{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:58:35Z","timestamp":1792213115346,"version":"4.4.0"},"reference-count":306,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172962"],"award-info":[{"award-number":["82172962"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejphar.2025.178401","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:30:20Z","timestamp":1764117020000},"page":"178401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["The impact of multidimensional interactions among Helicobacter pylori infection, tumor microenvironment, and gut microbiota on gastric cancer immune response"],"prefix":"10.1016","volume":"1011","author":[{"given":"Chao","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4265-5833","authenticated-orcid":false,"given":"Zhangang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueshui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.ejphar.2025.178401_bib1","doi-asserted-by":"crossref","first-page":"6114","DOI":"10.1002\/cam4.2497","article-title":"Risk factors predisposing to cardia gastric adenocarcinoma: insights and new perspectives","volume":"8","author":"Abdi","year":"2019","journal-title":"Cancer Med."},{"key":"10.1016\/j.ejphar.2025.178401_bib2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jconrel.2019.12.047","article-title":"Current challenges and emerging opportunities of CAR-T cell therapies","volume":"319","author":"Abreu","year":"2020","journal-title":"J. Contr. Release"},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib3","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1002\/cncr.21814","article-title":"An open-label, multinational, multicenter study of G17DT vaccination combined with cisplatin and 5-fluorouracil in patients with untreated, advanced gastric or gastroesophageal cancer: the GC4 study","volume":"106","author":"Ajani","year":"2006","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1158\/0008-5472.CAN-22-1890","article-title":"Stromal reprogramming through dual PDGFR\u03b1\/\u03b2 blockade boosts the efficacy of Anti-PD-1 immunotherapy in fibrotic tumors","volume":"83","author":"Akiyama","year":"2023","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15051329","article-title":"Homology-directed-repair-based genome editing in HSPCs for the treatment of inborn errors of immunity and blood disorders","volume":"15","author":"Allen","year":"2023","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s40644-023-00598-z","article-title":"FAP-targeted PET imaging in gastrointestinal malignancies: a comprehensive review","volume":"23","author":"Ar\u00e7ay \u00d6zt\u00fcrk","year":"2023","journal-title":"Cancer Imaging"},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15030794","article-title":"CAR-T cell therapy and the Gut Microbiota","volume":"15","author":"Asokan","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ejphar.2025.178401_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2021.06.009","article-title":"The crosstalk between H. pylori virulence factors and the PD1:PD-L1 immune checkpoint inhibitors in progression to gastric cancer","volume":"239","author":"Ayd\u0131n","year":"2021","journal-title":"Immunol. Lett."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.humimm.2020.10.005","article-title":"Increased Indoleamine 2, 3-Dioxygenase expression modulates Th1\/Th17\/Th22 and Treg pathway in humans with helicobacter pylori-infected gastric mucosa","volume":"82","author":"Azadegan-Dehkordi","year":"2021","journal-title":"Hum. Immunol."},{"issue":"20","key":"10.1016\/j.ejphar.2025.178401_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15205075","article-title":"Gastric cancer: molecular mechanisms, novel targets, and immunotherapies: from bench to clinical therapeutics","volume":"15","author":"Baccili Cury Megid","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib11","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12866-021-02315-x","article-title":"Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis","volume":"21","author":"Bakhti","year":"2021","journal-title":"BMC Microbiol."},{"issue":"23","key":"10.1016\/j.ejphar.2025.178401_bib12","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1016\/j.cell.2024.08.029","article-title":"Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy","volume":"187","author":"Baldwin","year":"2024","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.ejphar.2025.178401_bib13","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1128\/IAI.01146-10","article-title":"Role of gastric epithelial cell-derived transforming growth factor beta in reduced CD4+ T cell proliferation and development of regulatory T cells during Helicobacter pylori infection","volume":"79","author":"Beswick","year":"2011","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib14","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1523-5378.2008.00625.x","article-title":"Monocyte and macrophage killing of helicobacter pylori: relationship to bacterial virulence factors","volume":"13","author":"Borlace","year":"2008","journal-title":"Helicobacter"},{"issue":"26","key":"10.1016\/j.ejphar.2025.178401_bib15","doi-asserted-by":"crossref","first-page":"9300","DOI":"10.1073\/pnas.0409873102","article-title":"NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein","volume":"102","author":"Brandt","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"8","key":"10.1016\/j.ejphar.2025.178401_bib16","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nri1668","article-title":"Regulation of immune responses by L-arginine metabolism","volume":"5","author":"Bronte","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib17","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1158\/0008-5472.CAN-08-1191","article-title":"Helicobacter pylori cytotoxin-associated gene A activates the signal transducer and activator of transcription 3 pathway in vitro and in vivo","volume":"69","author":"Bronte-Tinkew","year":"2009","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib18","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1258\/002367787781268846","article-title":"Recirculation anaesthesia for laboratory fish","volume":"21","author":"Brown","year":"1987","journal-title":"Lab. Anim."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib19","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/s41591-020-0864-x","article-title":"Author correction: safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma","volume":"26","author":"Brudno","year":"2020","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.chom.2022.02.004","article-title":"Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis","volume":"30","author":"Cai","year":"2022","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib21","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1186\/s12967-024-05606-9","article-title":"Re-analysis of single cell and spatial transcriptomics data reveals B cell landscape in gastric cancer microenvironment and its potential crosstalk with tumor cells for clinical prognosis","volume":"22","author":"Cai","year":"2024","journal-title":"J. Transl. Med."},{"issue":"11","key":"10.1016\/j.ejphar.2025.178401_bib22","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/cdd.2010.42","article-title":"Endosome-mitochondria juxtaposition during apoptosis induced by H. pylori VacA","volume":"17","author":"Calore","year":"2010","journal-title":"Cell Death Differ."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178401_bib23","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1038\/bjc.2015.175","article-title":"Case\u2013control study of epstein\u2013barr virus and Helicobacter pylori serology in Latin American patients with gastric disease","volume":"112","author":"C\u00e1rdenas-Mondrag\u00f3n","year":"2015","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16289-2","article-title":"Dysbiosis of the microbiome in gastric carcinogenesis","volume":"7","author":"Casta\u00f1o-Rodr\u00edguez","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178401_bib25","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1016\/j.ymthe.2023.11.001","article-title":"The state of cell and gene therapy in 2023","volume":"31","author":"Chancellor","year":"2023","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1909459","article-title":"The interplay between Helicobacter pylori and gastrointestinal microbiota","volume":"13","author":"Chen","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ejphar.2025.178401_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120988","article-title":"Asynchronous blockade of PD-L1 and CD155 by polymeric nanoparticles inhibits triple-negative breast cancer progression and metastasis","volume":"275","author":"Chen","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejphar.2025.178401_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215834","article-title":"Single cell RNA-seq reveals the CCL5\/SDC1 receptor-ligand interaction between T cells and tumor cells in pancreatic cancer","volume":"545","author":"Chen","year":"2022","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12943-023-01830-x","article-title":"Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer","volume":"22","author":"Chen","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ejphar.2025.178401_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1288383","article-title":"CAR-T treatment for cancer: prospects and challenges","volume":"13","author":"Chen","year":"2023","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib31","article-title":"Helicobacter pylori CagA mediated mitophagy to attenuate the NLRP3 inflammasome activation and enhance the survival of infected cells","volume":"14","author":"Chen","year":"2024","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib32","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1046\/j.1365-2958.1999.01271.x","article-title":"Essential role of Helicobacter pylori gamma-glutamyltranspeptidase for the colonization of the gastric mucosa of mice","volume":"31","author":"Chevalier","year":"1999","journal-title":"Mol. Microbiol."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib33","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3748\/wjg.v30.i4.286","article-title":"Revolutionizing gastric cancer treatment: the potential of immunotherapy","volume":"30","author":"Christodoulidis","year":"2024","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib34","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nm.2087","article-title":"Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity","volume":"16","author":"Clarke","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2025.178401_bib35","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.3389\/fimmu.2019.02923","article-title":"Helicobacter pylori dampens HLA-II expression on macrophages via the Up-Regulation of miRNAs targeting CIITA","volume":"10","author":"Codolo","year":"2019","journal-title":"Front. Immunol."