{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:09:34Z","timestamp":1786972174810,"version":"build-2736575974"},"reference-count":245,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2021-124932OB-100"],"award-info":[{"award-number":["PID2021-124932OB-100"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2024-156556OB-I00"],"award-info":[{"award-number":["PID2024-156556OB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008807","name":"Ministerio de Ciencia, Tecnolog\u00eda y Medio Ambiente","doi-asserted-by":"publisher","award":["PN385LH007-003"],"award-info":[{"award-number":["PN385LH007-003"]}],"id":[{"id":"10.13039\/501100008807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ejphar.2025.178064","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T06:37:24Z","timestamp":1755153444000},"page":"178064","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Pulmonary surfactant in asthma"],"prefix":"10.1016","volume":"1005","author":[{"given":"Odalys","family":"Blanco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercyleidi","family":"D\u00edaz-Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Labrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Autilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"P\u00e9rez-Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.178064_bib1","doi-asserted-by":"crossref","DOI":"10.1378\/chest.123.3_suppl.355S","article-title":"Hydrolysis of surfactant phospholipids catalyzed by phospholipase A2 and eosinophil lysophospholipases causes surfactant dysfunction: a mechanism for small airway closure in asthma","volume":"123","author":"Ackerman","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.ejphar.2025.178064_bib2","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.bbalip.2012.09.010","article-title":"Surfactant phospholipid metabolism","volume":"1831","author":"Agassandian","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.ejphar.2025.178064_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228279","article-title":"Decreased surfactant lipids correlate with lung function in chronic obstructive pulmonary disease (COPD)","volume":"15","author":"Agudelo","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2025.178064_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.21292\/2075-1230-2019-97-4-25-29","article-title":"Changes in hemodynamics during the course of surfactant therapy in patients with hormone-dependent asthma","volume":"97","author":"Akulova","year":"2019","journal-title":"Tuberculosis Lung Dis."},{"key":"10.1016\/j.ejphar.2025.178064_bib5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1203\/01.PDR.0000054655.95452.06","article-title":"Effect of exogenous surfactant on the development of surfactant synthesis in premature rabbit lung","volume":"53","author":"Amato","year":"2003","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib6","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1001\/jama.1997.03550170056032","article-title":"Effects of aerosolized surfactant in patients with stable chronic bronchitis: a prospective randomized controlled trial","volume":"278","author":"Anzueto","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2025.178064_bib7","doi-asserted-by":"crossref","first-page":"F443","DOI":"10.1136\/archdischild-2018-315413","article-title":"Understanding the principle biophysics concepts of pulmonary surfactant in health and disease","volume":"104","author":"Autilio","year":"2019","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.ejphar.2025.178064_bib8","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1183\/09031936.03.00069202","article-title":"Inhaled synthetic surfactant abolishes the early allergen-induced response in asthma","volume":"21","author":"Babu","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2025.178064_bib9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1515\/JPM.2009.100","article-title":"Effect of exogenous surfactant therapy on levels of pulmonary surfactant proteins A and D in preterm infants with respiratory distress syndrome","volume":"27","author":"Bae","year":"2009","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib10","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1183\/09031936.00026410","article-title":"Surfactant protein B polymorphisms, pulmonary function and COPD in 10,231 individuals","volume":"37","author":"B\u00e6kvad-Hansen","year":"2011","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2025.178064_bib11","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.rmed.2009.10.012","article-title":"Two novel mutations in surfactant protein-C, lung function and obstructive lung disease","volume":"104","author":"B\u00e6kvad-Hansen","year":"2010","journal-title":"Respir. Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1465-9921-7-34","article-title":"Airway smooth muscle relaxation results from a reduction in the frequency of Ca 2+ oscillations induced by a cAMP-mediated inhibition of the IP 3 receptor","volume":"7","author":"Bai","year":"2006","journal-title":"Respir. Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1210\/edrv-10-2-165","article-title":"Hormonal regulation of pulmonary surfactant","volume":"10","author":"Ballard","year":"1989","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2025.178064_bib14","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1165\/ajrcmb.14.6.8652188","article-title":"Transcriptional regulation of human pulmonary surfactant proteins SP-B and SP-C by glucocorticoids","volume":"14","author":"Ballard","year":"1996","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2025.178064_bib15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/088532820001400304","article-title":"Exogenous surfactant therapy and mucus rheology in chronic obstructive airway diseases","volume":"14","author":"Banerjee","year":"2000","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.ejphar.2025.178064_bib16","doi-asserted-by":"crossref","first-page":"L145","DOI":"10.1152\/ajplung.90525.2008","article-title":"Molecular diversity and function of K+ channels in airway and alveolar epithelial cells","volume":"296","author":"Bardou","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000272062","article-title":"P63 (CKAP4) as an SP-A receptor: implications for surfactant turnover","volume":"25","author":"Bates","year":"2009","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejphar.2025.178064_bib18","doi-asserted-by":"crossref","first-page":"L325","DOI":"10.1152\/ajplung.00341.2007","article-title":"Surfactant protein-A plays an important role in lung surfactant clearance: evidence using the surfactant protein-A gene-targeted mouse","volume":"294","author":"Bates","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib19","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1203\/00006450-199807000-00005","article-title":"Natural porcine surfactant (curosurf) down-regulates mRNA of tumor necrosis factor-alpha (TNF-alpha) and TNF-Alpha type II receptor in lipopolysaccharide-stimulated monocytes","volume":"44","author":"Baur","year":"1998","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib20","first-page":"K57","article-title":"Lung surfactant prevents allergic bronchial constriction in ovalbumin sensitized Guinea pigs","volume":"44","author":"Becher","year":"1985","journal-title":"Biomed. Biochim. Acta"},{"key":"10.1016\/j.ejphar.2025.178064_bib21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1203\/01.PDR.0000054653.89527.F8","article-title":"Bronchoalveolar lavage surfactant protein A, B, and d concentrations in preterm infants ventilated for respiratory distress syndrome receiving natural and synthetic surfactants","volume":"53","author":"Beresford","year":"2003","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib22","first-page":"328","article-title":"[supression of angiotensin II-induced contraction of the isolated Guinea pig ileum by alveolar surfactants (author's transl)]","volume":"149","author":"Bergmann","year":"1977","journal-title":"Zeitschrift fur Erkrankungen der Atmungsorgane"},{"key":"10.1016\/j.ejphar.2025.178064_bib23","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.aanat.2016.08.003","article-title":"Lung surfactant: function and composition in the context of development and respiratory physiology","volume":"208","author":"Bernhard","year":"2016","journal-title":"Annals of anatomy = Anatomischer Anzeiger : Off. Organ Anatomische Gesellschaft"},{"key":"10.1016\/j.ejphar.2025.178064_bib24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1586\/eri.12.156","article-title":"Immunomodulatory properties of surfactant preparations","volume":"11","author":"Bersani","year":"2013","journal-title":"Expert Rev. Anti-infect. Ther."