{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:20:11Z","timestamp":1758043211121,"version":"3.44.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ejphar.2025.177990","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T15:04:00Z","timestamp":1753369440000},"page":"177990","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["In-depth study of gastrointestinal motility, intestinal barrier function and secretory function in an irritable bowel syndrome post-inflammatory rat model"],"prefix":"10.1016","volume":"1004","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0488-4248","authenticated-orcid":false,"given":"Nikita","family":"Hanning","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6424-2399","authenticated-orcid":false,"given":"Rosanne","family":"Verboven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1271-6191","authenticated-orcid":false,"given":"Annemieke","family":"Smet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2506-6252","authenticated-orcid":false,"given":"Jean-Pierre","family":"Timmermans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris G.","family":"De Man","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0327-6304","authenticated-orcid":false,"given":"Benedicte Y.","family":"De Winter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.177990_bib1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3109\/00365529609031978","article-title":"The X-ray contrast medium iodixanol detects increased colonic permeability equally well as 51Cr-labeled ethylenediaminetetraacetic acid in experimental colitis of rats","volume":"31","author":"Andersen","year":"1996","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2025.177990_bib2","first-page":"G703","article-title":"Prolonged colonic epithelial hyporesponsiveness after colitis: role of inducible nitric oxide synthase","volume":"276","author":"Asfaha","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2025.177990_bib3","first-page":"G622","article-title":"Disruption of colonic electrolyte transport in experimental colitis","volume":"268","author":"Bell","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2025.177990_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116833","article-title":"Changes in colonic contractility in response to inflammatory bowel disease: long-term assessment in a model of TNBS-induced inflammation in rats","volume":"236","author":"Calabresi","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.177990_bib5","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1136\/gutjnl-2019-318427","article-title":"Leaky gut: mechanisms, measurement and clinical implications in humans","volume":"68","author":"Camilleri","year":"2019","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2025.177990_bib6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2982.2012.01921.x","article-title":"Intestinal barrier function in health and gastrointestinal disease","volume":"24","author":"Camilleri","year":"2012","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.ejphar.2025.177990_bib7","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1111\/bph.14396","article-title":"Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post-inflammatory rat model for irritable bowel syndrome","volume":"175","author":"Ceuleers","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177990_bib8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/7651_2021_389","article-title":"Differentiating between tight junction-dependent and tight junction-independent intestinal barrier loss in vivo","volume":"2367","author":"Chanez-Paredes","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2025.177990_bib9","doi-asserted-by":"crossref","first-page":"246","DOI":"10.5114\/aoms.2015.55147","article-title":"Altered sympathovagal balance and pain hypersensitivity in TNBS-induced colitis","volume":"13","author":"Ciesielczyk","year":"2017","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.ejphar.2025.177990_bib10","doi-asserted-by":"crossref","first-page":"G1151","DOI":"10.1152\/ajpgi.90649.2008","article-title":"A guide to ussing chamber studies of mouse intestine","volume":"296","author":"Clarke","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2025.177990_bib12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1136\/gut.2006.104745","article-title":"Acute distal colitis impairs gastric emptying in rats via an extrinsic neuronal reflex pathway involving the pelvic nerve","volume":"56","author":"De Schepper","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2025.177990_bib13","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1136\/gutjnl-2013-305870","article-title":"Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity","volume":"63","author":"Deiteren","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2025.177990_bib14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/gastro\/gou022","article-title":"Effect of homocysteine on intestinal permeability in rats with experimental colitis, and its mechanism","volume":"2","author":"Ding","year":"2014","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"10.1016\/j.ejphar.2025.177990_bib15","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.intimp.2017.01.015","article-title":"Therapeutic efficacy of carboxyamidotriazole on 2,4,6-trinitrobenzene sulfonic acid-induced colitis model is associated with the inhibition of NLRP3 inflammasome and NF-\u03baB