},{"issue":"7556","key":"10.1016\/j.ejphar.2025.178401_bib36","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature14282","article-title":"IL-17-producing \u03b3\u03b4 T cells and neutrophils conspire to promote breast cancer metastasis","volume":"522","author":"Coffelt","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2025.178401_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.biosystems.2022.104635","article-title":"Computation in biological systems as a quantum mechanical simulation","volume":"214","author":"Cottam","year":"2022","journal-title":"Biosystems"},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10050176","article-title":"Special issue \"H. pylori Virulence Factors in the Induction of Gastric Cancer\"","volume":"10","author":"Crabtree","year":"2018","journal-title":"Toxins"},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib39","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/s41588-022-01157-1","article-title":"Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer","volume":"54","author":"Cui Zhou","year":"2022","journal-title":"Nat. Genet."},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib40","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nm1093","article-title":"Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival","volume":"10","author":"Curiel","year":"2004","journal-title":"Nat. Med."},{"issue":"20","key":"10.1016\/j.ejphar.2025.178401_bib41","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1016\/j.cell.2022.08.026","article-title":"Epstein-Barr virus: biology and clinical disease","volume":"185","author":"Damania","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2025.178401_bib42","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.molimm.2019.06.006","article-title":"TLR1\/TLR2 signaling blocks the suppression of monocytic myeloid-derived suppressor cell by promoting its differentiation into M1-type macrophage","volume":"112","author":"Deng","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ejphar.2025.178401_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.923477","article-title":"Effects of helicobacter pylori on tumor microenvironment and immunotherapy responses","volume":"13","author":"Deng","year":"2022","journal-title":"Front. Immunol."},{"issue":"47","key":"10.1016\/j.ejphar.2025.178401_bib44","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.3748\/wjg.v30.i47.5097","article-title":"Role of gut microbiota and Helicobacter pylori in inflammatory bowel disease through immune-mediated synergistic actions","volume":"30","author":"Deng","year":"2024","journal-title":"World J. Gastroenterol."},{"issue":"8","key":"10.1016\/j.ejphar.2025.178401_bib45","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1172\/JCI82529","article-title":"Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia","volume":"126","author":"Ding","year":"2016","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2025.178401_bib46","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3389\/fonc.2018.00386","article-title":"Tumor-Intrinsic PD-L1 signaling in cancer initiation, development and treatment: beyond immune evasion","volume":"8","author":"Dong","year":"2018","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/nyas.14449","article-title":"Reconsidering the \"protective\" hypothesis of Helicobacter pylori infection in eosinophilic esophagitis","volume":"1481","author":"Doulberis","year":"2020","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2025.178401_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1339750","article-title":"Effects of Helicobacter pylori infection on intestinal microbiota, immunity and colorectal cancer risk","volume":"14","author":"Engelsberger","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib50","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202201159","article-title":"Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis","volume":"221","author":"Eskandari","year":"2022","journal-title":"J. Cell Biol."},{"issue":"8","key":"10.1016\/j.ejphar.2025.178401_bib51","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16081601","article-title":"Treatment of gastric cancer means surgery, but not surgery alone","volume":"16","author":"Fabbi","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib52","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nsmb.2296","article-title":"The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC","volume":"19","author":"Fabian","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ejphar.2025.178401_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.953718","article-title":"The interplay between Helicobacter pylori and the gut microbiota: an emerging driver influencing the immune system homeostasis and gastric carcinogenesis","volume":"12","author":"Fakharian","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib54","article-title":"The influence of Helicobacter pylori on human gastric and gut microbiota","volume":"12","author":"Fiorani","year":"2023","journal-title":"Antibiotics (Basel)"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib55","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56631-4","article-title":"Helicobacter pylori infection associates with fecal microbiota composition and diversity","volume":"9","author":"Frost","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.178401_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2020.102015","article-title":"The role of tumor-associated macrophages in gastric cancer development and their potential as a therapeutic target","volume":"86","author":"Gambardella","year":"2020","journal-title":"Cancer Treat Rev."},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib57","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nnano.2007.260","article-title":"Intrinsic peroxidase-like activity of ferromagnetic nanoparticles","volume":"2","author":"Gao","year":"2007","journal-title":"Nat. Nanotechnol."},{"issue":"13","key":"10.1016\/j.ejphar.2025.178401_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14133276","article-title":"An immune signature for risk stratification and therapeutic prediction in helicobacter pylori-infected gastric cancer","volume":"14","author":"Geng","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ejphar.2025.178401_bib59","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jconrel.2023.02.041","article-title":"Safe engineering of cancer-associated fibroblasts enhances checkpoint blockade immunotherapy","volume":"356","author":"Geng","year":"2023","journal-title":"J. Contr. Release"},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib60","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.4049\/jimmunol.1401075","article-title":"Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori","volume":"193","author":"Gobert","year":"2014","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib61","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02174-19","article-title":"Bacterial pathogens hijack the innate immune response by activation of the reverse transsulfuration pathway","volume":"10","author":"Gobert","year":"2019","journal-title":"mBio"},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens10091203","article-title":"Role of Helicobacter pylori and other environmental factors in the development of gastric dysbiosis","volume":"10","author":"Gomez-Ramirez","year":"2021","journal-title":"Pathogens"},{"issue":"6371","key":"10.1016\/j.ejphar.2025.178401_bib63","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.aan4236","article-title":"Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients","volume":"359","author":"Gopalakrishnan","year":"2018","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib64","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41416-018-0333-1","article-title":"Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression","volume":"120","author":"Groth","year":"2019","journal-title":"Br. J. Cancer"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib65","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41419-021-03579-x","article-title":"The role of PKM2 nuclear translocation in the constant activation of the NF-\u03baB signaling pathway in cancer-associated fibroblasts","volume":"12","author":"Gu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2025.178401_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118231","article-title":"Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon","volume":"267","author":"Guo","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ejphar.2025.178401_bib67","article-title":"Gastric microbiota in gastric cancer: different roles of Helicobacter pylori and other microbes","volume":"12","author":"Guo","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ejphar.2025.178401_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.899248","article-title":"Effect of Helicobacter pylori eradication on Human gastric Microbiota: a systematic review and meta-analysis","volume":"12","author":"Guo","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib69","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-\u03baB in biology and targeted therapy: new insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib70","first-page":"139","article-title":"[Hospital watching: in relation to the rehabilitation of patients]","volume":"18","author":"Hamamura","year":"1988","journal-title":"Nasu Suteshon"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib71","first-page":"106","article-title":"Antitumor effects and persistence of a novel HER2 CAR T cells directed to gastric cancer in preclinical models","volume":"8","author":"Han","year":"2018","journal-title":"Am. J. Cancer Res."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib72","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.7150\/thno.50928","article-title":"Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes","volume":"11","author":"Han","year":"2021","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib73","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.chom.2014.02.008","article-title":"Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesis","volume":"15","author":"Hatakeyama","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"10","key":"10.1016\/j.ejphar.2025.178401_bib74","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1182\/blood.2019002779","article-title":"Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia","volume":"135","author":"He","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.ejphar.2025.178401_bib75","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8607671","article-title":"Effect of probiotic-assisted eradication of cagA+\/vacA s1m1 Helicobacter pylori on intestinal flora","volume":"2022","author":"He","year":"2022","journal-title":"BioMed Res. Int."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib76","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41577-021-00571-6","article-title":"Neutrophils in cancer: heterogeneous and multifaceted","volume":"22","author":"Hedrick","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2025.178401_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1429436","article-title":"Microbiota activation and regulation of adaptive immunity","volume":"15","author":"Heidari","year":"2024","journal-title":"Front. Immunol."