{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:51:20Z","timestamp":1791917480626,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20220531092209021"],"award-info":[{"award-number":["JCYJ20220531092209021"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["ZDSYS20210623092000002"],"award-info":[{"award-number":["ZDSYS20210623092000002"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004750","name":"Chinese Aeronautical Establishment Aeronautical Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81804067"],"award-info":[{"award-number":["81804067"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174291"],"award-info":[{"award-number":["82174291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022B1515120034"],"award-info":[{"award-number":["2022B1515120034"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ejphar.2025.177971","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T06:38:52Z","timestamp":1752734332000},"page":"177971","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["HBHP ameliorates CCL4-induced liver fibrosis in rats by inhibiting HMGB1-mediated inflammatory response through binding to the HMGB1-A box"],"prefix":"10.1016","volume":"1004","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2056-0238","authenticated-orcid":false,"given":"Lidan","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruili","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangdong","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ejphar.2025.177971_bib1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1586\/14737159.2014.928205","article-title":"Plasma high mobility group box 1 protein reflects fibrosis in pediatric nonalcoholic fatty liver disease","volume":"14","author":"Alisi","year":"2014","journal-title":"Expert Rev. Mol. Diagn"},{"issue":"12","key":"10.1016\/j.ejphar.2025.177971_bib2","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.3390\/cells10123323","article-title":"Post-translational modification of HMGB1 disulfide bonds in stimulating and inhibiting inflammation","volume":"10","author":"Andersson","year":"2021","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.ejphar.2025.177971_bib3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/humrep\/deu320","article-title":"Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis","volume":"30","author":"Aslani","year":"2015","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ejphar.2025.177971_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109121","article-title":"\u03b1-Iso-cubebene attenuates neointima formation by inhibiting HMGB1-induced monocyte to macrophage differentiation via suppressing ROS production","volume":"111","author":"Baek","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2025.177971_bib5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1177\/0394632017698713","article-title":"High-mobility group box protein 1 expression in inflammatory diseases of the middle ear","volume":"30","author":"Bellussi","year":"2017","journal-title":"Int. J. Immunopathol. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177971_bib6","doi-asserted-by":"crossref","first-page":"iii","DOI":"10.1055\/s-2008-1040491","article-title":"Connective tissue metabolism and hepatic fibrosis: an overview","volume":"10","author":"Bissell","year":"1990","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.ejphar.2025.177971_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2022.108470","article-title":"Polyethylene microplastics trigger cell apoptosis and inflammation via inducing oxidative stress and activation of the NLRP3 inflammasome in carp gills","volume":"132","author":"Cao","year":"2023","journal-title":"Fish Shellfish Immunol."},{"issue":"10","key":"10.1016\/j.ejphar.2025.177971_bib8","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/liv.14940","article-title":"Hepatic macrophages: key players in the development and progression of liver fibrosis","volume":"41","author":"Cheng","year":"2021","journal-title":"Liver Int."},{"issue":"2","key":"10.1016\/j.ejphar.2025.177971_bib9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/imm.13313","article-title":"LincRNA-EPS alleviates severe acute pancreatitis by suppressing HMGB1-triggered inflammation in pancreatic macrophages","volume":"163","author":"Chen","year":"2021","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.ejphar.2025.177971_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s12276-022-00736-w","article-title":"The mechanism of HMGB1 secretion and release","volume":"54","author":"Chen","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"10","key":"10.1016\/j.ejphar.2025.177971_bib11","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1016\/j.jid.2019.03.1148","article-title":"Oxidative stress-induced HMGB1 release from melanocytes: a paracrine mechanism underlying the cutaneous inflammation in vitiligo","volume":"139","author":"Cui","year":"2019","journal-title":"J. Invest. Dermatol."