{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:40:17Z","timestamp":1788964817616,"version":"build-2803163510"},"reference-count":236,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007831","name":"University of Tabriz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007831","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010519","name":"LSU Health New Orleans","doi-asserted-by":"publisher","award":["HL163588"],"award-info":[{"award-number":["HL163588"]}],"id":[{"id":"10.13039\/100010519","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ejphar.2025.178277","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:55:54Z","timestamp":1761353754000},"page":"178277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Overview of exosomal non-coding RNAs in cardiovascular disease using high throughput sequencing"],"prefix":"10.1016","volume":"1007","author":[{"given":"Mortaza","family":"Eivazi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Abkhooie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parnia","family":"Mobasheran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahereh","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3018-9313","authenticated-orcid":false,"given":"Vahideh","family":"Tarhriz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Lazartigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.178277_bib1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/stem.5530090307","article-title":"Carbohydrate composition of human megakaryocyte membranes in culture: identification using binding of seven lectins","volume":"9","author":"Abgrall","year":"1991","journal-title":"Int. J. Cell Clon."},{"key":"10.1016\/j.ejphar.2025.178277_bib2","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.3390\/ijms22094762","article-title":"The impact of microRNAs in renin-angiotensin-system-induced cardiac remodelling","volume":"22","author":"Adamcova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2022.105798","article-title":"Downregulation of ACE, AGTR1, and ACE2 genes mediating SARS-CoV-2 pathogenesis by gut microbiota members and their postbiotics on Caco-2 cells","volume":"173","author":"Ahmadi Badi","year":"2022","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.ejphar.2025.178277_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175233","article-title":"Downregulation of miR-21 as a promising strategy to overcome drug resistance in cancer","volume":"932","author":"Akhtarkhavari","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178277_bib5","first-page":"96","article-title":"LncRNAs NEAT1, HOTAIR, and GAS5 expression in hypertensive and non-hypertensive associated cerebrovascular stroke patients, and its link to clinical characteristics and severity score of the disease","volume":"8","author":"Ali","year":"2023","journal-title":"Noncod. RNA Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.742315","article-title":"De novo Drug Delivery Modalities for Treating Damaged Hearts: current Challenges and Emerging Solutions","volume":"8","author":"Alvi","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib7","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.150405","article-title":"Cardiomyocyte microRNA-150 confers cardiac protection and directly represses proapoptotic small proline-rich protein 1A","volume":"6","author":"Aonuma","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.ejphar.2025.178277_bib8","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.121.008686","article-title":"MiR-150 attenuates maladaptive cardiac remodeling mediated by long noncoding RNA MIAT and directly represses profibrotic Hoxa4","volume":"15","author":"Aonuma","year":"2022","journal-title":"Circ. Heart Fail"},{"key":"10.1016\/j.ejphar.2025.178277_bib9","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1073\/pnas.1019055108","article-title":"Argonaute 2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma","volume":"108","author":"Arroyo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2025.178277_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.666937","article-title":"Integrated analysis of whole genome and epigenome data using machine learning technology: toward the establishment of precision oncology","volume":"11","author":"Asada","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejphar.2025.178277_bib11","first-page":"14","article-title":"The effect of daidzein on renal injury in ovariectomized rats: interaction of angiotensin receptors and long non-coding RNAs H19, GAS5, MIAT, and rian","volume":"24","author":"Askaripour","year":"2023","journal-title":"Iran. J. Vet. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib12","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.2174\/0929867330666230515144133","article-title":"The impact of lncRNA-GAS5\/miRNA-200\/ACE2 molecular pathway on the severity of COVID-19","volume":"31","author":"Ayeldeen","year":"2024","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2025.178277_bib13","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.clinbiochem.2016.02.012","article-title":"Polymorphisms in the long non-coding RNA CDKN2B-AS1 may contribute to higher systolic blood pressure levels in hypertensive patients","volume":"49","author":"Bayoglu","year":"2016","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.ejphar.2025.178277_bib14","first-page":"27","article-title":"Targeting miRNAs and other non-coding RNAs as a therapeutic approach: an update","volume":"9","author":"Bayraktar","year":"2023","journal-title":"Noncod. RNA"},{"key":"10.1016\/j.ejphar.2025.178277_bib15","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/ATVBAHA.114.303240","article-title":"Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA","volume":"34","author":"Bell","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2025.178277_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216213","article-title":"Non-coding RNAs in human cancer and other diseases: overview of the diagnostic potential","volume":"24","author":"Be\u0148a\u010dka","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib17","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1161\/CIRCRESAHA.116.310531","article-title":"Identification and functional characterization of hypoxia-induced endoplasmic reticulum stress regulating lncRNA (HypERlnc) in pericytes","volume":"121","author":"Bischoff","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib18","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1172\/JCI38864","article-title":"Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir 143\/145 gene cluster","volume":"119","author":"Boettger","year":"2009","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2025.178277_bib19","first-page":"1433","article-title":"Early evidence for the role of lncRNA TUG1 in vascular remodelling in pulmonary hypertension","volume":"35","author":"Bonnet","year":"2019","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib20","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.biopha.2018.07.057","article-title":"Analyses of long non-coding RNA and mRNA profiles in right ventricle myocardium of acute right heart failure in pulmonary arterial hypertension rats","volume":"106","author":"Cao","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2025.178277_bib21","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3109\/10641963.2015.1036064","article-title":"Circulating miR-21 and eNOS in subclinical atherosclerosis in patients with hypertension","volume":"37","author":"Cengiz","year":"2015","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.ejphar.2025.178277_bib22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ajh.2010.211","article-title":"Interplay between miR-155, AT1R A1166C polymorphism, and AT1R expression in young untreated hypertensives","volume":"24","author":"Ceolotto","year":"2011","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ejphar.2025.178277_bib23","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.yjmcc.2013.07.002","article-title":"Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction","volume":"63","author":"Ceylan-Isik","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib24","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/2472630318780639","article-title":"Platforms for investigating LncRNA functions","volume":"23","author":"Charles Richard","year":"2018","journal-title":"SLAS Technol."},{"key":"10.1016\/j.ejphar.2025.178277_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1165\/rcmb.2017-0111OC","article-title":"The long noncoding RNA LnRPT is regulated by PDGF-BB and modulates the proliferation of pulmonary artery smooth muscle cells","volume":"58","author":"Chen","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ejphar.2025.178277_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/896861","article-title":"The ACE2\/Apelin signaling, MicroRNAs, and hypertension","volume":"2015","author":"Chen","year":"2015","journal-title":"Int. J. Hypertens."