{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:31:04Z","timestamp":1792161064819,"version":"4.4.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20221375"],"award-info":[{"award-number":["BK20221375"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20240949"],"award-info":[{"award-number":["BK20240949"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20230288"],"award-info":[{"award-number":["BK20230288"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401797"],"award-info":[{"award-number":["82401797"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009576","name":"Nantong City Health Commission","doi-asserted-by":"publisher","award":["QN2023035"],"award-info":[{"award-number":["QN2023035"]}],"id":[{"id":"10.13039\/501100009576","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009576","name":"Nantong City Health Commission","doi-asserted-by":"publisher","award":["MS2023033"],"award-info":[{"award-number":["MS2023033"]}],"id":[{"id":"10.13039\/501100009576","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ejphar.2025.178256","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T07:09:15Z","timestamp":1760512155000},"page":"178256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Monophosphoryl lipid A induces tolerance against single prolonged stress-induced PTSD-like behavior and neuroinflammatory responses in mice"],"prefix":"10.1016","volume":"1007","author":[{"given":"Fu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxiu","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5221-2115","authenticated-orcid":false,"given":"Chao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.178256_bib1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3389\/fphar.2018.00416","article-title":"Brain lipopolysaccharide preconditioning-induced gene reprogramming mediates a tolerance State in electroconvulsive shock model of epilepsy","volume":"9","author":"Amini","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178256_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.brat.2019.03.003","article-title":"Predictors of attendance and dropout in three randomized controlled trials of PTSD treatment for active duty service members","volume":"118","author":"Berke","year":"2019","journal-title":"Behav. Res. Ther."},{"key":"10.1016\/j.ejphar.2025.178256_bib3","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/s42003-024-07396-8","article-title":"Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism","volume":"7","author":"Bordes","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ejphar.2025.178256_bib4","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1002\/jclp.23591","article-title":"Clinician perspectives on technology-enhanced in vivo exposures during prolonged exposure therapy for PTSD","volume":"79","author":"Brown","year":"2023","journal-title":"J. Clin. Psychol."},{"key":"10.1016\/j.ejphar.2025.178256_bib5","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20220857","article-title":"Engineering an inhibitor-resistant human CSF1R variant for microglia replacement","volume":"220","author":"Chadarevian","year":"2023","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2025.178256_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108924","article-title":"Granulocyte-macrophage colony-stimulating factor-triggered innate immune tolerance against chronic stress-induced behavioral abnormalities in mice","volume":"109","author":"Chen","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2025.178256_bib7","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1128\/IAI.01150-12","article-title":"Adjuvant activity of naturally occurring monophosphoryl lipopolysaccharide preparations from mucosa-associated bacteria","volume":"81","author":"Chilton","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ejphar.2025.178256_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2021.101511","article-title":"Colony stimulating factors in the nervous system","volume":"54","author":"Chitu","year":"2021","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.ejphar.2025.178256_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2024.111201","article-title":"Methylone regulates fear memory and amygdala activity: a potential treatment for posttraumatic stress disorder?","volume":"136","author":"Chou","year":"2025","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2025.178256_bib10","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.bbi.2016.04.015","article-title":"Neurons and astroglia govern microglial endotoxin tolerance through macrophage colony-stimulating factor receptor-mediated ERK1\/2 signals","volume":"55","author":"Chu","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2025.178256_bib11","doi-asserted-by":"crossref","first-page":"6186","DOI":"10.4049\/jimmunol.0901474","article-title":"AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity","volume":"183","author":"Didierlaurent","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2025.178256_bib12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12974-020-01842-0","article-title":"Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice","volume":"17","author":"Dong","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2025.178256_bib13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/ejn.14547","article-title":"Neurobiology of resilience in depression: immune and vascular insights from human and animal studies","volume":"53","author":"Dudek","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2025.178256_bib14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1006\/jmcc.1997.0586","article-title":"Monophosphoryl lipid A induces delayed preconditioning against cardiac ischemia-reperfusion injury","volume":"30","author":"Elliott","year":"1998","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178256_bib15","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuron.2014.02.040","article-title":"Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain","volume":"82","author":"Elmore","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2025.178256_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115060","article-title":"Nicotine exposure in adolescence triggers the activation and subsequent damage of microglia in the dentate gyrus and promotes depression later in life","volume":"161","author":"Fang","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2025.178256_bib17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jpsychires.2022.07.053","article-title":"Social-single prolonged stress as an ether-free candidate animal model of post-traumatic stress disorder: female and male outcomings","volume":"154","author":"Fulco","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.ejphar.2025.178256_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113766","article-title":"BLA DBS improves anxiety and fear by correcting weakened synaptic transmission from BLA to adBNST and CeL in a mouse model of foot shock","volume":"43","author":"Gao","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2025.178256_bib19","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1038\/s41380-024-02456-1","article-title":"Enhanced fear memory after social defeat in mice is dependent on interleukin-1 