{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:06:45Z","timestamp":1789470405846,"version":"build-2803163510"},"reference-count":329,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013365","name":"Sichuan University West China Hospital","doi-asserted-by":"publisher","award":["ZYGD23008"],"award-info":[{"award-number":["ZYGD23008"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3403303"],"award-info":[{"award-number":["2023YFC3403303"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.ejphar.2025.177958","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T07:32:01Z","timestamp":1752651121000},"page":"177958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Nasal nanotherapeutics for central nervous system disorders: Bridging the translational gap in central nervous system drug delivery"],"prefix":"10.1016","volume":"1003","author":[{"given":"Yibing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Die","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7880-2113","authenticated-orcid":false,"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.177958_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117996","article-title":"Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions","volume":"256","author":"Abeysinghe","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.177958_bib2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jconrel.2023.08.018","article-title":"Lipid-based nanocarriers challenging the ocular biological barriers: current paradigm and future perspectives","volume":"362","author":"Abla","year":"2023","journal-title":"J. Contr. Release"},{"issue":"12","key":"10.1016\/j.ejphar.2025.177958_bib3","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1007\/s13346-022-01173-y","article-title":"Recent trends of bioconjugated nanomedicines through nose-to-brain delivery for neurological disorders","volume":"12","author":"Agnihotri","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ejphar.2025.177958_bib4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jconrel.2018.05.011","article-title":"Nose-to-brain drug delivery: an update on clinical challenges and progress towards approval of anti-Alzheimer drugs","volume":"281","author":"Agrawal","year":"2018","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.177958_bib5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jconrel.2020.07.044","article-title":"Stimuli-responsive in situ gelling system for nose-to-brain drug delivery","volume":"327","author":"Agrawal","year":"2020","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.177958_bib6","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jconrel.2020.02.020","article-title":"Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting","volume":"321","author":"Agrawal","year":"2020","journal-title":"J. Contr. Release"},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib7","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1039\/C6NR07581A","article-title":"Evidence of nose-to-brain delivery of nanoemulsions: cargoes but not vehicles","volume":"9","author":"Ahmad","year":"2017","journal-title":"Nanoscale"},{"key":"10.1016\/j.ejphar.2025.177958_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114849","article-title":"Novel therapeutic interventions for combating Parkinson's disease and prospects of nose-to-brain drug delivery","volume":"195","author":"Ahmad","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"6","key":"10.1016\/j.ejphar.2025.177958_bib9","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ac9267","article-title":"Development of cannabidiol nanoemulsion for direct nose to brain delivery: statistical optimization,in vitroandin vivoevaluation","volume":"17","author":"Ahmed","year":"2022","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.ejphar.2025.177958_bib10","doi-asserted-by":"crossref","first-page":"825","DOI":"10.2147\/IJN.S447429","article-title":"Nanosuspension-based drug delivery systems for topical applications","volume":"19","author":"Aldeeb","year":"2024","journal-title":"Int. J. Nanomed."},{"issue":"18","key":"10.1016\/j.ejphar.2025.177958_bib11","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1039\/D1BM00896J","article-title":"Local delivery to malignant brain tumors: potential biomaterial-based therapeutic\/adjuvant strategies","volume":"9","author":"Alghamdi","year":"2021","journal-title":"Biomater. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1124\/pharmrev.120.000108","article-title":"Inhaled medicines: past, present, and future","volume":"74","author":"Anderson","year":"2022","journal-title":"Pharmacol. Rev."},{"issue":"2","key":"10.1016\/j.ejphar.2025.177958_bib13","doi-asserted-by":"crossref","DOI":"10.1172\/JCI163447","article-title":"Immune checkpoint blockade in glioblastoma: from tumor heterogeneity to personalized treatment","volume":"133","author":"Arrieta","year":"2023","journal-title":"J. Clin. Investig."},{"issue":"19","key":"10.1016\/j.ejphar.2025.177958_bib14","doi-asserted-by":"crossref","first-page":"8693","DOI":"10.1039\/D1NR01127H","article-title":"Biomimetic camouflage delivery strategies for cancer therapy","volume":"13","author":"Asrorov","year":"2021","journal-title":"Nanoscale"},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib15","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.apsb.2022.07.003","article-title":"Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders","volume":"13","author":"Awad","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejphar.2025.177958_bib16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jconrel.2015.01.017","article-title":"Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles","volume":"201","author":"Baba","year":"2015","journal-title":"J. Contr. Release"},{"issue":"8","key":"10.1016\/j.ejphar.2025.177958_bib17","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1016\/j.drudis.2022.04.012","article-title":"Engineered nasal dry powder for the encapsulation of bioactive compounds","volume":"27","author":"Baldelli","year":"2022","journal-title":"Drug Discov. Today"},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrd.2015.21","article-title":"From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery","volume":"15","author":"Banks","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib19","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41591-020-0781-z","article-title":"A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease","volume":"26","author":"Barthelemy","year":"2020","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib20","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10555-021-09987-x","article-title":"Multiprong control of glioblastoma multiforme invasiveness: blockade of pro-inflammatory signaling, anti-angiogenesis, and homeostasis restoration","volume":"40","author":"Bazan","year":"2021","journal-title":"Cancer Metastasis Rev."},{"issue":"9","key":"10.1016\/j.ejphar.2025.177958_bib21","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/acs.chemrev.3c00705","article-title":"Polymeric nanoparticles for drug delivery","volume":"124","author":"Beach","year":"2024","journal-title":"Chem. Rev."},{"issue":"9","key":"10.1016\/j.ejphar.2025.177958_bib22","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S1474-4422(23)00274-0","article-title":"Preparing for disease-modifying therapies in Alzheimer's disease","volume":"22","author":"Belder","year":"2023","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2025.177958_bib23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jconrel.2020.11.049","article-title":"Injectable thermoresponsive hydrogels as drug delivery system for the treatment of central nervous system disorders: a review","volume":"329","author":"Bellotti","year":"2021","journal-title":"J. Contr. Release"},{"issue":"10423","key":"10.1016\/j.ejphar.2025.177958_bib24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(23)01419-8","article-title":"The epidemiology of Parkinson's disease","volume":"403","author":"Ben-Shlomo","year":"2024","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib25","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.tips.2020.04.008","article-title":"A perspective on multi-target drugs for Alzheimer's disease","volume":"41","author":"Benek","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib26","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s12098-014-1521-5","article-title":"Stem cell therapy: challenges ahead","volume":"82","author":"Bhagavati","year":"2015","journal-title":"Indian J. Pediatr."},{"key":"10.1016\/j.ejphar.2025.177958_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114858","article-title":"Inhaled drug delivery for the targeted treatment of asthma","volume":"198","author":"Boboltz","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41568-019-0220-y","article-title":"Brain metastasis","volume":"20","author":"Boire","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"8","key":"10.1016\/j.ejphar.2025.177958_bib29","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1158\/1078-0432.CCR-15-1399","article-title":"Dendritic cell-based immunotherapy: state of the art and beyond","volume":"22","author":"Bol","year":"2016","journal-title":"Clin. Cancer Res."},{"issue":"6","key":"10.1016\/j.ejphar.2025.177958_bib30","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/cns.13378","article-title":"Mesenchymal stem cell therapy alleviates the neuroinflammation associated with acquired brain injury","volume":"26","author":"Bonsack","year":"2020","journal-title":"CNS Neurosci. Ther."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib31","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/s13346-021-01086-2","article-title":"Using nanotechnology to deliver biomolecules from nose to brain - peptides, proteins, monoclonal antibodies and RNA","volume":"12","author":"Borrajo","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib32","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-021-00487-6","article-title":"Viral vector platforms within the gene therapy landscape","volume":"6","author":"Bulcha","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"8","key":"10.1016\/j.ejphar.2025.177958_bib33","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1208\/s12249-024-02946-z","article-title":"Non-invasive techniques of nose to brain delivery using nanoparticulate carriers: hopes and hurdles","volume":"25","author":"Butola","year":"2024","journal-title":"AAPS PharmSciTech"},{"issue":"9","key":"10.1016\/j.ejphar.2025.177958_bib34","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1093\/brain\/awad150","article-title":"Advances in understanding the function of alpha-synuclein: implications for Parkinson's disease","volume":"146","author":"Calabresi","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.ejphar.2025.177958_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124216","article-title":"Design and development of a chitosan-based nasal powder of dimethyl fumarate-cyclodextrin binary systems aimed at nose-to-brain administration. A stability study","volume":"659","author":"Cama","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"24","key":"10.1016\/j.ejphar.2025.177958_bib36","doi-asserted-by":"crossref","first-page":"16801","DOI":"10.1021\/acs.jmedchem.2c01605","article-title":"Discovery and optimization of potent, selective, and brain-penetrant 1-Heteroaryl-1H-Indazole LRRK2 kinase inhibitors for the treatment of Parkinson's disease","volume":"65","author":"Candito","year":"2022","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.ejphar.2025.177958_bib37","article-title":"A perspective current and past modes of inhalation therapy","volume":"17","author":"Canto Mangana","year":"2024","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.ejphar.2025.177958_bib38","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jconrel.2017.08.027","article-title":"A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin-derived peptide for brain-targeted drug delivery","volume":"264","author":"Chai","year":"2017","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.177958_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116564","article-title":"Prospects for the application of mesenchymal stem cells in Alzheimer's disease treatment","volume":"231","author":"Chakari-Khiavi","year":"2019","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib40","doi-asserted-by":"crossref","DOI":"10.1007\/s12668-024-01730-4","article-title":"Neuro-nanocarriers: redefining treatment pathways for brain disorders","volume":"15","author":"Chauhan","year":"2025","journal-title":"BioNanoScience"},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib41","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1148\/radiol.2020192793","article-title":"Predicting PET cerebrovascular reserve with deep learning by using baseline MRI: a pilot investigation of a drug-free brain stress test","volume":"296","author":"Chen","year":"2020","journal-title":"Radiology"},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib42","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1080\/17425247.2024.2336494","article-title":"Characterizing regional drug delivery within the nasal airways","volume":"21","author":"Chen","year":"2024","journal-title":"Expet Opin. Drug Deliv."