},{"issue":"22","key":"10.1016\/j.ejphar.2025.178401_bib78","doi-asserted-by":"crossref","first-page":"14428","DOI":"10.1073\/pnas.222375399","article-title":"Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites","volume":"99","author":"Higashi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib79","doi-asserted-by":"crossref","first-page":"9307","DOI":"10.1038\/s41598-020-65787-3","article-title":"Chronic in vivo exposure to Helicobacter pylori VacA: assessing the efficacy of automated and long-term intragastric toxin infusion","volume":"10","author":"Holland","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib80","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007468","article-title":"Increased programmed death-ligand 1 is an early epithelial cell response to Helicobacter pylori infection","volume":"15","author":"Holokai","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ejphar.2025.178401_bib81","doi-asserted-by":"crossref","first-page":"5932","DOI":"10.1038\/ncomms6932","article-title":"Innate sensing of microbial products promotes wound-induced skin cancer","volume":"6","author":"Hoste","year":"2015","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.ejphar.2025.178401_bib82","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.7314\/APJCP.2013.14.8.4607","article-title":"Effects of gastric cancer cells on the differentiation of Treg cells","volume":"14","author":"Hu","year":"2013","journal-title":"Asian Pac. J. Cancer Prev. APJCP"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib83","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1080\/15548627.2018.1557835","article-title":"Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells","volume":"15","author":"Hu","year":"2019","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib84","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1158\/0008-5472.CAN-05-1299","article-title":"Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host","volume":"66","author":"Huang","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2025.178401_bib85","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3389\/fcimb.2016.00159","article-title":"Adhesion and invasion of gastric Mucosa epithelial cells by Helicobacter pylori","volume":"6","author":"Huang","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib86","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax5032","article-title":"Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer","volume":"6","author":"Huang","year":"2020","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib87","doi-asserted-by":"crossref","first-page":"796","DOI":"10.7150\/thno.67375","article-title":"Repurposing ferumoxytol: diagnostic and therapeutic applications of an FDA-approved nanoparticle","volume":"12","author":"Huang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.ejphar.2025.178401_bib88","article-title":"CAR-T cell therapy for hematological malignancies: limitations and optimization strategies","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib89","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.chom.2021.04.006","article-title":"Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis","volume":"29","author":"Imai","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ejphar.2025.178401_bib90","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.omto.2020.06.021","article-title":"Boosting replication and penetration of oncolytic adenovirus by paclitaxel eradicate peritoneal metastasis of gastric cancer","volume":"18","author":"Ishikawa","year":"2020","journal-title":"Mol. Ther. Oncolytics"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib91","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1053\/j.gastro.2017.03.046","article-title":"Activation of transforming growth factor beta 1 signaling in gastric cancer-associated fibroblasts increases their motility, via expression of rhomboid 5 homolog 2, and ability to induce invasiveness of gastric cancer cells","volume":"153","author":"Ishimoto","year":"2017","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib92","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41568-020-0281-y","article-title":"Neutrophil diversity and plasticity in tumour progression and therapy","volume":"20","author":"Jaillon","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib93","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2044721","article-title":"Host immune response mediates changes in cagA copy number and virulence potential of Helicobacter pylori","volume":"14","author":"Jang","year":"2022","journal-title":"Gut Microbes"},{"issue":"23","key":"10.1016\/j.ejphar.2025.178401_bib94","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.1158\/1078-0432.CCR-21-0792","article-title":"Spatially distinct reprogramming of the tumor microenvironment based on tumor invasion in diffuse-type gastric cancers","volume":"27","author":"Jeong","year":"2021","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib95","article-title":"Helicobacter pylori and immunotherapy for gastrointestinal cancer","volume":"5","author":"Jia","year":"2024","journal-title":"Innovation"},{"issue":"22","key":"10.1016\/j.ejphar.2025.178401_bib96","article-title":"Platelet membrane-camouflaged magnetic nanoparticles for ferroptosis-enhanced cancer immunotherapy","volume":"16","author":"Jiang","year":"2020","journal-title":"Small"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib97","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2025.178401_bib98","article-title":"Recent progress and future perspectives of immunotherapy in advanced gastric cancer","volume":"13","author":"Jin","year":"2022","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.ejphar.2025.178401_bib99","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006631","article-title":"The bacterial virulence factor CagA induces microbial dysbiosis that contributes to excessive epithelial cell proliferation in the Drosophila gut","volume":"13","author":"Jones","year":"2017","journal-title":"PLoS Pathog."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib100","first-page":"264","article-title":"Current treatment and recent progress in gastric cancer","volume":"71","author":"Joshi","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib101","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1272\/jnms1923.55.191","article-title":"Effect of bromhexine on Sj\u00f6gren's syndrome accompanied by rheumatoid arthritis","volume":"55","author":"Kawashima","year":"1988","journal-title":"Nihon Ika Daigaku Zasshi"},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib102","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198347","article-title":"Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer","volume":"13","author":"Kim","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib103","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10120-021-01222-4","article-title":"Association between triglyceride-glucose index and gastric carcinogenesis: a health checkup cohort study","volume":"25","author":"Kim","year":"2022","journal-title":"Gastric Cancer"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib104","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1158\/2159-8290.CD-21-0888","article-title":"Early tumor-immune microenvironmental remodeling and response to first-line fluoropyrimidine and platinum chemotherapy in advanced gastric cancer","volume":"12","author":"Kim","year":"2022","journal-title":"Cancer Discov."},{"issue":"10","key":"10.1016\/j.ejphar.2025.178401_bib105","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1111\/cas.13332","article-title":"Interleukin-6\/STAT3 signaling as a promising target to improve the efficacy of cancer immunotherapy","volume":"108","author":"Kitamura","year":"2017","journal-title":"Cancer Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib106","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2741\/3608","article-title":"Brain temperature homeostasis: physiological fluctuations and pathological shifts","volume":"15","author":"Kiyatkin","year":"2010","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.ejphar.2025.178401_bib107","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.canlet.2021.06.007","article-title":"Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids","volume":"518","author":"Koh","year":"2021","journal-title":"Cancer Lett."},{"issue":"13","key":"10.1016\/j.ejphar.2025.178401_bib108","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.7150\/thno.19987","article-title":"Biodegradable hollow mesoporous silica nanoparticles for regulating tumor microenvironment and enhancing antitumor efficiency","volume":"7","author":"Kong","year":"2017","journal-title":"Theranostics"},{"issue":"14","key":"10.1016\/j.ejphar.2025.178401_bib109","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1038\/onc.2014.135","article-title":"Matrix metalloproteinase 7 restrains helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization","volume":"34","author":"Krakowiak","year":"2015","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.ejphar.2025.178401_bib110","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1128\/IAI.69.8.5080-5087.2001","article-title":"Vacuolating cytotoxin of Helicobacter pylori induces apoptosis in the human gastric epithelial cell line AGS","volume":"69","author":"Kuck","year":"2001","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib111","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.immuni.2020.06.016","article-title":"An oncogenic alteration creates a microenvironment that promotes tumor progression by conferring a metabolic advantage to regulatory T cells","volume":"53","author":"Kumagai","year":"2020","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.ejphar.2025.178401_bib112","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.4049\/jimmunol.175.7.4583","article-title":"Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells","volume":"175","author":"Kusmartsev","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.ejphar.2025.178401_bib113","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fendo.2014.00144","article-title":"Contributions of colonic short-chain fatty acid receptors in energy homeostasis","volume":"5","author":"Kuwahara","year":"2014","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ejphar.2025.178401_bib114","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.3389\/fimmu.2018.01830","article-title":"Aspects of gut microbiota and immune system interactions in infectious diseases, immunopathology, and cancer","volume":"9","author":"Lazar","year":"2018","journal-title":"Front. Immunol."},{"issue":"6012","key":"10.1016\/j.ejphar.2025.178401_bib115","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1126\/science.1195568","article-title":"Has the microbiota played a critical role in the evolution of the adaptive immune system?","volume":"330","author":"Lee","year":"2010","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib116","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2025.2461679","article-title":"Artificial intelligence-assisted diagnosis of early gastric cancer: present practice and future prospects","volume":"57","author":"Lei","year":"2025","journal-title":"Ann. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib117","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/gutjnl-2013-305178","article-title":"Gastric colonisation with a restricted commensal microbiota replicates the promotion of neoplastic lesions by diverse intestinal microbiota in the Helicobacter pylori INS-GAS mouse model of gastric carcinogenesis","volume":"63","author":"Lertpiriyapong","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2025.178401_bib118","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1294082","article-title":"Bacterial infection and microbiota in carcinogenesis and tumor development","volume":"13","author":"Li","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"7820","key":"10.1016\/j.ejphar.2025.178401_bib119","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41586-020-2564-6","article-title":"Mucosal or systemic microbiota exposures shape the B cell repertoire","volume":"584","author":"Li","year":"2020","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib120","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.349","article-title":"Signaling pathways in macrophages: molecular mechanisms and therapeutic targets","volume":"2023. 4","author":"Li","year":"2020","journal-title":"MedComm"},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib121","article-title":"Advances in clinical immunotherapy for gastric cancer","volume":"1876","author":"Li","year":"2021","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"issue":"12","key":"10.1016\/j.ejphar.2025.178401_bib122","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123497","article-title":"Development of stem cell-derived immune cells for off-the-shelf cancer immunotherapies","volume":"10","author":"Li","year":"2021","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.ejphar.2025.178401_bib123","article-title":"Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy","volume":"2","author":"Li","year":"2021","journal-title":"Cell Rep. Med."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib124","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s10120-022-01339-0","article-title":"Correction to: propionibacterium acnes overabundance in gastric cancer promote M2 polarization of macrophages via a TLR4\/PI3K\/Akt signaling","volume":"25","author":"Li","year":"2022","journal-title":"Gastric Cancer"},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib125","doi-asserted-by":"crossref","first-page":"15471","DOI":"10.1021\/acsnano.2c08013","article-title":"Immunogenic cell death augmented by manganese zinc sulfide nanoparticles for metastatic melanoma immunotherapy","volume":"16","author":"Li","year":"2022","journal-title":"ACS Nano"},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib126","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104859","article-title":"Off-the-shelf third-party HSC-engineered iNKT cells for ameliorating GvHD while preserving GvL effect in the treatment of blood cancers","volume":"25","author":"Li","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.ejphar.2025.178401_bib127","article-title":"Emerging role of Helicobacter pylori in the immune evasion mechanism of gastric cancer: an Insight into tumor microenvironment-pathogen interaction","volume":"12","author":"Li","year":"2022","journal-title":"Front. Oncol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib128","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.stem.2023.02.009","article-title":"Advancing cell-based cancer immunotherapy through stem cell engineering","volume":"30","author":"Li","year":"2023","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib129","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10120-024-01486-6","article-title":"Specific lineage transition of tumor-associated macrophages elicits immune evasion of ascitic tumor cells in gastric cancer with peritoneal metastasis","volume":"27","author":"Li","year":"2024","journal-title":"Gastric Cancer"},{"issue":"23","key":"10.1016\/j.ejphar.2025.178401_bib130","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1097\/CM9.0000000000003348","article-title":"Impacts of Helicobacter pylori infection and eradication on gastrointestinal microbiota: an up-to-date critical review and future perspectives","volume":"137","author":"Li","year":"2024","journal-title":"Chin. Med. J. (Engl)."},{"issue":"10","key":"10.1016\/j.ejphar.2025.178401_bib131","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010354","article-title":"Impact of Helicobacter pylori on immunotherapy in gastric cancer","volume":"12","author":"Li","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib132","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1186\/s12951-024-02883-w","article-title":"Ultrasound-responsive nanocarriers with siRNA and Fe(3)O(4) regulate macrophage polarization and phagocytosis for augmented non-small cell lung cancer immunotherapy","volume":"22","author":"Li","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"21","key":"10.1016\/j.ejphar.2025.178401_bib133","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1089\/scd.2013.0166","article-title":"Bone marrow-derived mesenchymal stem cells favor the immunosuppressive T cells skewing in a Helicobacter pylori model of gastric cancer","volume":"22","author":"Lin","year":"2013","journal-title":"Stem Cell. Dev."},{"issue":"10","key":"10.1016\/j.ejphar.2025.178401_bib134","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1136\/gutjnl-2018-316324","article-title":"Tumour-associated macrophages-derived CXCL8 determines immune evasion through autonomous PD-L1 expression in gastric cancer","volume":"68","author":"Lin","year":"2019","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.ejphar.2025.178401_bib135","doi-asserted-by":"crossref","DOI":"10.3390\/antiox10081293","article-title":"Statins' regulation of the virulence factors of Helicobacter pylori and the production of ROS May inhibit the development of gastric cancer","volume":"10","author":"Lin","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejphar.2025.178401_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115123","article-title":"IPSC-derived CAR-NK cells for cancer immunotherapy","volume":"165","author":"Lin","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib137","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131460","article-title":"Instrumental role of Helicobacter pylori \u03b3-Glutamyl transpeptidase in VacA-Dependent vacuolation in gastric epithelial cells","volume":"10","author":"Ling","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2025.178401_bib138","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3389\/fimmu.2019.00533","article-title":"Regulatory T cells and plasmacytoid dendritic cells within the tumor microenvironment in gastric cancer are correlated with gastric microbiota dysbiosis: a preliminary study","volume":"10","author":"Ling","year":"2019","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178401_bib139","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/cmi.2017.88","article-title":"Innate immunity in tuberculosis: host defense vs pathogen evasion","volume":"14","author":"Liu","year":"2017","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib140","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/advances\/nmx009","article-title":"Butyrate: a double-edged sword for health?","volume":"9","author":"Liu","year":"2018","journal-title":"Adv. Nutr."},{"issue":"8","key":"10.1016\/j.ejphar.2025.178401_bib141","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/mc.23309","article-title":"H. pylori infection induces CXCL8 expression and promotes gastric cancer progress through downregulating KLF4","volume":"60","author":"Liu","year":"2021","journal-title":"Mol. Carcinog."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib142","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41392-021-00762-6","article-title":"Wnt\/\u03b2-catenin signalling: function, biological mechanisms, and therapeutic opportunities","volume":"7","author":"Liu","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejphar.2025.178401_bib143","article-title":"Tumor microenvironment-mediated immune tolerance in development and treatment of gastric cancer","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"issue":"22","key":"10.1016\/j.ejphar.2025.178401_bib144","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1111\/febs.16059","article-title":"Signaling pathways and defense mechanisms of ferroptosis","volume":"289","author":"Liu","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.ejphar.2025.178401_bib145","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jconrel.2022.03.021","article-title":"Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy","volume":"345","author":"Liu","year":"2022","journal-title":"J. Contr. Release"},{"issue":"11","key":"10.1016\/j.ejphar.2025.178401_bib146","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11112818","article-title":"Notch signaling regulates the function and phenotype of dendritic cells in Helicobacter pylori infection","volume":"11","author":"Liu","year":"2023","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib147","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13046-024-03034-7","article-title":"Unveiling the gastric microbiota: implications for gastric carcinogenesis, immune responses, and clinical prospects","volume":"43","author":"Liu","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib148","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41419-024-07318-w","article-title":"Helicobacter pylori CagA promotes gastric cancer immune escape by upregulating SQLE","volume":"16","author":"Liu","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2025.178401_bib149","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2022.103841","article-title":"Characteristics of gastric cancer around the world","volume":"181","author":"L\u00f3pez","year":"2023","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib151","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13045-024-01535-8","article-title":"Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy","volume":"17","author":"Lu","year":"2024","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib152","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1038\/s41467-024-46343-3","article-title":"synNotch-programmed iPSC-derived NK cells usurp TIGIT and CD73 activities for glioblastoma therapy","volume":"15","author":"Lupo","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib153","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13045-019-0704-y","article-title":"Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer","volume":"12","author":"Lv","year":"2019","journal-title":"J. Hematol. Oncol."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib154","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1111\/ajco.13302","article-title":"Correlations between CD4(+) FoxP3(+) Treg and expression of FoxM1 and Ki-67 in gastric cancer patients","volume":"17","author":"Ma","year":"2021","journal-title":"Asia Pac. J. Clin. Oncol."