{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:05:55Z","timestamp":1793084755317,"version":"4.5.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008552","name":"Haryana State Council for Science and Technology","doi-asserted-by":"publisher","award":["D\/2022\/2954"],"award-info":[{"award-number":["D\/2022\/2954"]}],"id":[{"id":"10.13039\/501100008552","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.ejphar.2025.178503","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:09:44Z","timestamp":1766102984000},"page":"178503","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Soy isoflavone ameliorates gut-brain axis dysfunction via ER-\u03b2 activation and \u03b2-glucuronidase modulation in estrogen-deficient rats"],"prefix":"10.1016","volume":"1013","author":[{"given":"Rishabh","family":"Chaudhary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowvik","family":"Bag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Lal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra","family":"Bishnoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanthi Kiran","family":"Kondepudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanwaljit","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2889-0004","authenticated-orcid":false,"given":"Seema","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2025.178503_bib1","first-page":"671","article-title":"Effect of isoflavone on memory in rat model of surgically induced menopause; possible role of glutamate and gamma amino butyric acid","volume":"38","author":"Abouhammad","year":"2021","journal-title":"Benha Med. J."},{"key":"10.1016\/j.ejphar.2025.178503_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037540","article-title":"Soy isoflavones genistein and daidzein exert anti-apoptotic actions via a selective ER-mediated mechanism in neurons following HIV-1 Tat1\u201386 exposure","volume":"7","author":"Adams","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2025.178503_bib3","article-title":"Evaluation of the in vitro and in vivo antioxidant potentials of food grade Phycocyanin","volume":"1\u20139","author":"Agrawal","year":"2021","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.ejphar.2025.178503_bib4","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1136\/gutjnl-2021-325021","article-title":"Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites","volume":"71","author":"Bai","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2025.178503_bib5","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/fcp.12677","article-title":"Everolimus: a potential therapeutic agent targeting PI3K\/Akt pathway in brain insulin system dysfunction and associated neurobehavioral deficits","volume":"35","author":"Bansal","year":"2021","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178503_bib6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ygcen.2014.06.013","article-title":"Distinct role of estrogen receptor-alpha and beta on postmenopausal diabetes-induced vascular dysfunction","volume":"206","author":"Bansal","year":"2014","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.ejphar.2025.178503_bib7","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1097\/GME.0000000000000435","article-title":"Differential role of estrogen receptor modulators in depression-like behavior and memory impairment in rats with postmenopausal diabetes","volume":"22","author":"Bansal","year":"2015","journal-title":"Menopause"},{"key":"10.1016\/j.ejphar.2025.178503_bib8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.mce.2017.07.017","article-title":"Selective ER-\u03b1 agonist alleviates vascular endothelial dysfunction in ovariectomized type 2 diabetic rats","volume":"460","author":"Bansal","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ejphar.2025.178503_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.4103\/ijp.IJP_233_18","article-title":"Construction of time-response curve for neuronal and vascular endothelial dysfunction in ovariectomized rats","volume":"53","author":"Bansal","year":"2021","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178503_bib10","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1177\/1073858413519865","article-title":"Estrogen receptors, the hippocampus, and memory","volume":"20","author":"Bean","year":"2014","journal-title":"Neuroscientist"},{"key":"10.1016\/j.ejphar.2025.178503_bib11","doi-asserted-by":"crossref","first-page":"901","DOI":"10.3390\/molecules21070901","article-title":"Polyphenols: extraction methods, antioxidative action, bioavailability and anticarcinogenic effects","volume":"21","author":"Brglez Mojzer","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2025.178503_bib12","first-page":"1","article-title":"Gut microbiota metabolic axis dysfunction in estrogen deficient stressed rats","author":"Chaudhary","year":"2025","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.ejphar.2025.178503_bib13","article-title":"Temporal and regional intestinal changes in permeability, tight junction, and cytokine gene expression following ovariectomy\u2010induced estrogen deficiency","volume":"5","author":"Collins","year":"2017","journal-title":"Phys. Rep."