},{"key":"10.1016\/j.ejphar.2025.177958_bib43","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.jconrel.2021.12.020","article-title":"Insights into nucleic acid-based self-assembling nanocarriers for targeted drug delivery and controlled drug release","volume":"341","author":"Chen","year":"2022","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib44","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41392-021-00631-2","article-title":"Recent progress in targeted delivery vectors based on biomimetic nanoparticles","volume":"6","author":"Chen","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejphar.2025.177958_bib45","doi-asserted-by":"crossref","first-page":"10435","DOI":"10.2147\/IJN.S265659","article-title":"Nose-to-Brain delivery by nanosuspensions-based in situ gel for breviscapine","volume":"15","author":"Chen","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib46","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12974-023-02853-3","article-title":"Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation","volume":"20","author":"Chen","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2025.177958_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2024.115196","article-title":"Intranasal drug delivery: the interaction between nanoparticles and the nose-to-brain pathway","volume":"207","author":"Chen","year":"2024","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"11","key":"10.1016\/j.ejphar.2025.177958_bib48","doi-asserted-by":"crossref","first-page":"10049","DOI":"10.1021\/acsnano.6b04695","article-title":"Cancer cell membrane-biomimetic nanoparticles for homologous-targeting dual-modal imaging and photothermal therapy","volume":"10","author":"Chen","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejphar.2025.177958_bib49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neuropharm.2016.02.013","article-title":"Viral vectors for therapy of neurologic diseases","volume":"120","author":"Choudhury","year":"2017","journal-title":"Neuropharmacology"},{"issue":"12","key":"10.1016\/j.ejphar.2025.177958_bib51","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41582-023-00883-2","article-title":"Tau-targeting therapies for Alzheimer disease: current status and future directions","volume":"19","author":"Congdon","year":"2023","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib52","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2200057120","article-title":"Intranasal delivery of full-length anti-Nogo-A antibody: a potential alternative route for therapeutic antibodies to central nervous system targets","volume":"120","author":"Correa","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib53","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.apsb.2021.02.012","article-title":"Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: a current overview of in vivo studies","volume":"11","author":"Costa","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib54","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/ar.23816","article-title":"Cranial pair I: the olfactory nerve","volume":"302","author":"Crespo","year":"2019","journal-title":"Anat Rec (Hoboken)"},{"key":"10.1016\/j.ejphar.2025.177958_bib55","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.lfs.2017.12.025","article-title":"Mechanism of intranasal drug delivery directly to the brain","volume":"195","author":"Crowe","year":"2018","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib56","article-title":"Alzheimer's disease drug development pipeline: 2021","volume":"7","author":"Cummings","year":"2021","journal-title":"Alzheimers Dement (N Y)"},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib57","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3233\/JAD-180766","article-title":"Treatment combinations for Alzheimer's Disease: current and future pharmacotherapy options","volume":"67","author":"Cummings","year":"2019","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib58","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11095-022-03433-5","article-title":"CNS delivery of nucleic acid therapeutics: beyond the blood-brain barrier and towards specific cellular targeting","volume":"40","author":"D'Souza","year":"2023","journal-title":"Pharm. Res."},{"issue":"30","key":"10.1016\/j.ejphar.2025.177958_bib59","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.2217\/nnm-2021-0311","article-title":"Nasal delivery of nanotherapeutics for CNS diseases: challenges and opportunities","volume":"16","author":"D'Souza","year":"2021","journal-title":"Nanomedicine (Lond)"},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2025.177958_bib60","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.3727\/096368914X684970","article-title":"Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer's and Parkinson's disease","volume":"23","author":"Danielyan","year":"2014","journal-title":"Cell Transplant."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib61","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/rej.2010.1130","article-title":"Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease","volume":"14","author":"Danielyan","year":"2011","journal-title":"Rejuvenation Res."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib62","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/s41385-022-00500-3","article-title":"Correction: cellular and functional heterogeneity of the airway epithelium","volume":"15","author":"Davis","year":"2022","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.ejphar.2025.177958_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114397","article-title":"Therapeutic nanotechnologies for Alzheimer's disease: a critical analysis of recent trends and findings","volume":"187","author":"Delbreil","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2024.103954","article-title":"Design, development, and technical considerations for dry powder inhaler devices","volume":"29","author":"Dhoble","year":"2024","journal-title":"Drug Discov. Today"},{"issue":"6","key":"10.1016\/j.ejphar.2025.177958_bib65","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.7150\/thno.21254","article-title":"Current strategies for brain drug delivery","volume":"8","author":"Dong","year":"2018","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib66","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40035-025-00481-w","article-title":"Nose-to-brain drug delivery: from bench to bedside","volume":"14","author":"Drath","year":"2025","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.ejphar.2025.177958_bib67","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.brainresbull.2018.10.009","article-title":"Evaluation of intranasal delivery route of drug administration for brain targeting","volume":"143","author":"Erdo","year":"2018","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib68","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1186\/s40001-025-02696-z","article-title":"Promising biomedical applications using superparamagnetic nanoparticles","volume":"30","author":"Fahim","year":"2025","journal-title":"Eur. J. Med. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib69","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41571-022-00699-x","article-title":"Targeting drugs to tumours using cell membrane-coated nanoparticles","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib70","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13643-025-02791-6","article-title":"Safety and effectiveness of inhaled sedation in critically ill patients: a systematic review and meta-analysis","volume":"14","author":"Feng","year":"2025","journal-title":"Syst. Rev."},{"issue":"10423","key":"10.1016\/j.ejphar.2025.177958_bib71","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0140-6736(23)01429-0","article-title":"Medical, surgical, and physical treatments for Parkinson's disease","volume":"403","author":"Foltynie","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2025.177958_bib72","article-title":"On a highway to the brain: a review on nose-to-brain drug delivery using nanoparticles","volume":"29","author":"Formica","year":"2022","journal-title":"Appl. Mater. Today"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib73","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41582-020-00436-x","article-title":"The neuroanatomical-functional paradox in spinal cord injury","volume":"17","author":"Fouad","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.ejphar.2025.177958_bib74","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.addr.2020.02.006","article-title":"Intrathecal drug delivery in the era of nanomedicine","volume":"165\u2013166","author":"Fowler","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib75","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4155\/tde-2017-0013","article-title":"Biomimetic and bioinspired nanoparticles for targeted drug delivery","volume":"8","author":"Gagliardi","year":"2017","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.ejphar.2025.177958_bib76","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jconrel.2023.01.083","article-title":"Dry powder inhaler with the technical and practical obstacles, and forthcoming platform strategies","volume":"355","author":"Gaikwad","year":"2023","journal-title":"J. Contr. Release"},{"issue":"26","key":"10.1016\/j.ejphar.2025.177958_bib77","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1056\/NEJMe2205032","article-title":"Virotherapy for brain tumors - defining the path to success","volume":"386","author":"Galanis","year":"2022","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.ejphar.2025.177958_bib78","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41583-024-00829-7","article-title":"Gene therapy for CNS disorders: modalities, delivery and translational challenges","volume":"25","author":"Gao","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"issue":"8034","key":"10.1016\/j.ejphar.2025.177958_bib79","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-024-07906-y","article-title":"Engineered T cell therapy for central nervous system injury","volume":"634","author":"Gao","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2025.177958_bib80","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jconrel.2022.11.051","article-title":"Mucus adhesion vs. mucus penetration? Screening nanomaterials for nasal inhalation by MD simulation","volume":"353","author":"Gao","year":"2023","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.177958_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.123819","article-title":"In-situ gel: a smart carrier for drug delivery","volume":"652","author":"Garg","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib50","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1474-4422(24)00038-3","article-title":"Global, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the global burden of disease study 2021","volume":"23","year":"2024","journal-title":"Lancet Neurol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib82","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1208\/s12249-024-02810-0","article-title":"In-depth mechanism, challenges, and opportunities of delivering therapeutics in brain using intranasal route","volume":"25","author":"Ghosh","year":"2024","journal-title":"AAPS PharmSciTech"},{"issue":"8","key":"10.1016\/j.ejphar.2025.177958_bib83","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1308573","article-title":"A randomized trial of bevacizumab for newly diagnosed glioblastoma","volume":"370","author":"Gilbert","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib84","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1080\/10717544.2018.1428242","article-title":"In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates","volume":"25","author":"Giuliani","year":"2018","journal-title":"Drug Deliv."