bib1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrn.2017.45","article-title":"Adult hippocampal neurogenesis and cognitive flexibility - linking memory and mood","volume":"18","author":"Anacker","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"issue":"7712","key":"10.1016\/j.ejphar.2025.177931_bib2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41586-018-0262-4","article-title":"Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus","volume":"559","author":"Anacker","year":"2018","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.ejphar.2025.177931_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abk2376","article-title":"Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms","volume":"8","author":"Bao","year":"2022","journal-title":"Sci. Adv."},{"issue":"11","key":"10.1016\/j.ejphar.2025.177931_bib4","doi-asserted-by":"crossref","first-page":"6723","DOI":"10.1038\/s41380-021-01122-0","article-title":"Role of adult hippocampal neurogenesis in the antidepressant actions of lactate","volume":"26","author":"Carrard","year":"2021","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ejphar.2025.177931_bib5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.ejphar.2025.177931_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2022.968320","article-title":"Stereotaxic atlas of the infant rat brain at postnatal days 7-13","volume":"16","author":"Chen","year":"2022","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.ejphar.2025.177931_bib7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.toxlet.2022.10.003","article-title":"PGAM5 regulates DRP1-mediated mitochondrial fission\/mitophagy flux in lipid overload-induced renal tubular epithelial cell necroptosis","volume":"372","author":"Dan","year":"2023","journal-title":"Toxicol. Lett."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177931_bib8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s12264-012-1260-4","article-title":"Sevoflurane exposure in 7-day-old rats affects neurogenesis, neurodegeneration and neurocognitive function","volume":"28","author":"Fang","year":"2012","journal-title":"Neurosci. Bull."},{"issue":"32","key":"10.1016\/j.ejphar.2025.177931_bib9","doi-asserted-by":"crossref","first-page":"E1028","DOI":"10.1503\/cmaj.170313","article-title":"Anesthetic neurotoxicity and the developing brain","volume":"189","author":"Ho","year":"2017","journal-title":"CMAJ (Can. Med. Assoc. J.)"},{"issue":"5398","key":"10.1016\/j.ejphar.2025.177931_bib10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.283.5398.70","article-title":"Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain","volume":"283","author":"Ikonomidou","year":"1999","journal-title":"Science"},{"issue":"6505","key":"10.1016\/j.ejphar.2025.177931_bib11","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1126\/science.aba9760","article-title":"Mitochondrial dynamics in postmitotic cells regulate neurogenesis","volume":"369","author":"Iwata","year":"2020","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ejphar.2025.177931_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/bja\/aet177","article-title":"Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg seminar","volume":"111","author":"Jevtovic-Todorovic","year":"2013","journal-title":"Br. J. Anaesth."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177931_bib13","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41420-022-01179-y","article-title":"Sevoflurane induces microRNA-18a to delay rat neurodevelopment via suppression of the RUNX1\/Wnt\/beta-catenin axis","volume":"8","author":"Jiang","year":"2022","journal-title":"Cell Death Discov."},{"issue":"10","key":"10.1016\/j.ejphar.2025.177931_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24108696","article-title":"Sevoflurane exposure in neonates perturbs the expression patterns of specific genes that may underly the observed learning and memory deficits","volume":"24","author":"Jimenez-Tellez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ejphar.2025.177931_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000412","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"8","author":"Kilkenny","year":"2010","journal-title":"PLoS Biol."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177931_bib16","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1001\/jamapsychiatry.2022.4539","article-title":"Serotonin 4 receptor brain binding in major depressive disorder and association with memory dysfunction","volume":"80","author":"Kohler-Forsberg","year":"2023","journal-title":"JAMA Psychiatry"},{"issue":"5","key":"10.1016\/j.ejphar.2025.177931_bib17","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41593-022-01065-x","article-title":"Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior","volume":"25","author":"Li","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2025.177931_bib18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.freeradbiomed.2022.01.031","article-title":"Sevoflurane induced neurotoxicity in neonatal mice links to a GSK3\u03b2\/Drp1-dependent mitochondrial fission and apoptosis","volume":"181","author":"Liu","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"19","key":"10.1016\/j.ejphar.2025.177931_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/cells11193002","article-title":"Current understanding of the neural stem cell niches","volume":"11","author":"Llorente","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2025.177931_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109334","article-title":"Knockdown of long noncoding RNA WNT5A-AS restores the fate of neural stem cells exposed to sevoflurane via inhibiting WNT5A\/Ryk-ROS signaling","volume":"118","author":"Lu","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.ejphar.2025.177931_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076746","article-title":"Sevoflurane induces a cyclophilin D-Dependent decrease of neural progenitor cells migration","volume":"24","author":"Lu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"13","key":"10.1016\/j.ejphar.2025.177931_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz0361","article-title":"DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation","volume":"6","author":"Ma","year":"2020","journal-title":"Sci. Adv."