{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:11:05Z","timestamp":1790809865531,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304106"],"award-info":[{"award-number":["82304106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173494"],"award-info":[{"award-number":["82173494"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ejphar.2025.178118","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T06:45:53Z","timestamp":1756881953000},"page":"178118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["MPTP controls the release of mtDNA and induces endothelial cell PANoptosis in trichloroethylene-induced immune kidney injury"],"prefix":"10.1016","volume":"1005","author":[{"given":"Haibo","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.ejphar.2025.178118_bib1","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1080\/15548627.2021.1874209","article-title":"Autophagy restricts mitochondrial DNA damage-induced release of ENDOG (endonuclease G) to regulate genome stability","volume":"17","author":"Chao","year":"2021","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178118_bib2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4161\/cam.2.4.7251","article-title":"Cyclosporin A inhibits CD11a\/CD18 adhesion molecules due to inhibition of TNFalpha and IL-1 beta levels in the mouse model of pleurisy induced by carrageenan","volume":"2","author":"Dalmarco","year":"2008","journal-title":"Cell Adhes. Migrat."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178118_bib3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1136\/oemed-2019-106171","article-title":"Utility evaluation of HLA-B\u221713:01 screening in preventing trichloroethylene-induced hypersensitivity syndrome in a prospective cohort study","volume":"77","author":"Dai","year":"2020","journal-title":"Occup. Environ. Med."},{"issue":"11","key":"10.1016\/j.ejphar.2025.178118_bib4","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.3390\/cells10112898","article-title":"Molecular mechanisms of mtDNA-mediated inflammation","volume":"10","author":"De Gaetano","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2025.178118_bib5","article-title":"Inflammatory signaling induces mitochondrial dysfunction and neuronal death in traumatic brain injury via downregulation of OXPHOS genes","author":"Dong","year":"2024","journal-title":"Biochem. Genet."},{"issue":"9","key":"10.1016\/j.ejphar.2025.178118_bib6","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1161\/CIRCRESAHA.122.322227","article-title":"ZBP1 protects against mtDNA-induced myocardial inflammation in failing hearts","volume":"132","author":"Enzan","year":"2023","journal-title":"Circ. Res."},{"issue":"6338","key":"10.1016\/j.ejphar.2025.178118_bib7","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/352803a0","article-title":"Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A","volume":"352","author":"Flanagan","year":"1991","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.ejphar.2025.178118_bib8","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1073\/pnas.89.9.3686","article-title":"Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A","volume":"89","author":"Fruman","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"8","key":"10.1016\/j.ejphar.2025.178118_bib9","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/s41423-024-01185-3","article-title":"Chaperone- and PTM-mediated activation of IRF1 tames radiation-induced cell death and the inflammatory response","volume":"21","author":"Geng","year":"2024","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.ejphar.2025.178118_bib10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jconrel.2016.01.056","article-title":"Reformulating cyclosporine A (CsA): more than just a life cycle management strategy","volume":"225","author":"Guada","year":"2016","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"},{"issue":"15","key":"10.1016\/j.ejphar.2025.178118_bib11","doi-asserted-by":"crossref","first-page":"17008","DOI":"10.1021\/acsami.1c22804","article-title":"VB12-Sericin-PBLG-IR780 nanomicelles for programming cell pyroptosis via photothermal (PTT)\/Photodynamic (PDT) effect-induced mitochondrial DNA (mitoDNA) oxidative damage","volume":"14","author":"Guo","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178118_bib12","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12958-020-00658-0","article-title":"Cyclosporin A protects JEG-3 cells against oxidative stress-induced apoptosis by inhibiting the p53 and JNK\/p38 signaling pathways","volume":"18","author":"He","year":"2020","journal-title":"Reprod. Biol. Endocrinol. : RB Elektron."},{"key":"10.1016\/j.ejphar.2025.178118_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114051","article-title":"RVG29 and platelet membrane-modified pseudo-mitochondria for cascade targeting of cyclosporin a in traumatic brain injury","volume":"385","author":"Hu","year":"2025","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"},{"issue":"74","key":"10.1016\/j.ejphar.2025.178118_bib14","doi-asserted-by":"crossref","first-page":"eabo6294","DOI":"10.1126\/sciimmunol.abo6294","article-title":"ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection","volume":"7","author":"Karki","year":"2022","journal-title":"Science immunology"},{"key":"10.1016\/j.ejphar.2025.178118_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2023.102348","article-title":"PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis","volume":"83","author":"Karki","year":"2023","journal-title":"Curr. Opin. Immunol."