{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:13:35Z","timestamp":1792725215730,"version":"4.5.0"},"reference-count":105,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ejphar.2025.178075","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T14:39:03Z","timestamp":1755614343000},"page":"178075","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["siRNA nanodelivery systems in the treatment of skin Diseases: Research progress and clinical translation prospects"],"prefix":"10.1016","volume":"1005","author":[{"given":"Yanmin","family":"Jian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8534-9936","authenticated-orcid":false,"given":"Yi","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.178075_bib1","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1039\/C4LC00999A","article-title":"Pumpless microfluidic platform for drug testing on human skin equivalents","volume":"15","author":"Abaci","year":"2015","journal-title":"Lab Chip"},{"key":"10.1016\/j.ejphar.2025.178075_bib2","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/s12276-023-00998-y","article-title":"Where should siRNAs go: applicable organs for siRNA drugs","volume":"55","author":"Ahn","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ejphar.2025.178075_bib3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.34172\/apb.2023.030","article-title":"Chitosan and its structural modifications for siRNA delivery","volume":"13","author":"Al-Absi","year":"2023","journal-title":"Adv. Pharmaceut. Bull."},{"key":"10.1016\/j.ejphar.2025.178075_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fonc.2017.00167","article-title":"The IL-6\/STAT3 signaling pathway is an early target of manuka honey-induced suppression of human breast cancer cells","volume":"7","author":"Aryappalli","year":"2017","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejphar.2025.178075_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4049\/jimmunol.1601145","article-title":"Intratumoral delivery of immunotherapy\u2014act locally, think globally","volume":"198","author":"Aznar","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2025.178075_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1390775","article-title":"Prevalence of skin manifestations in patients with COVID-19: a systematic review and meta-analysis","volume":"11","author":"de Aguiar","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.ejphar.2025.178075_bib7","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1634\/theoncologist.2016-0450","article-title":"Impact of age on outcomes with immunotherapy for patients with melanoma","volume":"22","author":"Betof","year":"2017","journal-title":"Oncologist"},{"key":"10.1016\/j.ejphar.2025.178075_bib8","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ejpb.2020.11.018","article-title":"The impact of skin massage frequency on the intrafollicular transport of silica nanoparticles: validation of the ratchet effect on an ex vivo porcine skin model","volume":"158","author":"Busch","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ejphar.2025.178075_bib9","series-title":"Gene Therapy - Tools and Potential Applications","article-title":"siRNA and gene formulation for efficient gene therapy","author":"Blagbrough","year":"2013"},{"key":"10.1016\/j.ejphar.2025.178075_bib10","doi-asserted-by":"crossref","first-page":"9742","DOI":"10.1073\/pnas.171251798","article-title":"Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems","volume":"98","author":"Caplen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2025.178075_bib11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3390\/microorganisms8010039","article-title":"HHV-6A infection and systemic sclerosis: clues of a possible association","volume":"8","author":"Caselli","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.ejphar.2025.178075_bib12","doi-asserted-by":"crossref","first-page":"699","DOI":"10.4254\/wjh.v15.i5.699","article-title":"Liver steatosis in patients with rheumatoid arthritis treated with methotrexate is associated with body mass index","volume":"15","author":"Castiella","year":"2023","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.ejphar.2025.178075_bib13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1089\/ars.2015.6378","article-title":"TrxR1 as a potent regulator of the Nrf2-Keap1 response system","volume":"23","author":"Cebula","year":"2015","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2025.178075_bib14","article-title":"Autocrine activity of BDNF induced by the STAT3 signaling pathway causes prolonged TrkB activation and promotes human non-small-cell lung cancer proliferation","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.178075_bib15","first-page":"756","article-title":"Analysis of secular trends in incidence of skin cancer in China based on joinpoint regression and age-period-cohort model","volume":"26","author":"Chen","year":"2022","journal-title":"Chin. J. Dis. Control Prev."