},{"issue":"10172","key":"10.1016\/j.ejphar.2025.177931_bib24","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0140-6736(18)32485-1","article-title":"Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial","volume":"393","author":"McCann","year":"2019","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.ejphar.2025.177931_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add5220","article-title":"Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells","volume":"9","author":"Petrelli","year":"2023","journal-title":"Sci. Adv."},{"issue":"42","key":"10.1016\/j.ejphar.2025.177931_bib26","doi-asserted-by":"crossref","first-page":"8200","DOI":"10.1523\/JNEUROSCI.1157-19.2019","article-title":"Pleiotropic mitochondria: the influence of mitochondria on neuronal development and disease","volume":"39","author":"Rangaraju","year":"2019","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177931_bib27","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.bja.2018.01.014","article-title":"Persistent alteration in behavioural reactivity to a mild social stressor in rhesus monkeys repeatedly exposed to sevoflurane in infancy","volume":"120","author":"Raper","year":"2018","journal-title":"Br. J. Anaesth."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177931_bib28","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1213\/ANE.0000000000001171","article-title":"The effects of the toll-like receptor 4 antagonist, ibudilast, on sevoflurane's minimum alveolar concentration and the delayed remifentanil-induced increase in the minimum alveolar concentration in rats","volume":"122","author":"Ruiz-P\u00e9rez","year":"2016","journal-title":"Anesth. Analg."},{"issue":"6","key":"10.1016\/j.ejphar.2025.177931_bib29","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.cell.2013.05.002","article-title":"Dynamics of hippocampal neurogenesis in adult humans","volume":"153","author":"Spalding","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2025.177931_bib30","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.68394","article-title":"Fine-tuned repression of Drp1-driven mitochondrial fission primes a 'stem\/progenitor-like state' to support neoplastic transformation","volume":"10","author":"Spurlock","year":"2021","journal-title":"eLife"},{"issue":"6","key":"10.1016\/j.ejphar.2025.177931_bib31","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10565-021-09677-y","article-title":"Mechanistic insight into sevoflurane-associated developmental neurotoxicity","volume":"38","author":"Sun","year":"2022","journal-title":"Cell Biol. Toxicol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177931_bib32","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcae325","article-title":"Childhood anaesthesia and autism risk: population and murine study","volume":"6","author":"Sun","year":"2024","journal-title":"Brain Commun"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177931_bib33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/ALN.0000000000002232","article-title":"Neuropsychological and behavioral outcomes after exposure of young children to procedures requiring general anesthesia: the Mayo anesthesia safety in kids (mask) study","volume":"129","author":"Warner","year":"2018","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177931_bib34","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1038\/s41467-020-16312-7","article-title":"Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics","volume":"11","author":"Yu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2025.177931_bib35","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.biopha.2016.12.062","article-title":"Neonatal anesthetic neurotoxicity: insight into the molecular mechanisms of long-term neurocognitive deficits","volume":"87","author":"Yu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2025.177931_bib36","article-title":"Repeated early-life exposure to anaesthesia and surgery causes subsequent anxiety-like behaviour and gut microbiota dysbiosis in juvenile rats","author":"Zhou","year":"2022","journal-title":"Br. J. Anaesth."},{"issue":"2","key":"10.1016\/j.ejphar.2025.177931_bib37","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bja.2022.06.039","article-title":"Repeated early-life exposure to anaesthesia and surgery causes subsequent anxiety-like behaviour and gut microbiota dysbiosis in juvenile rats","volume":"130","author":"Zhou","year":"2023","journal-title":"Br. J. Anaesth."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177931_bib38","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-Induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925006855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925006855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:52:10Z","timestamp":1777459930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925006855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":37,"alternative-id":["S0014299925006855"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177931","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wnt5a-AS knockdown alleviates sevoflurane-induced depression by promoting hippocampal neurogenesis and mitochondrial fusion in adolescent rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177931","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"177931"}}