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib85","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13024-022-00523-1","article-title":"Alzheimer's disease - the journey of a healthy brain into organ failure","volume":"17","author":"Golde","year":"2022","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejphar.2025.177958_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104952","article-title":"Central nervous system delivery of molecules across the blood-brain barrier","volume":"144","author":"Gosselet","year":"2021","journal-title":"Neurochem. Int."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib87","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1093\/brain\/awaa090","article-title":"Microglial exosomes facilitate alpha-synuclein transmission in Parkinson's disease","volume":"143","author":"Guo","year":"2020","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib88","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13024-020-00391-7","article-title":"Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease","volume":"15","author":"Guo","year":"2020","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib89","doi-asserted-by":"crossref","first-page":"8021","DOI":"10.1038\/s41467-024-52329-y","article-title":"Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier","volume":"15","author":"Guo","year":"2024","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib90","article-title":"Influencing factors of particle deposition in the human nasal cavity","volume":"9","author":"Guo","year":"2024","journal-title":"Laryngoscope Investig. Otolaryngol."},{"key":"10.1016\/j.ejphar.2025.177958_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113961","article-title":"Dosing extracellular vesicles","volume":"178","author":"Gupta","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.ejphar.2025.177958_bib92","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/alz.12694","article-title":"Global estimates on the number of persons across the Alzheimer's disease continuum","volume":"19","author":"Gustavsson","year":"2023","journal-title":"Alzheimer's Dement."},{"issue":"6","key":"10.1016\/j.ejphar.2025.177958_bib93","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S1474-4422(24)00140-6","article-title":"B cell-targeting chimeric antigen receptor T cells as an emerging therapy in neuroimmunological diseases","volume":"23","author":"Haghikia","year":"2024","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib94","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12951-024-02301-1","article-title":"Magnetic resonance imaging with upconversion nanoprobes capable of crossing the blood-cerebrospinal fluid barrier","volume":"22","author":"Han","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"8","key":"10.1016\/j.ejphar.2025.177958_bib95","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1016\/j.apsb.2020.11.023","article-title":"Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies","volume":"11","author":"Han","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejphar.2025.177958_bib96","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jconrel.2023.04.022","article-title":"Spatiotemporal tracking of gold nanorods after intranasal administration for brain targeting","volume":"357","author":"Han","year":"2023","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.177958_bib97","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jconrel.2015.03.033","article-title":"Exosomes as drug delivery vehicles for Parkinson's disease therapy","volume":"207","author":"Haney","year":"2015","journal-title":"J. Contr. Release"},{"issue":"Pt 6","key":"10.1016\/j.ejphar.2025.177958_bib98","article-title":"Development and optimization of in-situ gel containing chitosan nanoparticles for possible nose-to-brain delivery of vinpocetine","volume":"253","author":"Hard","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib99","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1039\/D2BM01572B","article-title":"Recent progress in nanomedicines for imaging and therapy of brain tumors","volume":"11","author":"Hasan","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.ejphar.2025.177958_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110298","article-title":"Cell membrane-coated nanosized active targeted drug delivery systems homing to tumor cells: a review","volume":"106","author":"He","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib101","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"issue":"23","key":"10.1016\/j.ejphar.2025.177958_bib102","doi-asserted-by":"crossref","first-page":"13693","DOI":"10.1021\/acs.chemrev.3c00479","article-title":"Parkinson's disease: advances in treatment and the syntheses of various classes of pharmaceutical drug substances","volume":"123","author":"Hill","year":"2023","journal-title":"Chem. Rev."},{"issue":"10","key":"10.1016\/j.ejphar.2025.177958_bib103","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat. Rev. Neurol."},{"issue":"22","key":"10.1016\/j.ejphar.2025.177958_bib104","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202303266","article-title":"Physiological barriers and strategies of lipid-based nanoparticles for nucleic acid drug delivery","volume":"36","author":"Hu","year":"2024","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib105","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1080\/17425247.2024.2339335","article-title":"Nanomedicines for intranasal delivery: understanding the nano-bio interactions at the nasal mucus-mucosal barrier","volume":"21","author":"Hua","year":"2024","journal-title":"Expet Opin. Drug Deliv."},{"issue":"12","key":"10.1016\/j.ejphar.2025.177958_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsps.2024.102193","article-title":"Rise of implantable drugs: a chronicle of breakthroughs in drug delivery systems","volume":"32","author":"Huanbutta","year":"2024","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.ejphar.2025.177958_bib107","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jconrel.2023.12.054","article-title":"Nanotechnology for enhanced nose-to-brain drug delivery in treating neurological diseases","volume":"366","author":"Huang","year":"2024","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.177958_bib108","first-page":"131","article-title":"Inhalation drug delivery devices: technology update","volume":"8","author":"Ibrahim","year":"2015","journal-title":"Med. Dev. (Auckl)"},{"key":"10.1016\/j.ejphar.2025.177958_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114968","article-title":"siRNA drug delivery across the blood-brain barrier in Alzheimer's disease","volume":"199","author":"Imran Sajid","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"11","key":"10.1016\/j.ejphar.2025.177958_bib110","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1093\/neuonc\/noac113","article-title":"Molecular biomarker-defined brain tumors: epidemiology, validity, and completeness in the United States","volume":"24","author":"Iorgulescu","year":"2022","journal-title":"Neuro Oncol."},{"issue":"12","key":"10.1016\/j.ejphar.2025.177958_bib111","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.ymthe.2019.08.010","article-title":"Systemic exosomal delivery of shRNA minicircles prevents Parkinsonian pathology","volume":"27","author":"Izco","year":"2019","journal-title":"Mol. Ther."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib112","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA research framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer's Dement."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib113","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s40005-022-00589-5","article-title":"Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors","volume":"53","author":"Jeong","year":"2023","journal-title":"J. Pharm. Investig."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib114","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s41565-023-01548-3","article-title":"Combinatorial development of nebulized mRNA delivery formulations for the lungs","volume":"19","author":"Jiang","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.ejphar.2025.177958_bib115","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jconrel.2024.09.012","article-title":"Amyloid-beta-targeting immunotherapies for Alzheimer's disease","volume":"375","author":"Jin","year":"2024","journal-title":"J. Contr. Release"},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib116","article-title":"Mucus physically restricts influenza A viral particle access to the epithelium","volume":"9","author":"Kaler","year":"2025","journal-title":"Adv. Biol. (Weinh)"},{"issue":"9996","key":"10.1016\/j.ejphar.2025.177958_bib117","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson's disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"issue":"36","key":"10.1016\/j.ejphar.2025.177958_bib118","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1016\/j.biomaterials.2013.08.036","article-title":"Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles","volume":"34","author":"Kanazawa","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejphar.2025.177958_bib119","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jconrel.2023.01.067","article-title":"AAV vectors applied to the treatment of CNS disorders: clinical status and challenges","volume":"355","author":"Kang","year":"2023","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib120","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jaci.2020.06.037","article-title":"Proteomic analysis of nasal mucus samples of healthy patients and patients with chronic rhinosinusitis","volume":"147","author":"Kao","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib121","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/10717544.2018.1428243","article-title":"Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer's disease","volume":"25","author":"Karthivashan","year":"2018","journal-title":"Drug Deliv."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib122","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s13346-020-00891-5","article-title":"Intranasal drug delivery: opportunities and toxicologic challenges during drug development","volume":"12","author":"Keller","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib123","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nrclinonc.2016.25","article-title":"The future of cancer treatment: immunomodulation, CARs and combination immunotherapy","volume":"13","author":"Khalil","year":"2016","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2025.177958_bib124","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jconrel.2017.09.001","article-title":"Progress in brain targeting drug delivery system by nasal route","volume":"268","author":"Khan","year":"2017","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.177958_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2021.105892","article-title":"Revisiting inorganic nanoparticles as promising therapeutic agents: a paradigm shift in oncological theranostics","volume":"164","author":"Khan","year":"2021","journal-title":"Eur. J. Pharmaceut. Sci."