{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T05:01:19Z","timestamp":1780203679352,"version":"3.54.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009881","name":"Juvenile Diabetes Research Foundation Canada","doi-asserted-by":"publisher","award":["2-SRA-2022-1210-S- B"],"award-info":[{"award-number":["2-SRA-2022-1210-S- B"]}],"id":[{"id":"10.13039\/100009881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK103616"],"award-info":[{"award-number":["DK103616"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P42 ES004699"],"award-info":[{"award-number":["P42 ES004699"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R35 ES030443-01"],"award-info":[{"award-number":["R35 ES030443-01"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR003107"],"award-info":[{"award-number":["UL1TR003107"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["I-0011"],"award-info":[{"award-number":["I-0011"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008231","name":"Arkansas Biosciences Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008480","name":"Arkansas Research Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ejphar.2025.178132","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T06:52:02Z","timestamp":1757659922000},"page":"178132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Dual acting inhibitor of soluble epoxide hydrolase and Cyclooxygenase-2, attenuates glomerular injury in renal hypoplasia mice"],"prefix":"10.1016","volume":"1006","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5940-9300","authenticated-orcid":false,"given":"Md Abdul","family":"Hye Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0342-6966","authenticated-orcid":false,"given":"Samaneh","family":"Goorani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8079-3351","authenticated-orcid":false,"given":"Anna","family":"Atamanchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1495-9509","authenticated-orcid":false,"given":"Wojceich","family":"Jankiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Yeboah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2269-2525","authenticated-orcid":false,"given":"Scott D.","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9219-7845","authenticated-orcid":false,"given":"John R.","family":"Falck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9891-928X","authenticated-orcid":false,"given":"Sung H.","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodgan","family":"Barnych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1408-8317","authenticated-orcid":false,"given":"Bruce D.","family":"Hammock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3114-5312","authenticated-orcid":false,"given":"Ashraf","family":"El-Meanawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9668-2899","authenticated-orcid":false,"given":"John D.","family":"Imig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.ejphar.2025.178132_bib1","article-title":"New pyrimidine\/thiazole hybrids endowed with analgesic, anti-inflammatory, and lower cardiotoxic activities: design, synthesis, and COX-2\/sEH dual inhibition","volume":"355","author":"Abdel-Aziz","year":"2022","journal-title":"Arch. Pharm. (Weinh.)"},{"issue":"3","key":"10.1016\/j.ejphar.2025.178132_bib2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1177\/1470320310367929","article-title":"Interstitial expression of angiotensin II and AT1 receptor are increased in patients with progressive glomerulopathies","volume":"11","author":"Bahiense-Oliveira","year":"2010","journal-title":"J. Renin-Angiotensin-Aldosterone Syst. JRAAS"},{"issue":"20","key":"10.1016\/j.ejphar.2025.178132_bib3","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1039\/C7OB00789B","article-title":"Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs","volume":"15","author":"Barnych","year":"2017","journal-title":"Org. Biomol. Chem."},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2025.178132_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000481634","article-title":"Protecting podocytes: a key target for therapy of focal segmental glomerulosclerosis","volume":"47","author":"Campbell","year":"2018","journal-title":"Am. J. Nephrol."},{"issue":"7","key":"10.1016\/j.ejphar.2025.178132_bib5","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1074\/jbc.M113.508416","article-title":"The Cyp2c44 epoxygenase regulates epithelial sodium channel activity and the blood pressure responses to increased dietary salt","volume":"289","author":"Capdevila","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.ejphar.2025.178132_bib6","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1159\/000517619","article-title":"Transforming growth factor-\u03b21\/Smad signaling in Glomerulonephritis and its association with progression to chronic kidney disease","volume":"52","author":"Chalkia","year":"2021","journal-title":"Am. J. Nephrol."},{"issue":"9","key":"10.1016\/j.ejphar.2025.178132_bib7","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1681\/ASN.2009010039","article-title":"Distinct roles for basal and induced COX-2 in podocyte injury","volume":"20","author":"Cheng","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178132_bib8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1681\/ASN.2006090990","article-title":"Overexpression of cyclooxygenase-2 predisposes to podocyte injury","volume":"18","author":"Cheng","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178132_bib9","first-page":"56","article-title":"Expression of Wilms' tumor 1 Antigen, Vimentin, and Corticotropin-Releasing factor in the human kidney with focal segmental glomerulosclerosis and effect of oxidative stress on these markers in HEK 293 cells. Kidney blood press","volume":"48","author":"Csurgy\u00f3k","year":"2023","journal-title":"Res."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178132_bib10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/sj.ki.5002655","article-title":"Podocyte injury in focal segmental glomerulosclerosis: Lessons from animal models (a play in five acts)","volume":"73","author":"D'Agati","year":"2008","journal-title":"Kidney Int."