},{"key":"10.1016\/j.ejphar.2025.178064_bib25","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2024-086394","article-title":"Recombinant fragment of human surfactant protein D to prevent neonatal chronic lung disease (RESPONSE): a protocol for a phase I safety trial in a tertiary neonatal unit","volume":"14","author":"Bhatt","year":"2024","journal-title":"BMJ Open"},{"key":"10.1016\/j.ejphar.2025.178064_bib26","doi-asserted-by":"crossref","first-page":"984","DOI":"10.3390\/cells11060984","article-title":"Novel insights into the therapeutic potential of lung-targeted gene transfer in the most common respiratory diseases","volume":"11","author":"Bisserier","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2025.178064_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2007.04.035","article-title":"Biochemical and pharmacological differences between preparations of exogenous natural surfactant used to treat respiratory distress syndrome: role of the different components in an efficient pulmonary surfactant","volume":"568","author":"Blanco","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178064_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108391","article-title":"Protective effects of surfacen\u00ae in allergen-induced asthma mice model","volume":"102","author":"Blanco","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2025.178064_bib29","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/ppul.1092","article-title":"Glucocorticoids and lung development in the fetus and preterm infant","volume":"32","author":"Bolt","year":"2001","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.ejphar.2025.178064_bib30","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.jaci.2008.02.011","article-title":"Surfactant protein D alters allergic lung responses in mice and human subjects","volume":"121","author":"Brandt","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib31","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1152\/japplphysiol.00523.2004","article-title":"Surfactant function in children with chronic airway inflammation","volume":"97","author":"Braun","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib32","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1097\/00003246-200010000-00001","article-title":"Treatment with exogenous surfactant stimulates endogenous surfactant synthesis in premature infants with respiratory distress syndrome","volume":"28","author":"Bunt","year":"2000","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.resp.2015.01.004","article-title":"Pulmonary surfactant in the airway physiology: a direct relaxing effect on the smooth muscle","volume":"209","author":"Calkovska","year":"2015","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib34","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1111\/cea.14124","article-title":"Down\u2010regulated surfactant protein B in Obese asthmatics","volume":"52","author":"Cao","year":"2022","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ejphar.2025.178064_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2020.100118","article-title":"The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources","volume":"13","author":"Caraballo","year":"2020","journal-title":"World Allergy Organ J."},{"key":"10.1016\/j.ejphar.2025.178064_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2021.108850","article-title":"Structural hallmarks of lung surfactant: lipid-protein interactions, membrane structure and future challenges","volume":"703","author":"Castillo-S\u00e1nchez","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ejphar.2025.178064_bib37","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/s41374-021-00618-1","article-title":"Surfactant protein A modulates the activities of the JAK\/STAT pathway in suppressing Th1 and Th17 polarization in murine OVA-induced allergic asthma","volume":"101","author":"Chen","year":"2021","journal-title":"Lab. Invest."},{"key":"10.1016\/j.ejphar.2025.178064_bib38","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1183\/09031936.00.16583100","article-title":"Increased levels of surfactant protein A and D in bronchoalveolar lavage fluids in patients with bronchial asthma","volume":"16","author":"Cheng","year":"2000","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2025.178064_bib39","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1053\/rmed.2000.1012","article-title":"Compositional and functional changes of pulmonary surfactant in a guinea-pig model of chronic asthma","volume":"95","author":"Cheng","year":"2001","journal-title":"Respir. Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/83348","article-title":"PPAR-\u03b1 and PPAR-\u03b3 activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway","volume":"7","author":"Chinetti","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib41","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.bbalip.2009.01.009","article-title":"Lipid ligand-activated transcription factors regulating lipid storage and release in human macrophages","volume":"1791","author":"Chinetti-Gbaguidi","year":"2009","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.ejphar.2025.178064_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11882-020-00968-8","article-title":"Pulmonary surfactants: a new therapeutic target in asthma","volume":"20","author":"Choi","year":"2020","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.ejphar.2025.178064_bib43","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000272047","article-title":"Pulmonary surfactant: an immunological perspective","volume":"25","author":"Chroneos","year":"2010","journal-title":"Cell. Physiol. Biochem. : Int. J. Experiment. Cell. Physiol., Biochem., Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178064_bib44","doi-asserted-by":"crossref","first-page":"L608","DOI":"10.1152\/ajplung.00434.2004","article-title":"Pulmonary surfactant in allergic inflammation: new insights into the molecular mechanisms of surfactant function","volume":"288","author":"Cochrane","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib45","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1126\/science.1948032","article-title":"Pulmonary surfactant protein B (SP-B): structure-function relationships","volume":"254","author":"Cochrane","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2025.178064_bib46","article-title":"Gene therapy potential for genetic disorders of surfactant dysfunction","volume":"3","author":"Cooney","year":"2022","journal-title":"Front. Genome Edit."},{"key":"10.1016\/j.ejphar.2025.178064_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/PL00007554","article-title":"The pulmonary surfactant system: biochemical and clinical aspects","volume":"175","author":"Creuwels","year":"1997","journal-title":"Lung"},{"key":"10.1016\/j.ejphar.2025.178064_bib48","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jconrel.2015.09.004","article-title":"Bio-inspired materials in drug delivery: exploring the role of pulmonary surfactant in siRNA inhalation therapy","volume":"220","author":"De Backer","year":"2015","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.178064_bib49","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.intimp.2014.05.020","article-title":"Effect of natural porcine surfactant in Staphylococcus aureus induced pro-inflammatory cytokines and reactive oxygen species generation in monocytes and neutrophils from human blood","volume":"21","author":"de Guevara","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2025.178064_bib50","first-page":"549","article-title":"Surfactant replacement therapy: an update on applications","volume":"45","author":"Dekowski","year":"1998","journal-title":"Pediatr. Clin."},{"key":"10.1016\/j.ejphar.2025.178064_bib51","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s11033-010-0254-4","article-title":"Relationship between surfactant protein A polymorphisms and allergic rhinitis in a Chinese Han population","volume":"38","author":"Deng","year":"2011","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.ejphar.2025.178064_bib52","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1399-0039.2009.01232.x","article-title":"Association between single nucleotide polymorphisms of surfactant protein D and allergic rhinitis in Chinese patients","volume":"73","author":"Deng","year":"2009","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.ejphar.2025.178064_bib53","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.3390\/pharmaceutics13101580","article-title":"Physiologic effects of instilled and aerosolized surfactant using a breath-synchronized nebulizer on surfactant-deficient rabbits","volume":"13","author":"DiBlasi","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2025.178064_bib54","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1146\/annurev.physiol.67.040403.102553","article-title":"Exocytosis of lung surfactant: from the secretory vesicle to the air-liquid interface","volume":"67","author":"Dietl","year":"2005","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib55","doi-asserted-by":"crossref","first-page":"30749","DOI":"10.1074\/jbc.R000015200","article-title":"Fatty acid regulation of gene transcription","volume":"275","author":"Duplus","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2025.178064_bib56","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.4049\/jimmunol.1900546","article-title":"Genetic variation in surfactant protein-A2 delays resolution of eosinophilia in asthma","volume":"203","author":"Dy","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib57","article-title":"The emerging roles of surfactant Protein-A in asthma","volume":"9","author":"Dy","year":"2018","journal-title":"J. Clin. Cell. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib58","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0140-6736(17)31448-4","article-title":"Trends in international asthma mortality: analysis of data from the WHO mortality database from 46 countries (1993-2012)","volume":"390","author":"Ebmeier","year":"2017","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.ejphar.2025.178064_bib59","doi-asserted-by":"crossref","first-page":"951","DOI":"10.4155\/tde.13.72","article-title":"Delivery and performance of surfactant replacement therapies to treat pulmonary disorders","volume":"4","author":"El-Gendy","year":"2013","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.ejphar.2025.178064_bib60","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/all.12603","article-title":"Sputum and BAL clara cell secretory protein and surfactant protein D levels in asthma","volume":"70","author":"Emmanouil","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.ejphar.2025.178064_bib61","article-title":"Pulmonary surfactant function in alveoli and conducting airways","volume":"3","author":"Enhorning","year":"1996","journal-title":"Can. Respir. J. J. Can. Thorac. Soc."},{"key":"10.1016\/j.ejphar.2025.178064_bib62","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1378\/chest.07-2404","article-title":"Surfactant in airway disease","volume":"133","author":"Enhorning","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.ejphar.2025.178064_bib63","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1164\/ajrccm.151.2.7842219","article-title":"Pulmonary surfactant maintains patency of conducting airways in the rat","volume":"151","author":"Enhorning","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib64","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1139\/y96-062","article-title":"Increased airway resistance due to surfactant dysfunction can be alleviated with aerosol surfactant","volume":"74","author":"Enhorning","year":"1996","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178064_bib65","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1164\/rccm.200301-104OC","article-title":"Natural porcine surfactant augments airway inflammation after allergen challenge in patients with asthma","volume":"169","author":"Erpenbeck","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib66","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00210-008-0354-z","article-title":"Therapeutic use of surfactant components in allergic asthma","volume":"379","author":"Erpenbeck","year":"2009","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.ejphar.2025.178064_bib67","doi-asserted-by":"crossref","first-page":"L692","DOI":"10.1152\/ajplung.00362.2004","article-title":"Surfactant protein D increases phagocytosis and aggregation of pollen-allergen starch granules","volume":"288","author":"Erpenbeck","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib68","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nri3786","article-title":"Type 2 inflammation in asthma\u2014present in most, absent in many","volume":"15","author":"Fahy","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib69","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/resp.13193","article-title":"Surfactant protein D multimerization and gene polymorphism in COPD and asthma","volume":"23","author":"Fakih","year":"2018","journal-title":"Respirology"},{"key":"10.1016\/j.ejphar.2025.178064_bib70","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1080\/14767058.2016.1256994","article-title":"Association of SP-C gene codon 186 polymorphism (rs1124) and risk of RDS","volume":"30","author":"Fatahi","year":"2017","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1125984","article-title":"Airway allergy causes alveolar macrophage death, profound alveolar disorganization and surfactant dysfunction","volume":"14","author":"Feo-Lucas","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib72","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/0005-2760(90)90239-T","article-title":"Purification and characterization of a phospholipase A2 associated with rabbit lung microsomes: some evidence for its mitochondrial origin","volume":"1046","author":"Filgueiras","year":"1990","journal-title":"Biochim. Biophys. Acta Lipids Lipid. Metabol."},{"key":"10.1016\/j.ejphar.2025.178064_bib73","doi-asserted-by":"crossref","first-page":"L748","DOI":"10.1152\/ajplung.2001.280.4.L748","article-title":"Lysosomal-type PLA2 and turnover of alveolar DPPC","volume":"280","author":"Fisher","year":"2001","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib74","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1136\/thorax-2024-221947","article-title":"Surfactant protein B deficiency: the RespiRare cohort","volume":"80","author":"Fleury","year":"2025","journal-title":"Thorax"},{"key":"10.1016\/j.ejphar.2025.178064_bib75","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1086\/315866","article-title":"Surfactant protein genetic marker alleles identify a subgroup of tuberculosis in a Mexican population","volume":"182","author":"Floros","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.ejphar.2025.178064_bib76","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.681639","article-title":"Human surfactant protein SP-A1 and SP-A2 variants differentially affect the alveolar microenvironment, surfactant structure, regulation and function of the alveolar macrophage, and animal and human survival under various conditions","volume":"12","author":"Floros","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib77","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.4049\/jimmunol.1901227","article-title":"Surfactant Protein-A protects against IL-13\u2013induced inflammation in asthma","volume":"204","author":"Francisco","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.900022","article-title":"Small peptide derivatives within the carbohydrate recognition domain of SP-A2 modulate asthma outcomes in mouse models and human cells","volume":"13","author":"Francisco","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib79","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000088653","article-title":"Glucocorticoid metabolism in the human fetal lung: implications for lung development and the pulmonary surfactant system","volume":"89","author":"Garbrecht","year":"2006","journal-title":"Neonatology"},{"key":"10.1016\/j.ejphar.2025.178064_bib80","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1250350","article-title":"Novel opportunities from bioimaging to understand the trafficking and maturation of intracellular pulmonary surfactant and its role in lung diseases","volume":"14","author":"Garcia","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12931-019-1124-9","article-title":"Tracing exogenous surfactant in vivo in rabbits by the natural variation of 13 C","volume":"20","author":"Giambelluca","year":"2019","journal-title":"Respir. Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib82","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0005-2760(84)90155-3","article-title":"Stimulation of phosphatidylcholine synthesis by exogenous phosphatidylglycerol in primary cultures of type II pneumocytes","volume":"794","author":"Gilfillan","year":"1984","journal-title":"Biochim. Biophys. Acta Lipids Lipid. Metabol."},{"key":"10.1016\/j.ejphar.2025.178064_bib83","first-page":"181","article-title":"Eosinophilic and neutrophilic airway inflammation in the phenotyping of mild-to-moderate asthma and chronic obstructive pulmonary disease","volume":"14","author":"G\u00f3rska","year":"2017","journal-title":"COPD J. Chronic Obstr. Pulm. Dis."},{"key":"10.1016\/j.ejphar.2025.178064_bib84","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1164\/ajrccm.152.3.7663782","article-title":"Pharmacokinetics of bovine surfactant in neonatal respiratory distress syndrome","volume":"152","author":"Griese","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib85","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jconrel.2018.10.012","article-title":"Pulmonary surfactant and drug delivery: focusing on the role of surfactant proteins","volume":"291","author":"Guagliardo","year":"2018","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.178064_bib86","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1164\/ajrccm.159.1.9612005","article-title":"Surfactant subtype conversion is related to loss of surfactant apoprotein B and surface activity in large surfactant aggregates: experimental and clinical studies","volume":"159","author":"Gunther","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib87","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000121454","article-title":"Surfactant collectins and innate immunity","volume":"93","author":"Haagsman","year":"2008","journal-title":"Neonatology"},{"key":"10.1016\/j.ejphar.2025.178064_bib88","doi-asserted-by":"crossref","first-page":"L755","DOI":"10.1152\/ajplung.00062.2002","article-title":"The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice","volume":"283","author":"Haczku","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib89","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1513\/AnnalsATS.201411-507FR","article-title":"The role of surfactant in lung disease and host defense against pulmonary infections","volume":"12","author":"Han","year":"2015","journal-title":"Annals Am. Thoracic Soc."