activation","volume":"45","author":"Du","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2025.177990_bib16","doi-asserted-by":"crossref","first-page":"G817","DOI":"10.1152\/ajpgi.00257.2012","article-title":"Altered colorectal afferent function associated with TNBS-induced visceral hypersensitivity in mice","volume":"303","author":"Feng","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2025.177990_bib17","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/nmo.12871","article-title":"The complex task of measuring intestinal permeability in basic and clinical science","volume":"28","author":"Galipeau","year":"2016","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.ejphar.2025.177990_bib18","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1016\/j.bbagen.2016.08.010","article-title":"Targeting immunoproteasome and glutamine supplementation prevent intestinal hyperpermeability","volume":"1861","author":"Ghouzali","year":"2017","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.ejphar.2025.177990_bib19","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1038\/ajg.2012.260","article-title":"Prevalence of symptoms meeting criteria for irritable bowel syndrome in inflammatory bowel disease: systematic review and meta-analysis","volume":"107","author":"Halpin","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2025.177990_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13060811","article-title":"Local colonic administration of a serine protease inhibitor improves post-inflammatory visceral hypersensitivity in rats","volume":"13","author":"Hanning","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2025.177990_bib21","doi-asserted-by":"crossref","DOI":"10.1177\/1756284821993586","article-title":"Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review","volume":"14","author":"Hanning","year":"2021","journal-title":"Therap Adv Gastroenterol"},{"key":"10.1016\/j.ejphar.2025.177990_bib22","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.4758","article-title":"Measuring myeloperoxidase activity as a marker of inflammation in gut tissue samples of mice and rat","volume":"13","author":"Hanning","year":"2023","journal-title":"Bio Protoc"},{"key":"10.1016\/j.ejphar.2025.177990_bib23","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12975-010-0049-x","article-title":"High and low molecular weight fluorescein isothiocyanate (FITC)-dextrans to assess blood-brain barrier disruption: technical considerations","volume":"2","author":"Hoffmann","year":"2011","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.ejphar.2025.177990_bib24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41575-023-00766-3","article-title":"Paracellular permeability and tight junction regulation in gut health and disease","volume":"20","author":"Horowitz","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2025.177990_bib25","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/jat.2849","article-title":"Early detection of renal injury using urinary vanin-1 in rats with experimental colitis","volume":"34","author":"Hosohata","year":"2014","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ejphar.2025.177990_bib26","series-title":"Clinical Methods: the History, Physical, and Laboratory Examinations","article-title":"BUN and creatinine","author":"Hosten","year":"1990"},{"key":"10.1016\/j.ejphar.2025.177990_bib27","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1139\/cjpp-2018-0017","article-title":"Bile acid malabsorption is associated with diarrhea in acute phase of colitis","volume":"96","author":"Hou","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177990_bib28","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1007\/s00018-021-04000-8","article-title":"Revisiting definition and assessment of intestinal trans-epithelial passage","volume":"78","author":"Ilchmann-Diounou","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"year":"1969","series-title":"Properties and Applications of Dextrans","author":"Ingelman","key":"10.1016\/j.ejphar.2025.177990_bib29"},{"key":"10.1016\/j.ejphar.2025.177990_bib30","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1365-2982.2010.01498.x","article-title":"The intestinal barrier and its regulation by neuroimmune factors","volume":"22","author":"Keita","year":"2010","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.ejphar.2025.177990_bib31","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1080\/00365520410007953","article-title":"Colonic responses to Lactobacillus farciminis treatment in trinitrobenzene sulphonic acid-induced colitis in rats","volume":"39","author":"Lamine","year":"2004","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2025.177990_bib32","doi-asserted-by":"crossref","first-page":"18207","DOI":"10.3748\/wjg.v20.i48.18207","article-title":"2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-\u03b21 signaling","volume":"20","author":"Loeuillard","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2025.177990_bib33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0165-1838(98)00113-1","article-title":"Protective role of vagal afferents in experimentally-induced colitis in rats","volume":"73","author":"Mazelin","year":"1998","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.ejphar.2025.177990_bib34","first-page":"R1001","article-title":"Characterization of suppression of food intake following acute colon inflammation in the rat","volume":"265","author":"McHugh","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2025.177990_bib35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/MPG.0b013e3181aa3aa9","article-title":"Effects