},{"key":"10.1016\/j.ejphar.2025.178075_bib16","doi-asserted-by":"crossref","first-page":"9804","DOI":"10.3390\/ijms16059804","article-title":"Microfluidic impedance flow cytometry enabling high-throughput single-cell electrical property characterization","volume":"16","author":"Chen","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178075_bib17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41584-022-00798-0","article-title":"Group for research and assessment of psoriasis and psoriatic arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021","volume":"18","author":"Coates","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ejphar.2025.178075_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2024.1424919","article-title":"Role of molecular adsorbent recirculating system in methotrexate-induced acute liver failure: a case report and literature review","volume":"12","author":"Corbisier","year":"2024","journal-title":"Front Pediatr"},{"key":"10.1016\/j.ejphar.2025.178075_bib19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.20473\/jbe.V9I12021.70-78","article-title":"Profile of psoriasis vulgaris patients treated with methotrexate at dr. soetomo hospital, surabaya, 2017\u20132018","volume":"9","author":"Damayanti","year":"2021","journal-title":"J Berk Epidemiol"},{"key":"10.1016\/j.ejphar.2025.178075_bib20","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1470-2045(18)30142-6","article-title":"Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF -mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial","volume":"19","author":"Dummer","year":"2018","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ejphar.2025.178075_bib21","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/S1470-2045(15)70122-1","article-title":"Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial","volume":"16","author":"Eggermont","year":"2015","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ejphar.2025.178075_bib22","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/35078107","article-title":"Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells","volume":"411","author":"Elbashir","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2025.178075_bib23","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.3390\/molecules28083318","article-title":"A straightforward method for the development of positively charged gold nanoparticle-based vectors for effective siRNA delivery","volume":"28","author":"Elizarova","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2025.178075_bib24","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.3390\/nano12244450","article-title":"Chemical modifications influence the number of siRNA molecules adsorbed on gold nanoparticles and the efficiency of downregulation of a target protein","volume":"12","author":"Epanchintseva","year":"2022","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ejphar.2025.178075_bib25","article-title":"Benign lipomatous soft tissue tumors in nigerians: an analysis of the clinical and morphological features of a common but important entity","volume":"16","author":"Ezike","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.ejphar.2025.178075_bib26","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3390\/pharmaceutics13050749","article-title":"In vivo follow-up of gene inhibition in solid tumors using peptide-based nanoparticles for siRNA delivery","volume":"13","author":"Ferreiro","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2025.178075_bib27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1159\/000250839","article-title":"Severe psoriasis--oral therapy with a new retinoid","volume":"157","author":"Fredriksson","year":"1978","journal-title":"Dermatologica (Basel)"},{"key":"10.1016\/j.ejphar.2025.178075_bib29","article-title":"Rationale and application of PEGylated lipid-based system for advanced target delivery of siRNA","volume":"11","author":"Ge","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178075_bib30","article-title":"A library of custom PEG-lipids reveals a double-PEG-lipid with drastically enhanced paclitaxel solubility and human cancer cell cytotoxicity when used in fluid micellar nanoparticles","volume":"8","author":"Ghasemizadeh","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.ejphar.2025.178075_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.609584","article-title":"Distribution and antibiotic resistance patterns of pathogenic bacteria in patients with chronic cutaneous wounds in China","volume":"8","author":"Guan","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.ejphar.2025.178075_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2013.56","article-title":"Gene silencing in skin after deposition of self-delivery siRNA with a motorized microneedle array device","volume":"2","author":"Hickerson","year":"2013","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.ejphar.2025.178075_bib33","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.3390\/ijms25105424","article-title":"Supramolecular nanoparticles of histone and hyaluronic acid for co-delivery of siRNA and photosensitizer in vitro","volume":"25","author":"Hu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178075_bib34","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.immuni.2022.12.004","article-title":"Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing","volume":"56","author":"du Halgouet","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.ejphar.2025.178075_bib35","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-039894","article-title":"Epidemiology and disease burden of complex wounds for inpatients in China: an observational study from Sichuan province","volume":"10","author":"Jiang","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.ejphar.2025.178075_bib36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1360\/SSM-2020-0026","article-title":"Modeling and prediction for the trend of outbreak of NCP based on a time-delay dynamic system","volume":"50","author":"Jin","year":"2020","journal-title":"Sci. Sin.