},{"issue":"10","key":"10.1016\/j.ejphar.2025.178401_bib156","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007699","article-title":"Impact of Helicobacter pylori infection status on outcomes among patients with advanced gastric cancer treated with immune checkpoint inhibitors","volume":"11","author":"Magahis","year":"2023","journal-title":"J. Immunother. Cancer"},{"issue":"6510","key":"10.1016\/j.ejphar.2025.178401_bib157","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1126\/science.abc3421","article-title":"Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy","volume":"369","author":"Mager","year":"2020","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib158","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108677","article-title":"Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells","volume":"34","author":"Maisonneuve","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2025.178401_bib159","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.951214","article-title":"The cancer-associated fibroblast-related signature predicts prognosis and indicates immune microenvironment infiltration in gastric cancer","volume":"13","author":"Mak","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178401_bib160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.691134","article-title":"Lactate-dependent regulation of immune responses by dendritic cells and macrophages","volume":"12","author":"Manoharan","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178401_bib161","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1412709","article-title":"Targeting gut-microbiota for gastric cancer treatment: a systematic review","volume":"11","author":"Marashi","year":"2024","journal-title":"Front. Med."},{"issue":"15","key":"10.1016\/j.ejphar.2025.178401_bib162","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10153258","article-title":"Gastric Microenvironment-A partnership between innate immunity and gastric microbiota tricks Helicobacter pylori","volume":"10","author":"M\u0103rginean","year":"2021","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib163","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40364-023-00482-9","article-title":"New cell sources for CAR-based immunotherapy","volume":"11","author":"Mazinani","year":"2023","journal-title":"Biomark. Res."},{"key":"10.1016\/j.ejphar.2025.178401_bib164","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1298571","article-title":"The role of immune checkpoints in antitumor response: a potential antitumor immunotherapy","volume":"14","author":"Mej\u00eda-Guarnizo","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178401_bib165","author":"Meng","year":"2025","journal-title":"Mol. Diagn. Ther."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib166","doi-asserted-by":"crossref","first-page":"498","DOI":"10.7150\/thno.37745","article-title":"Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells","volume":"10","author":"Miao","year":"2020","journal-title":"Theranostics"},{"issue":"16","key":"10.1016\/j.ejphar.2025.178401_bib167","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.3748\/wjg.v20.i16.4516","article-title":"Adjuvant chemotherapy for gastric cancer: current evidence and future challenges","volume":"20","author":"Miceli","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib168","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41565-021-00864-w","article-title":"Author correction: antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy","volume":"16","author":"Min","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.ejphar.2025.178401_bib169","article-title":"Role of microbiota-derived short-chain fatty acids in cancer development and prevention","volume":"139","author":"Mirzaei","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2025.178401_bib170","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1017\/erm.2023.17","article-title":"Helicobacter pylori virulence factors: subversion of host immune system and development of various clinical outcomes","volume":"25","author":"Mohammadzadeh","year":"2023","journal-title":"Expet Rev. Mol. Med."},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib171","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1099\/0022-1317-49-9-817","article-title":"Profiling of bacterial flora in gastric biopsies from patients with Helicobacter pylori-associated gastritis and histologically normal control individuals by temperature gradient gel electrophoresis and 16S rDNA sequence analysis","volume":"49","author":"Monstein","year":"2000","journal-title":"J. Med. Microbiol."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib172","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.stem.2018.12.011","article-title":"Organoid-Induced differentiation of conventional T cells from human pluripotent stem cells","volume":"24","author":"Montel-Hagen","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ejphar.2025.178401_bib173","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.981847","article-title":"Unraveling the role of Breg cells in digestive tract cancer and infectious immunity","volume":"13","author":"Moreira","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178401_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122316","article-title":"Role of lncRNAs in Helicobacter pylori and Epstein-Barr virus associated gastric cancers","volume":"336","author":"Mostaghimi","year":"2024","journal-title":"Life Sci."},{"issue":"32","key":"10.1016\/j.ejphar.2025.178401_bib175","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1038\/sj.onc.1210251","article-title":"Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells","volume":"26","author":"Murata-Kamiya","year":"2007","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib177","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2022.2108655","article-title":"The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management","volume":"14","author":"Nabavi-Rad","year":"2022","journal-title":"Gut Microbes"},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib178","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/ijc.30475","article-title":"ICOS(+) Foxp3(+) TILs in gastric cancer are prognostic markers and effector regulatory T cells associated with Helicobacter pylori","volume":"140","author":"Nagase","year":"2017","journal-title":"Int. J. Cancer"},{"issue":"18","key":"10.1016\/j.ejphar.2025.178401_bib179","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21186586","article-title":"The crosstalk between microbiome and immune response in gastric cancer","volume":"21","author":"Nasr","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib180","article-title":"Helicobacter pylori infections in children","volume":"12","author":"Nguyen","year":"2023","journal-title":"Antibiotics (Basel)"},{"issue":"5457","key":"10.1016\/j.ejphar.2025.178401_bib181","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.287.5457.1497","article-title":"Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion","volume":"287","author":"Odenbreit","year":"2000","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib182","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.20162024","article-title":"Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer","volume":"214","author":"\u00d6hlund","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2025.178401_bib183","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.3389\/fimmu.2017.01288","article-title":"Helicobacter pylori affects the antigen presentation activity of macrophages modulating the expression of the immune receptor CD300E through miR-4270","volume":"8","author":"Pagliari","year":"2017","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.ejphar.2025.178401_bib184","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13081878","article-title":"Role of bacterial and viral pathogens in gastric carcinogenesis","volume":"13","author":"Palrasu","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib186","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.03074-20","article-title":"Epigenetic regulation of tumor suppressors by Helicobacter pylori enhances EBV-induced proliferation of gastric epithelial cells","volume":"11","author":"Pandey","year":"2020","journal-title":"mBio"},{"issue":"23","key":"10.1016\/j.ejphar.2025.178401_bib187","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1016\/j.cell.2022.10.007","article-title":"Macrophages in health and disease","volume":"185","author":"Park","year":"2022","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.ejphar.2025.178401_bib188","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1158\/2326-6066.CIR-22-0107","article-title":"Gastric microbiome alterations are associated with decreased CD8+ tissue-resident memory T cells in the tumor microenvironment of gastric cancer","volume":"10","author":"Peng","year":"2022","journal-title":"Cancer Immunol. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib189","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12941-024-00666-7","article-title":"Impact of Helicobacter pylori colonization density and depth on gastritis severity","volume":"23","author":"Peng","year":"2024","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib190","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1158\/1535-7163.MCT-17-0688","article-title":"Therapeutic impact of nanoparticle therapy targeting tumor-associated macrophages","volume":"17","author":"Penn","year":"2018","journal-title":"Mol. Cancer Therapeut."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib191","doi-asserted-by":"crossref","DOI":"10.1111\/hel.12777","article-title":"Cholesterol glucosylation-based survival strategy in Helicobacter pylori","volume":"26","author":"Qaria","year":"2021","journal-title":"Helicobacter"},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib192","doi-asserted-by":"crossref","first-page":"9536","DOI":"10.1021\/acsnano.7b05465","article-title":"Molecular-targeted immunotherapeutic strategy for melanoma via dual-targeting nanoparticles delivering small interfering RNA to tumor-associated macrophages","volume":"11","author":"Qian","year":"2017","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib193","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1128\/IAI.69.4.2604-2611.2001","article-title":"Helicobacter pylori resists phagocytosis by macrophages: quantitative assessment by confocal microscopy and fluorescence-activated cell sorting","volume":"69","author":"Ramarao","year":"2001","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib194","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41572-020-0160-6","article-title":"Immune-related adverse events of checkpoint inhibitors","volume":"6","author":"Ramos-Casals","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"21","key":"10.1016\/j.ejphar.2025.178401_bib195","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14215442","article-title":"Role of CAR T cell metabolism for therapeutic efficacy","volume":"14","author":"Rial Saborido","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib196","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23042034","article-title":"PLGA-based composites for various biomedical applications","volume":"23","author":"Rocha","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178401_bib197","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1600-065X.2008.00608.x","article-title":"Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives","volume":"222","author":"Rodr\u00edguez","year":"2008","journal-title":"Immunol. Rev."