{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:38:22Z","timestamp":1790933902707,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005063","name":"Excellent Young Talents Fund Program of Higher Education Institutions of Anhui Province","doi-asserted-by":"publisher","award":["gxgwfx2019010"],"award-info":[{"award-number":["gxgwfx2019010"]}],"id":[{"id":"10.13039\/501100005063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Province Department of Education","doi-asserted-by":"publisher","award":["KJ2021A0327"],"award-info":[{"award-number":["KJ2021A0327"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Province Department of Education","doi-asserted-by":"publisher","award":["2022jyjxggyj203"],"award-info":[{"award-number":["2022jyjxggyj203"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejphar.2025.178424","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T16:26:45Z","timestamp":1764779205000},"page":"178424","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Hyperuricemia exacerbates myocardial ischemia-reperfusion injury by inducing ferroptosis via NCOA4 and xCT-GPX4 axis dysregulation"],"prefix":"10.1016","volume":"1011","author":[{"given":"Meng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5217-0227","authenticated-orcid":false,"given":"Qiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlong","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.178424_bib1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tcm.2022.02.005","article-title":"'Myocardial ischemia-reperfusion injury and the influence of inflammation'","volume":"33","author":"Algoet","year":"2023","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2025.178424_bib2","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMra1606915","article-title":"Acute myocardial infarction","volume":"376","author":"Anderson","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2025.178424_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.112107","article-title":"The role and behavior of voltage-gated calcium channels in ischemia\/reperfusion","volume":"136","author":"Ay","year":"2025","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejphar.2025.178424_bib4","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1161\/HYPERTENSIONAHA.122.17956","article-title":"Uric acid and hypertension: a review of evidence and future perspectives for the management of cardiovascular risk","volume":"79","author":"Borghi","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.178424_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5603\/CJ.a2021.0001","article-title":"Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk: 2021 update","volume":"28","author":"Borghi","year":"2021","journal-title":"Cardiol. J."},{"key":"10.1016\/j.ejphar.2025.178424_bib6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20110162","article-title":"Assessing mitochondrial dysfunction in cells","volume":"435","author":"Brand","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2025.178424_bib7","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1161\/CIRCULATIONAHA.122.060257","article-title":"Alox15\/15-HpETE aggravates myocardial ischemia-reperfusion injury by promoting cardiomyocyte ferroptosis","volume":"147","author":"Cai","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2025.178424_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123609","article-title":"Dexmedetomidine inhibits ferroptosis through the Akt\/GSK3\u03b2\/Nrf2 axis and alleviates adriamycin-induced cardiotoxicity","volume":"371","author":"Cao","year":"2025","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.178424_bib9","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1038\/onc.2017.146","article-title":"ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner","volume":"36","author":"Chen","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2025.178424_bib10","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-031-82990-1","article-title":"'Ophiopogon japonicus polysaccharide reduces doxorubicin-induced myocardial ferroptosis injury by activating Nrf2\/GPX4 signaling and alleviating iron accumulation'","volume":"31","author":"Chen","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2025.178424_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23310","article-title":"DUSP12 ameliorates myocardial ischemia-reperfusion injury through HSPB8-induced mitophagy","volume":"37","author":"Cheng","year":"2023","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.ejphar.2025.178424_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1158\/0008-5472.CAN-22-1433","article-title":"Immunotherapeutic targeting and PET imaging of DLL3 in small-cell neuroendocrine prostate cancer","volume":"83","author":"Chou","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2025.178424_bib13","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"'Ferroptosis: an iron-dependent form of nonapoptotic cell death'","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2025.178424_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178424_bib15","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1021\/acscentsci.0c01592","article-title":"Inhibiting ferroptosis through disrupting the NCOA4-FTH1 interaction: a new mechanism of action","volume":"7","author":"Fang","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.ejphar.2025.178424_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"'Role of Mitochondria in Ferroptosis'","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejphar.2025.178424_bib17","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s12033-024-01173-y","article-title":"Management of ROS and regulatory cell death in myocardial ischemia-reperfusion injury","volume":"67","author":"Gong","year":"2025","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.ejphar.2025.178424_bib18","article-title":"'Corrigendum: deferoxamine alleviates osteoarthritis by inhibiting chondrocyte ferroptosis and activating the Nrf2 pathway'","volume":"14","author":"Guo","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178424_bib19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1172\/JCI62874","article-title":"'Myocardial ischemia-reperfusion injury: a neglected therapeutic target'","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2025.178424_bib20","article-title":"'Inflammation-Targeted Nanomedicines Alleviate Oxidative Stress and Reprogram Macrophages Polarization for Myocardial Infarction Treatment'","volume":"11","author":"Hu","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.ejphar.2025.178424_bib21","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1161\/CIRCULATIONAHA.120.045470","article-title":"4HNE impairs myocardial bioenergetics in congenital heart disease-induced right ventricular failure","volume":"142","author":"Hwang","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2025.178424_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/01616412.2016.1251711","article-title":"Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders","volume":"39","author":"Islam","year":"2017","journal-title":"Neurol. Res."