},{"issue":"23","key":"10.1016\/j.ejphar.2025.178132_bib11","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.3390\/molecules25235488","article-title":"Small molecule soluble epoxide hydrolase inhibitors in Multitarget and Combination therapies for inflammation and cancer","volume":"25","author":"Das Mahapatra","year":"2020","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178132_bib12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ekir.2022.10.004","article-title":"Novel treatment Paradigms: focal segmental glomerulosclerosis","volume":"8","author":"de Cos","year":"2022","journal-title":"Kidney Int. Rep"},{"issue":"6","key":"10.1016\/j.ejphar.2025.178132_bib13","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/CS20040125","article-title":"Rofecoxib decreases renal injury in obese Zucker rats","volume":"107","author":"Dey","year":"2004","journal-title":"Clin. Sci."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178132_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2023.100319","article-title":"COX-2\/sEH-Mediated macrophage activation is a target for pulmonary protection in mouse models of chronic obstructive pulmonary disease","volume":"104","author":"Duan","year":"2023","journal-title":"Lab. Invest."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178132_bib15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nrneph.2014.216","article-title":"Causes and pathogenesis of focal segmental glomerulosclerosis","volume":"11","author":"Fogo","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178132_bib16","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.kint.2016.07.024","article-title":"Improved kinetic model for the transcutaneous measurement of glomerular filtration rate in experimental animals","volume":"90","author":"Friedemann","year":"2016","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178132_bib17","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1046\/j.1523-1755.2003.00319.x","article-title":"Cyclooxygenase-2 (COX-2) inhibition limits abnormal COX-2 expression and progressive injury in the remnant kidney","volume":"64","author":"Fujihara","year":"2003","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178132_bib18","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1073\/pnas.1803999116","article-title":"Suppression of chemotherapy-induced cytokine\/lipid mediator surge and ovarian cancer by a dual COX-2\/sEH inhibitor","volume":"116","author":"Gartung","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178132_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000535809","article-title":"Kidney injury by Unilateral Ureteral obstruction in mice Lacks sex Differences","volume":"49","author":"Goorani","year":"2024","journal-title":"Kidney Blood Press. Res."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178132_bib20","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178132_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00004872-200401000-00010","article-title":"Do COX-2 inhibitors reduce renal fibrosis?","volume":"22","author":"Harding","year":"2004","journal-title":"J. Hypertens."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178132_bib22","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1172\/JCI118539","article-title":"Dissociation of glomerular hypertrophy, cell proliferation, and glomerulosclerosis in mouse strains heterozygous for a mutation (Os) which induces a 50% reduction in nephron number","volume":"97","author":"He","year":"1996","journal-title":"J. Clin. Investig."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178132_bib23","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.mayocp.2017.09.011","article-title":"The Incidence of primary vs secondary focal segmental glomerulosclerosis: a Clinicopathologic study","volume":"92","author":"Hommos","year":"2017","journal-title":"Mayo Clin. Proc."},{"issue":"Pt 1","key":"10.1016\/j.ejphar.2025.178132_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1113\/jphysiol.2010.199505","article-title":"Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension","volume":"589","author":"Honetschl\u00e4gerov\u00e1","year":"2011","journal-title":"J. Physiol."},{"issue":"8","key":"10.1016\/j.ejphar.2025.178132_bib25","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1021\/jm2001376","article-title":"Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase","volume":"54","author":"Hwang","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2025.178132_bib26","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.prostaglandins.2016.07.003","article-title":"A dual COX-2\/sEH inhibitor improves the metabolic profile and reduces kidney injury in Zucker diabetic fatty rat","volume":"125","author":"Hye Khan","year":"2016","journal-title":"Prostag. Other Lipid Mediat."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178132_bib27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000353898","article-title":"Low birthweight and premature birth are risk factors for podocytopenia and focal segmental glomerulosclerosis","volume":"38","author":"Ikezumi","year":"2013","journal-title":"Am. J. Nephrol."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178132_bib28","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1161\/01.HYP.0000176237.74820.75","article-title":"An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension","volume":"46","author":"Imig","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.178132_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.744776","article-title":"Dual sEH\/COX-2 inhibition using PTUPB-A promising Approach to Antiangiogenesis-induced nephrotoxicity","volume":"12","author":"Jankiewicz","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178132_bib30","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/j.1523-1755.2004.00851.x","article-title":"Renal phenotype is exacerbated in Os and lpr double mutant mice","volume":"66","author":"Jarad","year":"2004","journal-title":"Kidney Int."},{"issue":"22","key":"10.1016\/j.ejphar.2025.178132_bib31","doi-asserted-by":"crossref","first-page":"4468","DOI":"10.1111\/bph.15623","article-title":"Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats","volume":"178","author":"Khan","year":"2021","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.ejphar.2025.178132_bib32","doi-asserted-by":"crossref","first-page":"F971","DOI":"10.1152\/ajprenal.00256.2014","article-title":"Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation","volume":"307","author":"Kim","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178132_bib33","first-page":"43","article-title":"Renal cyclooxygenase-2 (COX-2). Physiological, pathophysiological, and clinical implications. Kidney Blood Press","volume":"27","author":"Kr\u00e4mer","year":"2003","journal-title":"Res."