{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:15:57Z","timestamp":1792066557461,"version":"4.4.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015406","name":"Tianjin Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["24ZYCGSN01310"],"award-info":[{"award-number":["24ZYCGSN01310"]}],"id":[{"id":"10.13039\/501100015406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072222"],"award-info":[{"award-number":["82072222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020763","name":"Ministry of Emergency Management of the People&apos;s Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejphar.2025.178441","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T17:15:25Z","timestamp":1765473325000},"page":"178441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Azathioprine ameliorates cellular senescence in rhabdomyolysis-induced acute kidney injury by inhibiting the Vav1\/Rac2\/NF-\u03baB pathway in macrophages"],"prefix":"10.1016","volume":"1011","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0135-9114","authenticated-orcid":false,"given":"Hongshuang","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1263-0176","authenticated-orcid":false,"given":"Qihui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4414-9501","authenticated-orcid":false,"given":"Lishuang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5335-2825","authenticated-orcid":false,"given":"Keke","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4911-7730","authenticated-orcid":false,"given":"Congcong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4264-003X","authenticated-orcid":false,"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8027-4760","authenticated-orcid":false,"given":"Mengke","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayinuer","family":"Paredong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Shou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9264-1187","authenticated-orcid":false,"given":"Heng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ejphar.2025.178441_bib1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/jnen\/nlad006","article-title":"Rac2 enhances activation of microglia and astrocytes, inflammatory response, and apoptosis via activating JNK signaling pathway and suppressing SIRT1 expression in chronic constriction injury-induced neuropathic pain","volume":"82","author":"An","year":"2023","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"8","key":"10.1016\/j.ejphar.2025.178441_bib2","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.4049\/jimmunol.164.8.3971","article-title":"Specific subdomains of vav differentially affect T cell and NK cell activation","volume":"164","author":"Billadeau","year":"2000","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178441_bib3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41420-024-01831-9","article-title":"Cellular senescence of renal tubular epithelial cells in acute kidney injury","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178441_bib4","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02391-23","article-title":"Vav proteins do not influence dengue virus replication but are associated with induction of phospho-ERK, IL-6, and viperin mRNA following DENV infection in vitro","volume":"12","author":"Cowell","year":"2024","journal-title":"Microbiol. Spectr."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178441_bib5","first-page":"e55","article-title":"Prevalence of compartment syndrome and disseminated intravascular coagulation following rhabdomyolysis; a systematic review and meta-analysis","volume":"11","author":"Danaei","year":"2023","journal-title":"Arch Acad Emerg Med"},{"key":"10.1016\/j.ejphar.2025.178441_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2021.104234","article-title":"Anti-angiogenic activity of azathioprine","volume":"138","author":"de Melo Bisneto","year":"2021","journal-title":"Microvasc. Res."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178441_bib7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cyto.a.24506","article-title":"Rac1\/pSTAT3 expression: a pharmacodynamic marker panel as a first step toward optimization of thiopurine therapy in inflammatory bowel disease patients","volume":"101","author":"Deben","year":"2022","journal-title":"Cytometry A"},{"issue":"3","key":"10.1016\/j.ejphar.2025.178441_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23031384","article-title":"10-Dehydrogingerdione Attenuates tramadol-induced nephrotoxicity by modulating renal oxidative stress, inflammation and apoptosis in experimental rats: role of HO-1 activation and TLR4\/NF-\u03baB\/ERK inhibition","volume":"23","author":"Elnagar","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"Pt 1","key":"10.1016\/j.ejphar.2025.178441_bib9","article-title":"SILAC proteomics based on 3D cell spheroids unveils the role of RAC2 in regulating the crosstalk between triple-negative breast cancer cells and tumor-associated macrophages","volume":"254","author":"Guo","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178441_bib10","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.cell.2018.02.001","article-title":"Mapping the mouse cell Atlas by microwell-seq","volume":"172","author":"Han","year":"2018","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178441_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041341","article-title":"The Rho\/Rac guanine Nucleotide Exchange factor Vav1 regulates Hif-1\u03b1 and Glut-1 expression and glucose uptake in the brain","volume":"21","author":"Hong","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178441_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.822816","article-title":"Why senescent cells are resistant to apoptosis: an Insight for senolytic development","volume":"10","author":"Hu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178441_bib13","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/jleuko\/qiad032","article-title":"Rac2 regulates immune complex-mediated granule polarization and exocytosis in neutrophils","volume":"114","author":"Ilarraza","year":"2023","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ejphar.2025.178441_bib14","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.919150","article-title":"Effect of grilled nux vomica on differential RNA expression profile of Gastrocnemius Muscle and toll-like receptor 4 (TLR-4)\/Nuclear factor kappa B (NF-\u03baB) signaling in Experimental autoimmune Myasthenia Gravis rats","volume":"26","author":"Jiang","year":"2020","journal-title":"Med. Sci. Monit."