},{"key":"10.1016\/j.ejphar.2025.178064_bib90","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.70026","article-title":"Pulmonary surfactant and prostaglandin E2 in airway smooth muscle relaxation of human and male Guinea pigs","volume":"12","author":"Hanusrichterova","year":"2024","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.ejphar.2025.178064_bib91","doi-asserted-by":"crossref","first-page":"C798","DOI":"10.1152\/ajpcell.00337.2024","article-title":"Factors influencing airway smooth muscle tone: a comprehensive review with a special emphasis on pulmonary surfactant","volume":"327","author":"Hanusrichterova","year":"2024","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib92","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1164\/ajrccm.154.2.8756826","article-title":"Lung function in premature rabbits treated with recombinant human surfactant protein-C","volume":"154","author":"Hawgood","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib93","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41390-020-0750-8","article-title":"Surfactant replacement therapy: from biological basis to current clinical practice","volume":"88","author":"Hentschel","year":"2020","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.02.067","article-title":"Surfactant protein B-derived peptides as endosomal escape enhancers for pulmonary delivery of siRNA","volume":"381","author":"Herman","year":"2025","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.178064_bib95","doi-asserted-by":"crossref","first-page":"L610","DOI":"10.1152\/ajplung.00273.2004","article-title":"Surfactant phospholipid changes after antigen challenge: a role for phosphatidylglycerol in dysfunction","volume":"288","author":"Hite","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib96","doi-asserted-by":"crossref","first-page":"L618","DOI":"10.1152\/ajplung.00274.2004","article-title":"Lysophospholipid generation and phosphatidylglycerol depletion in phospholipase A2-mediated surfactant dysfunction","volume":"288","author":"Hite","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib97","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1016\/j.bbamcr.2016.04.028","article-title":"A small key unlocks a heavy door: the essential function of the small hydrophobic proteins SP-B and SP-C to trigger adsorption of pulmonary surfactant lamellar bodies","volume":"1863","author":"Hobi","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2025.178064_bib98","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/iid3.560","article-title":"Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults","volume":"10","author":"Hoffmann\u2010Petersen","year":"2022","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.ejphar.2025.178064_bib99","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1183\/09031936.97.10102198","article-title":"Aerosolized surfactant inhibits acetylcholine-induced airway obstruction in rats","volume":"10","author":"Hohlfeld","year":"1997","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2025.178064_bib100","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/rr176","article-title":"The role of surfactant in asthma","volume":"3","author":"Hohlfeld","year":"2002","journal-title":"Respir. Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib101","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1164\/ajrccm.159.6.9806145","article-title":"Dysfunction of pulmonary surfactant in asthmatics after segmental allergen challenge","volume":"159","author":"Hohlfeld","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib102","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jaci.2003.12.008","article-title":"Eosinophil cationic protein alters pulmonary surfactant structure and function in asthma","volume":"113","author":"Hohlfeld","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib103","article-title":"Alveolar macrophages in pulmonary alveolar proteinosis: origin, function, and therapeutic strategies","volume":"14","author":"Huang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib104","doi-asserted-by":"crossref","DOI":"10.1136\/bmjresp-2020-000804","article-title":"non-invasive particles in exhaled air method to explore the lining fluid of small airways -a European population- based cohort study","volume":"8","author":"Hussain-Alkhateeb","year":"2021","journal-title":"BMJ Open Respir. Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib105","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/MOL.0000000000000209","article-title":"Cholesterol efflux capacity, macrophage reverse cholesterol transport and cardioprotective HDL","volume":"26","author":"Hutchins","year":"2015","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.ejphar.2025.178064_bib106","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1152\/japplphysiol.91567.2008","article-title":"Surfactant protein-D regulates the postnatal maturation of pulmonary surfactant lipid pool sizes","volume":"106","author":"Ikegami","year":"2009","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib107","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1111\/cea.12358","article-title":"Re\u2010defining the unique roles for eosinophils in allergic respiratory inflammation","volume":"44","author":"Jacobsen","year":"2014","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ejphar.2025.178064_bib108","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1183\/09031936.03.00000103","article-title":"Understanding the regulation of surfactant gene expression","volume":"22","author":"Jacot","year":"2003","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2025.178064_bib109","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fimmu.2019.00122","article-title":"Lipophilic allergens, different modes of allergen-lipid interaction and their impact on asthma and allergy","volume":"10","author":"Jappe","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib110","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1164\/ajrccm.160.1.9806155","article-title":"Antigen-induced airway inflammation in atopic subjects generates dysfunction of pulmonary surfactant","volume":"160","author":"Jarjour","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib111","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev.physiol.62.1.825","article-title":"Lung development and function in preterm infants in the surfactant treatment era","volume":"62","author":"Jobe","year":"2000","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib112","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/joim.12845","article-title":"Synthetic surfactants with SP-B and SP-C analogues to enable worldwide treatment of neonatal respiratory distress syndrome and other lung diseases","volume":"285","author":"Johansson","year":"2019","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib113","doi-asserted-by":"crossref","first-page":"L887","DOI":"10.1152\/ajplung.00340.2013","article-title":"Surfactant protein D is a candidate biomarker for subclinical tobacco smoke-induced lung damage","volume":"306","author":"Johansson","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib114","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1038\/s41467-020-17577-8","article-title":"A lung tropic AAV vector improves survival in a mouse model of surfactant B deficiency","volume":"11","author":"Kang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2025.178064_bib115","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cmet.2005.01.002","article-title":"ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation","volume":"1","author":"Kennedy","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejphar.2025.178064_bib116","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.biotechadv.2018.03.017","article-title":"Clinical, technological, and economic issues associated with developing new lung surfactant therapeutics","volume":"36","author":"Kim","year":"2018","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ejphar.2025.178064_bib117","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1165\/rcmb.2005-0228OC","article-title":"Surfactant as an airway smooth muscle relaxant","volume":"34","author":"Koetzler","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2025.178064_bib118","first-page":"94","article-title":"Surfactant protein A: an innate immune modulator and therapeutic in asthma","volume":"134","author":"Kraft","year":"2024","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"10.1016\/j.ejphar.2025.178064_bib119","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1460-9592.2006.02126.x","article-title":"Early administration of surfactant in spontaneous breathing with nCPAP: feasibility and outcome in extremely premature infants (postmenstrual age <\/=27 weeks)","volume":"17","author":"Kribs","year":"2007","journal-title":"Paediatr. Anaesth."