},{"key":"10.1016\/j.ejphar.2025.178277_bib27","doi-asserted-by":"crossref","first-page":"22047","DOI":"10.18632\/oncotarget.25173","article-title":"MiR-33 promotes myocardial fibrosis by inhibiting MMP16 and stimulating p38 MAPK signaling","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2025.178277_bib28","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1126\/science.1108625","article-title":"Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution","volume":"308","author":"Cheng","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2025.178277_bib29","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/s41467-019-08895-7","article-title":"Circulating myocardial microRNAs from infarcted hearts are carried in exosomes and mobilise bone marrow progenitor cells","volume":"10","author":"Cheng","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2025.178277_bib30","article-title":"Global burden of cardiovascular diseases: projections from 2025 to 2050","volume":"281","author":"Chong","year":"2024","journal-title":"Eur J. Prev. Cardiol. zwae"},{"key":"10.1016\/j.ejphar.2025.178277_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151515","article-title":"miR-410 and miR-495 are dynamically regulated in diverse cardiomyopathies and their inhibition attenuates pathological hypertrophy","volume":"11","author":"Clark","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2025.178277_bib32","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1161\/CIRCRESAHA.116.305178","article-title":"TGF\u03b2 triggers miR-143\/145 transfer from smooth muscle cells to endothelial cells, thereby modulating vessel stabilization","volume":"116","author":"Climent","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib33","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/s41467-017-01629-7","article-title":"Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells","volume":"8","author":"Das","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2025.178277_bib34","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1161\/CIRCRESAHA.118.313207","article-title":"A novel angiotensin II-Induced long noncoding RNA giver regulates oxidative stress, inflammation, and proliferation in vascular smooth muscle cells","volume":"123","author":"Das","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib35","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1161\/CIRCRESAHA.118.313207","article-title":"A novel angiotensin II-Induced long noncoding RNA giver regulates oxidative stress, inflammation, and proliferation in vascular smooth muscle cells","volume":"123","author":"Das","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib36","doi-asserted-by":"crossref","first-page":"9232","DOI":"10.1073\/pnas.1102281108","article-title":"miR-33a\/b contribute to the regulation of fatty acid metabolism and insulin signaling","volume":"108","author":"D\u00e1valos","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2025.178277_bib37","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1186\/s12967-023-04339-5","article-title":"Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development","volume":"21","author":"Dave","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib38","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41569-020-0389-5","article-title":"Native and bioengineered extracellular vesicles for cardiovascular therapeutics","volume":"17","author":"de Abreu","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib39","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3390\/biom11030388","article-title":"Circulating extracellular vesicles as biomarkers and drug delivery vehicles in cardiovascular diseases","volume":"11","author":"de Freitas","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.ejphar.2025.178277_bib40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12920-020-00817-7","article-title":"Genomic analysis of circular RNAs in heart","volume":"13","author":"Dong","year":"2020","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.ejphar.2025.178277_bib41","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1002\/jcp.29165","article-title":"CircRNA expression profiles and function prediction in peripheral blood mononuclear cells of patients with acute ischemic stroke","volume":"235","author":"Dong","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib42","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1161\/CIRCULATIONAHA.123.067861","article-title":"LncRNA DCRT protects against dilated cardiomyopathy by preventing NDUFS2 alternative splicing by binding to PTBP1","volume":"150","author":"Du","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2025.178277_bib43","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkr774","article-title":"Label-free high-throughput microRNA expression profiling from total RNA","volume":"39","author":"Duan","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2024.102173","article-title":"Control of endothelial cell function and arteriogenesis by MEG3:EZH2 epigenetic regulation of integrin expression","volume":"35","author":"Dunn-Davies","year":"2024","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.ejphar.2025.178277_bib45","first-page":"557","article-title":"[Ultrastructure and histology in \u201chealed\u201d stromal herpes keratitis]","volume":"84","author":"Ehgartner","year":"1987","journal-title":"Fortschr. Ophthalmol."},{"key":"10.1016\/j.ejphar.2025.178277_bib46","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.molcel.2019.12.005","article-title":"The dynamics of cytoplasmic mRNA metabolism","volume":"77","author":"Eisen","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejphar.2025.178277_bib47","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/cdd.2009.153","article-title":"The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease","volume":"16","author":"Elia","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2025.178277_bib48","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2025.178277_bib49","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.1021\/acsomega.2c07960","article-title":"LncRNA-GAS5 and \u03b2-Catenin as independent predictors of asymptomatic organ damage in nondiabetic hypertensive patients","volume":"8","author":"Esawy","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.ejphar.2025.178277_bib50","doi-asserted-by":"crossref","first-page":"11190","DOI":"10.3390\/ijms140611190","article-title":"Angiotensin II regulates microRNA-132\/-212 in hypertensive rats and humans","volume":"14","author":"Eskildsen","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib51","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1177\/1470320314539367","article-title":"The microRNA-132\/212 family fine-tunes multiple targets in Angiotensin II signalling in cardiac fibroblasts","volume":"16","author":"Eskildsen","year":"2015","journal-title":"J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.ejphar.2025.178277_bib52","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20182229","article-title":"LncRNA MRAK048635_P1 is critical for vascular smooth muscle cell function and phenotypic switching in essential hypertension","volume":"39","author":"Fang","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ejphar.2025.178277_bib53","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s12967-015-0672-0","article-title":"Circulating microRNAs as biomarkers for diffuse myocardial fibrosis in patients with hypertrophic cardiomyopathy","volume":"13","author":"Fang","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib54","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1161\/CIRCRESAHA.120.316489","article-title":"miR-128-3p is a novel regulator of vascular smooth muscle cell phenotypic switch and vascular diseases","volume":"126","author":"Farina","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib55","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1161\/CIRCRESAHA.120.316489","article-title":"miR-128-3p is a novel regulator of vascular smooth muscle cell phenotypic switch and vascular diseases","volume":"126","author":"Farina","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-76202-6","article-title":"Understanding the heterogeneous performance of variant effect predictors across human protein-coding genes","volume":"14","author":"Fawzy","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.178277_bib57","doi-asserted-by":"crossref","first-page":"638","DOI":"10.3390\/cells10030638","article-title":"Molecular and genetic profiling for precision medicines in pulmonary arterial hypertension","volume":"10","author":"Fazal","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2025.178277_bib58","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/HYPERTENSIONAHA.111.185801","article-title":"Exercise training prevents the microvascular rarefaction in hypertension balancing angiogenic and apoptotic factors: role of microRNAs-16, -21, and -126","volume":"59","author":"Fernandes","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.178277_bib59","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3389\/fimmu.2014.00370","article-title":"Extracellular vesicles as therapeutic tools in cardiovascular diseases","volume":"5","author":"Fleury","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178277_bib60","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.09.008","article-title":"Plasma miR-126 and miR-143 as potential novel biomarkers for cerebral atherosclerosis","volume":"28","author":"Gao","year":"2019","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.ejphar.2025.178277_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101596","article-title":"Optimized protocols for RNA-induced silencing complex assembly and cleavage in cultured drosophila cells","volume":"3","author":"Gao","year":"2022","journal-title":"STAR Protoc."