-Math."},{"key":"10.1016\/j.ejphar.2025.178075_bib37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.addr.2016.06.011","article-title":"Recent progress in development of siRNA delivery vehicles for cancer therapy","volume":"104","author":"Kim","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejphar.2025.178075_bib38","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2165\/00128071-200506060-00005","article-title":"The psychosocial burden of psoriasis","volume":"6","author":"Kimball","year":"2005","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.ejphar.2025.178075_bib39","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.yexcr.2010.03.019","article-title":"Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo","volume":"316","author":"Kioka","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2025.178075_bib40","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41698-022-00312-5","article-title":"MatchMiner: an open-source platform for cancer precision medicine","volume":"6","author":"Klein","year":"2022","journal-title":"npj Precis. Oncol."},{"key":"10.1016\/j.ejphar.2025.178075_bib41","article-title":"Nanoparticle-based drug delivery systems for induction of tolerance and treatment of autoimmune diseases","volume":"10","author":"Li","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ejphar.2025.178075_bib42","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.2147\/IJN.S66368","article-title":"Cationic star-shaped polymer as an siRNA carrier for reducing MMP-9 expression in skin fibroblast cells and promoting wound healing in diabetic rats","volume":"9","author":"Li","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejphar.2025.178075_bib43","article-title":"Nanomaterials manipulate macrophages for rheumatoid arthritis treatment","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178075_bib44","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jconrel.2012.06.002","article-title":"Improvement of drug safety by the use of lipid-based nanocarriers","volume":"163","author":"Lim","year":"2012","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.178075_bib45","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1186\/s12951-022-01600-9","article-title":"Mesoporous silica-coated silver nanoparticles as ciprofloxacin\/siRNA carriers for accelerated infected wound healing","volume":"20","author":"Liu","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ejphar.2025.178075_bib46","first-page":"2751","article-title":"Progress in delivering biotechnology drugs on microneedles","volume":"59","author":"Liu","year":"2024","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.ejphar.2025.178075_bib47","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1200\/JCO.19.02362","article-title":"Improved risk prediction calculator for sentinel node positivity in patients with melanoma: the melanoma institute Australia nomogram","volume":"38","author":"Lo","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2025.178075_bib48","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMoa1708539","article-title":"Adjuvant dabrafenib plus trametinib in stage III BRAF -mutated melanoma","volume":"377","author":"Long","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2025.178075_bib49","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","article-title":"Immunology of psoriasis","volume":"32","author":"Lowes","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2025.178075_bib50","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.3390\/app11114915","article-title":"Applications of nanosized-lipid-based drug delivery systems in wound care","volume":"11","author":"Matei","year":"2021","journal-title":"Appl. Sci."},{"key":"10.1016\/j.ejphar.2025.178075_bib51","first-page":"289","article-title":"Incidence rates and time trends of skin cancer in golestan province, northeastern Iran, 2005-2018","volume":"27","author":"Mehri","year":"2024","journal-title":"Arch. Iran. Med."},{"key":"10.1016\/j.ejphar.2025.178075_bib52","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.addr.2017.08.001","article-title":"Nanomedicine and advanced technologies for burns: preventing infection and facilitating wound healing","volume":"123","author":"Mofazzal Jahromi","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejphar.2025.178075_bib53","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1039\/C5NR06246B","article-title":"Highly efficient siRNA delivery from core-shell mesoporous silica nanoparticles with multifunctional polymer caps","volume":"8","author":"M\u00f6ller","year":"2016","journal-title":"Nanoscale"},{"key":"10.1016\/j.ejphar.2025.178075_bib54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3390\/pharmacy11050149","article-title":"Development and refinement of a matrix competency framework, with associated entrustable professional activities, to support initial pharmacy education in Kuwait","volume":"11","author":"Moreau","year":"2023","journal-title":"Pharmacy (Basel)"},{"key":"10.1016\/j.ejphar.2025.178075_bib55","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.biomaterials.2015.07.005","article-title":"Dermal