},{"key":"10.1016\/j.ejphar.2025.178064_bib120","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1165\/ajrcmb\/7.4.358","article-title":"The role of peroxisomes in cholesterol metabolism","volume":"7","author":"Krisans","year":"1992","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2025.178064_bib121","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1399-3038.2005.00353.x","article-title":"Amino acid variants in surfactant protein D are not associated with bronchial asthma","volume":"17","author":"Krueger","year":"2006","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib122","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1365-2222.1997.tb00713.x","article-title":"Effect of surfactant inhalation on allergic bronchoconstriction in Guinea pigs","volume":"27","author":"Kurashima","year":"1997","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ejphar.2025.178064_bib123","first-page":"160","article-title":"A pilot study of surfactant inhalation in the treatment of asthmatic attack","volume":"40","author":"Kurashima","year":"1991","journal-title":"Arerugi = [Allergy]"},{"key":"10.1016\/j.ejphar.2025.178064_bib124","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.jaci.2006.12.614","article-title":"Combined activities of secretory phospholipases and eosinophil lysophospholipases induce pulmonary surfactant dysfunction by phospholipid hydrolysis","volume":"119","author":"Kwatia","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib125","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"Lambrecht","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib126","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-49696-8","article-title":"Reversal of surfactant protein B deficiency in patient specific human induced pluripotent stem cell derived lung organoids by gene therapy","volume":"9","author":"Leibel","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.178064_bib127","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1021\/acs.langmuir.2c03349","article-title":"Surfactant proteins SP-B and SP-C in pulmonary surfactant monolayers: physical properties controlled by specific protein-lipid interactions","volume":"39","author":"Liekkinen","year":"2023","journal-title":"Langmuir : ACS J. Surf. Coll."},{"key":"10.1016\/j.ejphar.2025.178064_bib128","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1034\/j.1399-0004.2000.580305.x","article-title":"Polymorphisms of human SP\u2010A, SP\u2010B, and SP\u2010D genes: association of SP\u2010B Thr131Ile with ARDS","volume":"58","author":"Lin","year":"2000","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ejphar.2025.178064_bib129","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1111\/j.1365-2222.2005.02387.x","article-title":"Mite allergen induces nitric oxide production in alveolar macrophage cell lines via CD14\/toll\u2010like receptor 4, and is inhibited by surfactant protein D","volume":"35","author":"Liu","year":"2005","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ejphar.2025.178064_bib130","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1365-2222.2005.02205.x","article-title":"Therapeutic effect of surfactant protein D in allergic inflammation of mite\u2010sensitized mice","volume":"35","author":"Liu","year":"2005","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.ejphar.2025.178064_bib131","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1365-2222.1995.tb03251.x","article-title":"Surfactant dysfunction develops when the immunized guinea-pig is challenged with ovalbumin aerosol","volume":"25","author":"Liu","year":"1995","journal-title":"Clin. Exp. Allergy : J. Br. Soc. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib132","first-page":"802","article-title":"Dysfunction of guinea-pig pulmonary surfactant and type II pneumocytes after repetitive challenge with aerosolized ovalbumin","volume":"27","author":"Liu","year":"1997","journal-title":"Clin. Exp. Allergy : J. Br. Soc. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib133","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1365-2222.1996.tb00091.x","article-title":"Pulmonary surfactant given prophylactically alleviates an asthma attack in guinea-pigs","volume":"26","author":"Liu","year":"1996","journal-title":"Clin. Exp. Allergy : J. Br. Soc. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib134","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.bbamem.2014.01.028","article-title":"Structure-function relationships in pulmonary surfactant membranes: from biophysics to therapy","volume":"1838","author":"Lopez-Rodriguez","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2025.178064_bib135","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1388-1981(01)00135-4","article-title":"Transcriptional regulation of the lung fatty acid synthase gene by glucocorticoid, thyroid hormone and transforming growth factor-\u03b21","volume":"1532","author":"Lu","year":"2001","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.ejphar.2025.178064_bib136","doi-asserted-by":"crossref","DOI":"10.37757\/MR2022.V24.N3-4.7","article-title":"Effect of Cuban porcine pulmonary surfactant (Surfacen) and rCmPI-II protease inhibitor on neutrophil elastase activity","author":"Lugones Ladr\u00f3n de Guevara","year":"2022","journal-title":"Med. Rev."},{"key":"10.1016\/j.ejphar.2025.178064_bib137","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bbamem.2006.03.005","article-title":"Production and characterisation of recombinant forms of human pulmonary surfactant protein C (SP-C): structure and surface activity","volume":"1758","author":"Lukovic","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2025.178064_bib138","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.chest.2015.11.012","article-title":"Airway surfactant protein D deficiency in adults with severe asthma","volume":"149","author":"Mackay","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.ejphar.2025.178064_bib139","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1128\/iai.65.8.3171-3179.1997","article-title":"Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages","volume":"65","author":"Madan","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejphar.2025.178064_bib140","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1113210","article-title":"Updates on the role of surfactant proteins A and D in innate immune responses","volume":"13","author":"Madan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib141","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1194\/jlr.M085431","article-title":"Metabolism of a synthetic compared with a natural therapeutic pulmonary surfactant in adult mice","volume":"59","author":"Madsen","year":"2018","journal-title":"JLR (J. Lipid Res.)"},{"key":"10.1016\/j.ejphar.2025.178064_bib142","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1586\/14789450.2014.897612","article-title":"Surfactant protein SP-D modulates activity of immune cells: proteomic profiling of its interaction with eosinophilic cells","volume":"11","author":"Mahajan","year":"2014","journal-title":"Expet Rev. Proteonomics"},{"key":"10.1016\/j.ejphar.2025.178064_bib143","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/intimm\/dxn058","article-title":"Recombinant surfactant protein-D selectively increases apoptosis in eosinophils of allergic asthmatics and enhances uptake of apoptotic eosinophils by macrophages","volume":"20","author":"Mahajan","year":"2008","journal-title":"Int. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib144","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF01145960","article-title":"Pollen grains bind to lung alveolar type II cells (A549) via lung surfactant protein A (SP-A)","volume":"13","author":"Malhotra","year":"1993","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ejphar.2025.178064_bib145","first-page":"4600","article-title":"Pulmonary surfactant protein SP-B promotes exocytosis of lamellar bodies in alveolar type II cells","volume":"32","author":"Mart\u00ednez-Calle","year":"2018","journal-title":"FASEB (Fed. Am. Soc. Exp. Biol.) J."},{"key":"10.1016\/j.ejphar.2025.178064_bib146","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1089\/hum.2022.172","article-title":"Progress in respiratory gene therapy","volume":"33","author":"McLachlan","year":"2022","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.ejphar.2025.178064_bib147","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0077-2021","article-title":"Revisiting the role of pulmonary surfactant in chronic inflammatory lung diseases and environmental exposure","volume":"30","author":"Milad","year":"2021","journal-title":"Eur. Respir. Rev. : Off. J. Eur. Respir. Soc."},{"key":"10.1016\/j.ejphar.2025.178064_bib148","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0005-2760(83)90104-2","article-title":"Incorporation of [3H] palmitate into disaturated phosphatidylcholines in alveolar type II cells isolated by centrifugal elutriation","volume":"753","author":"Miles","year":"1983","journal-title":"Biochim. Biophys. Acta Lipids Lipid. Metabol."},{"key":"10.1016\/j.ejphar.2025.178064_bib149","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2174\/092986708783497364","article-title":"Synthetic pulmonary surfactant preparations: new developments and future trends","volume":"15","author":"Mingarro","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2025.178064_bib150","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.chest.2015.12.038","article-title":"Surfactant Protein-D and asthma","volume":"149","author":"Mitchell","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.ejphar.2025.178064_bib151","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12890-025-03654-5","article-title":"Surfactant proteins levels in asthmatic patients and their correlation with severity of asthma: a systematic review","volume":"25","author":"Mohamed","year":"2025","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib152","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00424-011-0997-3","article-title":"Characterization of P2Y receptors mediating ATP induced relaxation in Guinea pig airway smooth muscle: involvement of prostaglandins and K+ channels","volume":"462","author":"Monta\u00f1o","year":"2011","journal-title":"Pflueg. Arch. Eur. J. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib153","doi-asserted-by":"crossref","first-page":"90","DOI":"10.33084\/bjop.v3iSpecial-1.1397","article-title":"Global pandemic conditions and list of possible medications and vaccines for the treatment of COVID-19: a review","volume":"3","author":"Mukim","year":"2020","journal-title":"Borneo J. Pharm."