},{"key":"10.1016\/j.ejphar.2025.178277_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175220","article-title":"The key roles of non-coding RNAs in the pathophysiology of hypertension","volume":"931","author":"Ghafouri-Fard","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178277_bib63","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1093\/cvr\/cvae163","article-title":"Hypoxia-responsive zinc finger E-box-binding homeobox 2 (ZEB2) regulates a network of calcium-handling genes in the injured heart","volume":"120","author":"Gladka","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib64","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/ajh\/hpaa144","article-title":"MicroRNA-183 as a novel regulator protects against cardiomyocytes hypertrophy via targeting TIAM1","volume":"35","author":"Gong","year":"2022","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.ejphar.2025.178277_bib65","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1933719109351935","article-title":"Brain renin-angiotensin system: fetal epigenetic programming by maternal protein restriction during pregnancy","volume":"17","author":"Goyal","year":"2010","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib66","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.3892\/mmr.2014.3102","article-title":"Aberrant expression of long noncoding RNAs in chronic thromboembolic pulmonary hypertension","volume":"11","author":"Gu","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2025.178277_bib67","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202114060","article-title":"rs41291957 controls miR-143 and miR-145 expression and impacts coronary artery disease risk","volume":"13","author":"Hall","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib68","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3389\/fgene.2020.00212","article-title":"Circular RNA-expression profiling reveals a potential role of Hsa_circ_0097435 in heart failure via sponging multiple MicroRNAs","volume":"11","author":"Han","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.ejphar.2025.178277_bib69","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13045-022-01280-w","article-title":"Single-cell sequencing: a promising approach for uncovering the mechanisms of tumor metastasis","volume":"15","author":"Han","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ejphar.2025.178277_bib70","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2025.178277_bib71","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1073\/pnas.0707493105","article-title":"MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1","volume":"105","author":"Harris","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2025.178277_bib72","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1161\/CIRCRESAHA.121.318082","article-title":"Pathophysiology of hypertension: the mosaic theory and beyond","volume":"128","author":"Harrison","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib73","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s12935-023-03080-9","article-title":"The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies","volume":"23","author":"Hassani","year":"2023","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.ejphar.2025.178277_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105478","article-title":"miR-125a-5p\/miR-125b-5p contributes to pathological activation of angiotensin II-AT1R in mouse distal convoluted tubule cells by the suppression of Atrap","volume":"299","author":"Hirota","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2025.178277_bib75","doi-asserted-by":"crossref","first-page":"bbad307","DOI":"10.1093\/bib\/bbad307","article-title":"A systematic benchmark of machine learning methods for protein-RNA interaction prediction","volume":"24","author":"Horlacher","year":"2023","journal-title":"Briefings Bioinf."},{"key":"10.1016\/j.ejphar.2025.178277_bib76","article-title":"Mechanical stretch suppresses microRNA-145 expression by activating extracellular signal-regulated kinase 1\/2 and upregulating angiotensin-converting enzyme to alter vascular smooth muscle cell phenotype","volume":"9","author":"Hu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2025.178277_bib77","first-page":"2","article-title":"Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease","volume":"21","author":"Hu","year":"2019","journal-title":"Anatol. J. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib78","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2018.1518628","article-title":"lncRNA MALAT1 binds chromatin remodeling subunit BRG1 to epigenetically promote inflammation-related hepatocellular carcinoma progression","volume":"8","author":"Huang","year":"2019","journal-title":"OncoImmunology"},{"key":"10.1016\/j.ejphar.2025.178277_bib79","doi-asserted-by":"crossref","first-page":"6860","DOI":"10.1111\/jcmm.15343","article-title":"Overexpression of long non-coding RNA ANRIL promotes post-ischaemic angiogenesis and improves cardiac functions by targeting Akt","volume":"24","author":"Huang","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib80","first-page":"192","article-title":"Identification of differentially expressed circular RNAs during TGF-\u00df1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells","volume":"19","author":"Huang","year":"2018","journal-title":"Anatol. J. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.773314","article-title":"miR-208a in cardiac hypertrophy and remodeling","volume":"8","author":"Huang","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib82","first-page":"4055","article-title":"microRNA-125b contributes to high glucose-induced reactive oxygen species generation and apoptosis in HK-2 renal tubular epithelial cells by targeting angiotensin-converting enzyme 2","volume":"20","author":"Huang","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib83","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/s42003-024-07050-3","article-title":"MiR-21-3p inhibitor exerts myocardial protective effects by altering macrophage polarization state and reducing excessive mitophagy","volume":"7","author":"Huang","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ejphar.2025.178277_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003694","article-title":"Detection of microRNA expression in human peripheral blood microvesicles","volume":"3","author":"Hunter","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2025.178277_bib85","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/s41440-020-0453-x","article-title":"Neural suppression of miRNA-181a in the kidney elevates renin expression and exacerbates hypertension in Schlager mice","volume":"43","author":"Jackson","year":"2020","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib86","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1167\/iovs.14-14803","article-title":"Identification of a novel mucin gene HCG22 associated with steroid-induced ocular hypertension","volume":"56","author":"Jeong","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib87","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/kjm2.12774","article-title":"Mesenchymal stem cells-derived extracellular vesicle-incorporated H19 attenuates cardiac remodeling in rats with heart failure","volume":"40","author":"Jiao","year":"2024","journal-title":"Kaohsiung J. Med. Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib88","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1161\/HYPERTENSIONAHA.117.09651","article-title":"AK098656, a novel vascular smooth muscle cell-dominant long noncoding RNA, promotes hypertension","volume":"71","author":"Jin","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.178277_bib89","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/apha.12700","article-title":"PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells","volume":"218","author":"Josipovic","year":"2016","journal-title":"Acta Physiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib90","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1161\/CIR.0000000000001256","article-title":"Forecasting the burden of cardiovascular disease and stroke in the United States through 2050-Prevalence of risk factors and disease: a presidential advisory from the American heart association","volume":"150","author":"Joynt Maddox","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2025.178277_bib91","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/HYPERTENSIONAHA.119.13412","article-title":"Noncoding RNAs in hypertension","volume":"74","author":"Jusic","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.178277_bib92","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.yjmcc.2014.06.008","article-title":"Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system","volume":"75","author":"Kemp","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib93","doi-asserted-by":"crossref","first-page":"11667","DOI":"10.1073\/pnas.0904715106","article-title":"Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression","volume":"106","author":"Khalil","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2025.178277_bib94","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.3390\/ijms25105507","article-title":"Long noncoding RNA MALAT1: salt-sensitive hypertension","volume":"25","author":"Khan","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2023.101821","article-title":"Advances and challenges for GWAS analysis in cardiac diseases: a focus on coronary artery disease (CAD)","volume":"48","author":"Khan","year":"2023","journal-title":"Curr. Probl. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib96","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.phrs.2017.11.003","article-title":"Hypertension and cardiovascular risk: general aspects","volume":"129","author":"Kjeldsen","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib97","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2013.09.006","article-title":"The next-generation sequencing revolution and its impact on genomics","volume":"155","author":"Koboldt","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2025.178277_bib98","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1161\/CIRCRESAHA.113.301282","article-title":"AMP-Activated protein kinase regulates endothelial cell angiotensin-converting enzyme expression via p53 and the post-transcriptional regulation of microRNA-143\/145","volume":"112","author":"Kohlstedt","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib99","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/jhh.2013.117","article-title":"Differential expression of vascular smooth muscle-modulating microRNAs in human peripheral blood mononuclear cells: novel targets in essential hypertension","volume":"28","author":"Kontaraki","year":"2014","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.ejphar.2025.178277_bib100","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1161\/CIRCRESAHA.114.303915","article-title":"Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure","volume":"114","author":"Kumarswamy","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib101","doi-asserted-by":"crossref","first-page":"H1276","DOI":"10.1152\/ajpheart.00571.2020","article-title":"Characterization of \u03b2ARKct engineered cellular extracellular vesicles and model specific cardioprotection","volume":"320","author":"Kwon","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib102","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijcard.2015.07.043","article-title":"Micro-RNA and mRNA myocardial tissue expression in biopsy specimen from patients with heart failure","volume":"199","author":"Lai","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib103","article-title":"Elevated MicroRNA 183 impairs trophoblast migration and invasiveness by downregulating FOXP1 expression and elevating GNG7 expression during preeclampsia","volume":"41","author":"Lai","year":"2020","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2025.178277_bib104","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.2174\/138161207780618911","article-title":"The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases","volume":"13","author":"Lazartigues","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejphar.2025.178277_bib105","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/CIRCULATIONAHA.116.026991","article-title":"Long noncoding RNA MANTIS facilitates endothelial angiogenic function","volume":"136","author":"Leisegang","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2025.178277_bib106","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCRESAHA.112.300849","article-title":"Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells","volume":"113","author":"Leung","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib107","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1161\/CIRCULATIONAHA.116.023926","article-title":"MicroRNA-21 lowers blood pressure in spontaneous hypertensive rats by upregulating mitochondrial translation","volume":"134","author":"Li","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2025.178277_bib108","first-page":"87","article-title":"An NGS workflow blueprint for DNA sequencing data and its application in individualized molecular oncology","volume":"14","author":"Li","year":"2015","journal-title":"Cancer Inf."},{"key":"10.1016\/j.ejphar.2025.178277_bib109","first-page":"1701","article-title":"Expression of miR-376 in blood of pregnant women with preeclampsia and its effect on 25-hydroxyvitamin D","volume":"16","author":"Li","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib110","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/febs.14191","article-title":"Biogenesis of circular RNAs and their roles in cardiovascular development and pathology","volume":"285","author":"Li","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.ejphar.2025.178277_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176315","article-title":"Sodium butyrate alleviates right ventricular hypertrophy in pulmonary arterial hypertension by inhibiting H19 and affecting the activation of let-7g-5p\/IGF1 receptor\/ERK","volume":"965","author":"Li","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178277_bib112","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2024.109912","article-title":"Exosomal lncRNA-MIAT promotes neovascularization via the miR-133a-3p\/MMP-X1 axis in diabetic retinopathy","volume":"243","author":"Li","year":"2024","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib113","first-page":"2796","article-title":"Downregulated microRNA-133a induces HUVECs injury: potential role of the (pro) renin receptor in angiotensin II-dependent hypertension","volume":"20","author":"Liu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2025.178277_bib114","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s12012-024-09915-9","article-title":"Exosomes from hypoxic pretreatment ADSCs ameliorate cardiac damage Post-MI via activated circ-Stt3b\/miR-15a-5p\/GPX4 signaling and decreased ferroptosis","volume":"24","author":"Liu","year":"2024","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.ejphar.2025.178277_bib115","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1097\/HJH.0000000000001769","article-title":"MicroRNA-19a\/b-3p protect the heart from hypertension-induced pathological cardiac hypertrophy through PDE5A","volume":"36","author":"Liu","year":"2018","journal-title":"J. Hypertens."