delivery of HSP47 siRNA with NOX4-modulating mesoporous silica-based nanoparticles for treating fibrosis","volume":"66","author":"Morry","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejphar.2025.178075_bib56","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.3390\/pharmaceutics13101546","article-title":"Selection and incorporation of siRNA carrying non-viral vector for sustained delivery from gellan gum hydrogels","volume":"13","author":"Nalbadis","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2025.178075_bib57","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3390\/cancers16030606","article-title":"Epidemiology of keratinocyte skin cancer with a focus on cutaneous squamous cell carcinoma","volume":"16","author":"Nanz","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ejphar.2025.178075_bib58","first-page":"60","article-title":"Analysis of clinical presentation and management of diabetic foot ulcer cases with preventive measures in a tertiary care hospital","volume":"16","author":"Narayani","year":"2017","journal-title":"Government Medical College And Esi Hospital. Coimbatore. IOSR JDMS"},{"key":"10.1016\/j.ejphar.2025.178075_bib59","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1515\/ntrev-2021-0046","article-title":"Metal nanoparticles and biomaterials: the multipronged approach for potential diabetic wound therapy","volume":"10","author":"Nor Azlan","year":"2021","journal-title":"Nanotechnol. Rev."},{"key":"10.1016\/j.ejphar.2025.178075_bib60","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/cncr.35178","article-title":"BRAF\/MEK inhibitor rechallenge in advanced melanoma patients","volume":"130","author":"Van Not","year":"2024","journal-title":"Cancer"},{"key":"10.1016\/j.ejphar.2025.178075_bib61","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1067\/mjd.2000.105948","article-title":"Treatment with anti-tumor necrosis factor alpha (TNF-alpha) monoclonal antibody dramatically decreases the clinical activity of psoriasis lesions","volume":"42","author":"Oh","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ejphar.2025.178075_bib62","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1089\/nat.2018.0725","article-title":"Improving siRNA delivery in vivo through lipid conjugation","volume":"28","author":"Osborn","year":"2018","journal-title":"Nucleic Acid Therapeut."},{"key":"10.1016\/j.ejphar.2025.178075_bib63","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s10753-023-01825-2","article-title":"Nintedanib ameliorates bleomycin-induced pulmonary fibrosis, inflammation, apoptosis, and oxidative stress by modulating PI3K\/Akt\/mTOR pathway in mice","volume":"46","author":"Pan","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2025.178075_bib65","doi-asserted-by":"crossref","first-page":"259","DOI":"10.18821\/0507-4088-2017-62-6-259-265","article-title":"Comparison of influenza virus inhibition in vitro by siRNA complexes with chitosan derivatives, polyethyleneimine and hybrid polyarginine-inorganic microcapsules","volume":"62","author":"Petrova-Brodskaya","year":"2017","journal-title":"Vopr. Virusol."},{"key":"10.1016\/j.ejphar.2025.178075_bib66","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.3390\/cancers15153754","article-title":"Efficacy and safety of rechallenge with BRAF\/MEK inhibitors in advanced melanoma patients: a systematic review and meta-analysis","volume":"15","author":"Priantti","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ejphar.2025.178075_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2017.04.001","article-title":"Novel lipoproteoplex delivers keap1 siRNA based gene therapy to accelerate diabetic wound healing","volume":"132","author":"Rabbani","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejphar.2025.178075_bib68","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.cell.2018.06.025","article-title":"Toward minimal residual disease-directed therapy in melanoma","volume":"174","author":"Rambow","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2025.178075_bib69","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0140-6736(21)00125-2","article-title":"Bimekizumab versus ustekinumab for the treatment of moderate to severe plaque psoriasis (BE VIVID): efficacy and safety from a 52-week, multicentre, double-blind, active comparator and placebo controlled phase 3 trial","volume":"397","author":"Reich","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2025.178075_bib70","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2017.08.027","article-title":"Oncolytic virotherapy promotes intratumoral T cell infiltration and improves anti-PD-1 immunotherapy","volume":"170","author":"Ribas","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2025.178075_bib71","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3390\/pharmaceutics15020430","article-title":"Antibiotic-loaded gold nanoparticles: a nano-arsenal against ESBL producer-resistant pathogens","volume":"15","author":"Rizvi","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2025.178075_bib72","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1056\/NEJMoa1412082","article-title":"Nivolumab in previously untreated melanoma without BRAF