},{"issue":"24","key":"10.1016\/j.ejphar.2025.178401_bib198","doi-asserted-by":"crossref","first-page":"21123","DOI":"10.1074\/jbc.M110675200","article-title":"Regulation of T cell receptor CD3zeta chain expression by L-arginine","volume":"277","author":"Rodriguez","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.ejphar.2025.178401_bib199","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1084\/jem.20050715","article-title":"Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma","volume":"202","author":"Rodriguez","year":"2005","journal-title":"J. Exp. Med."},{"issue":"7142","key":"10.1016\/j.ejphar.2025.178401_bib200","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature05765","article-title":"Helicobacter pylori CagA targets PAR1\/MARK kinase to disrupt epithelial cell polarity","volume":"447","author":"Saadat","year":"2007","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib201","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s11095-021-03067-z","article-title":"Induced pluripotent stem cells (iPSCs) provide a potentially unlimited T cell source for CAR-T cell development and off-the-shelf products","volume":"38","author":"Sadeqi Nezhad","year":"2021","journal-title":"Pharm. Res."},{"issue":"18","key":"10.1016\/j.ejphar.2025.178401_bib202","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.3748\/wjg.v28.i18.1875","article-title":"Gut microbiota in various childhood disorders: implication and indications","volume":"28","author":"Saeed","year":"2022","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib203","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032895","article-title":"Helicobacter pylori and gastric cancer: pathogenetic mechanisms","volume":"24","author":"Salvatori","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib204","first-page":"119","article-title":"Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg effect","volume":"38","author":"San-Mill\u00e1n","year":"2017","journal-title":"Carcinogenesis"},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib205","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1349-7006.2003.tb01522.x","article-title":"Immunological evaluation of peptide vaccination for patients with gastric cancer based on pre-existing cellular response to peptide","volume":"94","author":"Sato","year":"2003","journal-title":"Cancer Sci."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib206","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41590-019-0346-9","article-title":"Adaptive plasticity of IL-10(+) and IL-35(+) T(reg) cells cooperatively promotes tumor T cell exhaustion","volume":"20","author":"Sawant","year":"2019","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib207","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.cell.2020.04.022","article-title":"Microbiota-induced type I interferons instruct a poised basal state of dendritic cells","volume":"181","author":"Schaupp","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib208","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1128\/JB.00848-09","article-title":"Cytoplasmic histidine kinase (HP0244)-regulated assembly of urease with UreI, a channel for urea and its metabolites, CO2, NH3, and NH4(+), is necessary for acid survival of Helicobacter pylori","volume":"192","author":"Scott","year":"2010","journal-title":"J. Bacteriol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib209","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nmeth.4237","article-title":"Generation of mature T cells from human hematopoietic stem and progenitor cells in artificial thymic organoids","volume":"14","author":"Seet","year":"2017","journal-title":"Nat. Methods"},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2025.178401_bib210","article-title":"Review: helicobacter pylori infection in children","volume":"25","author":"Seo","year":"2020","journal-title":"Helicobacter"},{"issue":"11","key":"10.1016\/j.ejphar.2025.178401_bib211","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1007\/s10620-021-07371-x","article-title":"Breastfeeding is associated with lower likelihood of Helicobacter Pylori colonization in babies, based on a prospective USA maternal-infant cohort","volume":"67","author":"Shah","year":"2022","journal-title":"Dig. Dis. Sci."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib212","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.stem.2024.03.018","article-title":"Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer","volume":"31","author":"Shah","year":"2024","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib213","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.484","article-title":"Activated neutrophils polarize protumorigenic interleukin-17A-producing T helper subsets through TNF-\u03b1-B7-H2-dependent pathway in human gastric cancer","volume":"11","author":"Shan","year":"2021","journal-title":"Clin. Transl. Med."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib214","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.6959","article-title":"Regulation of regulatory T cells and tumor-associated macrophages in gastric cancer tumor microenvironment","volume":"13","author":"Shaopeng","year":"2024","journal-title":"Cancer Med."},{"issue":"10","key":"10.1016\/j.ejphar.2025.178401_bib215","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13376","article-title":"The Helicobacter pylori type IV secretion system upregulates epithelial cortactin expression by a CagA- and JNK-dependent pathway","volume":"23","author":"Sharafutdinov","year":"2021","journal-title":"Cell. Microbiol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib216","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s42770-021-00675-0","article-title":"Helicobacter pylori: an up-to-date overview on the virulence and pathogenesis mechanisms","volume":"53","author":"Sharndama","year":"2022","journal-title":"Braz. J. Microbiol."},{"issue":"37","key":"10.1016\/j.ejphar.2025.178401_bib217","doi-asserted-by":"crossref","first-page":"20530","DOI":"10.1021\/acsami.5b06043","article-title":"Preparation of a thermosensitive gel composed of a mPEG-PLGA-PLL-cRGD nanodrug delivery system for pancreatic tumor therapy","volume":"7","author":"Shen","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib218","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00772-21","article-title":"Gastric non-helicobacter pylori urease-positive Staphylococcus epidermidis and Streptococcus salivarius isolated from humans have contrasting effects on H. Pylori-associated gastric pathology and host immune responses in a murine model of gastric cancer","volume":"7","author":"Shen","year":"2022","journal-title":"mSphere"},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib219","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20192282","article-title":"Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling","volume":"217","author":"Shi","year":"2020","journal-title":"J. Exp. Med."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib220","doi-asserted-by":"crossref","first-page":"e285","DOI":"10.1016\/j.cllc.2021.10.012","volume":"23","author":"Shiraishi","year":"2022","journal-title":"Clin. Lung Cancer"},{"key":"10.1016\/j.ejphar.2025.178401_bib221","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.868225","article-title":"Helicobacter pylori and the role of lipopolysaccharide variation in innate immune evasion","volume":"13","author":"Sijmons","year":"2022","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib222","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/cgt.2014.69","article-title":"Manufacture of T cells using the sleeping beauty system to enforce expression of a CD19-specific chimeric antigen receptor","volume":"22","author":"Singh","year":"2015","journal-title":"Cancer Gene Ther."},{"issue":"11","key":"10.1016\/j.ejphar.2025.178401_bib223","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1002\/stem.2115","article-title":"In vitro T-Cell generation from adult, embryonic, and induced pluripotent stem cells: many roads to one destination","volume":"33","author":"Smith","year":"2015","journal-title":"Stem Cell."},{"key":"10.1016\/j.ejphar.2025.178401_bib224","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.788875","article-title":"Gastrin vaccine alone and in combination with an immune checkpoint antibody inhibits growth and metastases of gastric cancer","volume":"11","author":"Smith","year":"2021","journal-title":"Front. Oncol."},{"issue":"10251","key":"10.1016\/j.ejphar.2025.178401_bib225","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib226","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41551-022-00973-4","article-title":"Induction of T-helper-17-cell-mediated anti-tumour immunity by pathogen-mimicking polymer nanoparticles","volume":"7","author":"Son","year":"2023","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.ejphar.2025.178401_bib227","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.imlet.2018.01.011","article-title":"Therapeutic cancer vaccines: from initial findings to prospects","volume":"196","author":"Song","year":"2018","journal-title":"Immunol. Lett."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib228","article-title":"Advancements in immunotherapy for gastric cancer: unveiling the potential of immune checkpoint inhibitors and emerging strategies","volume":"1880","author":"Song","year":"2025","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib229","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.161042","article-title":"Metagenomic and single-cell RNA-seq survey of the helicobacter pylori-infected stomach in asymptomatic individuals","volume":"8","author":"Sorini","year":"2023","journal-title":"JCI Insight"},{"issue":"16","key":"10.1016\/j.ejphar.2025.178401_bib230","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612890","article-title":"CXCR4 expressed by tumor-infiltrating B cells in gastric cancer related to survival in the tumor microenvironment: an analysis combining single-cell RNA sequencing with bulk RNA sequencing","volume":"24","author":"Su","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178401_bib231","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/308574","article-title":"Strategies and advancements in harnessing the immune system for gastric cancer immunotherapy","volume":"2015","author":"Subhash","year":"2015","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.ejphar.2025.178401_bib232","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.omto.2020.03.022","article-title":"Efficacy of a third-generation oncolytic herpes virus G47\u0394 in advanced stage models of human gastric cancer","volume":"17","author":"Sugawara","year":"2020","journal-title":"Mol. Ther. Oncolytics"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib233","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.celrep.2019.12.081","article-title":"Treg-cell-derived IL-35-Coated extracellular vesicles promote infectious tolerance","volume":"30","author":"Sullivan","year":"2020","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib234","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1038\/s41467-022-32627-z","article-title":"scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory","volume":"13","author":"Sun","year":"2022","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.ejphar.2025.178401_bib235","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/s41419-022-05320-8","article-title":"The role of cancer-associated fibroblasts in tumorigenesis of gastric cancer","volume":"13","author":"Sun","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2025.178401_bib236","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1257817","article-title":"Helicobacter pylori infection: a dynamic process from diagnosis to treatment","volume":"13","author":"Sun","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib237","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.chom.2008.11.010","article-title":"Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation","volume":"5","author":"Suzuki","year":"2009","journal-title":"Cell Host Microbe"},{"issue":"20","key":"10.1016\/j.ejphar.2025.178401_bib238","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.1093\/emboj\/18.20.5517","article-title":"Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity","volume":"18","author":"Szab\u00f2","year":"1999","journal-title":"EMBO J."