},{"issue":"11","key":"10.1016\/j.ejphar.2025.177958_bib126","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2174\/1570159X18666200528142429","article-title":"Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer's disease","volume":"18","author":"Khan","year":"2020","journal-title":"Curr. Neuropharmacol."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib127","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2174\/1570159X20666220507022701","article-title":"Nanotechnological advances for nose to brain delivery of therapeutics to improve the parkinson therapy","volume":"21","author":"Khatri","year":"2023","journal-title":"Curr. Neuropharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib128","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00262-014-1613-0","article-title":"Randomized controlled phase III trial of adjuvant chemo-immunotherapy with activated killer T cells and dendritic cells in patients with resected primary lung cancer","volume":"64","author":"Kimura","year":"2015","journal-title":"Cancer Immunol. Immunother."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib129","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1768","article-title":"Designing nanoformulation for the nose-to-brain delivery in Parkinson's disease: advancements and barrier","volume":"14","author":"Kiran","year":"2022","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib130","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1208\/s12249-025-03113-8","article-title":"Enhancing intracellular uptake of ivermectin through liposomal encapsulation","volume":"26","author":"Kocas","year":"2025","journal-title":"AAPS PharmSciTech"},{"issue":"11","key":"10.1016\/j.ejphar.2025.177958_bib131","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1021\/acs.nanolett.2c05056","article-title":"Intranasal pathway for nanoparticles to enter the central nervous system","volume":"23","author":"Kou","year":"2023","journal-title":"Nano Lett."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib132","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20160617","article-title":"Solid-phase supported design of carriers for therapeutic nucleic acid delivery","volume":"37","author":"Krhac Levacic","year":"2017","journal-title":"Biosci. Rep."},{"issue":"6","key":"10.1016\/j.ejphar.2025.177958_bib133","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41565-021-00898-0","article-title":"The current landscape of nucleic acid therapeutics","volume":"16","author":"Kulkarni","year":"2021","journal-title":"Nat. Nanotechnol."},{"issue":"12","key":"10.1016\/j.ejphar.2025.177958_bib134","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1021\/acs.bioconjchem.8b00548","article-title":"Passive immunotherapies for central nervous system disorders: current delivery challenges and new approaches","volume":"29","author":"Kumar","year":"2018","journal-title":"Bioconjug. Chem."},{"issue":"7\u20138","key":"10.1016\/j.ejphar.2025.177958_bib135","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s10495-023-01848-y","article-title":"Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues","volume":"28","author":"Kumari","year":"2023","journal-title":"Apoptosis"},{"key":"10.1016\/j.ejphar.2025.177958_bib136","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jconrel.2022.03.017","article-title":"Nose-to-brain\/spinal cord delivery kinetics of liposomes with different surface properties","volume":"344","author":"Kurano","year":"2022","journal-title":"J. Contr. Release"},{"issue":"10145","key":"10.1016\/j.ejphar.2025.177958_bib137","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0140-6736(18)30990-5","article-title":"Primary brain tumours in adults","volume":"392","author":"Lapointe","year":"2018","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib138","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1208\/s12248-024-00967-x","article-title":"Liposomal formulations of anti-alzheimer drugs and siRNA for nose-to-brain delivery: design, safety and efficacy in vitro","volume":"26","author":"Lee","year":"2024","journal-title":"AAPS J."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib139","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1038\/s41598-019-43969-y","article-title":"Red blood cell membrane bioengineered Zr-89 labelled hollow mesoporous silica nanosphere for overcoming phagocytosis","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"issue":"16","key":"10.1016\/j.ejphar.2025.177958_bib140","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.2217\/nnm-2018-0017","article-title":"The potential of biomimetic nanoparticles for tumor-targeted drug delivery","volume":"13","author":"Li","year":"2018","journal-title":"Nanomedicine (Lond)"},{"issue":"2","key":"10.1016\/j.ejphar.2025.177958_bib141","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/17425247.2018.1378642","article-title":"Intranasal delivery of stem cell-based therapies for the treatment of brain malignancies","volume":"15","author":"Li","year":"2018","journal-title":"Expet Opin. Drug Deliv."},{"issue":"12","key":"10.1016\/j.ejphar.2025.177958_bib142","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1093\/nsr\/nwaa161","article-title":"Lipid-oligonucleotide conjugates for bioapplications","volume":"7","author":"Li","year":"2020","journal-title":"Natl. Sci. Rev."},{"issue":"2","key":"10.1016\/j.ejphar.2025.177958_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103864","article-title":"Mapping the evolution of inhaled drug delivery research: trends, collaborations, and emerging frontiers","volume":"29","author":"Li","year":"2024","journal-title":"Drug Discov. Today"},{"issue":"34","key":"10.1016\/j.ejphar.2025.177958_bib144","doi-asserted-by":"crossref","first-page":"22752","DOI":"10.1021\/acsnano.4c06851","article-title":"Advanced noninvasive strategies for the brain delivery of therapeutic proteins and peptides","volume":"18","author":"Lin","year":"2024","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib145","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1474-4422(22)00517-8","article-title":"Safety, tolerability, and efficacy of zavegepant 10 mg nasal spray for the acute treatment of migraine in the USA: a phase 3, double-blind, randomised, placebo-controlled multicentre trial","volume":"22","author":"Lipton","year":"2023","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2025.177958_bib146","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.114604","article-title":"Biomaterial-based drug delivery strategies for oral mucosa","volume":"251","author":"Liu","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib147","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1016\/j.drudis.2022.04.003","article-title":"Repurposing small-molecule drugs for modulating toxic protein aggregates in neurodegenerative diseases","volume":"27","author":"Liu","year":"2022","journal-title":"Drug Discov. Today"},{"issue":"19","key":"10.1016\/j.ejphar.2025.177958_bib148","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202307081","article-title":"Customized intranasal hydrogel delivering methylene blue ameliorates cognitive dysfunction against Alzheimer's disease","volume":"36","author":"Liu","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejphar.2025.177958_bib149","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.bbi.2019.07.026","article-title":"IL-17A exacerbates neuroinflammation and neurodegeneration by activating microglia in rodent models of Parkinson's disease","volume":"81","author":"Liu","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib150","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.addr.2011.11.002","article-title":"Intranasal delivery of biologics to the central nervous system","volume":"64","author":"Lochhead","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib151","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s40263-022-00930-4","article-title":"Using the intranasal route to administer drugs to treat neurological and psychiatric illnesses: Rationale, successes, and future needs","volume":"36","author":"Lofts","year":"2022","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ejphar.2025.177958_bib152","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.jconrel.2024.12.063","article-title":"Nose-to-brain delivery of lithium via a sprayable in situ-forming hydrogel composed of chelating starch nanoparticles","volume":"378","author":"Lofts","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.177958_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104795","article-title":"Nose to brain drug delivery - a promising strategy for active components from herbal medicine for treating cerebral ischemia reperfusion","volume":"159","author":"Long","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"8","key":"10.1016\/j.ejphar.2025.177958_bib154","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.neuron.2024.01.024","article-title":"Mechanisms of sex differences in Alzheimer's disease","volume":"112","author":"Lopez-Lee","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2025.177958_bib155","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.2147\/IJN.S61288","article-title":"Current approaches to enhance CNS delivery of drugs across the brain barriers","volume":"9","author":"Lu","year":"2014","journal-title":"Int. J. Nanomed."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib156","doi-asserted-by":"crossref","DOI":"10.1111\/cts.70205","article-title":"Large language models and their applications in drug discovery and development: a primer","volume":"18","author":"Lu","year":"2025","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.ejphar.2025.177958_bib157","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jconrel.2023.06.001","article-title":"Intranasal administration of edaravone nanoparticles improves its stability and brain bioavailability","volume":"359","author":"Lu","year":"2023","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib158","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41392-022-01298-z","article-title":"Nucleic acid drug vectors for diagnosis and treatment of brain diseases","volume":"8","author":"Lu","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"Pt B","key":"10.1016\/j.ejphar.2025.177958_bib159","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jconrel.2015.07.019","article-title":"Cell membrane-camouflaged nanoparticles for drug delivery","volume":"220","author":"Luk","year":"2015","journal-title":"J. Contr. Release"},{"issue":"26","key":"10.1016\/j.ejphar.2025.177958_bib160","article-title":"Delivering the promise of gene therapy with nanomedicines in treating central nervous system diseases","volume":"9","author":"Luo","year":"2022","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib161","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1021\/acs.molpharmaceut.0c00195","article-title":"Potential therapeutic applications and developments of exosomes in Parkinson's disease","volume":"17","author":"Luo","year":"2020","journal-title":"Mol. Pharm."},{"issue":"42","key":"10.1016\/j.ejphar.2025.177958_bib162","doi-asserted-by":"crossref","first-page":"28894","DOI":"10.1021\/acsnano.4c09097","article-title":"Small molecule hydrogels loading small molecule drugs from Chinese medicine for the enhanced treatment of traumatic brain injury","volume":"18","author":"Luo","year":"2024","journal-title":"ACS Nano"},{"issue":"9","key":"10.1016\/j.ejphar.2025.177958_bib163","article-title":"The science of solid lipid nanoparticles: from fundamentals to applications","volume":"16","author":"M","year":"2024","journal-title":"Cureus"},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib164","first-page":"1813","article-title":"Biomarkers of Parkinson's disease: from basic research to clinical practice","volume":"15","author":"Ma","year":"2024","journal-title":"Aging Dis."