receptor signaling in glutamatergic neurons","volume":"29","author":"Goodman","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ejphar.2025.178256_bib20","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bbi.2020.11.002","article-title":"Tolerance-inducing effect and properties of innate immune stimulation on chronic stress-induced behavioral abnormalities in mice","volume":"91","author":"Gu","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2025.178256_bib21","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/0031-9384(91)90360-Z","article-title":"Sex differences in the behavioral consequences of inescapable footshocks depend on time since shock","volume":"49","author":"Heinsbroek","year":"1991","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejphar.2025.178256_bib22","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1007\/s11064-018-2619-3","article-title":"Monophosphoryl lipid A and Pam3Cys prevent the increase in seizure susceptibility and epileptogenesis in rats undergoing traumatic brain injury","volume":"43","author":"Hesam","year":"2018","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ejphar.2025.178256_bib23","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1073\/pnas.1812155116","article-title":"PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R)","volume":"116","author":"Horti","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2025.178256_bib24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bbr.2018.02.045","article-title":"Neuroprotective effect of monophosphoryl lipid A, a detoxified lipid A derivative, in photothrombotic model of unilateral selective hippocampal ischemia in rat","volume":"347","author":"Hosseini","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2025.178256_bib25","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.neuroscience.2019.04.020","article-title":"Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy","volume":"408","author":"Hosseinzadeh","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2025.178256_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109126","article-title":"Innate immune stimulation prevents chronic stress-induced depressive and anxiogenic-like behaviors in female mice","volume":"111","author":"Hu","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2025.178256_bib27","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202301923RR","article-title":"Toll-like receptor 4-dependent innate immune responses are mediated by intracrine corticosteroids and activation of glycogen synthase kinase-3\u03b2 in astrocytes","volume":"38","author":"Lai","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2025.178256_bib28","doi-asserted-by":"crossref","first-page":"e82","DOI":"10.1016\/j.biopsych.2015.09.003","article-title":"Deep brain stimulation of the basolateral amygdala for treatment-refractory posttraumatic stress disorder","volume":"79","author":"Langevin","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2025.178256_bib29","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bbi.2016.05.005","article-title":"Vesicular acetylcholine transporter knock down-mice are more susceptible to inflammation, c-Fos expression and sickness behavior induced by lipopolysaccharide","volume":"57","author":"Leite","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2025.178256_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12974-020-02069-9","article-title":"Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice","volume":"18","author":"Li","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2025.178256_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119422","article-title":"Minocycline alleviates peripheral nerve adhesion by promoting regulatory macrophage polarization via the TAK1 and its downstream pathway","volume":"276","author":"Li","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.178256_bib32","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0306-4530(97)00044-9","article-title":"Stress-restress: effects on ACTH and fast feedback","volume":"22","author":"Liberzon","year":"1997","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.ejphar.2025.178256_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114004","article-title":"Fluoxetine protects against inflammation and promotes autophagy in mice model of post-traumatic stress disorder","volume":"433","author":"Lou","year":"2022","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2025.178256_bib34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-3-031-55529-9_9","article-title":"Microglial phagocytosis during embryonic and postnatal development","volume":"37","author":"Mar\u00edn-Teva","year":"2024","journal-title":"Adv. Neurobiol."},{"key":"10.1016\/j.ejphar.2025.178256_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.650176","article-title":"Prevention of diabetes-associated cognitive dysfunction through oral administration of lipopolysaccharide derived from Pantoea agglomerans","volume":"12","author":"Mizobuchi","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178256_bib36","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1096\/fj.201900567RR","article-title":"Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration","volume":"34","author":"Neal","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2025.178256_bib37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bbi.2020.12.002","article-title":"Acute neuroinflammation, sickness behavior and working memory responses to acute systemic LPS challenge following noradrenergic lesion in mice","volume":"94","author":"O'Neill","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2025.178256_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.829966","article-title":"Indole-3-Carbinol selectively prevents chronic stress-induced depression-but not anxiety-like behaviors via suppressing pro-inflammatory cytokine production and oxido-nitrosative stress in the brain","volume":"13","author":"Pan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178256_bib39","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1152\/jn.00458.2024","article-title":"Microglial modulation of neuronal network function and plasticity","volume":"133","author":"Pe\u00f1a-Ortega","year":"2025","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2025.178256_bib40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41593-024-01818-w","article-title":"Microglia as hunters or gatherers of brain synapses","volume":"28","author":"Pereira-Iglesias","year":"2025","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2025.178256_bib41","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbr.2016.01.056","article-title":"Severe, multimodal stress exposure induces PTSD-like characteristics in a mouse model of single prolonged stress","volume":"303","author":"Perrine","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2025.178256_bib42","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jbtep.2015.01.002","article-title":"Prolonged exposure, paroxetine and the combination in the treatment of PTSD following a motor vehicle accident. A randomized clinical trial - the \"TRAKT\" study","volume":"48","author":"Popiel","year":"2015","journal-title":"J. Behav. Ther. Exp. Psychiatry"},{"key":"10.1016\/j.ejphar.2025.178256_bib43","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jpsychires.2024.03.011","article-title":"Impact of PTSD treatment on postconcussive symptoms in veterans: a comparison of sertraline, prolonged exposure, and their combination","volume":"173","author":"Porter","year":"2024","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.ejphar.2025.178256_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111405","article-title":"Mobilization of the innate immune response by a specific immunostimulant \u03b2-glucan confers resistance to chronic stress-induced depression-like behavior by preventing neuroinflammatory responses","volume":"127","author":"Ren","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2025.178256_bib45","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.neuroscience.2024.09.045","article-title":"Sex differences in fear expression and persistence in an animal model of Post-Traumatic Stress Disorder","volume":"560","author":"Riccardi","year":"2024","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2025.178256_bib46","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00210-023-02578-3","article-title":"Cilostazol pretreatment prevents PTSD-related anxiety behavior through reduction of hippocampal neuroinflammation","volume":"397","author":"Sadeghi","year":"2024","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.ejphar.2025.178256_bib47","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbi.2015.03.013","article-title":"Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing","volume":"48","author":"Schaafsma","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2025.178256_bib48","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1521\/psyc.2008.71.2.134","article-title":"Nonresponse and dropout rates in outcome studies on PTSD: review and methodological considerations","volume":"71","author":"Schottenbauer","year":"2008","journal-title":"Psychiatry"},{"key":"10.1016\/j.ejphar.2025.178256_bib49","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021857","article-title":"CSF-1 receptor signaling in myeloid cells","volume":"6","author":"Stanley","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.ejphar.2025.178256_bib50","doi-asserted-by":"crossref","first-page":"8456","DOI":"10.1523\/JNEUROSCI.0821-11.2011","article-title":"Multiple preconditioning paradigms converge on interferon regulatory factor-dependent signaling to promote tolerance to ischemic brain injury","volume":"31","author":"Stevens","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2025.178256_bib51","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk9878","article-title":"Macrophage depletion protects against cisplatin-induced ototoxicity and nephrotoxicity","volume":"10","author":"Sung","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejphar.2025.178256_bib52","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1038\/s12276-024-01365-1","article-title":"ErbB4 precludes the occurrence of PTSD-like fear responses by supporting the bimodal activity of the central amygdala","volume":"56","author":"Sung","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ejphar.2025.178256_bib53","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.bbi.2023.02.015","article-title":"Purinergic P2X7 receptor-mediated inflammation precedes PTSD-related behaviors in rats","volume":"110","author":"Torres-Rodr\u00edguez","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2025.178256_bib54","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1742-2094-8-140","article-title":"LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury","volume":"8","author":"Vartanian","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2025.178256_bib55","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1210\/en.2004-0846","article-title":"Gender and puberty interact on the stress-induced activation of parvocellular neurosecretory neurons and corticotropin-releasing hormone messenger ribonucleic acid expression in the rat","volume":"146","author":"Viau","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2025.178256_bib56","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbi.2022.06.015","article-title":"Adolescent microglia stimulation produces long-lasting protection against chronic stress-induced behavioral abnormalities in adult male mice","volume":"105","author":"Wang","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2025.178256_bib57","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0736-5748(98)00021-5","article-title":"Gender differences in sympathoadrenal activity in rats at rest and in response to footshock stress","volume":"16","author":"Weinstock","year":"1998","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.ejphar.2025.178256_bib58","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade5987","article-title":"Reversal of hyperactive higher-order thalamus attenuates defensiveness in a mouse model of PTSD","volume":"9","author":"Xi","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejphar.2025.178256_bib59","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.bbi.2024.05.016","article-title":"Cannabidiol ameliorates PTSD-like symptoms by inhibiting neuroinflammation through its action on CB2 receptors in the brain of male mice","volume":"119","author":"Xie","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"Pt A","key":"10.1016\/j.ejphar.2025.178256_bib60","article-title":"Innate immune tolerance against adolescent intermittent alcohol exposure-induced behavioral abnormalities in adult mice","volume":"113","author":"Ye","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2025.178256_bib61","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.bbi.2024.08.049","article-title":"Central innate immunization induces tolerance against post-traumatic stress disorder-like behavior and neuroinflammatory responses in male mice","volume":"122","author":"Ye","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2025.178256_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176288","article-title":"Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of \u03b2-glucan on chronic stress-induced depression-like behaviors in mice","volume":"964","author":"Zhao","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178256_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176763","article-title":"Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence","volume":"978","author":"Zhu","year":"2024","journal-title":"Eur. J. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925010106?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925010106?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:30:07Z","timestamp":1779323407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925010106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":63,"alternative-id":["S0014299925010106"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178256","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Monophosphoryl lipid A induces tolerance against single prolonged stress-induced PTSD-like behavior and neuroinflammatory responses in mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178256","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178256"}}