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178118_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.80","article-title":"Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury","volume":"5","author":"Kim","year":"2014","journal-title":"Cell Death Dis."},{"issue":"7876","key":"10.1016\/j.ejphar.2025.178118_bib17","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-021-03875-8","article-title":"AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence","volume":"597","author":"Lee","year":"2021","journal-title":"Nature"},{"issue":"14","key":"10.1016\/j.ejphar.2025.178118_bib18","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1016\/j.cell.2023.05.039","article-title":"Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity","volume":"186","author":"Lei","year":"2023","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.ejphar.2025.178118_bib19","first-page":"705","article-title":"Analysis on dynamic change of cytokines in patients with occupational trichloroethylene-induced medicamentosa-like dermatitis","volume":"47","author":"Li","year":"2020","journal-title":"China Occupational Medicine"},{"issue":"Pt 3","key":"10.1016\/j.ejphar.2025.178118_bib20","article-title":"Quercetin protects against silicon dioxide particles-induced spleen ZBP1-mediated PANoptosis by regulating the Nrf2\/Drp1\/mtDNA axis","volume":"143","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178118_bib21","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41420-025-02451-7","article-title":"Inhibition of Zbp1-PANoptosome-mediated PANoptosis effectively attenuates acute pancreatitis","volume":"11","author":"Li","year":"2025","journal-title":"Cell Death Discov."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178118_bib22","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1681\/ASN.0000000000000098","article-title":"Activation of angiopoietin-Tie2 signaling protects the kidney from ischemic injury by modulation of endothelial-specific pathways","volume":"34","author":"Li","year":"2023","journal-title":"J. Am. Soc. Nephrol. : JASN (J. Am. Soc. Nephrol.)"},{"key":"10.1016\/j.ejphar.2025.178118_bib23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.freeradbiomed.2025.04.015","article-title":"Intermedin protects peritubular capillaries by inhibiting eNOS uncoupling through AMPK\/GTPCH-I\/BH4 pathway and alleviate CKD following AKI","volume":"234","author":"Lin","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178118_bib24","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1007\/s12026-024-09538-w","article-title":"Anti-inflammatory effects of 1,7-dihydroxy-3,4-dimethoxyxanthone through inhibition of M1-phenotype macrophages via arginine\/mitochondrial axis","volume":"72","author":"Liu","year":"2024","journal-title":"Immunol. Res."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178118_bib25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s13239-019-00404-7","article-title":"Cyclosporin A protected cardiomyocytes against oxidative stress injury by inhibition of NF-\u03baB signaling pathway","volume":"10","author":"Ma","year":"2019","journal-title":"Cardiovascular engineering and technology"},{"issue":"12","key":"10.1016\/j.ejphar.2025.178118_bib26","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1016\/j.ekir.2024.09.019","article-title":"Unraveling diabetic kidney disease: the roles of mitochondrial dysfunction and immunometabolism","volume":"9","author":"Narongkiatikhun","year":"2024","journal-title":"Kidney international reports"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178118_bib27","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1074\/jbc.271.4.2185","article-title":"Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel","volume":"271","author":"Nicolli","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"21","key":"10.1016\/j.ejphar.2025.178118_bib28","doi-asserted-by":"crossref","first-page":"11269","DOI":"10.1021\/acs.analchem.5c01359","article-title":"An NAG-activatable glow-type chemiluminescent probe for sensitive and early diagnosis of acute kidney injury through urinalysis","volume":"97","author":"Pan","year":"2025","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178118_bib29","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.molmed.2023.10.001","article-title":"Therapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes","volume":"30","author":"Pandeya","year":"2024","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejphar.2025.178118_bib30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.redox.2018.09.001","article-title":"Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease","volume":"19","author":"P\u00e9rez","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2025.178118_bib31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cytogfr.2024.03.005","article-title":"Z-DNA binding protein 1 orchestrates innate immunity and inflammatory cell death","volume":"77","author":"Song","year":"2024","journal-title":"Cytokine Growth Factor Rev."