},{"key":"10.1016\/j.ejphar.2025.178277_bib116","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12265-017-9784-7","article-title":"miRNA profiling of exosomes from spontaneous hypertensive rats using next-generation sequencing","volume":"12","author":"Liu","year":"2019","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib117","doi-asserted-by":"crossref","first-page":"149","DOI":"10.31083\/j.fbl2904149","article-title":"Exosomal CircRNAs in circulation serve as diagnostic biomarkers for acute myocardial infarction","volume":"29","author":"Liu","year":"2024","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.ejphar.2025.178277_bib118","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1002\/jcp.26279","article-title":"LncRNA-TCONS_00034812 in cell proliferation and apoptosis of pulmonary artery smooth muscle cells and its mechanism","volume":"233","author":"Liu","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib119","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1161\/HYPERTENSIONAHA.120.14592","article-title":"Developmental and early life origins of cardiometabolic risk factors: novel findings and implications","volume":"77","author":"Lurbe","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.178277_bib120","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.734514","article-title":"A bibliometric analysis of exosomes in cardiovascular diseases from 2001 to 2021","volume":"8","author":"Ma","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib121","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41580-023-00612-z","article-title":"The contribution of databases towards understanding the universe of long non-coding RNAs","volume":"24","author":"Ma","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2025.178277_bib122","doi-asserted-by":"crossref","first-page":"H954","DOI":"10.1152\/ajpheart.00835.2012","article-title":"Cardiac myocyte exosomes: stability, HSP60, and proteomics","volume":"304","author":"Malik","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib123","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1042\/BST0361091","article-title":"Next-generation sequencing: applications beyond genomes","volume":"36","author":"Marguerat","year":"2008","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.ejphar.2025.178277_bib124","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1161\/CIRCRESAHA.112.265736","article-title":"Direct and indirect involvement of microRNA-499 in clinical and experimental cardiomyopathy","volume":"111","author":"Matkovich","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib125","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2025.178277_bib126","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.3390\/ijms22031390","article-title":"Novel identified circular transcript of RCAN2, circ-RCAN2, shows deviated expression pattern in pig reperfused infarcted myocardium and hypoxic Porcine cardiac progenitor cells in vitro","volume":"22","author":"Mester-Tonczar","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib127","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1161\/CIRCRESAHA.114.303265","article-title":"Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth","volume":"114","author":"Michalik","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib128","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1186\/s13104-017-2715-5","article-title":"TNF-\u03b1-induced miR-155 regulates IL-6 signaling in rheumatoid synovial fibroblasts","volume":"10","author":"Migita","year":"2017","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.ejphar.2025.178277_bib129","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1042\/CS20200483","article-title":"Brain angiotensin converting enzyme-2 in central cardiovascular regulation","volume":"134","author":"Mohammed","year":"2020","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.ejphar.2025.178277_bib130","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/jcmm.12236","article-title":"Methodological challenges in utilizing miRNAs as circulating biomarkers","volume":"18","author":"Moldovan","year":"2014","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib131","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1161\/CIRCULATIONAHA.111.030932","article-title":"Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure","volume":"124","author":"Montgomery","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2025.178277_bib132","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3390\/genes1010070","article-title":"Next generation sequencing of miRNAs - Strategies, resources and methods","volume":"1","author":"Motameny","year":"2010","journal-title":"Genes"},{"key":"10.1016\/j.ejphar.2025.178277_bib133","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41420-022-01295-9","article-title":"MiR-150 blunts cardiac dysfunction in mice with cardiomyocyte loss of \u03b21-adrenergic receptor\/\u03b2-arrestin signaling and controls a unique transcriptome","volume":"8","author":"Moukette","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.ejphar.2025.178277_bib134","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1172\/JCI61716","article-title":"MicroRNA-155 promotes atherosclerosis by repressing Bcl 6 in macrophages","volume":"122","author":"Nazari-Jahantigh","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2025.178277_bib135","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00395-024-01048-y","article-title":"Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival","volume":"119","author":"Neufeldt","year":"2024","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib136","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.53514","article-title":"Cost-effectiveness of whole-genome vs whole-exome sequencing among children with suspected genetic disorders","volume":"7","author":"Nurchis","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.ejphar.2025.178277_bib137","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12967-020-02298-9","article-title":"Optimization of small RNA library preparation protocol from human urinary exosomes","volume":"18","author":"Olivares","year":"2020","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib138","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1161\/CIRCULATIONAHA.113.007917","article-title":"Cross talk of combined gene and cell therapy in ischemic heart disease: role of exosomal microRNA transfer","volume":"130","author":"Ong","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2025.178277_bib139","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1172\/JCI81676","article-title":"MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis","volume":"125","author":"Ouimet","year":"2015","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2025.178277_bib140","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1161\/HYPERTENSIONAHA.124.22072","article-title":"Genetic and epigenetic mechanisms regulating blood pressure and kidney dysfunction","volume":"81","author":"Pandey","year":"2024","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.178277_bib141","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/HYPERTENSIONAHA.120.16598","article-title":"Urinary- and plasma-derived exosomes reveal a distinct MicroRNA signature associated with albuminuria in hypertension","volume":"77","author":"Perez-Hernandez","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.178277_bib142","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1093\/nar\/gkt1300","article-title":"Combining DGE and RNA-sequencing data to identify new polyA+ non-coding transcripts in the human genome","volume":"42","author":"Philippe","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib143","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1093\/eurheartj\/ehx165","article-title":"Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives","volume":"39","author":"Poller","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ejphar.2025.178277_bib144","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1161\/CIRCRESAHA.117.306949","article-title":"Novel role of miR-33 in regulating of mitochondrial function","volume":"117","author":"Price","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib145","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.lfs.2019.05.012","article-title":"Current research trends and challenges in tissue engineering for mending broken hearts","volume":"229","author":"Qasim","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib146","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1083\/jcb.200912096","article-title":"MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro","volume":"189","author":"Quintavalle","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejphar.2025.178277_bib147","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0274277","article-title":"A meta-analysis of the relationship between circulating microRNA-155 and coronary artery disease","volume":"18","author":"Ran","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2025.178277_bib148","doi-asserted-by":"crossref","DOI":"10.1002\/jex2.152","article-title":"Bone marrow-fibroblast progenitor cell-derived small extracellular vesicles promote cardiac fibrosis via miR-21-5p and integrin subunit \u03b1V signalling","volume":"3","author":"Ranjan","year":"2024","journal-title":"J. Extracell Biol."