{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:01:01Z","timestamp":1784592061293,"version":"3.55.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002964","name":"Cukurova University","doi-asserted-by":"publisher","award":["TDK-2021- 13519"],"award-info":[{"award-number":["TDK-2021- 13519"]}],"id":[{"id":"10.13039\/501100002964","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ejphar.2025.178252","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T03:03:43Z","timestamp":1760497423000},"page":"178252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Effects of apigenin on mesangial GATA3 expression and PDGFR-\u03b2\/NF-\u03baB signaling pathway in experimental diabetic nephropathy model"],"prefix":"10.1016","volume":"1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6927-3582","authenticated-orcid":false,"given":"Tugce","family":"Sapmaz Er\u00e7akalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8219-2816","authenticated-orcid":false,"given":"G\u00fclfidan","family":"Coskun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-4226","authenticated-orcid":false,"given":"Dilek","family":"Saker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6301-0308","authenticated-orcid":false,"given":"Leman","family":"Sencar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3065-1683","authenticated-orcid":false,"given":"G\u00fclfiliz","family":"G\u00f6nl\u00fc\u015fen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-8831","authenticated-orcid":false,"given":"Sait","family":"Polat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ejphar.2025.178252_bib1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.yexcr.2012.02.025","article-title":"Mesangial cell biology","volume":"318","author":"Abboud","year":"2012","journal-title":"Exp. Cell Res."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178252_bib2","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.2215\/CJN.11491116","article-title":"Diabetic kidney disease: challenges, progress, and possibilities","volume":"12","author":"Alicic","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol. : CJASN"},{"issue":"1\u20132","key":"10.1016\/j.ejphar.2025.178252_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0009-8981(03)00322-X","article-title":"Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats","volume":"338","author":"Andallu","year":"2003","journal-title":"Clinica Chimica Acta Int. J. Clin. Chem."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178252_bib4","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/s41440-019-0226-6","article-title":"Pathogenic role of angiotensin II and the NF-\u03baB system in a model of malignant hypertensive nephrosclerosis","volume":"42","author":"\u00c1vila","year":"2019","journal-title":"Hypertens. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178252_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/abbi.1998.0618","article-title":"Dithiocarbamate toxicity toward thymocytes involves their copper-catalyzed conversion to thiuram disulfides, which oxidize glutathione in a redox cycle without the release of reactive oxygen species","volume":"353","author":"Burkitt","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178252_bib6","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1034\/j.1600-079X.2003.00082.x","article-title":"Protective effects of chronic melatonin treatment against renal injury in streptozotocin-induced diabetic rats","volume":"35","author":"Cam","year":"2003","journal-title":"J. Pineal Res."},{"issue":"9","key":"10.1016\/j.ejphar.2025.178252_bib7","first-page":"1553","article-title":"Low molecular weight fucoidan ameliorates diabetic nephropathy via inhibiting epithelial-mesenchymal transition and fibrotic processes","volume":"7","author":"Chen","year":"2015","journal-title":"Am. J. Tourism Res."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178252_bib8","first-page":"119","article-title":"Quercetin suppresses NF-\u03baB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model","volume":"30","author":"Chen","year":"2012","journal-title":"Int. J. Mol. Med."},{"issue":"7\u20138","key":"10.1016\/j.ejphar.2025.178252_bib9","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.intimp.2009.03.018","article-title":"Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene","volume":"9","author":"Choi","year":"2009","journal-title":"Int. Immunopharmacol."},{"issue":"1 Suppl. l","key":"10.1016\/j.ejphar.2025.178252_bib10","doi-asserted-by":"crossref","first-page":"A7","DOI":"10.1053\/j.ajkd.2013.11.001","article-title":"US renal data system 2013 annual data report","volume":"63","author":"Collins","year":"2014","journal-title":"Am. J. Kidney Dis. : Off.J. Natl. Kidney Found."