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178118_bib32","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/s41419-024-07231-2","article-title":"Slc25a21 in cisplatin-induced acute kidney injury: a new target for renal tubular epithelial protection by regulating mitochondrial metabolic homeostasis","volume":"15","author":"Su","year":"2024","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178118_bib33","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1186\/s12964-024-01744-1","article-title":"IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte damage in osteoarthritis","volume":"22","author":"Sun","year":"2024","journal-title":"Cell Commun. Signal. : CCS"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178118_bib34","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/imr.13279","article-title":"PANoptosis: mechanisms, biology, and role in disease","volume":"321","author":"Sun","year":"2024","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178118_bib35","first-page":"173","article-title":"Renal tubular cell necroptosis: a novel mechanism of kidney damage in trichloroethylene hypersensitivity syndrome mice","volume":"18","author":"Wang","year":"2021","journal-title":"J. Immunot."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178118_bib36","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1177\/1091581815591222","article-title":"An animal model of trichloroethylene-induced skin sensitization in BALB\/c mice","volume":"34","author":"Wang","year":"2015","journal-title":"Int. J. Toxicol."},{"issue":"10","key":"10.1016\/j.ejphar.2025.178118_bib37","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/s41419-024-07175-7","article-title":"Sensing of endogenous retroviruses-derived RNA by ZBP1 triggers PANoptosis in DNA damage and contributes to toxic side effects of chemotherapy","volume":"15","author":"Wang","year":"2024","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178118_bib38","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41420-022-00981-y","article-title":"Akt-GSK3\u03b2-mPTP pathway regulates the mitochondrial dysfunction contributing to odontoblasts apoptosis induced by glucose oxidative stress","volume":"8","author":"Wu","year":"2022","journal-title":"Cell Death Discov."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178118_bib39","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/s12276-025-01443-y","article-title":"Porphyromonas gingivalis induces Zbp1-mediated macrophages PANoptosis in periodonitis pathophysiology","volume":"57","author":"Wu","year":"2025","journal-title":"Exp. Mol. Med."},{"issue":"Pt 2","key":"10.1016\/j.ejphar.2025.178118_bib40","article-title":"TNF-\u03b1-downregulated SIRT1 regulates mitochondrial-autophagy and apoptosis in renal vascular endothelial cells involved in trichloroethylene-induced immune kidney injury","volume":"143","author":"Xie","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2025.178118_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116433","article-title":"The role of PANoptosis in renal vascular endothelial cells: implications for trichloroethylene-induced kidney injury","volume":"278","author":"Xie","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.ejphar.2025.178118_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114067","article-title":"Effects of mitochondrial reactive oxygen species-induced NLRP3 inflammasome activation on trichloroethylene-mediated kidney immune injury","volume":"244","author":"Xie","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178118_bib43","article-title":"SREBP1c-Mediated transcriptional repression of YME1L1 contributes to acute kidney injury by inducing mitochondrial dysfunction in tubular epithelial cells","volume":"12","author":"Xin","year":"2025","journal-title":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"},{"issue":"25","key":"10.1016\/j.ejphar.2025.178118_bib44","article-title":"Tailored \"Three-stage booster\" nano-extinguisher for synergistic treatment of severe acute pancreatitis by rectifying mitochondrial dysfunction and inhibiting pancreatic autodigestion","volume":"S1742\u20137061","author":"Yan","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ejphar.2025.178118_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2024.136743","article-title":"Trichloroethylene detoxification in low-permeability soil via electrokinetic-enhanced bioremediation technology: long-term feasibility and spatial-temporal patterns","volume":"484","author":"Yang","year":"2025","journal-title":"J. Hazard Mater."