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178441_bib15","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.125490","article-title":"Epithelial innate immunity mediates tubular cell senescence after kidney injury","volume":"4","author":"Jin","year":"2019","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178441_bib16","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ajpath.2019.09.013","article-title":"Innate immune signaling contributes to tubular cell senescence in the Glis2 knockout mouse model of nephronophthisis","volume":"190","author":"Jin","year":"2020","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178441_bib17","doi-asserted-by":"crossref","DOI":"10.1136\/tsaco-2021-000836","article-title":"Rhabdomyolysis: an American Association for the surgery of Trauma Critical Care Committee clinical consensus document","volume":"7","author":"Kodadek","year":"2022","journal-title":"Trauma Surg Acute Care Open"},{"issue":"11","key":"10.1016\/j.ejphar.2025.178441_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/cells10112808","article-title":"Rac GTPase signaling in immune-mediated mechanisms of atherosclerosis","volume":"10","author":"Lee","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178441_bib19","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202001855RR","article-title":"Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence","volume":"35","author":"Li","year":"2021","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178441_bib20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41420-022-00894-w","article-title":"Myoglobin promotes macrophage polarization to M1 type and pyroptosis via the RIG-I\/Caspase1\/GSDMD signaling pathway in CS-AKI","volume":"8","author":"Li","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.ejphar.2025.178441_bib21","doi-asserted-by":"crossref","DOI":"10.1007\/s00467-022-05532-2","article-title":"Cellular senescence and acute kidney injury","author":"Lin","year":"2022","journal-title":"Pediatr. Nephrol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178441_bib22","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s00011-020-01334-0","article-title":"Aquaporin 1 alleviates acute kidney injury via PI3K-mediated macrophage M2 polarization","volume":"69","author":"Liu","year":"2020","journal-title":"Inflamm. Res."},{"issue":"7","key":"10.1016\/j.ejphar.2025.178441_bib23","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3724\/abbs.2022055","article-title":"Albumin-induced premature senescence in human renal proximal tubular cells and its relationship with intercellular fibrosis","volume":"54","author":"Lu","year":"2022","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178441_bib24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12882-023-03125-1","article-title":"A potential link between fibroblast growth factor-23 and the progression of AKI to CKD","volume":"24","author":"Lu","year":"2023","journal-title":"BMC Nephrol."},{"issue":"10","key":"10.1016\/j.ejphar.2025.178441_bib25","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1681\/ASN.2020030263","article-title":"Cilastatin ameliorates rhabdomyolysis-induced AKI in mice","volume":"32","author":"Matsushita","year":"2021","journal-title":"J. Am. Soc. Nephrol."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178441_bib26","article-title":"Integration of spatial and single-cell transcriptomics localizes epithelial cell-immune cross-talk in kidney injury","volume":"6","author":"Melo Ferreira","year":"2021","journal-title":"JCI Insight"},{"issue":"7","key":"10.1016\/j.ejphar.2025.178441_bib27","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/CM9.0000000000002100","article-title":"Driving role of macrophages in transition from acute kidney injury to chronic kidney disease","volume":"135","author":"Meng","year":"2022","journal-title":"Chin Med J (Engl)"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178441_bib28","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.lfs.2006.01.015","article-title":"Inhibition of inducible nitric oxide synthesis by azathioprine in a macrophage cell line","volume":"79","author":"Moeslinger","year":"2006","journal-title":"Life Sci."},{"issue":"18","key":"10.1016\/j.ejphar.2025.178441_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25189793","article-title":"NF-kappaB Transcription factors: their distribution, family expansion, structural conservation, and evolution in animals","volume":"25","author":"Msweli","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178441_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1134661","article-title":"NF-\u03baB in monocytes and macrophages - an inflammatory master regulator in multitalented immune cells","volume":"14","author":"Mussbacher","year":"2023","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.ejphar.2025.178441_bib31","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.it.2024.06.004","article-title":"VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases","volume":"45","author":"Neurath","year":"2024","journal-title":"Trends Immunol."