{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:26:33Z","timestamp":1790803593437,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20180031"],"award-info":[{"award-number":["Y20180031"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejphar.2025.178480","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:43:25Z","timestamp":1765611805000},"page":"178480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Nobiletin ameliorates intervertebral disc degeneration by upregulating HIF-1\u03b1 to inhibit endoplasmic reticulum stress-induced apoptosis"],"prefix":"10.1016","volume":"1011","author":[{"given":"Yangcan","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiye","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaze","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianpeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongke","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ejphar.2025.178480_bib1","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s00586-024-08163-3","article-title":"ISSLS PRIZE in basic science 2024: superiority of nucleus pulposus cell- versus mesenchymal stromal cell-derived extracellular vesicles in attenuating disc degeneration and alleviating pain","volume":"33","author":"Ambrosio","year":"2024","journal-title":"Eur. Spine J."},{"issue":"12","key":"10.1016\/j.ejphar.2025.178480_bib2","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1038\/s12276-020-00545-z","article-title":"Spermidine attenuates bleomycin-induced lung fibrosis by inducing autophagy and inhibiting endoplasmic reticulum stress (ERS)-induced cell death in mice","volume":"52","author":"Baek","year":"2020","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178480_bib3","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13058-021-01462-3","article-title":"ESR1 mutation as an emerging clinical biomarker in metastatic hormone receptor-positive breast cancer","volume":"23","author":"Brett","year":"2021","journal-title":"Breast Cancer Res."},{"issue":"6692","key":"10.1016\/j.ejphar.2025.178480_bib4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/28867","article-title":"Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis","volume":"394","author":"Carmeliet","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2025.178480_bib5","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13844","article-title":"Nobiletin alleviates the hypoxia\/reoxygenation-induced damage in myocardial cells by modulating the miR-433\/SIRT1 axis","author":"Chen","year":"2021","journal-title":"J. Food Biochem."},{"issue":"22","key":"10.1016\/j.ejphar.2025.178480_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/cells11223552","article-title":"HIF-1\u03b1 regulates bone homeostasis and angiogenesis, participating in the occurrence of bone metabolic diseases","volume":"11","author":"Chen","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178480_bib7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","article-title":"Endoplasmic reticulum stress: molecular mechanism and therapeutic targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"50","key":"10.1016\/j.ejphar.2025.178480_bib8","doi-asserted-by":"crossref","first-page":"20105","DOI":"10.1021\/acs.jafc.3c06498","article-title":"Nobiletin ameliorates hepatic lipid deposition, oxidative stress, and inflammation by mechanisms that involve the Nrf2\/NF-\u03baB axis in nonalcoholic fatty liver disease","volume":"71","author":"Fan","year":"2023","journal-title":"J. Agric. Food Chem."},{"issue":"10137","key":"10.1016\/j.ejphar.2025.178480_bib9","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/S0140-6736(18)30480-X","article-title":"What low back pain is and why we need to pay attention","volume":"391","author":"Hartvigsen","year":"2018","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.ejphar.2025.178480_bib10","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1080\/15548627.2021.1872227","article-title":"HIF1A alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy","volume":"17","author":"He","year":"2021","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.ejphar.2025.178480_bib11","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41419-020-2680-0","article-title":"Stabilization of HIF-1\u03b1 alleviates osteoarthritis via enhancing mitophagy","volume":"11","author":"Hu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2025.178480_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114795","article-title":"Nobiletin alleviates myocardial ischemia-reperfusion injury via ferroptosis in rats with type-2 diabetes mellitus","volume":"163","author":"Huang","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.ejphar.2025.178480_bib13","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jcc.20945","article-title":"CHARMM-GUI: a web-based graphical user interface for CHARMM","volume":"29","author":"Jo","year":"2008","journal-title":"J. Comput. Chem."},{"issue":"10","key":"10.1016\/j.ejphar.2025.178480_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12968\/hmed.2023.0063","article-title":"The adult with low back pain: causes, diagnosis, imaging features and management","volume":"84","author":"Kabeer","year":"2023","journal-title":"Br. J. Hosp. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178480_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-48262-6","article-title":"Protective effect of nobiletin on isolated human islets survival and function against hypoxia and oxidative stress-induced apoptosis","volume":"9","author":"Keshtkar","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178480_bib16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/JP280572","article-title":"Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology","volume":"599","author":"Kierans","year":"2021","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2025.178480_bib17","article-title":"IL-17 induces autophagy dysfunction to promote inflammatory cell death and fibrosis in keloid fibroblasts via the STAT3 and HIF-1\u03b1 dependent signaling pathways","volume":"13","author":"Lee","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2025.178480_bib18","article-title":"Therapeutic framework nucleic acid complexes targeting oxidative stress and pyroptosis for