},{"key":"10.1016\/j.ejphar.2025.178064_bib154","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.omtm.2020.11.013","article-title":"A human surfactant B deficiency air-liquid interface cell culture model suitable for gene therapy applications","volume":"20","author":"Munis","year":"2021","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.ejphar.2025.178064_bib155","doi-asserted-by":"crossref","first-page":"L705","DOI":"10.1152\/ajplung.00546.2020","article-title":"Exercise-induced alterations in phospholipid hydrolysis, airway surfactant, and eicosanoids and their role in airway hyperresponsiveness in asthma","volume":"320","author":"Murphy","year":"2021","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02770903.2020.1827419","article-title":"Association analysis of the surfactant protein-C gene to childhood asthma","volume":"59","author":"Nefzi","year":"2022","journal-title":"J. Asthma"},{"key":"10.1016\/j.ejphar.2025.178064_bib157","doi-asserted-by":"crossref","first-page":"e328","DOI":"10.1542\/neo.26-5-014","article-title":"Genetic disorders of surfactant metabolism","volume":"26","author":"Nevel","year":"2025","journal-title":"NeoReviews"},{"key":"10.1016\/j.ejphar.2025.178064_bib158","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1002\/tox.24233","article-title":"Hibifolin protected pro-inflammatory response and oxidative stress in LPS-induced acute lung injury through antioxidative enzymes and the AMPK2\/Nrf-2 pathway","volume":"39","author":"Ni","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ejphar.2025.178064_bib159","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/MOP.0000000000000751","article-title":"Genetic causes of surfactant protein abnormalities","volume":"31","author":"Nogee","year":"2019","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.ejphar.2025.178064_bib160","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1172\/JCI117173","article-title":"A mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindreds","volume":"93","author":"Nogee","year":"1994","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2025.178064_bib161","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1164\/ajrccm.161.3.9903153","article-title":"Allelic heterogeneity in hereditary surfactant protein B (SP-B) deficiency","volume":"161","author":"Nogee","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib162","doi-asserted-by":"crossref","DOI":"10.4414\/smw.2014.14036","article-title":"Childhood asthma: causes, risks, and protective factors; a role of innate immunity","volume":"144","author":"Noutsios","year":"2014","journal-title":"Swiss Med. Wkly."},{"key":"10.1016\/j.ejphar.2025.178064_bib163","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbalip.2022.159139","article-title":"Anti-inflammatory and anti-viral actions of anionic pulmonary surfactant phospholipids. Biochimica et biophysica acta","volume":"1867","author":"Numata","year":"2022","journal-title":"Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.ejphar.2025.178064_bib164","doi-asserted-by":"crossref","first-page":"L37","DOI":"10.1152\/ajplung.1991.260.2.L37","article-title":"Glucocorticoid enhances pulmonary surfactant protein B gene transcription","volume":"260","author":"O'Reilly","year":"1991","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib165","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1164\/ajrccm.153.3.8630559","article-title":"Surfactant nebulization does not alter airflow obstruction and bronchial responsiveness to histamine in asthmatic children","volume":"153","author":"Oetomo","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib166","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1152\/jappl.1990.68.4.1590","article-title":"Surfactant treatments alter endogenous surfactant metabolism in rabbit lungs","volume":"68","author":"Oetomo","year":"1990","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib167","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.aanat.2016.09.008","article-title":"Pulmonary surfactant metabolism in the alveolar airspace: biogenesis, extracellular conversions, recycling","volume":"209","author":"Olmeda","year":"2017","journal-title":"Annals Anatomy-Anatomischer Anzeiger"},{"key":"10.1016\/j.ejphar.2025.178064_bib168","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3390\/ijms25031943","article-title":"Genetic diversity in bronchial asthma susceptibility: exploring the role of vitamin D receptor gene polymorphisms in varied geographic contexts","volume":"25","author":"Paramonova","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178064_bib169","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.chemphyslip.2014.09.002","article-title":"Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films","volume":"185","author":"Parra","year":"2015","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.ejphar.2025.178064_bib170","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/ejhg.2015.45","article-title":"Clinical and ultrastructural spectrum of diffuse lung disease associated with surfactant protein C mutations","volume":"23","author":"Peca","year":"2015","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ejphar.2025.178064_bib171","series-title":"Seminars in Fetal and Neonatal Medicine","article-title":"Towards personalized therapies for genetic disorders of surfactant dysfunction","author":"Peers de Nieuwburgh","year":"2023"},{"key":"10.1016\/j.ejphar.2025.178064_bib172","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1016\/j.bbamem.2008.05.003","article-title":"Structure of pulmonary surfactant membranes and films: the role of proteins and lipid-protein interactions","volume":"1778","author":"P\u00e9rez-Gil","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2025.178064_bib173","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.bj.2022.03.001","article-title":"A recipe for a good clinical pulmonary surfactant","volume":"45","author":"P\u00e9rez-Gil","year":"2022","journal-title":"Biomed. J."},{"key":"10.1016\/j.ejphar.2025.178064_bib174","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1152\/physiol.00006.2010","article-title":"Pulmonary surfactant pathophysiology: current models and open questions","volume":"25","author":"Perez-Gil","year":"2010","journal-title":"Physiology"},{"key":"10.1016\/j.ejphar.2025.178064_bib175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2350-8-15","article-title":"Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes","volume":"8","author":"Pettigrew","year":"2007","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.ejphar.2025.178064_bib176","doi-asserted-by":"crossref","first-page":"526","DOI":"10.2174\/0929867328666210825110421","article-title":"Pulmonary surfactant: a unique biomaterial with life-saving therapeutic applications","volume":"29","author":"Pioselli","year":"2022","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2025.178064_bib177","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1164\/ajrccm\/138.4.990","article-title":"A proposed nomenclature for pulmonary surfactant-associated proteins","volume":"138","author":"Possmayer","year":"1988","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.ejphar.2025.178064_bib178","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1095-6433(01)00317-8","article-title":"Surface activity in vitro: role of surfactant proteins. Comparative biochemistry and physiology. Part A","volume":"129","author":"Possmayer","year":"2001","journal-title":"Mol. Integrat. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib179","doi-asserted-by":"crossref","DOI":"10.1088\/1752-7163\/ac20c1","article-title":"The potential role of SP-D as an early biomarker of severity of asthma","volume":"15","author":"Principe","year":"2021","journal-title":"J. Breath Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2466-7-6","article-title":"Surfactant protein B polymorphisms are associated with severe respiratory syncytial virus infection, but not with asthma","volume":"7","author":"Puthothu","year":"2007","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib181","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1399-3038.2006.00467.x","article-title":"Haplotypes of surfactant protein C are associated with common paediatric lung diseases","volume":"17","author":"Puthothu","year":"2006","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib182","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.molimm.2012.10.039","article-title":"Linking surfactant protein SP-D and IL-13: implications in asthma and allergy","volume":"54","author":"Qaseem","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib183","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.3390\/genes13101870","article-title":"The genetic factors of the airway epithelium associated with the pathology of asthma","volume":"13","author":"Ranjbar","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.ejphar.2025.178064_bib184","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/s41598-018-38313-9","article-title":"The major allergen Der p 2 is a cholesterol binding protein","volume":"9","author":"Reginald","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.178064_bib185","doi-asserted-by":"crossref","first-page":"L201","DOI":"10.1152\/ajplung.1992.263.2.L201","article-title":"Localization of alveolar surfactant clearance in rabbit lung cells","volume":"263","author":"Rider","year":"1992","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib186","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1161\/ATVBAHA.107.158998","article-title":"Regulation of macrophage functions by PPAR-\u03b1, PPAR-\u03b3, and LXRs in mice and men","volume":"28","author":"Rigamonti","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2025.178064_bib187","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.bpj.2016.09.016","article-title":"Effect of lung surfactant protein SP-C and SP-C-promoted membrane fragmentation on cholesterol dynamics","volume":"111","author":"Roldan","year":"2016","journal-title":"Biophys. J."