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib165","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.3109\/10717544.2014.975382","article-title":"Curcumin-loaded nanostructured lipid carriers (NLCs) for nasal administration: design, characterization, and in vivo study","volume":"23","author":"Madane","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ejphar.2025.177958_bib166","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112899","article-title":"Nanoparticle-mediated gene therapy as a novel strategy for the treatment of retinoblastoma","volume":"220","author":"Mandal","year":"2022","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib167","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S1474-4422(10)70119-8","article-title":"Alzheimer's disease: clinical trials and drug development","volume":"9","author":"Mangialasche","year":"2010","journal-title":"Lancet Neurol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib168","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41590-021-00899-0","article-title":"Extracellular vesicles in immunomodulation and tumor progression","volume":"22","author":"Marar","year":"2021","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib169","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41419-024-06653-2","article-title":"Nose-to-brain selective drug delivery to glioma via ferritin-based nanovectors reduces tumor growth and improves survival rate","volume":"15","author":"Marrocco","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2025.177958_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118635","article-title":"Strategies to facilitate or block nose-to-brain drug delivery","volume":"570","author":"Martins","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"8","key":"10.1016\/j.ejphar.2025.177958_bib171","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1158\/1078-0432.CCR-15-1433","article-title":"Making better chimeric antigen receptors for adoptive T-cell therapy","volume":"22","author":"Maus","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2025.177958_bib172","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121830","article-title":"Superiority of microemulsion-based hydrogel for non-steroidal anti-inflammatory drug transdermal delivery: a comparative safety and anti-nociceptive efficacy study","volume":"622","author":"Mehanna","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib173","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1039\/D3LC00821E","article-title":"Microfluidic synthesis of lipid-based nanoparticles for drug delivery: recent advances and opportunities","volume":"24","author":"Mehraji","year":"2024","journal-title":"Lab Chip"},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib174","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/brain\/awy351","article-title":"CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling","volume":"142","author":"Meng","year":"2019","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib175","first-page":"381","article-title":"Brain and other central nervous system tumor statistics, 2021","volume":"71","author":"Miller","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib176","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/s41375-018-0106-0","article-title":"Clinical use of lentiviral vectors","volume":"32","author":"Milone","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.ejphar.2025.177958_bib177","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.colsurfb.2017.07.038","article-title":"Recent applications of PLGA based nanostructures in drug delivery","volume":"159","author":"Mir","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib178","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.nano.2018.05.021","article-title":"Lipid based nanocarriers: a translational perspective","volume":"14","author":"Mishra","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ejphar.2025.177958_bib179","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbr.2015.07.043","article-title":"Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer's disease","volume":"293","author":"Mita","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"44","key":"10.1016\/j.ejphar.2025.177958_bib180","doi-asserted-by":"crossref","first-page":"10046","DOI":"10.1039\/D0SM00885K","article-title":"Recent trends in the development of peptide and protein-based hydrogel therapeutics for the healing of CNS injury","volume":"16","author":"Mukherjee","year":"2020","journal-title":"Soft Matter"},{"key":"10.1016\/j.ejphar.2025.177958_bib181","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejpb.2022.11.016","article-title":"Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site","volume":"182","author":"Muresan","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"11","key":"10.1016\/j.ejphar.2025.177958_bib182","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1093\/gerona\/glz088","article-title":"Association between amyloid-beta, small-vessel disease, and neurodegeneration biomarker positivity, and progression to mild cognitive impairment in cognitively normal individuals","volume":"74","author":"Nadkarni","year":"2019","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"2","key":"10.1016\/j.ejphar.2025.177958_bib183","doi-asserted-by":"crossref","DOI":"10.3390\/gels9020130","article-title":"Intranasal administration of Dolutegravir-loaded nanoemulsion-based in situ gel for enhanced bioavailability and direct brain targeting","volume":"9","author":"Nair","year":"2023","journal-title":"Gels"},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib184","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/s41578-021-00394-w","article-title":"Drug delivery to the central nervous system","volume":"7","author":"Nance","year":"2022","journal-title":"Nat. Rev. Mater."},{"issue":"8","key":"10.1016\/j.ejphar.2025.177958_bib185","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.medj.2023.06.002","article-title":"Machine learning for cryosection pathology predicts the 2021 WHO classification of glioma","volume":"4","author":"Nasrallah","year":"2023","journal-title":"Med"},{"issue":"8","key":"10.1016\/j.ejphar.2025.177958_bib186","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.drudis.2016.06.003","article-title":"Targeting delivery in Parkinson's disease","volume":"21","author":"Newland","year":"2016","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejphar.2025.177958_bib187","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112117","article-title":"Nanotechnology-based drug delivery for central nervous system disorders","volume":"143","author":"Nguyen","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"6450","key":"10.1016\/j.ejphar.2025.177958_bib188","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav9518","article-title":"Amyloid beta oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes","volume":"365","author":"Nortley","year":"2019","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.ejphar.2025.177958_bib189","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nm.3407","article-title":"Development, maintenance and disruption of the blood-brain barrier","volume":"19","author":"Obermeier","year":"2013","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.ejphar.2025.177958_bib190","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.stem.2022.01.007","article-title":"iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders","volume":"29","author":"Okano","year":"2022","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.ejphar.2025.177958_bib191","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1474-4422(13)70293-X","article-title":"Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study","volume":"13","author":"Olanow","year":"2014","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib192","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41591-024-02886-y","article-title":"Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson's disease","volume":"30","author":"Pagano","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2025.177958_bib193","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.addr.2019.11.009","article-title":"The blood-brain barrier: physiology and strategies for drug delivery","volume":"165\u2013166","author":"Pandit","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejphar.2025.177958_bib194","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fnagi.2019.00373","article-title":"Blood-brain barrier and delivery of protein and gene therapeutics to brain","volume":"11","author":"Pardridge","year":"2019","journal-title":"Front. Aging Neurosci."},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib195","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1517\/17425247.2016.1171315","article-title":"CSF, blood-brain barrier, and brain drug delivery","volume":"13","author":"Pardridge","year":"2016","journal-title":"Expet Opin. Drug Deliv."},{"key":"10.1016\/j.ejphar.2025.177958_bib196","article-title":"Multilayer adjuvanted influenza protein nanoparticles improve intranasal delivery and antigen-specific immunity","author":"Park","year":"2025","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.ejphar.2025.177958_bib197","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202113671","article-title":"Virus-mimicking cell membrane-coated nanoparticles for cytosolic delivery of mRNA","volume":"61","author":"Park","year":"2022","journal-title":"Angew Chem. Int. Ed. Engl."},{"issue":"6","key":"10.1016\/j.ejphar.2025.177958_bib198","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1474-4422(19)30024-9","article-title":"CSF and blood biomarkers for Parkinson's disease","volume":"18","author":"Parnetti","year":"2019","journal-title":"Lancet Neurol."},{"issue":"Pt A","key":"10.1016\/j.ejphar.2025.177958_bib199","article-title":"Characterization of anatomical variations of the nasal cavity in a subset of European patients and their impact on intranasal drug delivery","volume":"667","author":"Pasteur","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib200","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S1474-4422(24)00476-9","article-title":"Crossing the blood-brain barrier: emerging therapeutic strategies for neurological disease","volume":"24","author":"Pedder","year":"2025","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib201","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1038\/s41467-019-13368-y","article-title":"Engineering dendritic cell vaccines to improve cancer immunotherapy","volume":"10","author":"Perez","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib202","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41420-023-01588-7","article-title":"Nogo-A antibody delivery through the olfactory mucosa mitigates experimental autoimmune encephalomyelitis in the mouse CNS","volume":"9","author":"Pernet","year":"2023","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib203","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1038\/s41598-025-85653-4","article-title":"Proximal tubule-on-chip as a model for predicting cation transport and drug transporter dynamics","volume":"15","author":"Petit","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.177958_bib204","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101658","article-title":"Brain drug delivery and neurodegenerative diseases: polymeric PLGA-based nanoparticles as a forefront platform","volume":"79","author":"Pinto","year":"2022","journal-title":"Ageing Res. Rev."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib205","doi-asserted-by":"crossref","first-page":"371","DOI":"10.14283\/jpad.2021.23","article-title":"Diagnosis of early Alzheimer's Disease: Clinical practice in 2021","volume":"8","author":"Porsteinsson","year":"2021","journal-title":"J. Prev. Alzheimers Dis."