mutation","volume":"372","author":"Robert","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2025.178075_bib73","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S1470-2045(19)30388-2","article-title":"Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study","volume":"20","author":"Robert","year":"2019","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.ejphar.2025.178075_bib74","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jconrel.2022.06.052","article-title":"Targeted delivery of lipid nanoparticle to lymphatic endothelial cells via anti-podoplanin antibody","volume":"349","author":"Sakurai","year":"2022","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.ejphar.2025.178075_bib75","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3390\/pharmaceutics13030382","article-title":"Novel PEGylated lipid nanoparticles have a high encapsulation efficiency and effectively deliver MRTF-B siRNA in conjunctival fibroblasts","volume":"13","author":"Sanghani","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2025.178075_bib76","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1586\/14787210.2015.1023291","article-title":"Chronic wound infections: the role of pseudomonas aeruginosa and staphylococcus aureus","volume":"13","author":"Serra","year":"2015","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.ejphar.2025.178075_bib77","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13550-021-00868-6","article-title":"Magnetic nanoparticles in theranostics of malignant melanoma","volume":"11","author":"Shevtsov","year":"2021","journal-title":"EJNMMI Res."},{"key":"10.1016\/j.ejphar.2025.178075_bib78","doi-asserted-by":"crossref","DOI":"10.57237\/j.life.2023.02.001","article-title":"Study on mechanism of shenqi dihuang decoction in treating diabetic nephropathy based on network pharmacology","author":"Shijing","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.ejphar.2025.178075_bib79","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.3390\/pharmaceutics14091969","article-title":"Oral nanomedicines for siRNA delivery to treat inflammatory bowel disease","volume":"14","author":"Shinn","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2025.178075_bib80","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1073\/pnas.75.1.285","article-title":"Inhibition of rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide","volume":"75","author":"Stephenson","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2025.178075_bib81","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ncrna.2023.05.008","article-title":"Advances in transdermal siRNAs delivery: a review of current research progress","volume":"8","author":"Sufianov","year":"2023","journal-title":"Noncoding RNA Res"},{"key":"10.1016\/j.ejphar.2025.178075_bib82","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13624","article-title":"MicroRNA-29c-tetrahedral framework nucleic acids: towards osteogenic differentiation of mesenchymal stem cells and bone regeneration in critical-sized calvarial defects","volume":"57","author":"Sun","year":"2024","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ejphar.2025.178075_bib83","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1084\/jem.20160247","article-title":"Epithelial fli1 deficiency drives systemic autoimmunity and fibrosis: possible roles in scleroderma","volume":"214","author":"Takahashi","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2025.178075_bib84","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychores.2022.111017","article-title":"The prevalence of alexithymia in psoriasis: a systematic review and meta-analysis","volume":"161","author":"Tang","year":"2022","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.ejphar.2025.178075_bib85","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3390\/nano7040077","article-title":"siRNA delivery strategies: a comprehensive review of recent developments","volume":"7","author":"Tatiparti","year":"2017","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ejphar.2025.178075_bib86","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3390\/ijms23010375","article-title":"CCN2 increases TGF-\u03b2 receptor type II expression in vascular smooth muscle cells: essential role of CCN2 in the TGF-\u03b2 pathway regulation","volume":"23","author":"Tejera-Mu\u00f1oz","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178075_bib87","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1006304","article-title":"A perspective on oligonucleotide therapy: approaches to patient customization","volume":"13","author":"Thakur","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178075_bib88","doi-asserted-by":"crossref","first-page":"192","DOI":"10.5530\/ijper.53.2.25","article-title":"Ethical and administrative implications of nanoscale technology for efficient and safe delivery of drugs: analytical and regulatory aspects","volume":"53","author":"Tiwari","year":"2019","journal-title":"Indian J Pharm Educ Res"},{"key":"10.1016\/j.ejphar.2025.178075_bib89","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202107960","article-title":"Nanocarriers for skin applications: where do we stand?","volume":"61","author":"Tiwari","year":"2022","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.ejphar.2025.178075_bib90","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3390\/ph16070961","article-title":"Antibacterial properties of mesoporous silica nanoparticles modified with fluoroquinolones