},{"issue":"12","key":"10.1016\/j.ejphar.2025.177971_bib12","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/s41419-018-1136-2","article-title":"Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis","volume":"9","author":"Dai","year":"2018","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177971_bib13","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.immuni.2018.08.016","article-title":"The endotoxin delivery protein HMGB1 mediates Caspase-11-Dependent lethality in sepsis","volume":"49","author":"Deng","year":"2018","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.ejphar.2025.177971_bib14","doi-asserted-by":"crossref","first-page":"7021","DOI":"10.1074\/jbc.M108417200","article-title":"HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences","volume":"277","author":"Dintilhac","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2025.177971_bib15","article-title":"HMGB1: new biomarker and therapeutic target of autoimmune and autoinflammatory skin diseases","volume":"16","author":"Fan","year":"2025","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.ejphar.2025.177971_bib16","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1002\/hep.30093","article-title":"High mobility group Box-1 drives fibrosis progression signaling via the receptor for advanced glycation end products in mice","volume":"68","author":"Ge","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2025.177971_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/915234","article-title":"The anti-inflammatory activity of HMGB1 A box is enhanced when fused with C-terminal acidic tail","volume":"2010","author":"Gong","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"issue":"2","key":"10.1016\/j.ejphar.2025.177971_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3390\/ijms19020457","article-title":"Scandoside exerts anti-inflammatory effect via suppressing NF-\u03baB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages","volume":"19","author":"He","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177971_bib19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41374-018-0141-5","article-title":"High-mobility group box 1 induces endoplasmic reticulum stress and activates hepatic stellate cells","volume":"99","author":"He","year":"2018","journal-title":"Lab. Invest."},{"key":"10.1016\/j.ejphar.2025.177971_bib20","article-title":"Exploring the therapeutic promise of targeting HMGB1 in rheumatoid arthritis","volume":"258","author":"Kaur","year":"2020","journal-title":"Life Sci."},{"issue":"21","key":"10.1016\/j.ejphar.2025.177971_bib21","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.3390\/ijms20215314","article-title":"Role of high-mobility group Box-1 in liver pathogenesis","volume":"20","author":"Khambu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177971_bib22","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.3390\/cells10051097","article-title":"Pathophysiology and treatment options for hepatic fibrosis: can it be completely cured?","volume":"10","author":"Khanam","year":"2021","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.ejphar.2025.177971_bib23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neulet.2012.07.040","article-title":"Intranasal delivery of HMGB1-binding heptamer peptide confers a robust neuroprotection in the postischemic brain","volume":"525","author":"Kim","year":"2012","journal-title":"Neurosci. Lett."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177971_bib24","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1053\/j.gastro.2012.09.008","article-title":"Sterile inflammation in the liver","volume":"143","author":"Kubes","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2025.177971_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103521","article-title":"ROS anchor PAMPs-mediated extracellular HMGB1 self-association and its dimerization enhances pro-inflammatory signaling","volume":"80","author":"Kwak","year":"2025","journal-title":"Redox Biol."},{"issue":"1\u20132","key":"10.1016\/j.ejphar.2025.177971_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF03402105","article-title":"Structural basis for the proinflammatory cytokine activity of high mobility group box 1","volume":"9","author":"Li","year":"2003","journal-title":"Mol. Med."},{"issue":"10","key":"10.1016\/j.ejphar.2025.177971_bib27","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-kappaB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177971_bib28","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1134\/S0006297910040103","article-title":"Expression and purification of the fusion protein HMGB1Abox-TMD1, a novel HMGB1 antagonist","volume":"75","author":"Li","year":"2010","journal-title":"Biochemistry (Mosc)."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177971_bib29","first-page":"548","article-title":"Boxb mediate BALB\/c mice corneal inflammation through a TLR4\/MyD88-dependent signaling pathway in Aspergillus fumigatus keratitis","volume":"11","author":"Liu","year":"2018","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.ejphar.2025.177971_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.990087","article-title":"Inhibition of inflammatory liver injury by the HMGB1-A box through HMGB1\/TLR-4\/NF-\u03baB signaling in an acute liver failure mouse model","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177971_bib31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.freeradbiomed.2017.02.016","article-title":"Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death","volume":"106","author":"Lv","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177971_bib32","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1002\/jcb.26653","article-title":"HMGB1-induced asthmatic airway inflammation through GRP75-mediated enhancement of ER-mitochondrial Ca2+ transfer and ROS increased","volume":"119","author":"Lv","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177971_bib33","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1159\/000374096","article-title":"Pathophysiology of liver fibrosis","volume":"33","author":"Pinzani","year":"2015","journal-title":"Dig. Dis."