},{"issue":"3\u20134","key":"10.1016\/j.ejphar.2025.177958_bib206","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/01677063.2020.1771333","article-title":"The discovery and consequences of the central role of the nervous system in the control of protein homeostasis","volume":"34","author":"Prahlad","year":"2020","journal-title":"J. Neurogenet."},{"issue":"6","key":"10.1016\/j.ejphar.2025.177958_bib207","article-title":"The nasal-brain drug delivery route: mechanisms and applications to central nervous system diseases","volume":"6","author":"Qiu","year":"2025","journal-title":"MedComm (2020)"},{"issue":"6","key":"10.1016\/j.ejphar.2025.177958_bib208","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70213","article-title":"The nasal-brain drug delivery route: mechanisms and applications to central nervous system diseases","volume":"6","author":"Qiu","year":"2025","journal-title":"MedComm"},{"issue":"23","key":"10.1016\/j.ejphar.2025.177958_bib209","doi-asserted-by":"crossref","DOI":"10.3390\/cells11233761","article-title":"Novel nano-drug delivery system for brain tumor treatment","volume":"11","author":"Qiu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2025.177958_bib210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120250","article-title":"Nose-to-brain delivery of disulfiram nanoemulsion in situ gel formulation for glioblastoma targeting therapy","volume":"597","author":"Qu","year":"2021","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib211","doi-asserted-by":"crossref","first-page":"4462","DOI":"10.1021\/acsami.7b17020","article-title":"Injectable and thermosensitive hydrogel and PDLLA electrospun nanofiber membrane composites for guided spinal fusion","volume":"10","author":"Qu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib212","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/s43587-023-00410-4","article-title":"Detection and treatment of Alzheimer's disease in its preclinical stage","volume":"3","author":"Rafii","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.ejphar.2025.177958_bib213","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2024.103204","article-title":"Advances in inorganic nanoparticles-based drug delivery in targeted breast cancer theranostics","volume":"329","author":"Rahimkhoei","year":"2024","journal-title":"Adv. Colloid Interface Sci."},{"issue":"8","key":"10.1016\/j.ejphar.2025.177958_bib214","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.neuron.2024.01.013","article-title":"Epigenetic dysregulation in Alzheimer's disease peripheral immunity","volume":"112","author":"Ramakrishnan","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2025.177958_bib215","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112119","article-title":"An insight into the risk factors of brain tumors and their therapeutic interventions","volume":"143","author":"Rasheed","year":"2021","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib216","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13024-022-00574-4","article-title":"ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies","volume":"17","author":"Raulin","year":"2022","journal-title":"Mol. Neurodegener."},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib217","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s40265-022-01717-z","article-title":"New drug delivery systems developed for brain targeting","volume":"82","author":"Rawal","year":"2022","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2025.177958_bib218","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121949","article-title":"Exosomes based strategies for brain drug delivery","volume":"293","author":"Rehman","year":"2023","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib219","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nrclinonc.2016.204","article-title":"Advances in the molecular genetics of gliomas - implications for classification and therapy","volume":"14","author":"Reifenberger","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2025.177958_bib220","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.omtn.2019.07.008","article-title":"Exosomal DNA aptamer targeting alpha-Synuclein aggregates reduced neuropathological deficits in a mouse Parkinson's disease model","volume":"17","author":"Ren","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"26","key":"10.1016\/j.ejphar.2025.177958_bib221","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202401213","article-title":"Effect of polymer and cell membrane coatings on theranostic applications of nanoparticles: a review","volume":"13","author":"Rezaei","year":"2024","journal-title":"Adv. Healthcare Mater."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib222","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41573-018-0006-z","article-title":"Delivery technologies for cancer immunotherapy","volume":"18","author":"Riley","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib223","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s13046-022-02349-7","article-title":"Emerging therapies for glioblastoma: current state and future directions","volume":"41","author":"Rong","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib224","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","article-title":"Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015","volume":"70","author":"Roth","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2025.177958_bib225","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.jconrel.2024.01.013","article-title":"Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment","volume":"366","author":"Ruan","year":"2024","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib226","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/cr.2016.157","article-title":"Dendritic cell-based immunotherapy","volume":"27","author":"Sabado","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.ejphar.2025.177958_bib227","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jconrel.2018.08.033","article-title":"Bioinspired and biomimetic systems for advanced drug and gene delivery","volume":"287","author":"Sabu","year":"2018","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib228","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41568-019-0224-7","article-title":"Brain immunology and immunotherapy in brain tumours","volume":"20","author":"Sampson","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"21","key":"10.1016\/j.ejphar.2025.177958_bib229","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1200\/JCO.2017.72.8089","article-title":"Immunotherapy for brain tumors","volume":"35","author":"Sampson","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2025.177958_bib230","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jconrel.2023.06.005","article-title":"Effective nose-to-brain drug delivery using a combination system targeting the olfactory region in monkeys","volume":"359","author":"Sasaki","year":"2023","journal-title":"J. Contr. Release"},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib231","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1001\/jama.2023.0023","article-title":"Glioblastoma and other primary brain malignancies in adults: a review","volume":"329","author":"Schaff","year":"2023","journal-title":"JAMA"},{"issue":"10284","key":"10.1016\/j.ejphar.2025.177958_bib232","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"issue":"7590","key":"10.1016\/j.ejphar.2025.177958_bib233","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nature16939","article-title":"Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid","volume":"530","author":"Schlager","year":"2016","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.ejphar.2025.177958_bib234","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1038\/s41591-023-02505-2","article-title":"Emerging diagnostics and therapeutics for Alzheimer disease","volume":"29","author":"Self","year":"2023","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.ejphar.2025.177958_bib235","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1515\/revneuro-2020-0062","article-title":"VEGF levels in patients with glioma: a systematic review and meta-analysis","volume":"32","author":"Seyedmirzaei","year":"2021","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2025.177958_bib236","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126471","article-title":"Nose to brain delivery of transferrin conjugated PLGA nanoparticles for clonidine","volume":"252","author":"Sharma","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejphar.2025.177958_bib237","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116405","article-title":"Strategies for measuring concentrations and forms of amyloid-beta peptides","volume":"259","author":"Shen","year":"2024","journal-title":"Biosens. Bioelectron."},{"issue":"41","key":"10.1016\/j.ejphar.2025.177958_bib238","article-title":"Anti-inflammatory nanotherapeutics by targeting matrix metalloproteinases for immunotherapy of spinal cord injury","volume":"17","author":"Shen","year":"2021","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib239","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/biom6010006","article-title":"Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies","volume":"6","author":"Simic","year":"2016","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib240","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41551-022-00987-y","article-title":"Challenges in the clinical advancement of cell therapies for Parkinson's disease","volume":"7","author":"Skidmore","year":"2023","journal-title":"Nat. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib241","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/npp.2011.212","article-title":"Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopa","volume":"37","author":"Smith","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2025.177958_bib242","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.736978","article-title":"Alpha-synuclein aggregation in Parkinson's disease","volume":"8","author":"Srinivasan","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.ejphar.2025.177958_bib243","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113320","article-title":"Alzheimer's disease and its treatment by different approaches: a review","volume":"216","author":"Srivastava","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"12","key":"10.1016\/j.ejphar.2025.177958_bib244","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41582-024-01034-x","article-title":"Parkinson disease therapy: current strategies and future research priorities","volume":"20","author":"Stocchi","year":"2024","journal-title":"Nat. Rev. Neurol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib245","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41571-019-0320-3","article-title":"Current approaches to the management of brain metastases","volume":"17","author":"Suh","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2025.177958_bib246","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119342","article-title":"Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide","volume":"218","author":"Sukumar","year":"2019","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib247","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1021\/acs.molpharmaceut.3c00588","article-title":"Versatile nanoparticulate systems as a prosperous platform for targeted nose-brain drug delivery","volume":"21","author":"Taha","year":"2024","journal-title":"Mol. Pharm."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib248","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1021\/acs.molpharmaceut.2c00943","article-title":"Topical administration of verapamil in poly(ethylene glycol)-modified liposomes for enhanced sinonasal tissue residence in chronic rhinosinusitis: ex vivo and in vivo evaluations","volume":"20","author":"Taha","year":"2023","journal-title":"Mol. Pharm."