},{"key":"10.1016\/j.ejphar.2025.178503_bib14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13073-022-01092-0","article-title":"Metabolic control by the microbiome","volume":"14","author":"Cox","year":"2022","journal-title":"Genome Med."},{"key":"10.1016\/j.ejphar.2025.178503_bib15","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1124\/pr.58.4.8","article-title":"International union of pharmacology. LXIV. Estrogen receptors","volume":"58","author":"Dahlman-Wright","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2025.178503_bib16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/jam.13765","article-title":"Lactobacillus plantarum MTCC 9510 supplementation protects from chronic unpredictable and sleep deprivation\u2010induced behaviour, biochemical and selected gut microbial aberrations in mice","volume":"125","author":"Dhaliwal","year":"2018","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.ejphar.2025.178503_bib17","doi-asserted-by":"crossref","first-page":"18586","DOI":"10.1074\/jbc.RA119.010950","article-title":"Gut microbial \u03b2-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens","volume":"294","author":"Ervin","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2025.178503_bib18","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.3390\/pathogens12091086","article-title":"A new paradigm in the relationship between gut microbiota and breast cancer: \u03b2-glucuronidase enzyme identified as potential therapeutic target","volume":"12","author":"Fern\u00e1ndez-Murga","year":"2023","journal-title":"Pathogens"},{"key":"10.1016\/j.ejphar.2025.178503_bib19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/09513590.2020.1832068","article-title":"Effects of soy isoflavones extract on the lipid profile and uterus in ovariectomized rats","volume":"37","author":"Fonseca","year":"2021","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.ejphar.2025.178503_bib20","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/jnci\/57.2.371","article-title":"The relationship between diet and rat fecal bacterial enzymes implicated in colon cancer","volume":"57","author":"Goldin","year":"1976","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.ejphar.2025.178503_bib21","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1053\/j.gastro.2020.07.003","article-title":"High-throughput screen identifies host and microbiota regulators of intestinal barrier function","volume":"159","author":"Grosheva","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2025.178503_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154270","article-title":"Flavonoids from Rhododendron nivale Hook. f delay aging via modulation of gut microbiota and glutathione metabolism","volume":"104","author":"Guo","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2025.178503_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.ctdb.2016.12.005","article-title":"Estrogen hormone biology","volume":"125","author":"Hamilton","year":"2017","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.ejphar.2025.178503_bib24","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1152\/physrev.00026.2006","article-title":"Estrogen receptors: how do they signal and what are their targets","volume":"87","author":"Heldring","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2025.178503_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2024.1408878","article-title":"The intersection between menopause and depression: overview of research using animal models","volume":"15","author":"Herrera-P\u00e9rez","year":"2024","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.ejphar.2025.178503_bib26","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2236749","article-title":"Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism","volume":"15","author":"Hu","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ejphar.2025.178503_bib27","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.placenta.2011.07.082","article-title":"Genistein upregulates placental corticotropin-releasing hormone expression in lipopolysaccharide-sensitized mice","volume":"32","author":"Huang","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.ejphar.2025.178503_bib28","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.3390\/nu16162644","article-title":"Nutrition intervention and microbiome modulation in the management of breast cancer","volume":"16","author":"Jiang","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.ejphar.2025.178503_bib29","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1271\/bbb.100238","article-title":"Genistein regulated serotonergic activity in the hippocampus of ovariectomized rats under forced swimming stress","volume":"74","author":"Kageyama","year":"2010","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.ejphar.2025.178503_bib30","first-page":"S19","article-title":"Effects of estrogen deprivation on depressive-like behavior and noradrenergic neurotransmitters in ovariectomized rats","volume":"99","author":"Kalandakanond-Thongsong","year":"2016","journal-title":"J. Med. Assoc. Thail."