the treatment of osteoarthritis","volume":"28","author":"Li","year":"2024","journal-title":"Mater. Today Bio"},{"issue":"27","key":"10.1016\/j.ejphar.2025.178480_bib19","doi-asserted-by":"crossref","first-page":"7112","DOI":"10.1021\/acs.jafc.0c01722","article-title":"Nobiletin protects against acute liver injury via targeting c-Jun N-Terminal kinase (JNK)-induced apoptosis of hepatocytes","volume":"68","author":"Li","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2025.178480_bib20","article-title":"Macrophage polarization regulates intervertebral disc degeneration by modulating cell proliferation, inflammation mediator secretion, and extracellular matrix metabolism","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"issue":"14","key":"10.1016\/j.ejphar.2025.178480_bib21","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.7150\/thno.33638","article-title":"Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo","volume":"9","author":"Liao","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178480_bib22","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1186\/s13018-021-02538-8","article-title":"Expression of miR-195 and its target gene Bcl-2 in human intervertebral disc degeneration and their effects on nucleus pulposus cell apoptosis","volume":"16","author":"Lin","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.ejphar.2025.178480_bib23","doi-asserted-by":"crossref","first-page":"570","DOI":"10.3389\/fphar.2019.00570","article-title":"Nobiletin inhibits IL-1\u03b2-Induced inflammation in chondrocytes via suppression of NF-\u03baB signaling and attenuates osteoarthritis in mice","volume":"10","author":"Lin","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178480_bib24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejphar.2019.03.056","article-title":"Nobiletin suppresses oxidative stress and apoptosis in H9c2 cardiomyocytes following hypoxia\/reoxygenation injury","volume":"854","author":"Liu","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178480_bib25","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41573-021-00320-3","article-title":"Pharmacological targeting of endoplasmic reticulum stress in disease","volume":"21","author":"Marciniak","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178480_bib26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/01.brs.0000148152.04401.20","article-title":"A novel rabbit model of mild, reproducible disc degeneration by an anulus needle puncture: correlation between the degree of disc injury and radiological and histological appearances of disc degeneration","volume":"30","author":"Masuda","year":"2005","journal-title":"Spine"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178480_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010208","article-title":"Discogenic low back pain: anatomy, pathophysiology and treatments of intervertebral disc degeneration","volume":"24","author":"Mohd Isa","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.ejphar.2025.178480_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20143380","article-title":"Potential benefits of nobiletin, A citrus flavonoid, against alzheimer's disease and parkinson's disease","volume":"20","author":"Nakajima","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ejphar.2025.178480_bib29","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1042\/CS20191099","article-title":"Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes","volume":"134","author":"Nguyen-Ngo","year":"2020","journal-title":"Clin. Sci. (Lond.)"},{"issue":"3","key":"10.1016\/j.ejphar.2025.178480_bib30","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ajpath.2020.11.012","article-title":"Hypoxia and hypoxia-inducible Factor-1\u03b1 regulate endoplasmic reticulum stress in nucleus pulposus cells: implications of endoplasmic reticulum stress for extracellular matrix secretion","volume":"191","author":"Novais","year":"2021","journal-title":"Am. J. Pathol."},{"issue":"11","key":"10.1016\/j.ejphar.2025.178480_bib31","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1113\/JP271142","article-title":"Endoplasmic reticulum-plasma membrane junctions: structure, function and dynamics","volume":"594","author":"Okeke","year":"2016","journal-title":"J. Physiol."},{"issue":"Pt 2","key":"10.1016\/j.ejphar.2025.178480_bib32","article-title":"Ethyl gallate suppresses ferroptosis and alleviates intervertebral disc degeneration through targeting AKT1","volume":"242","author":"Qiu","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.ejphar.2025.178480_bib33","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2025.178480_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1156749","article-title":"Intervertebral disc degeneration-current therapeutic options and challenges","volume":"11","author":"Samanta","year":"2023","journal-title":"Front. Public Health"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178480_bib35","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00018-015-2052-6","article-title":"The endoplasmic reticulum: structure, function and response to cellular signaling","volume":"73","author":"Schwarz","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178480_bib36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2015.01.002","article-title":"UPR, autophagy, and mitochondria crosstalk underlies the ER stress response","volume":"40","author":"Senft","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejphar.2025.178480_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105371","article-title":"Interaction of nobiletin with methotrexate ameliorates 7-OH methotrexate-induced nephrotoxicity through endoplasmic reticulum stress-dependent PERK\/CHOP signaling pathway","volume":"165","author":"Song","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2025.178480_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113895","article-title":"Ferristatin II protects nucleus pulposus against degeneration through inhibiting ferroptosis and activating HIF-1\u03b1 pathway mediated mitophagy","volume":"147","author":"Su","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.ejphar.2025.178480_bib39","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1089\/dna.2022.0353","article-title":"Endoplasmic reticulum stress and oxidative stress in inflammatory diseases","volume":"41","author":"Tang","year":"2022","journal-title":"DNA Cell Biol."