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib249","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/17425247.2022.2074975","article-title":"Recent advances in drug delivery to the central nervous system by inhalation","volume":"19","author":"Tai","year":"2022","journal-title":"Expet Opin. Drug Deliv."},{"issue":"8","key":"10.1016\/j.ejphar.2025.177958_bib250","doi-asserted-by":"crossref","first-page":"863","DOI":"10.7150\/thno.11852","article-title":"Cell or cell membrane-based drug delivery systems","volume":"5","author":"Tan","year":"2015","journal-title":"Theranostics"},{"issue":"19","key":"10.1016\/j.ejphar.2025.177958_bib251","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.2217\/nnm-2018-0088","article-title":"Nanoemulsions in drug delivery: formulation to medical application","volume":"13","author":"Tayeb","year":"2018","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.ejphar.2025.177958_bib252","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plipres.2017.07.001","article-title":"Beyond liposomes: recent advances on lipid based nanostructures for poorly soluble\/poorly permeable drug delivery","volume":"68","author":"Teixeira","year":"2017","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.ejphar.2025.177958_bib253","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.actbio.2024.09.027","article-title":"Navigating neurotoxicity and safety assessment of nanocarriers for brain delivery: strategies and insights","volume":"189","author":"Teixeira","year":"2024","journal-title":"Acta Biomater."},{"issue":"11","key":"10.1016\/j.ejphar.2025.177958_bib254","doi-asserted-by":"crossref","first-page":"16982","DOI":"10.1021\/acsnano.1c04996","article-title":"Lipid nanoparticles horizontal line from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement","volume":"15","author":"Tenchov","year":"2021","journal-title":"ACS Nano"},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib255","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41573-021-00139-y","article-title":"Strategies for delivering therapeutics across the blood-brain barrier","volume":"20","author":"Terstappen","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2025.177958_bib256","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jconrel.2015.08.059","article-title":"Drug and gene delivery across the blood-brain barrier with focused ultrasound","volume":"219","author":"Timbie","year":"2015","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.177958_bib257","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ejps.2017.09.027","article-title":"Opportunity and challenges of nasal powders: drug formulation and delivery","volume":"113","author":"Tiozzo Fasiolo","year":"2018","journal-title":"Eur. J. Pharmaceut. Sci."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177958_bib258","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson's disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177958_bib259","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/14789450.2020.1748502","article-title":"Nasal mucus proteome and its involvement in allergic rhinitis","volume":"17","author":"Tomazic","year":"2020","journal-title":"Expet Rev. Proteonomics"},{"key":"10.1016\/j.ejphar.2025.177958_bib260","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jconrel.2018.12.036","article-title":"Micro- and nanotechnology approaches to improve Parkinson's disease therapy","volume":"295","author":"Torres-Ortega","year":"2019","journal-title":"J. Contr. Release"},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib261","article-title":"Non-invasive strategies for nose-to-brain drug delivery","volume":"10","author":"Trevino","year":"2020","journal-title":"J. Clin. Trials"},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib262","doi-asserted-by":"crossref","first-page":"C621","DOI":"10.1152\/ajpcell.00228.2013","article-title":"Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages","volume":"306","author":"Turturici","year":"2014","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ejphar.2025.177958_bib263","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/869269","article-title":"Drug delivery systems, CNS protection, and the blood brain barrier","author":"Upadhyay","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib264","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2025.177958_bib265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drup.2015.02.002","article-title":"Overcoming the blood-brain tumor barrier for effective glioblastoma treatment","volume":"19","author":"van Tellingen","year":"2015","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.ejphar.2025.177958_bib266","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jconrel.2023.06.026","article-title":"Levodopa-loaded nanoparticles for the treatment of Parkinson's disease","volume":"360","author":"van Vliet","year":"2023","journal-title":"J. Contr. Release"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib267","first-page":"67","article-title":"Transdermal drug delivery systems: a focused review of the physical methods of permeation enhancement","volume":"14","author":"Vaseem","year":"2024","journal-title":"Adv. Pharmaceut. Bull."},{"key":"10.1016\/j.ejphar.2025.177958_bib268","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jconrel.2021.03.043","article-title":"The dawn of mRNA vaccines: the COVID-19 case","volume":"333","author":"Verbeke","year":"2021","journal-title":"J. Contr. Release"},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib269","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15071916","article-title":"Artificial intelligence in pharmaceutical technology and drug delivery design","volume":"15","author":"Vora","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2025.177958_bib270","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev-biochem-071322-021330","article-title":"Polyamines in Parkinson's disease: balancing between neurotoxicity and neuroprotection","volume":"92","author":"Vrijsen","year":"2023","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ejphar.2025.177958_bib271","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.conb.2020.02.003","article-title":"Amyloid beta-protein and beyond: the path forward in Alzheimer's disease","volume":"61","author":"Walsh","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"issue":"34","key":"10.1016\/j.ejphar.2025.177958_bib272","doi-asserted-by":"crossref","first-page":"23684","DOI":"10.1021\/acsnano.4c08279","article-title":"Tailored borneol-modified lipid nanoparticles nasal spray for enhanced nose-to-brain delivery to central nervous system diseases","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejphar.2025.177958_bib273","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102097","article-title":"Updates on brain regions and neuronal circuits of movement disorders in Parkinson's disease","volume":"92","author":"Wang","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"14","key":"10.1016\/j.ejphar.2025.177958_bib274","article-title":"Enhanced delivery of neuroactive drugs via nasal delivery with a self-healing supramolecular gel","volume":"8","author":"Wang","year":"2021","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.ejphar.2025.177958_bib275","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40035-020-00189-z","article-title":"Current understanding of metal ions in the pathogenesis of Alzheimer's disease","volume":"9","author":"Wang","year":"2020","journal-title":"Transl. Neurodegener."},{"issue":"9","key":"10.1016\/j.ejphar.2025.177958_bib276","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.4103\/1673-5374.391189","article-title":"Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury","volume":"19","author":"Wang","year":"2024","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib277","article-title":"Silk microneedle patch capable of On-Demand multidrug delivery to the brain for glioblastoma treatment","volume":"34","author":"Wang","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejphar.2025.177958_bib278","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125584","article-title":"The review of nasal drug delivery system: the strategies to enhance the efficiency of intranasal drug delivery by improving drug absorption","volume":"676","author":"Wei","year":"2025","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.ejphar.2025.177958_bib279","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1021\/acs.nanolett.9b01844","article-title":"Multiantigenic nanotoxoids for antivirulence vaccination against antibiotic-resistant gram-negative bacteria","volume":"19","author":"Wei","year":"2019","journal-title":"Nano Lett."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib280","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3233\/JPD-212989","article-title":"Appropriateness of applying cerebrospinal fluid biomarker cutoffs from Alzheimer's disease to Parkinson's disease","volume":"12","author":"Weinshel","year":"2022","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.ejphar.2025.177958_bib281","doi-asserted-by":"crossref","first-page":"11357","DOI":"10.2147\/IJN.S484838","article-title":"Nanoparticle-based drug delivery systems enhance treatment of cognitive defects","volume":"19","author":"Wilar","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejphar.2025.177958_bib282","article-title":"Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy","author":"Witten","year":"2024","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib283","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","article-title":"The blood-brain barrier: structure, regulation, and drug delivery","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejphar.2025.177958_bib284","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jconrel.2018.12.019","article-title":"Mesenchymal stem cell-based drug delivery strategy: from cells to biomimetic","volume":"294","author":"Wu","year":"2019","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.177958_bib285","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1214450","article-title":"Lipid-based nanoparticles via nose-to-brain delivery: a mini review","volume":"11","author":"Xinchen","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"18","key":"10.1016\/j.ejphar.2025.177958_bib286","doi-asserted-by":"crossref","first-page":"13152","DOI":"10.1021\/acs.jmedchem.1c00910","article-title":"Strategies for structural modification of small molecules to improve blood-brain barrier penetration: a recent perspective","volume":"64","author":"Xiong","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2025.177958_bib287","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104963","article-title":"Glioblastoma vaccines: past, present, and opportunities","volume":"100","author":"Xiong","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ejphar.2025.177958_bib288","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jconrel.2024.01.053","article-title":"Advances and future perspectives of intranasal drug delivery: a scientometric review","volume":"367","author":"Xu","year":"2024","journal-title":"J. Contr. Release"},{"issue":"2","key":"10.1016\/j.ejphar.2025.177958_bib289","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1956","article-title":"Nose-to-brain delivery of nanotherapeutics: transport mechanisms and applications","volume":"16","author":"Xu","year":"2024","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.ejphar.2025.177958_bib290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2020.02.002","article-title":"Immunotherapy for glioma: current management and future application","volume":"476","author":"Xu","year":"2020","journal-title":"Cancer Lett."