},{"key":"10.1016\/j.ejphar.2025.178277_bib149","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1053\/j.gastro.2012.03.040","article-title":"Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis","volume":"143","author":"Rautou","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2025.178277_bib150","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1126\/science.1189862","article-title":"MiR-33 contributes to the regulation of cholesterol homeostasis","volume":"328","author":"Rayner","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2025.178277_bib151","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1161\/HYPERTENSIONAHA.121.16509","article-title":"Advances in genomics research of blood pressure responses to dietary sodium and potassium intakes","volume":"78","author":"Razavi","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.178277_bib152","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","article-title":"Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs","volume":"129","author":"Rinn","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2025.178277_bib153","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1759","article-title":"Characterization of circular RNAs with advanced sequencing technologies in human complex diseases","volume":"14","author":"Ruan","year":"2023","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.ejphar.2025.178277_bib154","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1161\/01.RES.86.12.1266","article-title":"Angiotensin II activates nuclear transcription factor kappaB through AT(1) and AT(2) in vascular smooth muscle cells: molecular mechanisms","volume":"86","author":"Ruiz-Ortega","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib155","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1152\/physiolgenomics.00140.2023","article-title":"Integrated miRNA-mRNA networks underlie attenuation of chronic \u03b2-adrenergic stimulation-induced cardiac remodeling by minocycline","volume":"56","author":"Russell","year":"2024","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.ejphar.2025.178277_bib156","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3390\/ijms19030688","article-title":"Advances in the genetics of hypertension: the effect of rare variants","volume":"19","author":"Russo","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib157","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.molcel.2015.03.027","article-title":"Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed","volume":"58","author":"Rybak-Wolf","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejphar.2025.178277_bib158","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.3390\/cells10061480","article-title":"In silico identification of miRNA-lncRNA interactions in Male reproductive disorder associated with COVID-19 infection","volume":"10","author":"Sabetian","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2025.178277_bib159","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1172\/JCI69608","article-title":"Apelin is a positive regulator of ACE2 in failing hearts","volume":"123","author":"Sato","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2025.178277_bib160","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1042\/CS20140417","article-title":"Circulating toll-like receptor 4-responsive microRNA panel in patients with coronary artery disease: results from prospective and randomized study of treatment with renin-angiotensin system blockade","volume":"128","author":"Satoh","year":"2015","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.ejphar.2025.178277_bib161","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2174\/1872210517666230721123453","article-title":"The emergence of nanotechnology in the prognosis and treatment of myocardial infarctions","volume":"19","author":"Sharma","year":"2025","journal-title":"Recent Pat. Nanotechnol."},{"key":"10.1016\/j.ejphar.2025.178277_bib162","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.2174\/0113862073265220231004071645","article-title":"Alleviation of angiotensin II-Induced vascular endothelial cell injury through long non-coding RNA TUG1 inhibition","volume":"27","author":"Shi","year":"2024","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.ejphar.2025.178277_bib163","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.drudis.2015.05.007","article-title":"Mechanisms and therapeutic potential of microRNAs in hypertension","volume":"20","author":"Shi","year":"2015","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejphar.2025.178277_bib164","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.bbrc.2018.05.049","article-title":"The lncRNA TUG1\/miR-145-5p\/FGF10 regulates proliferation and migration in VSMCs of hypertension","volume":"501","author":"Shi","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2025.178277_bib165","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.yjmcc.2017.06.015","article-title":"Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease","volume":"109","author":"Siede","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib166","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.3390\/cells12121629","article-title":"Clinical significance of MicroRNAs, long non-coding RNAs, and CircRNAs in cardiovascular diseases","volume":"12","author":"Singh","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2025.178277_bib167","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejps.2019.02.013","article-title":"Effect of plasma MicroRNA on antihypertensive response to beta blockers in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) studies","volume":"131","author":"Solayman","year":"2019","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib168","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173374","article-title":"MicroRNA-122 aggravates angiotensin II-mediated apoptosis and autophagy imbalance in rat aortic adventitial fibroblasts via the modulation of SIRT6-elabela-ACE2 signaling","volume":"883","author":"Song","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178277_bib169","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56617-2","article-title":"Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy","volume":"9","author":"Sonnenschein","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.178277_bib170","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s44161-022-00018-8","article-title":"Extensive identification of genes involved in congenital and structural heart disorders and cardiomyopathy","volume":"1","author":"Spielmann","year":"2022","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib171","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s12931-018-0956-z","article-title":"LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through AT1R via sponging let-7b in monocrotaline-induced pulmonary arterial hypertension","volume":"19","author":"Su","year":"2018","journal-title":"Respir. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib172","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.gene.2019.04.010","article-title":"RNA sequencing revealing the role of AMP-activated protein kinase signaling in mice myocardial ischemia reperfusion injury","volume":"703","author":"Sun","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.ejphar.2025.178277_bib173","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s12957-021-02392-2","article-title":"Serum lncRNA-ANRIL and SOX9 expression levels in glioma patients and their relationship with poor prognosis","volume":"19","author":"Sun","year":"2021","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.ejphar.2025.178277_bib174","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1159\/000480218","article-title":"Long non-coding RNA MEG3 downregulation triggers human pulmonary artery smooth muscle cell proliferation and migration via the p53 signaling pathway","volume":"42","author":"Sun","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.ejphar.2025.178277_bib175","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s42003-022-03668-3","article-title":"Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM","volume":"5","author":"Suzuki","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.ejphar.2025.178277_bib176","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1042\/CS20100003","article-title":"Expression of miR-146a\/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin-angiotensin system blockade and statins on miRNA-146a\/b and Toll-like receptor 4 levels","volume":"119","author":"Takahashi","year":"2010","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.ejphar.2025.178277_bib177","first-page":"298","article-title":"A landscape of circular RNA expression in the human heart","volume":"113","author":"Tan","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib178","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1016\/j.bbadis.2019.05.022","article-title":"LncRNA GAS5 regulates vascular smooth muscle cell cycle arrest and apoptosis via p53 pathway","volume":"1865","author":"Tang","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.ejphar.2025.178277_bib179","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6758934","article-title":"Long noncoding RNA TUG1 promotes the function in ox-LDL-Treated HA-VSMCs via miR-141-3p\/ROR2 axis","author":"Tang","year":"2020","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.ejphar.2025.178277_bib180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21037\/cdt-20-518","article-title":"MiR-155 acts as an inhibitory factor in atherosclerosis-associated arterial pathogenesis by down-regulating NoxA 1 related signaling pathway in ApoE-\/- mouse","volume":"11","author":"Tang","year":"2021","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"10.1016\/j.ejphar.2025.178277_bib181","doi-asserted-by":"crossref","first-page":"E191","DOI":"10.1152\/ajpendo.00268.2017","article-title":"ANRIL regulates production of extracellular matrix proteins and vasoactive factors in diabetic complications","volume":"314","author":"Thomas","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2025.178277_bib182","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0219013","article-title":"Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute stanford type A aortic dissection","volume":"14","author":"Tian","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2025.178277_bib183","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41435-021-00154-4","article-title":"Dysregulation of long noncoding RNA MEG3 and NLRC5 expressions in patients with relapsing-remitting multiple sclerosis: is there any correlation?","volume":"22","author":"Torkamandi","year":"2021","journal-title":"Gene Immun."