},{"key":"10.1016\/j.ejphar.2025.178064_bib188","doi-asserted-by":"crossref","first-page":"L919","DOI":"10.1152\/ajplung.00383.2011","article-title":"Characterization of the Niemann-pick C pathway in alveolar type II cells and lamellar bodies of the lung","volume":"302","author":"Roszell","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib189","doi-asserted-by":"crossref","first-page":"L379","DOI":"10.1152\/ajplung.00176.2004","article-title":"Naturally derived commercial surfactants differ in composition of surfactant lipids and in surface viscosity","volume":"288","author":"R\u00fcdiger","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib190","series-title":"Anatomy & Physiology: the Unity of Form and Function","author":"Saladin","year":"2012"},{"key":"10.1016\/j.ejphar.2025.178064_bib191","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.molimm.2004.07.014","article-title":"The lung collectins, SP-A and SP-D, modulate pulmonary innate immunity","volume":"42","author":"Sano","year":"2005","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib192","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/01902148.2023.2238232","article-title":"Ultrastructural analysis of the intracellular surfactant in lungs of healthy and ovalbumin sensitized and challenged brown Norway rats","volume":"49","author":"Schmiedl","year":"2023","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib193","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/jmicro\/dfh056","article-title":"Influence of plasma and inflammatory proteins on the ultrastructure of exogenous surfactant","volume":"53","author":"Schmiedl","year":"2004","journal-title":"J. Electron. Microsc."},{"key":"10.1016\/j.ejphar.2025.178064_bib194","article-title":"The inhibitory effect of curosurf(\u00ae) and alveofact(\u00ae) on the formation of neutrophil extracellular traps","volume":"11","author":"Schulz","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib195","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0925-4439(98)00067-2","article-title":"Formation and structure of surface films: captive bubble surfactometry","volume":"1408","author":"Sch\u00fcrch","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2025.178064_bib196","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1183\/09031936.93.06070971","article-title":"Surfactant inhibition by plasma proteins: differential sensitivity of various surfactant preparations","volume":"6","author":"Seeger","year":"1993","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2025.178064_bib197","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3389\/fphys.2020.00386","article-title":"Alveolar dynamics and beyond - the importance of surfactant protein C and cholesterol in lung homeostasis and fibrosis","volume":"11","author":"Sehlmeyer","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib198","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/sj.bjc.6600353","article-title":"Surfactant protein B gene variations enhance susceptibility to squamous cell carcinoma of the lung in German patients","volume":"87","author":"Seifart","year":"2002","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejphar.2025.178064_bib199","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.chemphyslip.2006.02.017","article-title":"Protein-lipid interactions and surface activity in the pulmonary surfactant system","volume":"141","author":"Serrano","year":"2006","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.ejphar.2025.178064_bib200","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/BF02534515","article-title":"Lung surfactant phospholipids in different animal species","volume":"19","author":"Shelley","year":"1984","journal-title":"Lipids"},{"key":"10.1016\/j.ejphar.2025.178064_bib201","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029381","article-title":"Site of allergic airway narrowing and the influence of exogenous surfactant in the brown Norway rat","volume":"7","author":"Siddiqui","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2025.178064_bib202","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2741\/3935","article-title":"Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury","volume":"17","author":"Silveyra","year":"2012","journal-title":"Front. Biosci.: J. Vis. Literacy"},{"key":"10.1016\/j.ejphar.2025.178064_bib203","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1089\/hum.2022.130","article-title":"Gene therapeutics for surfactant dysfunction disorders: targeting the alveolar type 2 epithelial cell","volume":"33","author":"Sitaraman","year":"2022","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.ejphar.2025.178064_bib204","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1056\/NEJMoa033181","article-title":"Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome","volume":"351","author":"Spragg","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib205","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1164\/rccm.200207-782OC","article-title":"Treatment of acute respiratory distress syndrome with recombinant surfactant protein C surfactant","volume":"167","author":"Spragg","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib206","doi-asserted-by":"crossref","first-page":"255","DOI":"10.21103\/Article6(4)_OA1","article-title":"Influence of natural lung surfactant inhalations on clinical symptoms and pulmonary function parameters in patients with bronchial asthma. Communication 1","volume":"6","author":"Stepanova","year":"2016","journal-title":"Int. J. Biomed."},{"key":"10.1016\/j.ejphar.2025.178064_bib207","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1365-2249.2002.01968.x","article-title":"Intranasal delivery of a truncated recombinant human SP-D is effective at down-regulating allergic hypersensitivity in mice sensitized to allergens of Aspergillus fumigatus","volume":"130","author":"Strong","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib208","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1159\/000499361","article-title":"European consensus guidelines on the management of respiratory distress syndrome - 2019 update","volume":"115","author":"Sweet","year":"2019","journal-title":"Neonatology"},{"key":"10.1016\/j.ejphar.2025.178064_bib209","doi-asserted-by":"crossref","first-page":"F497","DOI":"10.1136\/archdischild-2017-312722","article-title":"A first-in-human clinical study of a new SP-B and SP-C enriched synthetic surfactant (CHF5633) in preterm babies with respiratory distress syndrome. Archives of disease in childhood","volume":"102","author":"Sweet","year":"2017","journal-title":"Fetal Neon. Ed."},{"key":"10.1016\/j.ejphar.2025.178064_bib210","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/CIRCRESAHA.115.306256","article-title":"Macrophage phenotype and function in different stages of atherosclerosis","volume":"118","author":"Tabas","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib211","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1286-4579(01)01379-X","article-title":"Immunomodulation by exogenous surfactant: effect on TNF-alpha secretion and luminol-enhanced chemiluminescence activity by murine macrophages stimulated with group B streptococci","volume":"3","author":"Talati","year":"2001","journal-title":"Microb. Infect."},{"key":"10.1016\/j.ejphar.2025.178064_bib212","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.3390\/v16111709","article-title":"Surfactant protein A inhibits human rhinovirus C binding and infection of airway epithelial cells from pediatric asthma","volume":"16","author":"Tanyaratsrisakul","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.ejphar.2025.178064_bib213","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1183\/09031936.96.09040752","article-title":"In vitro modulation of induced neutrophil activation by different surfactant preparations","volume":"9","author":"Tegtmeyer","year":"1996","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.ejphar.2025.178064_bib214","doi-asserted-by":"crossref","first-page":"S275","DOI":"10.33549\/physiolres.934410","article-title":"The effect of pulmonary surfactant on the airway smooth muscle after lipopolysaccharide exposure and its mechanisms","volume":"68","author":"Topercerova","year":"2019","journal-title":"Physiol. Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib215","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41572-019-0066-3","article-title":"Pulmonary alveolar proteinosis","volume":"5","author":"Trapnell","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ejphar.2025.178064_bib216","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0085-2020","article-title":"Genetic disorders of the surfactant system: focus on adult disease","volume":"30","author":"van Moorsel","year":"2021","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.ejphar.2025.178064_bib217","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1164\/ajrccm.152.6.8520748","article-title":"Pulmonary surfactant subfractions in patients with the acute respiratory distress syndrome","volume":"152","author":"Veldhuizen","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib218","doi-asserted-by":"crossref","first-page":"L674","DOI":"10.1152\/ajplung.1995.268.4.L674","article-title":"Characterization of the promoter of human pulmonary surfactant protein B gene","volume":"268","author":"Venkatesh","year":"1995","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib219","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-95999-0","article-title":"Aerosol, chemical and physical properties of dry powder synthetic lung surfactant for noninvasive treatment of neonatal respiratory distress syndrome","volume":"11","author":"Walther","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.178064_bib220","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/17476348.2019.1589372","article-title":"Advances in synthetic lung surfactant protein technology","volume":"13","author":"Walther","year":"2019","journal-title":"Expet Rev. Respir. Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib221","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.393","article-title":"Synthetic surfactant containing SP-B and SP-C mimics is superior to single-peptide formulations in rabbits with chemical acute lung injury","volume":"2","author":"Walther","year":"2014","journal-title":"PeerJ"},{"key":"10.1016\/j.ejphar.2025.178064_bib222","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1203\/00006450-199701000-00018","article-title":"Modified natural porcine surfactant inhibits superoxide anions and proinflammatory mediators released by resting and stimulated human monocytes","volume":"41","author":"Walti","year":"1997","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib223","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1164\/rccm.201402-0342OC","article-title":"Genotype\u2013phenotype correlations for infants and children with ABCA3 deficiency","volume":"189","author":"Wambach","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib224","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3389\/fimmu.2019.00561","article-title":"Differential effects of human SP-A1 and SP-A2 on the BAL proteome and signaling pathways in response to Klebsiella pneumoniae and ozone exposure","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib225","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1365-2249.1996.d01-838.x","article-title":"Interaction of human lung surfactant proteins A and D with mite (Dermatophagoides pteronyssinus) allergens","volume":"106","author":"Wang","year":"1996","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib226","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1164\/ajrccm.158.2.9709111","article-title":"Inhibitory effect of pulmonary surfactant proteins A and D on allergen-induced lymphocyte proliferation and histamine release in children with asthma","volume":"158","author":"Wang","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib227","doi-asserted-by":"crossref","first-page":"23742","DOI":"10.1074\/jbc.M102348200","article-title":"ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein","volume":"276","author":"Wang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2025.178064_bib228","doi-asserted-by":"crossref","first-page":"L598","DOI":"10.1152\/ajplung.00381.2010","article-title":"Surfactant protein A is defective in abrogating inflammation in asthma","volume":"301","author":"Wang","year":"2011","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib229","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0022-2275(20)37577-5","article-title":"Roles of different hydrophobic constituents in the adsorption of pulmonary surfactant","volume":"37","author":"Wang","year":"1996","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib230","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000492974","article-title":"Surfactant proteins A and D: trimerized innate immunity proteins with an affinity for viral fusion proteins","volume":"11","author":"Watson","year":"2019","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.ejphar.2025.178064_bib231","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejpb.2013.08.013","article-title":"Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for pulmonary application: a review of the state of the art","volume":"86","author":"Weber","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejphar.2025.178064_bib232","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2350\/09-01-0586.1","article-title":"Genetic disorders of surfactant dysfunction","volume":"12","author":"Wert","year":"2009","journal-title":"Pediatr. Dev. Pathol. : Off. J. Soc. Pediatric Pathol. Paediat. Pathol. Soc."},{"key":"10.1016\/j.ejphar.2025.178064_bib233","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-pathol-012513-104644","article-title":"Diseases of pulmonary surfactant homeostasis","volume":"10","author":"Whitsett","year":"2015","journal-title":"Annual Rev. Pathol."},{"key":"10.1016\/j.ejphar.2025.178064_bib234","series-title":"Revised Procedure for Updating Who's Model List of Essential Drugs: Report by the Secretariat","year":"2021"},{"key":"10.1016\/j.ejphar.2025.178064_bib235","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1465-9921-13-17","article-title":"Poractant alfa (Curosurf\u00ae) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo","volume":"13","author":"Willems","year":"2012","journal-title":"Respir. Res."},{"key":"10.1016\/j.ejphar.2025.178064_bib236","doi-asserted-by":"crossref","first-page":"L345","DOI":"10.1152\/ajplung.2001.281.2.L345","article-title":"Endocytosed SP-A and surfactant lipids are sorted to different organelles in rat type II pneumocytes","volume":"281","author":"Wissel","year":"2001","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib237","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1152\/jappl.2000.89.4.1283","article-title":"Altered airway surfactant phospholipid composition and reduced lung function in asthma","volume":"89","author":"Wright","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.ejphar.2025.178064_bib238","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00408-017-0006-5","article-title":"Associations of TIM-1 genetic polymorphisms with asthma: a meta-analysis","volume":"195","author":"Xie","year":"2017","journal-title":"Lung"},{"key":"10.1016\/j.ejphar.2025.178064_bib239","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2021.108822","article-title":"Surfactant protein-A inhibits thymic stromal lymphopoietin-mediated T follicular helper cell differentiation and IgE production in asthma","volume":"231","author":"Xue","year":"2021","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.ejphar.2025.178064_bib240","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.tcb.2020.09.006","article-title":"Lipid metabolism in regulation of macrophage functions","volume":"30","author":"Yan","year":"2020","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ejphar.2025.178064_bib241","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1165\/ajrcmb.24.1.4050","article-title":"BR22, a novel protein, interacts with thyroid transcription factor-1 and activates the human surfactant protein B promoter","volume":"24","author":"Yang","year":"2001","journal-title":"Am. J. Respir. Cell Mol. Biol. Rep."},{"key":"10.1016\/j.ejphar.2025.178064_bib242","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.bbamem.2011.03.006","article-title":"Comparative study of clinical pulmonary surfactants using atomic force microscopy","volume":"1808","author":"Zhang","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ejphar.2025.178064_bib243","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.pccm.2023.08.001","article-title":"From gene identifications to therapeutic targets for asthma: focus on great potentials of TSLP, ORMDL3, and GSDMB","volume":"1","author":"Zhang","year":"2023","journal-title":"Chin. Med. J. Pulmonary Critical Care Med."},{"key":"10.1016\/j.ejphar.2025.178064_bib244","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.618102","article-title":"The potential role of bioactive plasmalogens in lung surfactant","volume":"9","author":"Zhuo","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2025.178064_bib245","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.bbamem.2008.03.021","article-title":"Current perspectives in pulmonary surfactant--inhibition, enhancement and evaluation","volume":"1778","author":"Zuo","year":"2008","journal-title":"Biochim. Biophys. Acta"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925008180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925008180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:50:05Z","timestamp":1772801405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925008180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":245,"alternative-id":["S0014299925008180"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178064","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pulmonary surfactant in asthma","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"178064"}}