},{"issue":"14","key":"10.1016\/j.ejphar.2025.177958_bib291","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/j.scib.2024.05.027","article-title":"Swimming short fibrous nasal drops for nose-to-brain drug delivery","volume":"69","author":"Xu","year":"2024","journal-title":"Sci. Bull. (Beijing)"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib292","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41531-021-00272-w","article-title":"Cofilin 1 promotes the pathogenicity and transmission of pathological alpha-synuclein in mouse models of Parkinson's disease","volume":"8","author":"Yan","year":"2022","journal-title":"npj Parkinson's Dis."},{"issue":"2","key":"10.1016\/j.ejphar.2025.177958_bib293","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1853","article-title":"Nonviral nanoparticle gene delivery into the CNS for neurological disorders and brain cancer applications","volume":"15","author":"Yang","year":"2023","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.ejphar.2025.177958_bib294","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105218","article-title":"Exosome-mediated delivery of antisense oligonucleotides targeting alpha-synuclein ameliorates the pathology in a mouse model of Parkinson's disease","volume":"148","author":"Yang","year":"2021","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib295","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12943-022-01513-z","article-title":"Glioma targeted therapy: insight into future of molecular approaches","volume":"21","author":"Yang","year":"2022","journal-title":"Mol. Cancer"},{"issue":"30","key":"10.1016\/j.ejphar.2025.177958_bib296","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202203182","article-title":"Intranasal delivery of BACE1 siRNA and rapamycin by dual targets modified nanoparticles for Alzheimer's disease therapy","volume":"18","author":"Yang","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.ejphar.2025.177958_bib297","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jconrel.2021.12.034","article-title":"Enhanced nose-to-brain delivery of siRNA using hyaluronan-enveloped nanomicelles for glioma therapy","volume":"342","author":"Yang","year":"2022","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.177958_bib298","article-title":"Translational evaluation of metabolic risk factors impacting DBS efficacy for PD-Related sleep and depressive disorders: preclinical, prospective and cohort studies","author":"Yao","year":"2024","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.ejphar.2025.177958_bib299","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.carbpol.2017.01.044","article-title":"Formulation of olfactory-targeted microparticles with tamarind seed polysaccharide to improve nose-to-brain transport of drugs","volume":"163","author":"Yarragudi","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejphar.2025.177958_bib300","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2021.101266","article-title":"Focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN)","volume":"8","author":"Ye","year":"2021","journal-title":"MethodsX"},{"key":"10.1016\/j.ejphar.2025.177958_bib301","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104277","article-title":"Incisionless targeted adeno-associated viral vector delivery to the brain by focused ultrasound-mediated intranasal administration","volume":"84","author":"Ye","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ejphar.2025.177958_bib302","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jconrel.2018.07.020","article-title":"Focused ultrasound combined with microbubble-mediated intranasal delivery of gold nanoclusters to the brain","volume":"286","author":"Ye","year":"2018","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.177958_bib303","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev-pathmechdis-031521-034145","article-title":"Genetics and pathogenesis of parkinson's syndrome","volume":"18","author":"Ye","year":"2023","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.ejphar.2025.177958_bib304","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.jconrel.2014.06.017","article-title":"Agile delivery of protein therapeutics to CNS","volume":"190","author":"Yi","year":"2014","journal-title":"J. Contr. Release"},{"issue":"2","key":"10.1016\/j.ejphar.2025.177958_bib305","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1767","article-title":"Direct nose to the brain nanomedicine delivery presents a formidable challenge","volume":"14","author":"Yokel","year":"2022","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.ejphar.2025.177958_bib306","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.addr.2020.07.022","article-title":"Recent advances in siRNA delivery mediated by lipid-based nanoparticles","volume":"154\u2013155","author":"Yonezawa","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"7996","key":"10.1016\/j.ejphar.2025.177958_bib307","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s41586-023-06899-4","article-title":"Nasopharyngeal lymphatic plexus is a hub for cerebrospinal fluid drainage","volume":"625","author":"Yoon","year":"2024","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.ejphar.2025.177958_bib308","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adl6442","article-title":"Molecular beacon-based detection of circulating microRNA-containing extracellular vesicle as an alpha-synucleinopathy biomarker","volume":"10","author":"Yu","year":"2024","journal-title":"Sci. Adv."},{"issue":"22","key":"10.1016\/j.ejphar.2025.177958_bib309","doi-asserted-by":"crossref","DOI":"10.3390\/cells13221916","article-title":"Clinical and translational landscape of viral gene therapies","volume":"13","author":"Yudaeva","year":"2024","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib310","doi-asserted-by":"crossref","first-page":"5661","DOI":"10.1038\/s41467-024-49949-9","article-title":"Neuroimaging and fluid biomarkers in Parkinson's disease in an era of targeted interventions","volume":"15","author":"Zarkali","year":"2024","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.ejphar.2025.177958_bib311","article-title":"Intranasal delivery of functionalized polymeric nanomaterials to the brain","volume":"11","author":"Zha","year":"2022","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.ejphar.2025.177958_bib312","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102341","article-title":"Research progress in Alzheimer's disease and bone-brain axis","volume":"98","author":"Zhang","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib313","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41392-024-01911-3","article-title":"Recent advances in Alzheimer's disease: mechanisms, clinical trials and new drug development strategies","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"10","key":"10.1016\/j.ejphar.2025.177958_bib314","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1016\/j.apsb.2021.02.016","article-title":"Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease","volume":"11","author":"Zhang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib315","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/nsr\/nwz215","article-title":"Au(23)(CR)(14) nanocluster restores fibril Abeta's unfolded state with abolished cytotoxicity and dissolves endogenous Abeta plaques","volume":"7","author":"Zhang","year":"2020","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.ejphar.2025.177958_bib316","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102595","article-title":"Disease-modifying therapies for Alzheimer's disease: clinical trial progress and opportunity","volume":"103","author":"Zhang","year":"2025","journal-title":"Ageing Res. Rev."},{"issue":"12","key":"10.1016\/j.ejphar.2025.177958_bib317","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1016\/j.apsb.2023.06.011","article-title":"Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment","volume":"13","author":"Zhang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib318","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13287-021-02274-0","article-title":"Advances in intranasal application of stem cells in the treatment of central nervous system diseases","volume":"12","author":"Zhang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib319","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/s42003-023-05243-w","article-title":"Identifying the serious clinical outcomes of adverse reactions to drugs by a multi-task deep learning framework","volume":"6","author":"Zhao","year":"2023","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10717544.2022.2154409","article-title":"Recent advances in drug delivery systems for targeting brain tumors","volume":"30","author":"Zhao","year":"2023","journal-title":"Drug Deliv."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib321","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41398-024-02897-w","article-title":"Predictors for survival in patients with Alzheimer's disease: a large comprehensive meta-analysis","volume":"14","author":"Zheng","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.ejphar.2025.177958_bib322","doi-asserted-by":"crossref","first-page":"12343","DOI":"10.2147\/IJN.S497480","article-title":"Nose to brain: exploring the progress of intranasal delivery of solid lipid nanoparticles and nanostructured lipid carriers","volume":"19","author":"Zheng","year":"2024","journal-title":"Int. J. Nanomed."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib323","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41392-021-00572-w","article-title":"Small molecules in targeted cancer therapy: advances, challenges, and future perspectives","volume":"6","author":"Zhong","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"667","key":"10.1016\/j.ejphar.2025.177958_bib324","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn9380","article-title":"Synaptogenic effect of APP-Swedish mutation in familial Alzheimer's disease","volume":"14","author":"Zhou","year":"2022","journal-title":"Sci. Transl. Med."},{"issue":"9","key":"10.1016\/j.ejphar.2025.177958_bib325","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1080\/15548627.2023.2196889","article-title":"CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy","volume":"19","author":"Zhou","year":"2023","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177958_bib326","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40035-023-00378-6","article-title":"Role of dopamine in the pathophysiology of Parkinson's disease","volume":"12","author":"Zhou","year":"2023","journal-title":"Transl. Neurodegener."},{"issue":"6","key":"10.1016\/j.ejphar.2025.177958_bib327","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd7904","article-title":"Inhaled immunoantimicrobials for the treatment of chronic obstructive pulmonary disease","volume":"10","author":"Zhu","year":"2024","journal-title":"Sci. Adv."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177958_bib328","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.cell.2021.01.027","article-title":"Structural insights into the human D1 and D2 dopamine receptor signaling complexes","volume":"184","author":"Zhuang","year":"2021","journal-title":"Cell"},{"issue":"51","key":"10.1016\/j.ejphar.2025.177958_bib329","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201803717","article-title":"Effective and targeted human orthotopic glioblastoma xenograft therapy via a multifunctional biomimetic nanomedicine","volume":"30","author":"Zou","year":"2018","journal-title":"Adv. Mater."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925007125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925007125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:31:12Z","timestamp":1772760672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925007125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":329,"alternative-id":["S0014299925007125"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177958","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nasal nanotherapeutics for central nervous system disorders: Bridging the translational gap in central nervous system drug delivery","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177958"}}