},{"issue":"9123","key":"10.1016\/j.ejphar.2025.178252_bib11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0140-6736(98)01346-4","article-title":"Pathogenesis, prevention, and treatment of diabetic nephropathy","volume":"352","author":"Cooper","year":"1998","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.ejphar.2025.178252_bib12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.phymed.2018.01.026","article-title":"Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome","volume":"41","author":"Ding","year":"2018","journal-title":"Phytomedicine : Int. J. Phytother. Phytopharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178252_bib13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/0960327114531995","article-title":"Amelioration of streptozotocin-induced diabetic nephropathy by melatonin, quercetin, and resveratrol in rats","volume":"34","author":"Elbe","year":"2015","journal-title":"Hum. Exp. Toxicol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178252_bib14","first-page":"9","article-title":"Use of unripe plantain (Musa paradisiaca) in the management of diabetes and hepatic dysfunction in streptozotocin induced diabetes in rats","volume":"7","author":"Eleazu","year":"2015","journal-title":"Int. Med. Appl. Sci."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178252_bib15","first-page":"402","article-title":"Protective effect of the nuclear factor kappa B inhibitor pyrrolidine dithiocarbamate in lung injury in rats with streptozotocin-induced diabetes","volume":"79","author":"Eren","year":"2010","journal-title":"Resp. Int. Rev. Thoracic Dis."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178252_bib16","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.intimp.2012.10.004","article-title":"Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats","volume":"14","author":"Ghule","year":"2012","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178252_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/bbrc.2000.3452","article-title":"Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells","volume":"276","author":"Iseki","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2025.178252_bib18","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.biopha.2017.03.102","article-title":"The effect of hesperidin and quercetin on oxidative stress, NF-\u03baB and SIRT1 levels in a STZ-induced experimental diabetes model","volume":"90","author":"Iskender","year":"2017","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178252_bib19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1620\/tjem.206.163","article-title":"Nuclear factor-kappaB activation in diabetic rat kidney: evidence for involvement of P-selectin in diabetic nephropathy","volume":"206","author":"Iwamoto","year":"2005","journal-title":"Tohoku J. Exp. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178252_bib20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1523-1755.2002.00088.x","article-title":"Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2 rats","volume":"61","author":"Kelly","year":"2002","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178252_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.1079","article-title":"Tetrahydrocurcumin Add-On therapy to losartan in a rat model of diabetic nephropathy decreases blood pressure and markers of kidney injury","volume":"11","author":"Khazaeli","year":"2023","journal-title":"Pharmacol. Res.Perspect."},{"issue":"9\u201310","key":"10.1016\/j.ejphar.2025.178252_bib22","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.lfs.2008.12.014","article-title":"Attenuation of diabetic nephropathy by tocotrienol: involvement of NFkB signaling pathway","volume":"84","author":"Kuhad","year":"2009","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178252_bib23","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1159\/000076749","article-title":"Tubular and interstitial cell apoptosis in the streptozotocin-diabetic rat kidney","volume":"96","author":"Kumar","year":"2004","journal-title":"Nephron Exp. Nephrol."},{"issue":"1\u20132","key":"10.1016\/j.ejphar.2025.178252_bib24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.mce.2014.01.022","article-title":"Berberine attenuates high glucose-induced proliferation and extracellular matrix accumulation in mesangial cells: involvement of suppression of cell cycle progression and NF-\u03baB\/AP-1 pathways","volume":"384","author":"Lan","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178252_bib25","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00125-012-2805-9","article-title":"Attenuation of Armanni-Ebstein lesions in a rat model of diabetes by a new anti-fibrotic, anti-inflammatory agent, FT011","volume":"56","author":"Lau","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2025.178252_bib26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.phrs.2015.06.006","article-title":"Quercetin inhibits the mTORC1\/p70S6K signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in diabetic nephropathy","volume":"99","author":"Lu","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178252_bib27","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ejim.2008.12.012","article-title":"The role of tubular injury in diabetic nephropathy","volume":"20","author":"Magri","year":"2009","journal-title":"Eur. J. Intern. Med."