of timing, sex, and age on site-specific gastrointestinal permeability testing in children and adults","volume":"50","author":"McOmber","year":"2010","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.ejphar.2025.177990_bib36","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0016-5085(98)70636-5","article-title":"Discrimination of site-specific alterations in gastrointestinal permeability in the rat","volume":"114","author":"Meddings","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2025.177990_bib37","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0160-5402(81)90110-8","article-title":"Accurate measurement of intestinal transit in the rat","volume":"6","author":"Miller","year":"1981","journal-title":"J. Pharmacol. Methods"},{"key":"10.1016\/j.ejphar.2025.177990_bib38","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/B978-0-12-394596-9.00009-3","article-title":"Animal models of inflammatory bowel disease","volume":"105","author":"Mizoguchi","year":"2012","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10.1016\/j.ejphar.2025.177990_bib39","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10787-020-00763-x","article-title":"Euterpe oleracea Mart. (A\u00e7a\u00ed) attenuates experimental colitis in rats: involvement of TLR4\/COX-2\/NF-\u0138B","volume":"29","author":"Monteiro","year":"2021","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.ejphar.2025.177990_bib40","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0016-5085(89)80079-4","article-title":"Hapten-induced model of chronic inflammation and ulceration in the rat colon","volume":"96","author":"Morris","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2025.177990_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049547","article-title":"A low dose of fermented soy germ alleviates gut barrier injury, hyperalgesia and faecal protease activity in a rat model of inflammatory bowel disease","volume":"7","author":"Moussa","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2025.177990_bib42","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12906-021-03500-1","article-title":"A flavonoid rich standardized extract of Glycyrrhiza glabra protects intestinal epithelial barrier function and regulates the tight-junction proteins expression","volume":"22","author":"Murugan","year":"2022","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.ejphar.2025.177990_bib43","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/003655200750023769","article-title":"Mucosal in vitro permeability in the intestinal tract of the pig, the rat, and man: species- and region-related differences","volume":"35","author":"Nejdfors","year":"2000","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2025.177990_bib44","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.lfs.2004.09.019","article-title":"Disturbances in epithelial ionic secretion in different experimental models of colitis","volume":"76","author":"P\u00e9rez-Navarro","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.177990_bib45","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00210-005-1023-0","article-title":"Experimental inflammation of the rat distal colon inhibits ion secretion in the proximal colon by affecting the enteric nervous system","volume":"371","author":"P\u00e9rez-Navarro","year":"2005","journal-title":"N. Schmied. Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.177990_bib46","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1136\/gutjnl-2023-331835","article-title":"Prevalence of irritable bowel syndrome and functional dyspepsia after acute gastroenteritis: systematic review and meta-analysis","volume":"73","author":"Porcari","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2025.177990_bib47","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s00535-010-0321-6","article-title":"Systematic review of animal models of post-infectious\/post-inflammatory irritable bowel syndrome","volume":"46","author":"Qin","year":"2011","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2025.177990_bib48","doi-asserted-by":"crossref","first-page":"G157","DOI":"10.1152\/ajpgi.00367.2020","article-title":"Leptin-resistant Zucker rats with trinitrobenzene sulfonic acid colitis present a reduced inflammatory response but enhanced epithelial damage","volume":"321","author":"Rivero-Guti\u00e9rrez","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2025.177990_bib49","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3748\/wjg.v16.i6.703","article-title":"Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice","volume":"16","author":"Ruyssers","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.ejphar.2025.177990_bib50","doi-asserted-by":"crossref","first-page":"G692","DOI":"10.1152\/ajpgi.00248.2018","article-title":"Chronic colitis-induced visceral pain is associated with increased anxiety during quiescent phase","volume":"316","author":"Salameh","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ejphar.2025.177990_bib51","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s00424-002-0807-z","article-title":"Disturbances of colonic ion secretion in inflammation: role of the enteric nervous system and cAMP","volume":"444","author":"S\u00e1nchez de Medina","year":"2002","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.ejphar.2025.177990_bib52","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10753-020-01364-0","article-title":"Oridonin Attenuates TNBS-induced post-inflammatory irritable bowel syndrome via PXR\/NF-\u03baB signaling","volume":"44","author":"Shao","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2025.177990_bib53","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/jb\/mvx077","article-title":"Regulation of the epithelial barrier by post-translational modifications of tight junction membrane proteins","volume":"163","author":"Shigetomi","year":"2018","journal-title":"J. Biochem."