{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:35:24Z","timestamp":1787927724946,"version":"build-2784847793"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MH038"],"award-info":[{"award-number":["ZR2024MH038"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009108","name":"Shandong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072535"],"award-info":[{"award-number":["82072535"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271327"],"award-info":[{"award-number":["82271327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A6011"],"award-info":[{"award-number":["U23A6011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ejphar.2025.178153","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:36:09Z","timestamp":1758123369000},"page":"178153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Liposomes-loaded miR-128-3p exert neuroprotective effects in hypoxia-ischemia injury by targeting Rgs1 in neonatal mice"],"prefix":"10.1016","volume":"1006","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8729-393X","authenticated-orcid":false,"given":"Luyao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3173-6961","authenticated-orcid":false,"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.178153_bib1","first-page":"1","article-title":"Enhanced expression of miR-128 in peripheral blood mononuclear cells: a potent candidate diagnostic biomarker for multiple sclerosis","author":"Akhgari","year":"2025","journal-title":"Neurol. Res."},{"key":"10.1016\/j.ejphar.2025.178153_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22083967","article-title":"The role of microRNAs in development of Colitis-associated Colorectal Cancer","volume":"22","author":"Bocchetti","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178153_bib3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neulet.2011.11.023","article-title":"Expression of spinal cord microRNAs in a rat model of chronic neuropathic pain","volume":"506","author":"Brandenburger","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2025.178153_bib4","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/his.13106","volume":"70","author":"Carreras","year":"2017","journal-title":"Histopathology"},{"key":"10.1016\/j.ejphar.2025.178153_bib5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3389\/fphar.2017.00775","article-title":"Inhibition of miR-128-3p by Tongxinluo protects human Cardiomyocytes from ischemia\/reperfusion injury via upregulation of p70s6k1\/p-p70s6k1","volume":"8","author":"Chen","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178153_bib6","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s12264-025-01376-6","article-title":"Engineered extracellular vesicles loaded with MiR-100-5p Antagonist Selectively target the lesioned region to promote recovery from brain damage","volume":"41","author":"Cheng","year":"2025","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.ejphar.2025.178153_bib7","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-025-05030-0","article-title":"Neuroprotective effect of Salvianolic Acid C in neonatal rats following hypoxic-ischemic brain damage","author":"Dai","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2025.178153_bib8","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/ATVBAHA.109.194043","article-title":"Chronic hypoxia activates the Akt and beta-catenin pathways in human macrophages","volume":"29","author":"Deguchi","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2025.178153_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-0716-2954-3_5","article-title":"Ethanol Injection method for liposome preparation","volume":"2622","author":"Du","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2025.178153_bib10","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1007\/s12035-021-02296-y","article-title":"The coding and small non-coding hippocampal Synaptic RNAome","volume":"58","author":"Epple","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2025.178153_bib11","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.pedneo.2023.07.006","article-title":"A novel clinical risk scoring system for neurodevelopmental outcomes among survivors of neonatal hypoxic-ischemic encephalopathy (HIE)","volume":"65","author":"Estiphan","year":"2024","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.ejphar.2025.178153_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16070929","article-title":"Nasal drug delivery and Nose-to-brain delivery technology development status and Trend analysis: based on Questionnaire Survey and patent analysis","volume":"16","author":"Ge","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2025.178153_bib13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1080\/00207454.2024.2312998","article-title":"LncRNA PVT1 promotes neuroinflammation after intracerebral hemorrhage by regulating the miR-128-3p\/TXNIP axis","volume":"135","author":"Gong","year":"2025","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.ejphar.2025.178153_bib14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s13760-020-01308-3","article-title":"Pathophysiology of hypoxic-ischemic encephalopathy: a review of the past and a view on the future","volume":"120","author":"Greco","year":"2020","journal-title":"Acta Neurol. Belg."},{"key":"10.1016\/j.ejphar.2025.178153_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120571","article-title":"Design of liposomes as drug delivery system for therapeutic applications","volume":"601","author":"Guimar\u00e3es","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejphar.2025.178153_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1152279","article-title":"Identification of biomarkers differentiating Alzheimer's disease from other neurodegenerative diseases by integrated bioinformatic analysis and machine-learning strategies","volume":"16","author":"Jin","year":"2023","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2025.178153_bib17","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1038\/s41467-025-58070-4","article-title":"A functional screen uncovers circular RNAs regulating excitatory synaptogenesis in hippocampal neurons","volume":"16","author":"Kelly","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2025.178153_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/172351","article-title":"MicroRNAs as novel regulators of neuroinflammation","volume":"2013","author":"Ksiazek-Winiarek","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2025.178153_bib19","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.3233\/JAD-170205","article-title":"Changes in expression Profiles revealed by Transcriptomic analysis in peripheral blood mononuclear cells of Alzheimer's disease patients","volume":"66","author":"Leandro","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.ejphar.2025.178153_bib20","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.2147\/NDT.S300773","article-title":"Biliverdin protects against cerebral ischemia\/reperfusion injury by regulating the miR-27a-3p\/Rgs1 Axis","volume":"17","author":"Li","year":"2021","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"10.1016\/j.ejphar.2025.178153_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2147\/IJN.S339979","article-title":"Development and in vivo evaluation of Hydroxy-\u03b1-sanshool intranasal liposomes as a potential Remedial treatment for Alzheimer's disease","volume":"17","author":"Li","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejphar.2025.178153_bib22","article-title":"Aberrant neuronal excitation promotes neuroinflammation in the primary motor cortex of ischemic stroke mice","author":"Li","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2025.178153_bib23","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12306","article-title":"Upregulation of miR-128 inhibits neuronal cell apoptosis following spinal cord injury via FasL downregulation by repressing