},{"issue":"9","key":"10.1016\/j.ejphar.2025.178424_bib23","doi-asserted-by":"crossref","first-page":"11834","DOI":"10.1007\/s12035-025-05005-1","article-title":"ERR\u03b1 knockout promotes M2 microglial polarization and inhibits ferroptosis in sepsis-associated brain dysfunction","volume":"62","author":"Jin","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2025.178424_bib24","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1038\/s41440-023-01273-3","article-title":"'Update in uric acid, hypertension, and cardiovascular diseases'","volume":"46","author":"Kuwabara","year":"2023","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.ejphar.2025.178424_bib25","article-title":"The interplay between intracellular iron homeostasis and neuroinflammation in neurodegenerative diseases","volume":"12","author":"Lee","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.ejphar.2025.178424_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202409329","article-title":"Targeting the labile iron pool with engineered DFO nanosheets to inhibit ferroptosis for parkinson's disease therapy","volume":"36","author":"Lei","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ejphar.2025.178424_bib27","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.1039\/D5FO00580A","article-title":"'2'-Fucosyllactose evokes colonization of Alloprevotella and alleviates renal injury in hyperuricemia mice'","volume":"16","author":"Lei","year":"2025","journal-title":"Food Funct."},{"key":"10.1016\/j.ejphar.2025.178424_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167277","article-title":"HIF-1 induced tiRNA-Lys-CTT-003 is protective against cisplatin induced ferroptosis of renal tubular cells in mouse AKI model","volume":"1870","author":"Li","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.ejphar.2025.178424_bib29","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.7150\/ijbs.83348","article-title":"The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks","volume":"19","author":"Li","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ejphar.2025.178424_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112155","article-title":"'Oxidative medicine and cellular longevity the role and mechanism of NCOA4 in ferroptosis induced by intestinal ischemia reperfusion'","volume":"133","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2025.178424_bib31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41420-021-00656-0","article-title":"'Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia\/reperfusion injury'","volume":"7","author":"Li","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.ejphar.2025.178424_bib32","article-title":"'Calpain: the regulatory point of myocardial ischemia-reperfusion injury'","volume":"10","author":"Liu","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2025.178424_bib33","article-title":"Deubiquitinase OTUD5 as a novel protector against 4-HNE-Triggered ferroptosis in myocardial Ischemia\/Reperfusion Injury","volume":"10","author":"Liu","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.ejphar.2025.178424_bib34","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.numecd.2023.10.019","article-title":"'Hyperuricemia is associated with heart failure readmission in patients with heart failure and preserved ejection fraction-an observational study in Chinese'","volume":"34","author":"Liu","year":"2024","journal-title":"Nutr. Metabol. Cardiovasc. Dis."},{"key":"10.1016\/j.ejphar.2025.178424_bib35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijcard.2015.08.109","article-title":"'Regulation of uric acid metabolism and excretion'","volume":"213","author":"Maiuolo","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178424_bib36","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.33549\/physiolres.933555","article-title":"'Uric acid contributes greatly to hepatic antioxidant capacity besides protein'","volume":"66","author":"Mikami","year":"2017","journal-title":"Physiol. Res."},{"key":"10.1016\/j.ejphar.2025.178424_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2025.1632867","article-title":"Temporal regulation of genetic programs governing multiple cell death during myocardial ischemia-reperfusion injury","volume":"16","author":"Pang","year":"2025","journal-title":"Front. Genet."},{"key":"10.1016\/j.ejphar.2025.178424_bib38","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9743280","article-title":"NLRP3 inflammasome activation-mediated pyroptosis aggravates myocardial ischemia\/reperfusion injury in diabetic rats","volume":"2017","author":"Qiu","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejphar.2025.178424_bib39","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s40262-022-01151-0","article-title":"'Pharmacological Basis for Abrogating Myocardial Reperfusion Injury Through a Multi-Target Combined Antioxidant Therapy'","volume":"61","author":"San-Mart\u00edn-Mart\u00ednez","year":"2022","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ejphar.2025.178424_bib40","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1158\/2159-8290.CD-22-0043","article-title":"NCOA4-Mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins","volume":"12","author":"Santana-Codina","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.ejphar.2025.178424_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110990","article-title":"'Uric