},{"issue":"794","key":"10.1016\/j.ejphar.2025.178401_bib239","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abp9020","article-title":"The Helicobacter pylori CagA oncoprotein disrupts Wnt\/PCP signaling and promotes hyperproliferation of pyloric gland base cells","volume":"16","author":"Takahashi-Kanemitsu","year":"2023","journal-title":"Sci. Signal."},{"issue":"8","key":"10.1016\/j.ejphar.2025.178401_bib240","first-page":"667","article-title":"Global, regional, and national burden of early-onset gastric cancer","volume":"21","author":"Tan","year":"2024","journal-title":"Cancer Biol. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib241","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41392-023-01704-0","article-title":"Clinical applications of stem cell-derived exosomes","volume":"9","author":"Tan","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"7741","key":"10.1016\/j.ejphar.2025.178401_bib242","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-019-0878-z","article-title":"A defined commensal consortium elicits CD8 T cells and anti-cancer immunity","volume":"565","author":"Tanoue","year":"2019","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib243","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41577-024-01081-x","article-title":"Induced pluripotent stem cell-derived macrophages as a platform for modelling human disease","volume":"25","author":"Tiwari","year":"2025","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib244","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2314201","article-title":"The Helicobacter pylori cag pathogenicity island as a determinant of gastric cancer risk","volume":"16","author":"Tran","year":"2024","journal-title":"Gut Microbes"},{"issue":"17","key":"10.1016\/j.ejphar.2025.178401_bib245","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14174119","article-title":"Phototherapeutic induction of immunogenic cell death and CD8+ T cell-granzyme B mediated cytolysis in human lung cancer cells and organoids","volume":"14","author":"Valan\u010di\u016bt\u0117","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"8","key":"10.1016\/j.ejphar.2025.178401_bib246","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41577-020-00490-y","article-title":"Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity","volume":"21","author":"Veglia","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2025.178401_bib247","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4178607","article-title":"Gut microbial changes, interactions, and their implications on human lifecycle: an ageing perspective","author":"Vemuri","year":"2018","journal-title":"BioMed Res. Int."},{"issue":"6264","key":"10.1016\/j.ejphar.2025.178401_bib248","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.aad1329","article-title":"Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota","volume":"350","author":"V\u00e9tizou","year":"2015","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib249","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cytogfr.2012.09.003","article-title":"Pattern recognition receptors--molecular orchestrators of inflammation in inflammatory bowel disease","volume":"24","author":"Walsh","year":"2013","journal-title":"Cytokine Growth Factor Rev."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178401_bib250","first-page":"1821","article-title":"Advances in CagA protein and CagAmediated pathogenesis of helicobacter pylori-A review","volume":"56","author":"Wan","year":"2016","journal-title":"Weishengwu Xuebao"},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib251","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.clim.2014.10.002","article-title":"Effective response and delayed toxicities of refractory advanced diffuse large B-cell lymphoma treated by CD20-directed chimeric antigen receptor-modified T cells","volume":"155","author":"Wang","year":"2014","journal-title":"Clin. Immunol."},{"issue":"26","key":"10.1016\/j.ejphar.2025.178401_bib252","doi-asserted-by":"crossref","first-page":"8052","DOI":"10.3748\/wjg.v21.i26.8052","article-title":"Conjugation of toll-like receptor-7 agonist to gastric cancer antigen MG7-Ag exerts antitumor effects","volume":"21","author":"Wang","year":"2015","journal-title":"World J. Gastroenterol."},{"issue":"11","key":"10.1016\/j.ejphar.2025.178401_bib253","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1136\/gutjnl-2016-313075","article-title":"Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway","volume":"66","author":"Wang","year":"2017","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib254","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12967-018-1501-z","article-title":"Gastric cancer vaccines synthesized using a TLR7 agonist and their synergistic antitumor effects with 5-fluorouracil","volume":"16","author":"Wang","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejphar.2025.178401_bib255","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101319","article-title":"PRDX2 protects against oxidative stress induced by H. pylori and promotes resistance to cisplatin in gastric cancer","volume":"28","author":"Wang","year":"2020","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.ejphar.2025.178401_bib256","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s42255-020-0219-4","article-title":"Inosine is an alternative carbon source for CD8(+)-T-cell function under glucose restriction","volume":"2","author":"Wang","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.ejphar.2025.178401_bib257","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.3389\/fmicb.2020.01548","article-title":"Gastric mucosa-associated microbial signatures of early gastric cancer","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Microbiol."},{"issue":"615","key":"10.1016\/j.ejphar.2025.178401_bib258","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb6981","article-title":"Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment","volume":"13","author":"Wang","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib259","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1158\/2159-8290.CD-20-1243","article-title":"CRISPR screening of CAR T cells and cancer stem cells reveals critical dependencies for cell-based therapies","volume":"11","author":"Wang","year":"2021","journal-title":"Cancer Discov."},{"issue":"11","key":"10.1016\/j.ejphar.2025.178401_bib260","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1038\/s41418-022-01008-w","article-title":"Wnt\/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2025.178401_bib261","article-title":"Intestinal microbiota - an unmissable bridge to severe acute pancreatitis-associated acute lung injury","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib262","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.stem.2022.02.009","article-title":"3D-organoid culture supports differentiation of human CAR(+) iPSCs into highly functional CAR T cells","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.ejphar.2025.178401_bib263","article-title":"Oncolytic virus: a catalyst for the treatment of gastric cancer","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178401_bib264","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108414","article-title":"Helicobacter pylori CagA promotes immune evasion of gastric cancer by upregulating PD-L1 level in exosomes","volume":"26","author":"Wang","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.ejphar.2025.178401_bib265","article-title":"The role of the gut microbiota in gastric cancer: the immunoregulation and immunotherapy","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178401_bib266","article-title":"The role of microbiota in the development and treatment of gastric cancer","volume":"13","author":"Wang","year":"2023","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib267","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.it.2024.01.009","article-title":"Targeting MHC-I inhibitory pathways for cancer immunotherapy","volume":"45","author":"Wang","year":"2024","journal-title":"Trends Immunol."},{"key":"10.1016\/j.ejphar.2025.178401_bib268","article-title":"Advancements in research leveraging phage display technology for gastric cancer diagnosis and treatment","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejphar.2025.178401_bib269","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.876339","article-title":"Impact of manufacturing procedures on CAR T cell functionality","volume":"13","author":"Watanabe","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178401_bib270","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.692832","article-title":"Notch signaling ligand Jagged1 enhances macrophage-mediated response to Helicobacter pylori","volume":"12","author":"Wen","year":"2021","journal-title":"Front. Microbiol."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178401_bib271","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1016\/j.stem.2021.08.013","article-title":"Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy","volume":"28","author":"Woan","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib272","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/ijc.33848","article-title":"Oral and gastric microbiome in relation to gastric intestinal metaplasia","volume":"150","author":"Wu","year":"2022","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib273","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12943-023-01899-4","article-title":"Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects","volume":"22","author":"Wu","year":"2023","journal-title":"Mol. Cancer"},{"issue":"20","key":"10.1016\/j.ejphar.2025.178401_bib274","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16203547","article-title":"Gastrointestinal microbiota in gastric cancer: potential mechanisms and clinical Applications-A literature review","volume":"16","author":"Wu","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib275","doi-asserted-by":"crossref","DOI":"10.3390\/polym16091253","article-title":"Application of PLGA in tumor immunotherapy","volume":"16","author":"Wu","year":"2024","journal-title":"Polymers"},{"issue":"12","key":"10.1016\/j.ejphar.2025.178401_bib276","doi-asserted-by":"crossref","first-page":"19756","DOI":"10.1021\/acsnano.1c07180","article-title":"Cancer-erythrocyte hybrid membrane-camouflaged magnetic nanoparticles with enhanced photothermal-immunotherapy for ovarian cancer","volume":"15","author":"Xiong","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.ejphar.2025.178401_bib277","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.2147\/OTT.S164749","article-title":"Helicobacter pylori promotes gastric epithelial cell survival through the PLK1\/PI3K\/Akt pathway","volume":"11","author":"Xu","year":"2018","journal-title":"OncoTargets Ther."