ULK1","volume":"24","author":"Liu","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2025.178153_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104795","article-title":"Nose to brain drug delivery - a promising strategy for active components from herbal medicine for treating cerebral ischemia reperfusion","volume":"159","author":"Long","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2025.178153_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2025.115552","article-title":"MiR-29a-3p ameliorate behavioral deficiency in hypoxia-ischemia brain damage in neonatal mice by inhibiting BTG2","volume":"486","author":"Luo","year":"2025","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2025.178153_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26020747","article-title":"MicroRNA expression profile in acute ischemic stroke","volume":"26","author":"Mainali","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178153_bib27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00018-025-05601-3","article-title":"Aminophylline targets miR-128-3p\/Slc7a11 axis to attenuate neuronal ferroptosis after traumatic brain injury","volume":"82","author":"Manrui","year":"2025","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ejphar.2025.178153_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70131-w","article-title":"Transcriptomic profile of adverse neurodevelopmental outcomes after neonatal encephalopathy","volume":"10","author":"Montaldo","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.178153_bib29","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.siny.2012.07.008","article-title":"MicroRNAs and neuronal development","volume":"17","author":"Motti","year":"2012","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.ejphar.2025.178153_bib30","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1007\/s12035-024-04362-7","article-title":"MicroRNA-128-3p affects neuronal apoptosis and neurobehavior in cerebral palsy rats by targeting E3 Ubiquitin-Linking Enzyme Smurf2 and regulating YY1 expression","volume":"62","author":"Nie","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2025.178153_bib31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/leu.2015.183","article-title":"Aberrant expression of miR-9\/9\u2217 in myeloid progenitors inhibits neutrophil differentiation by post-transcriptional regulation of ERG","volume":"30","author":"Nowek","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.ejphar.2025.178153_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.113985","article-title":"Ryanodine receptor inhibitor dantrolene reduces hypoxic-ischemic brain injury in neonatal mice","volume":"351","author":"Ovcjak","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2025.178153_bib33","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1038\/ncomms7614","article-title":"RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling","volume":"6","author":"Patel","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2025.178153_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115356","article-title":"Potential pharmacological target of tight junctions to improve the BBB permeability in neonatal Hypoxic-Ischemic encephalopathy Diseases","volume":"207","author":"Paz","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178153_bib35","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/jclinpath-2016-203713","article-title":"RGS1 expression is associated with poor prognosis in multiple myeloma","volume":"70","author":"Roh","year":"2017","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.ejphar.2025.178153_bib36","doi-asserted-by":"crossref","first-page":"25910","DOI":"10.1039\/D5RA03578C","article-title":"Precision targeting of the CNS: recent progress in brain-directed nanodrug delivery","volume":"15","author":"Senanayake","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.ejphar.2025.178153_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.semperi.2022.151641","article-title":"Outcome prediction in newborn infants: past, present, and future","volume":"46","author":"Shukla","year":"2022","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.ejphar.2025.178153_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177471","article-title":"Liposome-loaded miR-34c-5p attenuates apoptosis and oxidative stress following hypoxia-ischemia brain damage in neonatal mice by targeting Arhgap26","volume":"998","author":"Song","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178153_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119342","article-title":"Intranasal delivery of targeted polyfunctional gold-iron oxide nanoparticles loaded with therapeutic microRNAs for combined theranostic multimodality imaging and presensitization of glioblastoma to temozolomide","volume":"218","author":"Sukumar","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejphar.2025.178153_bib40","first-page":"2673","article-title":"Critical role for non-GAP function of G\u03b1s in RGS1-mediated promotion of melanoma progression through AKT and ERK phosphorylation","volume":"39","author":"Sun","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejphar.2025.178153_bib41","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.scib.2024.03.013","article-title":"Swimming short fibrous nasal drops achieving intraventricular administration","volume":"69","author":"Wang","year":"2024","journal-title":"Sci. Bull."},{"key":"10.1016\/j.ejphar.2025.178153_bib42","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12887-021-02737-6","article-title":"Neonatal hypoxic-ischemic encephalopathy diagnosis and treatment: a National Survey in China","volume":"21","author":"Wang","year":"2021","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.ejphar.2025.178153_bib43","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.2147\/IJN.S508800","article-title":"Anti-inflammatory Combination of Puerarin and Ac2-26 using intranasal delivery for effective against ischemic stroke in rat model","volume":"20","author":"Xu","year":"2025","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejphar.2025.178153_bib44","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1007\/s12035-024-04441-9","article-title":"Correction to: hypoxic-ischemic encephalopathy: pathogenesis and promising Therapies","volume":"62","author":"Yang","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2025.178153_bib45","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101654RR","article-title":"Atorvastatin inhibits neuronal apoptosis via activating cAMP\/PKA\/p-CREB\/BDNF pathway in hypoxic-ischemic neonatal rats","volume":"36","author":"Yu","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2025.178153_bib46","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1021\/acsnano.3c10674","article-title":"Functionalized nanomaterials capable of crossing the blood-brain barrier","volume":"18","author":"Zha","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejphar.2025.178153_bib47","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.18632\/aging.102636","article-title":"HIF-1\u03b1\/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the Axin1-mediated Wnt\/\u03b2-catenin signaling pathway in Parkinson's disease models","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging (Albany NY)"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925009070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925009070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T04:26:18Z","timestamp":1780201578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925009070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":47,"alternative-id":["S0014299925009070"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178153","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liposomes-loaded miR-128-3p exert neuroprotective effects in hypoxia-ischemia injury by targeting Rgs1 in neonatal mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178153","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178153"}}