},{"key":"10.1016\/j.ejphar.2025.178503_bib31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.steroids.2015.01.004","article-title":"17\u03b1-Estradiol: a candidate neuroserm and non-feminizing estrogen for postmenopausal neuronal complications","volume":"96","author":"Kaur","year":"2015","journal-title":"Steroids"},{"key":"10.1016\/j.ejphar.2025.178503_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2139","article-title":"Estrogen attenuates physical and psychological stress\u2010induced cognitive impairments in ovariectomized rats","volume":"11","author":"Khaleghi","year":"2021","journal-title":"Brain Behav."},{"key":"10.1016\/j.ejphar.2025.178503_bib33","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.3390\/antiox10071064","article-title":"Current perspectives on the beneficial effects of soybean isoflavones and their metabolites for humans","volume":"10","author":"Kim","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejphar.2025.178503_bib34","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","article-title":"Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor \u03b2","volume":"139","author":"Kuiper","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2025.178503_bib35","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1476-5381.2011.01418.x","article-title":"Expression of Concern: role of LOX\/COX pathways in 3\u2010nitropropionic acid\u2010induced Huntington's disease\u2010like symptoms in rats: protective effect of licofelone","volume":"164","author":"Kumar","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2025.178503_bib36","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.bbagen.2010.04.011","article-title":"Role of estrogen receptors in pro-oxidative and anti-oxidative actions of estrogens: a perspective","volume":"1800","author":"Kumar","year":"2010","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.ejphar.2025.178503_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300688","article-title":"From gut to hormones: unraveling the role of gut microbiota in (phyto) estrogen modulation in health and disease","volume":"68","author":"Kumari","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejphar.2025.178503_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300688","article-title":"From gut to hormones: unraveling the role of gut microbiota in (Phyto) estrogen modulation in health and disease","author":"Kumari","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ejphar.2025.178503_bib39","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3233\/JAD-141875","article-title":"Update on the neuroprotective effect of estrogen receptor alpha against Alzheimer's disease","volume":"43","author":"Lan","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.ejphar.2025.178503_bib40","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5625\/lar.2012.28.2.71","article-title":"Functions and physiological roles of two types of estrogen receptors, ER\u03b1 and ER\u03b2, identified by estrogen receptor knockout mouse","volume":"28","author":"Lee","year":"2012","journal-title":"Lab. Anim. Res."},{"key":"10.1016\/j.ejphar.2025.178503_bib41","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.pnpbp.2013.10.018","article-title":"Impact of inflammation on neurotransmitter changes in major depression: an insight into the action of antidepressants","volume":"48","author":"Leonard","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2025.178503_bib42","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4162\/nrp.2023.17.2.371","article-title":"Role of soy lecithin combined with soy isoflavone on cerebral blood flow in rats of cognitive impairment and the primary screening of its optimum combination","volume":"17","author":"Li","year":"2023","journal-title":"Nutr. Res. Prac."},{"key":"10.1016\/j.ejphar.2025.178503_bib43","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bbr.2015.02.009","article-title":"Sex differences in the stress response in SD rats","volume":"284","author":"Lu","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2025.178503_bib44","doi-asserted-by":"crossref","first-page":"939","DOI":"10.5650\/jos.ess23062","article-title":"Prophylactic effects of hemp seed oil on perimenopausal depression: a role of HPA axis","volume":"72","author":"Ma","year":"2023","journal-title":"J. Oleo Sci."},{"key":"10.1016\/j.ejphar.2025.178503_bib45","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijpsycho.2023.05.350","article-title":"Never fear, the gut bacteria are here: estrogen and gut microbiome-brain axis interactions in fear extinction","volume":"189","author":"Maeng","year":"2023","journal-title":"Int. J. Psychophysiol."},{"key":"10.1016\/j.ejphar.2025.178503_bib46","doi-asserted-by":"crossref","first-page":"10985","DOI":"10.1523\/JNEUROSCI.22-24-10985.2002","article-title":"Effectiveness of estrogen replacement in restoration of cognitive function after long-term estrogen withdrawal in aging rats","volume":"22","author":"Markowska","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2025.178503_bib47","first-page":"13","article-title":"Pathophysiology of depression: inflammation and its relation with oxidative stress and the hypothalamic-pituitary-adrenal axis","volume":"8","author":"Nady","year":"2024","journal-title":"Arch. Pharm. Sci. Ain Shams Univ."