{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:30:10Z","timestamp":1790530210917,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ejphar.2025.178203","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T06:46:33Z","timestamp":1758869193000},"page":"178203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Remimazolam alleviates intracerebral hemorrhage outcomes by suppressing neuronal ferroptosis"],"prefix":"10.1016","volume":"1006","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlei","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3656-1843","authenticated-orcid":false,"given":"Jiayu","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4406-8860","authenticated-orcid":false,"given":"Chengya","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingji","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2858-9668","authenticated-orcid":false,"given":"Jingxiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.178203_bib1","article-title":"The application of approaches in detecting ferroptosis","volume":"10","author":"Chen","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.ejphar.2025.178203_bib2","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1161\/STROKEAHA.124.048507","article-title":"AX-024 inhibits antigen-specific T-Cell response and improves intracerebral hemorrhage outcomes in mice","volume":"56","author":"Chen","year":"2025","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2025.178203_bib3","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.2147\/DDDT.S495604","article-title":"Model-informed precision dosing of remimazolam in general anesthesia patients","volume":"19","author":"Chen","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ejphar.2025.178203_bib4","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.2174\/1381612822666161027150616","article-title":"Targeting the Nrf2-Heme Oxygenase-1 axis after intracerebral hemorrhage","volume":"23","author":"Chen-Roetling","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejphar.2025.178203_bib5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.14715\/cmb\/2023.69.11.16","article-title":"Effect of sleep deprivation by MMP-WM on rat neurological function and tau protein in hippocampus","volume":"69","author":"Cheng","year":"2023","journal-title":"Cell. Mol. Biol."},{"key":"10.1016\/j.ejphar.2025.178203_bib6","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41556-019-0305-6","article-title":"ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway","volume":"21","author":"Chu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ejphar.2025.178203_bib7","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2025.178203_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1203285","article-title":"Intracerebral hemorrhage, oxidative stress, and antioxidant therapy","volume":"2016","author":"Duan","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejphar.2025.178203_bib9","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/ALN.0000000000003102","article-title":"Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy Male volunteers: part II. Pharmacodynamics of electroencephalogram effects","volume":"132","author":"Eisenried","year":"2020","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2025.178203_bib10","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2147\/VHRM.S486834","article-title":"The effects of remimazolam versus propofol on endovascular thrombectomy for acute ischemic stroke: study protocol for a randomized controlled trial","volume":"20","author":"Fu","year":"2024","journal-title":"Vasc. Health Risk Manag."},{"key":"10.1016\/j.ejphar.2025.178203_bib11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/svn-2016-000042","article-title":"Brain iron overload following intracranial haemorrhage","volume":"1","author":"Garton","year":"2016","journal-title":"Stroke Vasc Neurol"},{"key":"10.1016\/j.ejphar.2025.178203_bib12","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the global burden of disease study 2019","volume":"20","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2025.178203_bib13","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.2147\/DDDT.S384155","article-title":"Remimazolam: an updated review of a new sedative and anaesthetic","volume":"16","author":"Hu","year":"2022","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ejphar.2025.178203_bib14","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.17305\/bb.2024.11415","article-title":"PF4 regulates neuronal ferroptosis in cerebral hemorrhage through CXCR3\/PI3K\/AKT\/Nrf2 pathway","volume":"25","author":"Hu","year":"2025","journal-title":"Biomolecul. Biomed."},{"key":"10.1016\/j.ejphar.2025.178203_bib15","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s12028-021-01401-2","article-title":"Ferrostatin-1 polarizes microglial cells toward M2 phenotype to alleviate inflammation after intracerebral hemorrhage","volume":"36","author":"Huang","year":"2022","journal-title":"Neurocritical Care"},{"key":"10.1016\/j.ejphar.2025.178203_bib16","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1038\/s44321-024-00117-y","article-title":"Histidine-rich glycoprotein modulates neutrophils and thrombolysis-associated hemorrhagic transformation","volume":"16","author":"Jiang","year":"2024","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ejphar.2025.178203_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14646","article-title":"Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1\/2: microglial heterogenization via the Nrf2\/HO1 pathway","volume":"30","author":"Jiang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.ejphar.2025.178203_bib18","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1053\/j.jvca.2023.06.027","article-title":"Propofol versus remimazolam on cognitive function, hemodynamics, and oxygenation during one-lung ventilation in older patients undergoing pulmonary lobectomy: a randomized controlled trial","volume":"37","author":"Kuang","year":"2023","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"10.1016\/j.ejphar.2025.178203_bib19","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.90777","article-title":"Inhibition of neuronal ferroptosis protects hemorrhagic brain","volume":"2","author":"Li","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.ejphar.2025.178203_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1123089","article-title":"Comparison of the effects of remimazolam and dexmedetomidine on early postoperative cognitive function in elderly patients with gastric cancer","volume":"15","author":"Liao","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ejphar.2025.178203_bib21","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1177\/10815589231167358","article-title":"Butylphthalide protects against ischemia-reperfusion injury in rats via reducing neuron ferroptosis and oxidative stress","volume":"71","author":"Lu","year":"2023","journal-title":"J. Invest. Med. : Off. Pub. Am. Federat. Clin. Res."