},{"issue":"28","key":"10.1016\/j.ejphar.2025.178118_bib46","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2500208122","article-title":"SARS-CoV-2 infection induces ZBP1-dependent PANoptosis in bystander cells","volume":"122","author":"Yang","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178118_bib47","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10565-024-09905-1","article-title":"ADAR1 prevents ZBP1-dependent PANoptosis via A-to-I RNA editing in developmental sevoflurane neurotoxicity","volume":"40","author":"Yang","year":"2024","journal-title":"Cell Biol. Toxicol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178118_bib48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40360-022-00601-6","article-title":"Beneficial effects of Cyclosporine A in combination with Nortriptyline on germ cell-specific apoptosis, oxidative stress and epididymal sperm qualities following testicular ischemia\/reperfusion in rats: a comparative study","volume":"23","author":"Yazdani","year":"2022","journal-title":"BMC pharmacology & toxicology"},{"issue":"2","key":"10.1016\/j.ejphar.2025.178118_bib49","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41401-024-01376-8","article-title":"Baicalin inhibits PANoptosis by blocking mitochondrial Z-DNA formation and ZBP1-PANoptosome assembly in macrophages","volume":"46","author":"You","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178118_bib50","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.cell.2020.09.020","article-title":"TDP-43 triggers mitochondrial DNA release via mPTP to activate cGAS\/STING in ALS","volume":"183","author":"Yu","year":"2020","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.ejphar.2025.178118_bib51","first-page":"1398","article-title":"Berberine mitigates sepsis-associated acute kidney injury in aged rats by preserving mitochondrial integrity and inhibiting TLR4\/NF-\u03baB and NLRP3 inflammasome activations","volume":"13","author":"Yubolphan","year":"2024","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"10.1016\/j.ejphar.2025.178118_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157037","article-title":"Danggui buxue decoction attenuates doxorubicin-induced cardiotoxicity by inhibiting ZBP1-mediated PANoptosis in vivo and in vitro","volume":"145","author":"Zhang","year":"2025","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"},{"issue":"25","key":"10.1016\/j.ejphar.2025.178118_bib53","article-title":"Mechanistic insights into TSH-mediated macrophage mitochondrial dysfunction via TSHR signaling in metabolic disorders","volume":"S0891\u20135849","author":"Zhang","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.ejphar.2025.178118_bib54","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1177\/0748233717731213","article-title":"The immune response in trichloroethylene hypersensitivity syndrome: a review","volume":"33","author":"Zhang","year":"2017","journal-title":"Toxicol. Ind. Health"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178118_bib55","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12951-019-0451-9","article-title":"Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats","volume":"17","author":"Zhang","year":"2019","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178118_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/1348-9585.12142","article-title":"Trichloroethylene and trichloroethanol induce skin sensitization with focal hepatic necrosis in Guinea pigs","volume":"62","author":"Zhao","year":"2020","journal-title":"J. Occup. Health"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178118_bib57","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"issue":"13","key":"10.1016\/j.ejphar.2025.178118_bib58","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1161\/CIRCULATIONAHA.124.069574","article-title":"METTL4-Mediated mitochondrial DNA N6-methyldeoxyadenosine promoting macrophage inflammation and atherosclerosis","volume":"151","author":"Zheng","year":"2025","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178118_bib59","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/imr.12909","article-title":"The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"297","author":"Zheng","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ejphar.2025.178118_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113795","article-title":"Hybrid membrane-coated Cyclosporine A nanocrystals preventing secondary brain injury via alleviating neuroinflammatory and oxidative stress","volume":"383","author":"Zhou","year":"2025","journal-title":"J. Contr. Release : official journal of the Controlled Release Society"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925008726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925008726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:49:54Z","timestamp":1772826594000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925008726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":60,"alternative-id":["S0014299925008726"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178118","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MPTP controls the release of mtDNA and induces endothelial cell PANoptosis in trichloroethylene-induced immune kidney injury","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178118","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178118"}}