},{"key":"10.1016\/j.ejphar.2025.178277_bib184","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12967-023-04820-1","article-title":"LIPCAR levels in plasma-derived extracellular vesicles is associated with left ventricle remodeling post-myocardial infarction","volume":"22","author":"Turkieh","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib185","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1582-4934.2008.00613.x","article-title":"Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis","volume":"13","author":"van Solingen","year":"2009","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib186","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s13059-015-0801-3","article-title":"Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development","volume":"16","author":"Ven\u00f8","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.ejphar.2025.178277_bib187","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1152\/physrev.00024.2022","article-title":"Genome-wide association studies of cardiovascular disease","volume":"103","author":"Walsh","year":"2023","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2025.178277_bib188","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12885-017-3151-6","article-title":"A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis","volume":"17","author":"Wang","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ejphar.2025.178277_bib189","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118788","article-title":"Circular RNA Arhgap12 modulates doxorubicin-induced cardiotoxicity by sponging miR-135a-5p","volume":"265","author":"Wang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib190","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13098-022-00783-3","article-title":"AK098656: a new biomarker of coronary stenosis severity in hypertensive and coronary heart disease patients","volume":"14","author":"Wang","year":"2022","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.ejphar.2025.178277_bib191","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1161\/HYPERTENSIONAHA.116.07259","article-title":"Long noncoding RNA-GAS5: a novel regulator of hypertension-induced vascular remodeling","volume":"68","author":"Wang","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.178277_bib192","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1373\/clinchem.2010.147405","article-title":"The microRNA spectrum in 12 body fluids","volume":"56","author":"Weber","year":"2010","journal-title":"Clin. Chem."},{"key":"10.1016\/j.ejphar.2025.178277_bib193","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3390\/medicina60010149","article-title":"In-Hospital levels of circulating MicroRNAs as potential predictors of left ventricular remodeling post-myocardial infarction","volume":"60","author":"W\u0119giel","year":"2024","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.ejphar.2025.178277_bib194","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/9497716","article-title":"miR-145 alleviates smooth muscle cell phenotype transition via ADAM17-Mediated ACE2 shedding","author":"Wen","year":"2023","journal-title":"Int. J. Hypertens."},{"key":"10.1016\/j.ejphar.2025.178277_bib195","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10863-020-09829-5","article-title":"Effect of miR-26a-5p targeting ADAM17 gene on apoptosis, inflammatory factors and oxidative stress response of myocardial cells in hypoxic model","volume":"52","author":"Wen","year":"2020","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.ejphar.2025.178277_bib196","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41573-021-00219-z","article-title":"Noncoding RNA therapeutics - challenges and potential solutions","volume":"20","author":"Winkle","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2025.178277_bib197","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/HYPERTENSIONAHA.118.11126","article-title":"Noncoding RNAs in the regulatory network of hypertension","volume":"72","author":"Wu","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.178277_bib198","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3892\/mmr.2021.12504","article-title":"Exosomal microRNA-302a promotes trophoblast migration and proliferation, and represses angiogenesis by regulating the expression levels of VEGFA in preeclampsia","volume":"24","author":"Wu","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2025.178277_bib199","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3178642","article-title":"Plasma-derived exosomal circular RNA hsa_circ_0005540 as a novel diagnostic biomarker for coronary artery disease","author":"Wu","year":"2020","journal-title":"Dis. Markers"},{"key":"10.1016\/j.ejphar.2025.178277_bib200","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1038\/s41467-019-09572-5","article-title":"Genome-wide association study of medication-use and associated disease in the UK biobank","volume":"10","author":"Wu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2025.178277_bib201","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s11906-010-0105-7","article-title":"Angiotensin-converting enzyme 2: central regulator for cardiovascular function","volume":"12","author":"Xia","year":"2010","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.ejphar.2025.178277_bib202","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1308345","article-title":"New insight on microglia activation in neurodegenerative diseases and therapeutics","volume":"17","author":"Xu","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejphar.2025.178277_bib203","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1177\/15353702211036055","article-title":"Circulating LIPCAR is a potential biomarker of heart failure in patients post-acute myocardial infarction","volume":"246","author":"Yan","year":"2021","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib204","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/cvr\/cvu254","article-title":"miR-21-3p regulates cardiac hypertrophic response by targeting histone deacetylase-8","volume":"105","author":"Yan","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib205","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114540","article-title":"MiR-520b inhibits endothelial activation by targeting NF-\u03baB p65-VCAM1 axis","volume":"188","author":"Yang","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178277_bib206","first-page":"4350","article-title":"Exosomes derived from cardiomyocytes promote cardiac fibrosis via myocyte-fibroblast cross-talk","volume":"10","author":"Yang","year":"2018","journal-title":"Am J. Transl. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib207","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116769","article-title":"LncRNA Tug1 involves in the pulmonary vascular remodeling in mice with hypoxic pulmonary hypertension via the microRNA-374c-mediated Foxc1","volume":"237","author":"Yang","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib208","first-page":"2700","article-title":"Notoginsenoside R1 reduces blood pressure in spontaneously hypertensive rats through a long non-coding RNA AK094457","volume":"8","author":"Yang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.ejphar.2025.178277_bib209","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.molcel.2010.03.021","article-title":"Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a","volume":"38","author":"Yap","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejphar.2025.178277_bib210","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1530\/REP-16-0373","article-title":"miR-361-3p regulates FSH by targeting FSHB in a porcine anterior pituitary cell model","volume":"153","author":"Ye","year":"2017","journal-title":"Reproduction"},{"key":"10.1016\/j.ejphar.2025.178277_bib211","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.3892\/etm.2017.4886","article-title":"Role of miR-128 in hypertension-induced myocardial injury","volume":"14","author":"Yin","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib212","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120317","article-title":"Angelol-A exerts anti-metastatic and anti-angiogenic effects on human cervical carcinoma cells by modulating the phosphorylated-ERK\/miR-29a-3p that targets the MMP2\/VEGFA axis","volume":"296","author":"Ying","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.178277_bib213","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s12931-024-02895-y","article-title":"LncRNAH19 acts as a ceRNA of let-7 g to facilitate endothelial-to-mesenchymal transition in hypoxic pulmonary hypertension via regulating TGF-\u03b2 signalling pathway","volume":"25","author":"Yu","year":"2024","journal-title":"Respir. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib214","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/cbin.12001","article-title":"HypERlnc attenuates angiotensin II-induced cardiomyocyte hypertrophy via promoting SIRT1 SUMOylation-mediated activation of PGC-1\u03b1\/PPAR\u03b1 pathway in AC16 cells","volume":"47","author":"Yue","year":"2023","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.ejphar.2025.178277_bib215","article-title":"Inhibition of miR-199a-3p in a murine hypertrophic cardiomyopathy (HCM) model attenuates fibrotic remodeling","volume":"6","author":"Zalivina","year":"2023","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib216","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1161\/CIRCRESAHA.110.226357","article-title":"Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes","volume":"107","author":"Zampetaki","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib217","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s12012-024-09922-w","article-title":"LncRNA MALAT1 to enhance pyroptosis in viral myocarditis through UPF1-Mediated SIRT6 mRNA decay and Wnt-\u03b2-Catenin signal pathway","volume":"24","author":"Zeng","year":"2024","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.ejphar.2025.178277_bib218","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1172\/JCI24403","article-title":"Ets-1 is a critical regulator of ang II-mediated vascular inflammation and remodeling","volume":"115","author":"Zhan","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2025.178277_bib219","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1111\/jcmm.13471","article-title":"ACE2-EPC-EXs protect ageing ECs against hypoxia\/reoxygenation-induced injury through the miR-18a\/Nox 2\/ROS pathway","volume":"22","author":"Zhang","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2025.178277_bib220","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/cvr\/cvy250","article-title":"Long noncoding RNA Hoxaas3 contributes to hypoxia-induced pulmonary artery smooth muscle cell proliferation","volume":"115","author":"Zhang","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ejphar.2025.178277_bib221","doi-asserted-by":"crossref","first-page":"7766","DOI":"10.3892\/mmr.2017.7575","article-title":"Circulating miRNA-21 is a promising biomarker for heart failure","volume":"16","author":"Zhang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2025.178277_bib222","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1161\/HYPERTENSIONAHA.120.16395","article-title":"Long noncoding RNA Tug1 promotes angiotensin II-Induced renal fibrosis by binding to mineralocorticoid receptor and negatively regulating MicroR-29b-3p","volume":"78","author":"Zhang","year":"2021","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.178277_bib223","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1471-2164-7-153","article-title":"Identical probes on different high-density oligonucleotide microarrays can produce different measurements of gene expression","volume":"7","author":"Zhang","year":"2006","journal-title":"BMC Genom."},{"key":"10.1016\/j.ejphar.2025.178277_bib224","first-page":"6981","article-title":"Anti-hypertensive effect of Lycium barbarum L. with down-regulated expression of renal endothelial lncRNA sONE in a rat model of salt-sensitive hypertension","volume":"8","author":"Zhang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.ejphar.2025.178277_bib225","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s11658-020-00237-6","article-title":"Upregulation of miR-361-3p suppresses serotonin-induced proliferation in human pulmonary artery smooth muscle cells by targeting SERT","volume":"25","author":"Zhang","year":"2020","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.ejphar.2025.178277_bib226","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1186\/s12859-021-04517-6","article-title":"Class similarity network for coding and long non-coding RNA classification","volume":"22","author":"Zhang","year":"2021","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.ejphar.2025.178277_bib227","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/4397829","article-title":"Endothelial progenitor cells affect the growth and apoptosis of renal cells by secreting microvesicles carrying dysregulated miR-205 and miR-206","volume":"2023","author":"Zhang","year":"2023","journal-title":"Dis. Markers"},{"key":"10.1016\/j.ejphar.2025.178277_bib228","doi-asserted-by":"crossref","first-page":"28588","DOI":"10.18632\/oncotarget.15544","article-title":"The long non-coding RNA H19 promotes cardiomyocyte apoptosis in dilated cardiomyopathy","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2025.178277_bib229","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2013-14-10-r109","article-title":"High-efficiency RNA cloning enables accurate quantification of miRNA expression by deep sequencing","volume":"14","author":"Zhang","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.ejphar.2025.178277_bib230","doi-asserted-by":"crossref","first-page":"19715","DOI":"10.1002\/jcp.28571","article-title":"Overexpressed long noncoding RNA CPS1-IT alleviates pulmonary arterial hypertension in obstructive sleep apnea by reducing interleukin-1\u03b2 expression via HIF1 transcriptional activity","volume":"234","author":"Zhang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2025.178277_bib231","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12872-020-01374-8","article-title":"Circular RNA expression profile and its potential regulative role in human abdominal aortic aneurysm","volume":"20","author":"Zhou","year":"2020","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.ejphar.2025.178277_bib232","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/15476286.2015.1122164","article-title":"Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-\u03baB pathway","volume":"13","author":"Zhou","year":"2016","journal-title":"RNA Biol."},{"key":"10.1016\/j.ejphar.2025.178277_bib233","first-page":"1660","article-title":"miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma","volume":"27","author":"Zhu","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejphar.2025.178277_bib234","doi-asserted-by":"crossref","first-page":"14328","DOI":"10.1074\/jbc.M611393200","article-title":"MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)","volume":"282","author":"Zhu","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2025.178277_bib235","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00424-018-2219-8","article-title":"Long noncoding RNA UCA1 promotes the proliferation of hypoxic human pulmonary artery smooth muscle cells","volume":"471","author":"Zhu","year":"2019","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.ejphar.2025.178277_bib236","doi-asserted-by":"crossref","first-page":"94997","DOI":"10.18632\/oncotarget.22031","article-title":"BANCR: a novel oncogenic long non-coding RNA in human cancers","volume":"8","author":"Zou","year":"2017","journal-title":"Oncotarget"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925010313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925010313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:33:58Z","timestamp":1779323638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925010313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":236,"alternative-id":["S0014299925010313"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178277","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overview of exosomal non-coding RNAs in cardiovascular disease using high throughput sequencing","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178277","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"178277"}}