},{"year":"2022","series-title":"Enzymatic creatinine_3 (Ecre3)","key":"10.1016\/j.ejphar.2025.177990_bib54"},{"key":"10.1016\/j.ejphar.2025.177990_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8101574","article-title":"Preclinical Study in vivo for new pharmacological approaches in inflammatory bowel disease: a systematic review of chronic model of TNBS-induced colitis","volume":"8","author":"Silva","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ejphar.2025.177990_bib56","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/jpn.12000","article-title":"Altered response to hydrogen sulphide during experimental colitis in rats","volume":"97","author":"Steidle","year":"2013","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.ejphar.2025.177990_bib57","first-page":"G203","article-title":"Disruption of intestinal barrier function associated with experimental colitis: possible role of mast cells","volume":"274","author":"Stein","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ejphar.2025.177990_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103140","article-title":"Gut bacteria exacerbates TNBS-induced colitis and kidney injury through oxidative stress","volume":"72","author":"Sui","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2025.177990_bib68","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12876-019-1002-4","article-title":"The Ussing chamber system for measuring intestinal permeability in health and disease","volume":"19","author":"Thomson","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.ejphar.2025.177990_bib59","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/jpn.12536","article-title":"Effect of a probiotic Lactobacillus plantarum TN8 strain on trinitrobenzene sulphonic acid-induced colitis in rats","volume":"101","author":"Trabelsi","year":"2017","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"10.1016\/j.ejphar.2025.177990_bib60","article-title":"Sacral nerve stimulation ameliorates colonic barrier functions in a rodent model of colitis","volume":"32","author":"Tu","year":"2020","journal-title":"Neuro Gastroenterol. Motil."},{"key":"10.1016\/j.ejphar.2025.177990_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.717925","article-title":"The role of intestinal permeability in gastrointestinal disorders and current methods of evaluation","volume":"8","author":"Vanuytsel","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.ejphar.2025.177990_bib62","first-page":"304","article-title":"The use of colonoscopy to follow the inflammatory time course of TNBS colitis in rats","volume":"74","author":"Vermeulen","year":"2011","journal-title":"Acta Gastroenterol. Belg."},{"key":"10.1016\/j.ejphar.2025.177990_bib63","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/mnfr.201400614","article-title":"Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function","volume":"59","author":"Xiong","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejphar.2025.177990_bib64","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/aps.2016.168","article-title":"Geniposide ameliorates TNBS-induced experimental colitis in rats via reducing inflammatory cytokine release and restoring impaired intestinal barrier function","volume":"38","author":"Xu","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2025.177990_bib65","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1039\/C5FO00378D","article-title":"Wild jujube polysaccharides protect against experimental inflammatory bowel disease by enabling enhanced intestinal barrier function","volume":"6","author":"Yue","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.ejphar.2025.177990_bib66","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1136\/gut.52.12.1714","article-title":"Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction","volume":"52","author":"Zamuner","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2025.177990_bib67","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s10620-007-9881-6","article-title":"Visceral and somatic hypersensitivity in TNBS-induced colitis in rats","volume":"53","author":"Zhou","year":"2008","journal-title":"Dig. Dis. Sci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925007447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925007447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T02:32:57Z","timestamp":1757644377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925007447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":67,"alternative-id":["S0014299925007447"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177990","relation":{},"ISSN":["0014-2999"],"issn-type":[{"type":"print","value":"0014-2999"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In-depth study of gastrointestinal motility, intestinal barrier function and secretory function in an irritable bowel syndrome post-inflammatory rat model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.177990","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"177990"}}