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178252_bib28","doi-asserted-by":"crossref","first-page":"F414","DOI":"10.1152\/ajprenal.00393.2016","article-title":"Apigenin ameliorates streptozotocin-induced diabetic nephropathy in rats via MAPK-NF-\u03baB-TNF-\u03b1 and TGF-\u03b21-MAPK-fibronectin pathways","volume":"313","author":"Malik","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178252_bib29","doi-asserted-by":"crossref","first-page":"F831","DOI":"10.1152\/ajprenal.00313.2016","article-title":"Rethinking glomerular basement membrane thickening in diabetic nephropathy: adaptive or pathogenic?","volume":"311","author":"Marshall","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178252_bib30","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1097\/01.ASN.0000065640.77499.D7","article-title":"Extracellular matrix metabolism in diabetic nephropathy","volume":"14","author":"Mason","year":"2003","journal-title":"J. Am. Soc. Nephrol. : JASN (J. Am. Soc. Nephrol.)"},{"issue":"3","key":"10.1016\/j.ejphar.2025.178252_bib31","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1254\/jphs.09116FP","article-title":"Pyrrolidine dithiocarbamate reduces vascular prostanoid-induced responses in aged type 2 diabetic rat model","volume":"110","author":"Matsumoto","year":"2009","journal-title":"J. Pharmacol. Sci."},{"issue":"17","key":"10.1016\/j.ejphar.2025.178252_bib32","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1128\/MCB.00173-16","article-title":"Gata3 hypomorphic mutant mice rescued with a yeast artificial chromosome transgene suffer a glomerular mesangial cell defect","volume":"36","author":"Moriguchi","year":"2016","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178252_bib33","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1080\/10942912.2023.2236329","article-title":"Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms","volume":"26","author":"Mushtaq","year":"2023","journal-title":"Int. J. Food Prop."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178252_bib34","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1186\/s13287-021-02447-x","article-title":"Human umbilical cord mesenchymal stem cells reduce oxidative damage and apoptosis in diabetic nephropathy by activating Nrf2","volume":"12","author":"Nie","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178252_bib35","doi-asserted-by":"crossref","first-page":"11325","DOI":"10.18632\/aging.103410","article-title":"CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+\/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats","volume":"12","author":"Ogura","year":"2020","journal-title":"Aging"},{"issue":"10","key":"10.1016\/j.ejphar.2025.178252_bib36","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1091\/mbc.3.10.1131","article-title":"Induction of NF-kappa B-like activity by platelet-derived growth factor in mouse fibroblasts","volume":"3","author":"Olashaw","year":"1992","journal-title":"Mol. Biol. Cell"},{"issue":"7","key":"10.1016\/j.ejphar.2025.178252_bib37","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s00467-011-1892-z","article-title":"The PDGF family in renal fibrosis","volume":"27","author":"Ostendorf","year":"2012","journal-title":"Pediatr. Nephrol."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178252_bib38","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1681\/ASN.V7122509","article-title":"Genetics of diabetic nephropathy","volume":"7","author":"Parving","year":"1996","journal-title":"J. Am. Soc. Nephrol.: JASN (J. Am. Soc. Nephrol.)"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178252_bib39","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S1734-1140(09)70111-2","article-title":"Role of NF-kappa B in the pathogenesis of diabetes and its associated complications","volume":"61","author":"Patel","year":"2009","journal-title":"Pharmacol. Rep.: PR"},{"issue":"10","key":"10.1016\/j.ejphar.2025.178252_bib40","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1007\/s00210-020-01906-1","article-title":"Pyrrolidine dithiocarbamate reduces alloxan-induced kidney damage by decreasing nox4, inducible nitric oxide synthase, and metalloproteinase-2","volume":"393","author":"Pereira","year":"2020","journal-title":"N. Schmied. Arch. Pharmacol."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178252_bib41","first-page":"1197","article-title":"Health functionality of apigenin: a review","volume":"20","author":"Rahul","year":"2016","journal-title":"Int. J. Food Prop."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178252_bib42","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3390\/ijms20061305","article-title":"The therapeutic potential of apigenin","volume":"20","author":"Salehi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.ejphar.2025.178252_bib43","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1038\/s12276-024-01318-8","article-title":"Renal fibroblasts are involved in fibrogenic changes in kidney fibrosis associated with dysfunctional telomeres","volume":"56","author":"Saraswati","year":"2024","journal-title":"Exp. Mol. Med."