},{"issue":"8","key":"10.1016\/j.ejphar.2025.177971_bib34","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3109\/08916934.2014.921811","article-title":"The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE","volume":"47","author":"Pisetsky","year":"2014","journal-title":"Autoimmunity"},{"issue":"1","key":"10.1016\/j.ejphar.2025.177971_bib35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s10020-023-00717-3","article-title":"HMGB1 and toll-like receptors: potential therapeutic targets in autoimmune diseases","volume":"29","author":"Ren","year":"2023","journal-title":"Mol. Med."},{"issue":"4","key":"10.1016\/j.ejphar.2025.177971_bib36","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3390\/cells9040875","article-title":"Liver fibrosis: mechanistic concepts and therapeutic perspectives","volume":"9","author":"Roehlen","year":"2020","journal-title":"Cells"},{"issue":"28","key":"10.1016\/j.ejphar.2025.177971_bib37","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.2174\/092986712803341520","article-title":"Role of oxidative stress and molecular changes in liver fibrosis: a review","volume":"19","author":"S\u00e1nchez-Valle","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2025.177971_bib38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuropharm.2018.08.040","article-title":"Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: evidence for a neuroimmune crosstalk","volume":"141","author":"Sekiguchi","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2025.177971_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114791","article-title":"Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-\u03baB and MAPK signaling pathways","volume":"284","author":"Shen","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"18","key":"10.1016\/j.ejphar.2025.177971_bib40","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1182\/blood-2016-05-719757","article-title":"C1q and HMGB1 reciprocally regulate human macrophage polarization","volume":"128","author":"Son","year":"2016","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.ejphar.2025.177971_bib41","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1097\/CCM.0b013e3181a930f7","article-title":"Neutralization of receptor for advanced glycation end-products and high mobility group box-1 attenuates septic diaphragm dysfunction in rats with peritonitis","volume":"37","author":"Susa","year":"2009","journal-title":"Crit. Care Med."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177971_bib42","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/s13287-022-03010-y","article-title":"Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6\/STAT3 pathway in macrophages","volume":"13","author":"Tian","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"5","key":"10.1016\/j.ejphar.2025.177971_bib43","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/joim.12276","article-title":"High-mobility group box-1 in sterile inflammation","volume":"276","author":"Tsung","year":"2014","journal-title":"J. Intern. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177971_bib44","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbrc.2007.05.130","article-title":"The HMGB1 acidic tail regulates HMGB1 DNA binding specificity by a unique mechanism","volume":"360","author":"Wang","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177971_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12731","article-title":"TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt 1\/Mitophagy signalling pathway","volume":"53","author":"Wu","year":"2020","journal-title":"Cell Prolif."},{"issue":"3","key":"10.1016\/j.ejphar.2025.177971_bib46","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1159\/000491970","article-title":"High Mobility Group B-1 (HMGB-1) promotes apoptosis of macrophage-derived foam cells by inducing endoplasmic reticulum stress","volume":"48","author":"Wu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"9","key":"10.1016\/j.ejphar.2025.177971_bib47","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1002\/eji.201141391","article-title":"Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model","volume":"41","author":"Youn","year":"2011","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.177971_bib48","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.1038\/s41598-019-42564-5","article-title":"HMGB1 is a central driver of dynamic pro-inflammatory networks in pediatric acute liver failure induced by acetaminophen","volume":"9","author":"Zamora","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.177971_bib49","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4350965","article-title":"ROS and ROS-mediated cellular signaling","volume":"2016","author":"Zhang","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejphar.2025.177971_bib50","article-title":"PAMPs and DAMPs as the bridge between periodontitis and atherosclerosis: the potential therapeutic targets","volume":"10","author":"Zhu","year":"2022","journal-title":"Front. Cell Dev. Biol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925007253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925007253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:26:45Z","timestamp":1778646405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925007253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":50,"alternative-id":["S0014299925007253"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177971","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HBHP ameliorates CCL4-induced liver fibrosis in rats by inhibiting HMGB1-mediated inflammatory response through binding to the HMGB1-A box","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177971","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177971"}}