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178480_bib40","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/14728214.2024.2339912","article-title":"Evolving role of VIADISC for chronic low back and discogenic pain: a narrative review","volume":"29","author":"Tolson","year":"2024","journal-title":"Expet Opin. Emerg. Drugs"},{"issue":"9","key":"10.1016\/j.ejphar.2025.178480_bib41","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1007\/s00586-016-4438-z","article-title":"The Pfirrmann classification of lumbar intervertebral disc degeneration: an independent inter- and intra-observer agreement assessment","volume":"25","author":"Urrutia","year":"2016","journal-title":"Eur. Spine J."},{"issue":"8","key":"10.1016\/j.ejphar.2025.178480_bib42","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/pme.12809","article-title":"Prevalence and characteristics of discogenic pain in tertiary practice: 223 consecutive cases utilizing lumbar discography","volume":"16","author":"Verrills","year":"2015","journal-title":"Pain Med."},{"issue":"3","key":"10.1016\/j.ejphar.2025.178480_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/cells12030512","article-title":"The role of TP53 in adaptation and evolution","volume":"12","author":"Voskarides","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2025.178480_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119702","article-title":"Integrating metabolomics and network pharmacology to study the mechanism of Er-Xian decoction in improving intervertebral disc degeneration","volume":"346","author":"Wang","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.ejphar.2025.178480_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13448","article-title":"Oxidative stress in intervertebral disc degeneration: molecular mechanisms, pathogenesis and treatment","volume":"56","author":"Wang","year":"2023","journal-title":"Cell Prolif."},{"issue":"4","key":"10.1016\/j.ejphar.2025.178480_bib46","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2021.4867","article-title":"Hydrogen sulfide inhibits endoplasmic reticulum stress through the GRP78\/mTOR pathway in rat chondrocytes subjected to oxidative stress","volume":"47","author":"Wu","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ejphar.2025.178480_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1089796","article-title":"Identification and validation of ferroptosis-related gene signature in intervertebral disc degeneration","volume":"14","author":"Xiang","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"10.1016\/j.ejphar.2025.178480_bib48","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1039\/C8FO01786G","article-title":"Inhibiting the PI3K\/AKT\/NF-\u03baB signal pathway with nobiletin for attenuating the development of osteoarthritis: in vitro and in vivo studies","volume":"10","author":"Xie","year":"2019","journal-title":"Food Funct."},{"issue":"2","key":"10.1016\/j.ejphar.2025.178480_bib49","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/15548627.2019.1606647","article-title":"MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint","volume":"16","author":"Yang","year":"2020","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.ejphar.2025.178480_bib50","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s10753-022-01732-y","article-title":"Hypoxia-inducible Factor-1\u03b1 protects against intervertebral disc degeneration through antagonizing mitochondrial oxidative stress","volume":"46","author":"Yang","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2025.178480_bib51","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.intimp.2019.04.060","article-title":"Nobiletin ameliorates myocardial ischemia and reperfusion injury by attenuating endoplasmic reticulum stress-associated apoptosis through regulation of the PI3K\/AKT signal pathway","volume":"73","author":"Zhang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2025.178480_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2023.101231","article-title":"The endoplasmic reticulum: homeostasis and crosstalk in retinal health and disease","volume":"98","author":"Zhang","year":"2024","journal-title":"Prog. Retin. Eye Res."},{"issue":"Pt 3","key":"10.1016\/j.ejphar.2025.178480_bib53","article-title":"Nordihydroguaiaretic acid suppresses ferroptosis and mitigates intervertebral disc degeneration through the NRF2\/GPX4 axis","volume":"143","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2025.178480_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109464","article-title":"HIF-1\u03b1\/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury","volume":"120","author":"Zhang","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.ejphar.2025.178480_bib55","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1080\/21655979.2021.2017700","article-title":"The protective effects of dezocine on interleukin-1\u03b2-induced inflammation, oxidative stress and apoptosis of human nucleus pulposus cells and the possible mechanisms","volume":"13","author":"Zhu","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.ejphar.2025.178480_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102094","article-title":"Can extracellular vesicles be considered as a potential frontier in the treatment of intervertebral disc disease?","volume":"92","author":"Zhu","year":"2023","journal-title":"Ageing Res. Rev."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925012348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925012348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:54:55Z","timestamp":1777398895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925012348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":56,"alternative-id":["S0014299925012348"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178480","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nobiletin ameliorates intervertebral disc degeneration by upregulating HIF-1\u03b1 to inhibit endoplasmic reticulum stress-induced apoptosis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178480","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178480"}}