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib278","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1080\/15384047.2019.1579957","article-title":"Activation of CD3(+) T cells by Helicobacter pylori DNA vaccines in potential immunotherapy of gastric carcinoma","volume":"20","author":"Xue","year":"2019","journal-title":"Cancer Biol. Ther."},{"issue":"7","key":"10.1016\/j.ejphar.2025.178401_bib279","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.tibtech.2023.02.003","article-title":"Induced pluripotent stem cell-derived engineered T cells, natural killer cells, macrophages, and dendritic cells in immunotherapy","volume":"41","author":"Xue","year":"2023","journal-title":"Trends Biotechnol."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib280","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.stem.2020.09.014","article-title":"Pluripotent stem cell-based cell therapy-promise and challenges","volume":"27","author":"Yamanaka","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"16","key":"10.1016\/j.ejphar.2025.178401_bib281","doi-asserted-by":"crossref","first-page":"11250","DOI":"10.1074\/jbc.M509404200","article-title":"Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation","volume":"281","author":"Yamasaki","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib282","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/cas.15244","article-title":"MEK inhibition suppresses metastatic progression of KRAS-mutated gastric cancer","volume":"113","author":"Yamasaki","year":"2022","journal-title":"Cancer Sci."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib283","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1158\/0008-5472.939.65.3","article-title":"Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation","volume":"65","author":"Yang","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2025.178401_bib284","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3389\/fcimb.2019.00375","article-title":"Helicobacter pylori infection aggravates dysbiosis of gut microbiome in children with gastritis","volume":"9","author":"Yang","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib285","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1186\/s12967-022-03650-x","article-title":"Microbiota and metabolites alterations in proximal and distal gastric cancer patients","volume":"20","author":"Yang","year":"2022","journal-title":"J. Transl. Med."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib286","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1021\/acsnano.2c00462","article-title":"Nano-ultrasonic contrast agent for chemoimmunotherapy of breast cancer by immune metabolism reprogramming and tumor autophagy","volume":"16","author":"Yang","year":"2022","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib287","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-006280","article-title":"Development of the oncolytic virus, CF33, and its derivatives for peritoneal-directed treatment of gastric cancer peritoneal metastases","volume":"11","author":"Yang","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ejphar.2025.178401_bib288","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.2147\/IJN.S207589","article-title":"Drug-free mannosylated liposomes inhibit tumor growth by promoting the polarization of tumor-associated macrophages","volume":"14","author":"Ye","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ejphar.2025.178401_bib289","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8825189","article-title":"The efficacy of washed microbiota transplantation on Helicobacter pylori eradication: a pilot study","volume":"2020","author":"Ye","year":"2020","journal-title":"Gastroenterol. Res. Pract."},{"issue":"7","key":"10.1016\/j.ejphar.2025.178401_bib290","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.1263","article-title":"Potential mechanisms and targeting strategies of the gut microbiota in antitumor immunity and immunotherapy","volume":"12","author":"Yin","year":"2024","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.ejphar.2025.178401_bib291","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12964-015-0111-0","article-title":"Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways","volume":"13","author":"Yong","year":"2015","journal-title":"Cell Commun. Signal."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib292","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-008422","article-title":"Impact of Helicobacter pylori infection status on outcomes among patients with advanced gastric cancer treated with immune checkpoint inhibitors","volume":"12","author":"Yu","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"7","key":"10.1016\/j.ejphar.2025.178401_bib293","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41575-022-00591-0","article-title":"The immune microenvironment in gastric adenocarcinoma","volume":"19","author":"Zavros","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178401_bib294","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22062907","article-title":"Investigating T cell immunity in cancer: achievements and prospects","volume":"22","author":"Zeng","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib295","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1038\/s41467-022-32805-z","article-title":"A compendium of 32,277 metagenome-assembled genomes and over 80 million genes from the early-life human gut microbiome","volume":"13","author":"Zeng","year":"2022","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178401_bib296","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1136\/gutjnl-2024-332815","article-title":"Stomach microbiota in gastric cancer development and clinical implications","volume":"73","author":"Zeng","year":"2024","journal-title":"Gut"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178401_bib298","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/path.5033","article-title":"Reduced lysosomal clearance of autophagosomes promotes survival and colonization of Helicobacter pylori","volume":"244","author":"Zhang","year":"2018","journal-title":"J. Pathol."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178401_bib299","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190354","article-title":"Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer","volume":"217","author":"Zhang","year":"2020","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178401_bib300","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s13045-020-00983-2","article-title":"Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions","volume":"13","author":"Zhang","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ejphar.2025.178401_bib301","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mib.2020.01.003","article-title":"Mechanisms of persistence, innate immune activation and immunomodulation by the gastric pathogen Helicobacter pylori","volume":"54","author":"Zhang","year":"2020","journal-title":"Curr. Opin. Microbiol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib302","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1158\/2159-8290.CD-20-0304","article-title":"Gut microbiome directs hepatocytes to recruit MDSCs and promote cholangiocarcinoma","volume":"11","author":"Zhang","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ejphar.2025.178401_bib303","article-title":"Alterations of gastric microbiota in gastric cancer and precancerous stages","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib304","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1007\/s10637-021-01122-5","article-title":"Helicobacter pylori infection as a potential favorable factor for immune checkpoint inhibitor therapy for gastric cancer","volume":"39","author":"Zhang","year":"2021","journal-title":"Invest. N. Drugs"},{"key":"10.1016\/j.ejphar.2025.178401_bib305","article-title":"Gastric microbiota dysbiosis and Helicobacter pylori infection","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Microbiol."},{"issue":"10","key":"10.1016\/j.ejphar.2025.178401_bib306","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.7150\/ijbs.96425","article-title":"Helicobacter pylori promotes gastric cancer through CagA-mediated mitochondrial cholesterol accumulation by targeting CYP11A1 redistribution","volume":"20","author":"Zhang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178401_bib307","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s10120-023-01461-7","article-title":"Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6","volume":"27","author":"Zhang","year":"2024","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.ejphar.2025.178401_bib308","article-title":"Advancements and challenges in immunotherapy for gastric cancer: current approaches and future directions","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178401_bib309","first-page":"2484","article-title":"MicroRNA-140 suppresses helicobacter pylori-positive gastric cancer growth by enhancing the antitumor immune response","volume":"20","author":"Zhao","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178401_bib310","doi-asserted-by":"crossref","first-page":"924","DOI":"10.7150\/ijms.71820","article-title":"Epstein-Barr virus is associated with gastric cancer precursor: atrophic gastritis","volume":"19","author":"Zhao","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.ejphar.2025.178401_bib311","article-title":"The effects of Helicobacter pylori infection on microbiota associated with gastric mucosa and immune factors in children","volume":"12","author":"Zheng","year":"2021","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.ejphar.2025.178401_bib312","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1136\/gutjnl-2014-307020","article-title":"A pro-inflammatory role for Th22 cells in Helicobacter pylori-associated gastritis","volume":"64","author":"Zhuang","year":"2015","journal-title":"Gut"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925011550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925011550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:35:18Z","timestamp":1773876918000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925011550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":306,"alternative-id":["S0014299925011550"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178401","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of multidimensional interactions among Helicobacter pylori infection, tumor microenvironment, and gut microbiota on gastric cancer immune response","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178401","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178401"}}