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178441_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/v14020386","article-title":"Vav proteins in development of the brain: a potential relationship to the pathogenesis of congenital zika syndrome?","volume":"14","author":"Norbury","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.ejphar.2025.178441_bib33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbrc.2022.06.018","article-title":"Single-cell transcriptomics identifies Col1a1 and Col1a2 as hub genes in obesity-induced cardiac fibrosis","volume":"618","author":"Pan","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178441_bib34","doi-asserted-by":"crossref","first-page":"640","DOI":"10.4049\/jimmunol.176.1.640","article-title":"Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of vav guanosine exchange activity on Rac proteins","volume":"176","author":"Poppe","year":"2006","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178441_bib35","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.kint.2022.10.008","article-title":"A macrophage-endothelial immunoregulatory axis ameliorates septic acute kidney injury","volume":"103","author":"Privratsky","year":"2023","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178441_bib36","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1007\/s00210-024-03569-8","article-title":"Contemporary and prospective use of azathioprine (AZA) in viral, rheumatic, and dermatological disorders: a review of pharmacogenomic and nanotechnology applications","volume":"398","author":"Rathi","year":"2025","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"14","key":"10.1016\/j.ejphar.2025.178441_bib37","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1158\/0008-5472.CAN-14-3103","article-title":"Targeting pancreatic cancer metastasis by inhibition of Vav1, a driver of tumor cell invasion","volume":"75","author":"Razidlo","year":"2015","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178441_bib38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41581-019-0248-y","article-title":"Targeting the progression of chronic kidney disease","volume":"16","author":"Ruiz-Ortega","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178441_bib39","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12882-024-03509-x","article-title":"Uric acid in predicting the traumatic rhabdomyolysis induced acute kidney injury; a systematic review and meta-analysis","volume":"25","author":"Safari","year":"2024","journal-title":"BMC Nephrol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178441_bib40","doi-asserted-by":"crossref","first-page":"C1201","DOI":"10.1152\/ajpcell.00471.2010","article-title":"NF-\u03baB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells","volume":"301","author":"Shimizu","year":"2011","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"10.1016\/j.ejphar.2025.178441_bib41","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrneph.2016.183","article-title":"Cellular senescence in renal ageing and disease","volume":"13","author":"Sturmlechner","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ejphar.2025.178441_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2025.1538526","article-title":"IL-6\/GATA2\/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury","volume":"12","author":"Su","year":"2025","journal-title":"Front. Mol. Biosci."},{"issue":"8","key":"10.1016\/j.ejphar.2025.178441_bib43","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1172\/JCI16432","article-title":"CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes","volume":"111","author":"Tiede","year":"2003","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178441_bib44","first-page":"58","article-title":"Rhabdomyolysis: pathogenesis, diagnosis, and treatment","volume":"15","author":"Torres","year":"2015","journal-title":"Ochsner J."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178441_bib45","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.coi.2005.04.003","article-title":"Vav-family proteins in T-cell signalling","volume":"17","author":"Tybulewicz","year":"2005","journal-title":"Curr. Opin. Immunol."},{"issue":"5","key":"10.1016\/j.ejphar.2025.178441_bib46","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1007\/s10753-022-01675-4","article-title":"Ulinastatin alleviates rhabdomyolysis-induced acute kidney injury by suppressing inflammation and apoptosis via inhibiting TLR4\/NF-kappaB signaling pathway","volume":"45","author":"Wang","year":"2022","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178441_bib47","first-page":"37","article-title":"RIG-I, a novel DAMPs sensor for myoglobin activates NF-kappaB\/caspase-3 signaling in CS-AKI model","volume":"8","author":"Wang","year":"2021","journal-title":"Mil Med Res"},{"key":"10.1016\/j.ejphar.2025.178441_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2019.111160","article-title":"NF-\u03baB signaling in skin aging","volume":"184","author":"Wang","year":"2019","journal-title":"Mech. Ageing Dev."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178441_bib49","article-title":"Single cell RNA sequencing identifies a unique inflammatory macrophage subset as a druggable target for alleviating acute kidney injury","volume":"9","author":"Yao","year":"2022","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"3","key":"10.1016\/j.ejphar.2025.178441_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25031755","article-title":"From acute to chronic: unraveling the pathophysiological mechanisms of the progression from acute Kidney injury to acute Kidney disease to chronic Kidney disease","volume":"25","author":"Yeh","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2025.178441_bib51","article-title":"Cellular senescence of renal tubular epithelial cells in renal fibrosis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Endocrinol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925011951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925011951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:41:32Z","timestamp":1773902492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925011951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":51,"alternative-id":["S0014299925011951"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178441","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Azathioprine ameliorates cellular senescence in rhabdomyolysis-induced acute kidney injury by inhibiting the Vav1\/Rac2\/NF-\u03baB pathway in macrophages","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178441","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178441"}}