},{"issue":"14","key":"10.1016\/j.ejphar.2025.178252_bib44","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.addr.2010.08.011","article-title":"Mesangial pathology in glomerular disease: targets for therapeutic intervention","volume":"62","author":"Scindia","year":"2010","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178252_bib45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000089720","article-title":"Resveratrol, a polyphenolic phytoalexin, attenuates diabetic nephropathy in rats","volume":"76","author":"Sharma","year":"2006","journal-title":"Pharmacology"},{"issue":"9","key":"10.1016\/j.ejphar.2025.178252_bib46","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2337\/diab.38.9.1077","article-title":"Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients","volume":"38","author":"Steffes","year":"1989","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178252_bib47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jaut.2004.01.005","article-title":"Immunosuppressive and anti-inflammatory action of antioxidants in rat autoimmune diabetes","volume":"22","author":"Stosic-Grujicic","year":"2004","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.ejphar.2025.178252_bib48","article-title":"Astragaloside II ameliorated podocyte injury and mitochondrial dysfunction in Streptozotocin-induced diabetic rats","volume":"12","author":"Su","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.ejphar.2025.178252_bib49","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1046\/j.1440-1681.2001.03530.x","article-title":"Effect of enalapril on diabetic nephropathy in OLETF rats: the role of an anti-oxidative action in its protective properties","volume":"28","author":"Sugimoto","year":"2001","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ejphar.2025.178252_bib50","series-title":"Brenner and Rector's the Kidney","first-page":"1411","article-title":"Diabetic nephropathy","author":"Taal","year":"2012"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178252_bib51","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13036-022-00299-4","article-title":"Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation","volume":"16","author":"Thomas","year":"2022","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.ejphar.2025.178252_bib52","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ijbiomac.2020.02.087","article-title":"Low molecular weight fucoidan alleviates diabetic nephropathy by binding fibronectin and inhibiting ECM-receptor interaction in human renal mesangial cells","volume":"150","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejphar.2025.178252_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.108702","article-title":"Human umbilical cord mesenchymal stem cells attenuate podocyte injury under high glucose via TLR2 and TLR4 signaling","volume":"173","author":"Wang","year":"2021","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"7","key":"10.1016\/j.ejphar.2025.178252_bib54","doi-asserted-by":"crossref","DOI":"10.1093\/mtomcs\/mfac034","article-title":"ZIP14 is involved in iron deposition and triggers ferroptosis in diabetic nephropathy","volume":"14","author":"Wu","year":"2022","journal-title":"Metallomics : Integr. Biometal Sci."},{"key":"10.1016\/j.ejphar.2025.178252_bib55","article-title":"Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation","volume":"137","author":"Wu","year":"2021","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"issue":"1\u20132","key":"10.1016\/j.ejphar.2025.178252_bib56","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.mce.2012.06.008","article-title":"Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-\u03baB signaling pathway in rat glomerular mesangial cells","volume":"362","author":"Xie","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178252_bib57","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jand.2015.10.014","article-title":"Association between self-weighing and percent weight change: mediation effects of adherence to energy intake and expenditure goals","volume":"116","author":"Zheng","year":"2016","journal-title":"J. Acad. Nutr. Diet."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925010064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925010064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:27:16Z","timestamp":1779323236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925010064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":57,"alternative-id":["S0014299925010064"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178252","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of apigenin on mesangial GATA3 expression and PDGFR-\u03b2\/NF-\u03baB signaling pathway in experimental diabetic nephropathy model","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178252","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178252"}}