},{"key":"10.1016\/j.ejphar.2025.178132_bib34","article-title":"CD38: a significant regulator of macrophage function","volume":"12","author":"Li","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejphar.2025.178132_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.554961","article-title":"Multi-target Approaches in metabolic syndrome","volume":"11","author":"Lillich","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178132_bib36","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/ki.2013.135","article-title":"Discrete functions of M2a and M2c macrophage subsets determine their relative efficacy in treating chronic kidney disease","volume":"84","author":"Lu","year":"2013","journal-title":"Kidney Int."},{"issue":"22","key":"10.1016\/j.ejphar.2025.178132_bib37","doi-asserted-by":"crossref","first-page":"9038","DOI":"10.1073\/pnas.1103482108","article-title":"Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance","volume":"108","author":"Luria","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178132_bib38","doi-asserted-by":"crossref","first-page":"F740","DOI":"10.1152\/ajprenal.00098.2009","article-title":"Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension","volume":"297","author":"Manhiani","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178132_bib39","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1093\/ckj\/sfaa164","article-title":"The complex interplay between kidney injury and inflammation","volume":"14","author":"McWilliam","year":"2020","journal-title":"Clin. Kidney J."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178132_bib40","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.krcp.2015.10.004","article-title":"Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney","volume":"34","author":"N\u00f8rregaard","year":"2015","journal-title":"Kidney Res. Clin. Pract."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178132_bib41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/CS20080039","article-title":"Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats","volume":"116","author":"Olearczyk","year":"2009","journal-title":"Clin. Sci."},{"key":"10.1016\/j.ejphar.2025.178132_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.597959","article-title":"CD38: an Immunomodulatory molecule in inflammation and Autoimmunity","volume":"11","author":"Piedra-Quintero","year":"2020","journal-title":"Front. Immunol."},{"issue":"17","key":"10.1016\/j.ejphar.2025.178132_bib43","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1073\/pnas.1616893114","article-title":"Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids","volume":"114","author":"Rand","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178132_bib44","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1194\/jlr.M094219","article-title":"Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2","volume":"60","author":"Rand","year":"2019","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178132_bib45","doi-asserted-by":"crossref","first-page":"502","DOI":"10.2215\/CJN.05960616","article-title":"Focal segmental glomerulosclerosis","volume":"12","author":"Rosenberg","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"1\u20132","key":"10.1016\/j.ejphar.2025.178132_bib46","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.prostaglandins.2009.04.004","article-title":"8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier","volume":"89","author":"Sharma","year":"2009","journal-title":"Prostag. Other Lipid Mediat."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178132_bib47","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.bbrc.2019.12.131","article-title":"PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice","volume":"523","author":"Sun","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.ejphar.2025.178132_bib48","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.7150\/thno.43108","article-title":"A COX-2\/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"issue":"8","key":"10.1016\/j.ejphar.2025.178132_bib49","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1111\/febs.15105","article-title":"COX-2\/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence","volume":"287","author":"Zhang","year":"2020","journal-title":"FEBS J."},{"key":"10.1016\/j.ejphar.2025.178132_bib50","article-title":"COX-2\/sEH dual inhibitor PTUPB attenuates epithelial-Mesenchymal Transformation of Alveolar epithelial cells via Nrf2-mediated inhibition of TGF-\u03b21\/Smad signaling","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178132_bib51","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0006-291X(92)91619-2","article-title":"Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenase","volume":"183","author":"Zhang","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2025.178132_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109907","article-title":"A COX-2\/sEH dual inhibitor PTUPB ameliorates cecal ligation and puncture-induced sepsis in mice via anti-inflammation and anti-oxidative stress","volume":"126","author":"Zhang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2025.178132_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.761517","article-title":"COX-2\/sEH dual inhibitor PTUPB alleviates CCl 4 -induced liver fibrosis and Portal hypertension","volume":"8","author":"Zhao","year":"2021","journal-title":"Front. Med."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925008866?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925008866?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T04:28:34Z","timestamp":1780201714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925008866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":53,"alternative-id":["S0014299925008866"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178132","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual acting inhibitor of soluble epoxide hydrolase and Cyclooxygenase-2, attenuates glomerular injury in renal hypoplasia mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"178132"}}