acid aggravates myocardial ischemia-reperfusion injury via ROS\/NLRP3 pyroptosis pathway'","volume":"133","author":"Shen","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2025.178424_bib42","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00210-020-01932-z","article-title":"'Ferroptosis occurs in phase of reperfusion but not ischemia in rat heart following ischemia or ischemia\/reperfusion'","volume":"394","author":"Tang","year":"2021","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.ejphar.2025.178424_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010106","article-title":"Understanding cellular redox homeostasis: a challenge for precision medicine","volume":"23","author":"Tretter","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178424_bib44","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1161\/HYPERTENSIONAHA.119.13643","article-title":"'Identification of the Uric Acid Thresholds Predicting an Increased Total and Cardiovascular Mortality Over 20 Years'","volume":"75","author":"Virdis","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.ejphar.2025.178424_bib45","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijcard.2022.12.018","article-title":"'Baicalein and luteolin inhibit ischemia\/reperfusion-induced ferroptosis in rat cardiomyocytes'","volume":"375","author":"Wang","year":"2023","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178424_bib46","article-title":"The multifaceted regulation of mitochondria in ferroptosis","volume":"11","author":"Wu","year":"2021","journal-title":"Life (Basel)"},{"key":"10.1016\/j.ejphar.2025.178424_bib47","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s00395-022-00930-x","article-title":"Blunting TRPML1 channels protects myocardial ischemia\/reperfusion injury by restoring impaired cardiomyocyte autophagy","volume":"117","author":"Xing","year":"2022","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.ejphar.2025.178424_bib48","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1089\/ars.2023.0473","article-title":"'High Uric Acid Orchestrates Ferroptosis to Promote Cardiomyopathy Via ROS-GPX4 Signaling'","volume":"41","author":"Xu","year":"2024","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.ejphar.2025.178424_bib49","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/s41419-020-03021-8","article-title":"Oxygen glucose deprivation\/re-oxygenation-induced neuronal cell death is associated with Lnc-D63785 m6A methylation and miR-422a accumulation","volume":"11","author":"Xu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2025.178424_bib50","doi-asserted-by":"crossref","first-page":"10052","DOI":"10.1039\/D3FO02633G","article-title":"'Fucoxanthin alleviated myocardial ischemia and reperfusion injury through inhibition of ferroptosis via the NRF2 signaling pathway'","volume":"14","author":"Yan","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.ejphar.2025.178424_bib51","article-title":"'Maresin1 Protect Against Ferroptosis-Induced Liver Injury Through ROS Inhibition and Nrf2\/HO-1\/GPX4 Activation'","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178424_bib52","article-title":"The coming age of antisense oligos for the treatment of hepatic ischemia\/reperfusion (IRI) and other liver disorders: role of oxidative stress and potential antioxidant effect","volume":"13","author":"Yao","year":"2024","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.ejphar.2025.178424_bib53","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1111\/jcmm.13754","article-title":"Knockdown of lncRNA AK139328 alleviates myocardial ischaemia\/reperfusion injury in diabetic mice via modulating miR-204-3p and inhibiting autophagy","volume":"22","author":"Yu","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2025.178424_bib54","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9304383","article-title":"High level of uric acid promotes atherosclerosis by targeting NRF2-Mediated autophagy dysfunction and ferroptosis","volume":"2022","author":"Yu","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.ejphar.2025.178424_bib55","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.1021\/acs.analchem.4c06892","article-title":"Tumor microenvironment-responsive lipid peroxidation amplifier: harnessing ferroptosis resistance to devastate the ferroptosis defense system","volume":"97","author":"Zeng","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.ejphar.2025.178424_bib56","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13019-024-03260-2","article-title":"miRNA-541-5p regulates myocardial ischemia-reperfusion injury by targeting ferroptosis","volume":"20","author":"Zhao","year":"2025","journal-title":"J. Cardiothorac. Surg."},{"key":"10.1016\/j.ejphar.2025.178424_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2025.123591","article-title":"Akt mitigates ER stress-instigated cardiac dysfunction via regulation of ferroptosis and mitochondrial integrity in a DHODH-dependent manner","volume":"371","author":"Zhou","year":"2025","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.178424_bib58","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1021\/acscentsci.7b00028","article-title":"On the mechanism of cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death","volume":"3","author":"Zilka","year":"2017","journal-title":"ACS Cent. Sci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925011781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925011781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:17:00Z","timestamp":1773861420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925011781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":58,"alternative-id":["S0014299925011781"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178424","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperuricemia exacerbates myocardial ischemia-reperfusion injury by inducing ferroptosis via NCOA4 and xCT-GPX4 axis dysregulation","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178424","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178424"}}