and copper or silver species","volume":"16","author":"Ugalde-Arbizu","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejphar.2025.178075_bib91","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1021\/nn901433u","article-title":"Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing","volume":"4","author":"Valencia","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejphar.2025.178075_bib92","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1093\/biolre\/iox008","article-title":"Uterine artery leptin receptors during the ovarian cycle and pregnancy regulate angiogenesis in ovine uterine artery endothelial cells","volume":"96","author":"Vargas","year":"2017","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ejphar.2025.178075_bib93","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201900635","article-title":"Upconversion nanoparticle powered microneedle patches for transdermal delivery of siRNA","volume":"9","author":"Wang","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.ejphar.2025.178075_bib94","article-title":"Deciphering the fibrotic process: mechanism of chronic radiation skin injury fibrosis","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178075_bib95","article-title":"Cryotherapy in the treatment of malignant tumors of the head and face skin","volume":"378","author":"Wang","year":"1985","journal-title":"Foreign Med. Sci."},{"key":"10.1016\/j.ejphar.2025.178075_bib97","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1001\/jamaoncol.2019.0393","article-title":"Treatment-related adverse events of PD-1 and PD-L1 inhibitors in clinical trials: a systematic review and meta-analysis","volume":"5","author":"Wang","year":"2019","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.ejphar.2025.178075_bib98","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1056\/NEJMoa1709030","article-title":"Adjuvant nivolumab versus ipilimumab in resected stage III or IV melanoma","volume":"377","author":"Weber","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2025.178075_bib99","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3389\/fmed.2016.00071","article-title":"The efficacy of triamcinolone acetonide in keloid treatment: a systematic review and meta-analysis","volume":"3","author":"Wong","year":"2016","journal-title":"Front. Med."},{"key":"10.1016\/j.ejphar.2025.178075_bib100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.omtm.2018.09.002","article-title":"Engineering nanoparticles for targeted delivery of nucleic acid therapeutics in tumor","volume":"12","author":"Xiao","year":"2019","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.ejphar.2025.178075_bib101","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3390\/biom12081072","article-title":"Anti-inflammatory microRNAs for treating inflammatory skin diseases","volume":"12","author":"Yang","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejphar.2025.178075_bib102","article-title":"Functionalization of nanomaterials for skin cancer theranostics","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ejphar.2025.178075_bib103","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/nar\/gkad1125","article-title":"Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo","volume":"52","author":"Zhang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2025.178075_bib104","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1007\/s13555-023-01041-8","article-title":"Cost-effectiveness of secukinumab versus other biologics in the treatment of moderate-to-severe plaque psoriasis: the Chinese healthcare system perspective","volume":"13","author":"Zhang","year":"2023","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.ejphar.2025.178075_bib105","article-title":"Activation of p2\u00d77 receptor promotes the invasion and migration of colon cancer cells via the STAT3 signaling","volume":"8","author":"Zhang","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2025.178075_bib106","article-title":"Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing","volume":"14","author":"Zhao","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178075_bib107","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/wrr.12708","article-title":"Roxadustat promotes angiogenesis through HIF-1\u03b1\/VEGF\/VEGFR2 signaling and accelerates cutaneous wound healing in diabetic rats","volume":"27","author":"Zhu","year":"2019","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.ejphar.2025.178075_bib108","first-page":"1393","article-title":"Advances in mechanisms for psoriasis and drug regulation","volume":"55","author":"Zhu","year":"2020","journal-title":"Acta Pharm. Sin."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925008295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925008295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:46:02Z","timestamp":1758055562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925008295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":105,"alternative-id":["S0014299925008295"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178075","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"siRNA nanodelivery systems in the treatment of skin Diseases: Research progress and clinical translation prospects","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178075","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178075"}}