},{"key":"10.1016\/j.ejphar.2025.178203_bib22","doi-asserted-by":"crossref","DOI":"10.1177\/09603271231160477","article-title":"Sevoflurane postconditioning attenuates cerebral ischemia-reperfusion injury by inhibiting SP1\/ACSL4-Mediated ferroptosis","volume":"42","author":"Lyu","year":"2023","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ejphar.2025.178203_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.111086","article-title":"Remimazolam ameliorates postoperative cognitive dysfunction after deep hypothermic circulatory arrest through HMGB1-TLR4-NF-\u03baB pathway","volume":"217","author":"Mao","year":"2024","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ejphar.2025.178203_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.117932","article-title":"Research progress on ferroptosis in cerebral hemorrhage","volume":"185","author":"Mao","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2025.178203_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.966478","article-title":"Neuronal ferroptosis after intracerebral hemorrhage","volume":"9","author":"Ren","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.ejphar.2025.178203_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.expneurol.2012.12.009","article-title":"Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage","volume":"241","author":"Rolland","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2025.178203_bib27","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/ALN.0000000000003103","article-title":"Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy Male volunteers: part I. Pharmacokinetics and clinical pharmacodynamics","volume":"132","author":"Sch\u00fcttler","year":"2020","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ejphar.2025.178203_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020753","article-title":"Midazolam ameliorates hyperglycemia-induced glomerular endothelial dysfunction by inhibiting transglutaminase 2 in diabetes","volume":"23","author":"Seo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178203_bib29","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1186\/s40001-024-02142-6","article-title":"Effect of remimazolam toluene sulfonate on the cognitive function of juveniles and its mechanism of action","volume":"29","author":"Shi","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.ejphar.2025.178203_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cells12010090","article-title":"Ferroptosis and iron metabolism after intracerebral hemorrhage","volume":"12","author":"Sun","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2025.178203_bib31","article-title":"Comparative analysis of the hemodynamic effects of remimazolam and propofol during general anesthesia: a retrospective study","volume":"16","author":"Tsukimoto","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.ejphar.2025.178203_bib32","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2025.178203_bib33","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1186\/s12974-020-02015-9","article-title":"NOD1\/RIP2 signalling enhances the microglia-driven inflammatory response and undergoes crosstalk with inflammatory cytokines to exacerbate brain damage following intracerebral haemorrhage in mice","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2025.178203_bib34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12974-022-02438-6","article-title":"Irisin ameliorates neuroinflammation and neuronal apoptosis through integrin \u03b1V\u03b25\/AMPK signaling pathway after intracerebral hemorrhage in mice","volume":"19","author":"Wang","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2025.178203_bib35","doi-asserted-by":"crossref","DOI":"10.1080\/03014460.2024.2334719","article-title":"Identification of mitophagy and ferroptosis-related hub genes associated with intracerebral haemorrhage through bioinformatics analysis","volume":"51","author":"Wang","year":"2024","journal-title":"Ann. Hum. Biol."},{"key":"10.1016\/j.ejphar.2025.178203_bib36","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.2174\/1381612822666161027152234","article-title":"Epidemiology, prognosis and prevention of non-traumatic intracerebral hemorrhage","volume":"23","author":"Weimar","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejphar.2025.178203_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.148975","article-title":"Remimazolam inhibits postoperative cognitive impairment after cardiopulmonary bypass by alleviating neuroinflammation and promoting microglia M2 polarization","volume":"1838","author":"Wen","year":"2024","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2025.178203_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102256","article-title":"Reduction of lactoferrin aggravates neuronal ferroptosis after intracerebral hemorrhagic stroke in hyperglycemic mice","volume":"50","author":"Xiao","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2025.178203_bib39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10571-022-01196-6","article-title":"Role of ferroptosis in stroke","volume":"43","author":"Xu","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2025.178203_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176276","article-title":"Remimazolam attenuates myocardial ischemia-reperfusion injury by inhibiting the NF-\u0138B pathway of macrophage inflammation","volume":"965","author":"Xu","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178203_bib41","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1007\/s12264-025-01355-x","article-title":"Fto-dependent Vdac3 m6A modification regulates neuronal ferroptosis induced by the Post-ICH mass effect and transferrin","volume":"41","author":"Xu","year":"2025","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.ejphar.2025.178203_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114906","article-title":"Neuronal HIPK2-HDAC3 axis regulates mitochondrial fragmentation to participate in stroke injury and post-stroke anxiety like behavior","volume":"380","author":"Yang","year":"2024","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2025.178203_bib43","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1213\/ANE.0000000000006263","article-title":"Combined arterial hypertension and ischemic stroke exaggerate anesthesia-related hypotension and cerebral oxygenation deficits: a preclinical study","volume":"137","author":"Zhang","year":"2023","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.ejphar.2025.178203_bib44","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1007\/s11064-024-04115-x","article-title":"Remimazolam attenuates LPS-derived cognitive dysfunction via subdiaphragmatic vagus nerve target \u03b17nAChR-Mediated Nrf2\/HO-1 signal pathway","volume":"49","author":"Zhou","year":"2024","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2025.178203_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.115268","article-title":"Remimazolam attenuates lipopolysaccharide-induced neuroinflammation and cognitive dysfunction","volume":"476","author":"Zhou","year":"2025","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2025.178203_bib46","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1161\/STROKEAHA.116.015609","article-title":"Neuronal death after hemorrhagic stroke in vitro and in vivo shares features of ferroptosis and necroptosis","volume":"48","author":"Zille","year":"2017","journal-title":"Stroke"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925009574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925009574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T04:35:51Z","timestamp":1780202151000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925009574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":46,"alternative-id":["S0014299925009574"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178203","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Remimazolam alleviates intracerebral hemorrhage outcomes by suppressing neuronal ferroptosis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178203","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"178203"}}