},{"key":"10.1016\/j.ejphar.2025.178503_bib48","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1289\/ehp.00108867","article-title":"Interactions of dietary estrogens with human estrogen receptors and the effect on estrogen receptor-estrogen response element complex formation","volume":"108","author":"Nikov","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ejphar.2025.178503_bib49","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nrd3551","article-title":"Development of subtype-selective oestrogen receptor-based therapeutics","volume":"10","author":"Nilsson","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2025.178503_bib50","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.lfs.2008.03.021","article-title":"Protective effect of apigenin on ovariectomy-induced bone loss in rats","volume":"82","author":"Park","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.178503_bib51","doi-asserted-by":"crossref","first-page":"E99","DOI":"10.1152\/ajpendo.00005.2018","article-title":"Low-dose brain estrogen prevents menopausal syndrome while maintaining the diversity of the gut microbiomes in estrogen-deficient rats","volume":"315","author":"Park","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2025.178503_bib52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.steroids.2014.06.012","article-title":"Estrogen receptors alpha (ER\u03b1) and beta (ER\u03b2): subtype-selective ligands and clinical potential","volume":"90","author":"Paterni","year":"2014","journal-title":"Steroids"},{"key":"10.1016\/j.ejphar.2025.178503_bib53","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1002\/ptr.7861","article-title":"A review on phytoestrogens: current status and future direction","volume":"37","author":"Patra","year":"2023","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejphar.2025.178503_bib54","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.pbb.2013.05.015","article-title":"Granulocyte colony stimulating factor (GCSF) improves memory and neurobehavior in an amyloid-\u03b2 induced experimental model of Alzheimer's disease","volume":"110","author":"Prakash","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2025.178503_bib55","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1894070","article-title":"The impact of the gut microbiota on the reproductive and metabolic endocrine system","volume":"13","author":"Qi","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ejphar.2025.178503_bib56","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration","volume":"55","author":"Qin","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2025.178503_bib57","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1111\/ejn.16360","article-title":"Estrogen signalling and Alzheimer's disease: decoding molecular mechanisms for therapeutic breakthrough","volume":"60","author":"Rishabh","year":"2024","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2025.178503_bib58","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9073816","article-title":"The phytoestrogen genistein produces similar effects as 17\u03b2\u2010Estradiol on anxiety-like behavior in rats at 12 weeks after ovariectomy","volume":"2017","author":"Rodr\u00edguez-Landa","year":"2017","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ejphar.2025.178503_bib59","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2017.01.011","article-title":"The interaction of dietary isoflavones and estradiol replacement on behavior and brain-derived neurotrophic factor in the ovariectomized rat","volume":"640","author":"Russell","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2025.178503_bib60","doi-asserted-by":"crossref","first-page":"267","DOI":"10.21608\/ajps.2022.269258","article-title":"Estrogen attenuates dimethylhydrazine-induced colon injury in female rats via abrogation of oxidative stress and inflammations","volume":"66","author":"Salama","year":"2022","journal-title":"Al-Azhar J. Pharm. Sci."},{"key":"10.1016\/j.ejphar.2025.178503_bib61","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.lfs.2010.04.002","article-title":"Effects of 17\u03b2-estradiol replacement on the apoptotic effects caused by ovariectomy in the rat hippocampus","volume":"86","author":"Sales","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2025.178503_bib62","series-title":"Role of Human Hydroxysteroid (17Beta) Dehydrogenase Type 1 (HSD17B1) in Steroid-dependent Diseases in females\u2013novel Indications for HSD17B1 Inhibitors","author":"Saloniemi","year":"2009"},{"key":"10.1016\/j.ejphar.2025.178503_bib63","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jare.2021.09.005","article-title":"Interplay of gut microbiota and oxidative stress: perspective on neurodegeneration and neuroprotection","volume":"38","author":"Shandilya","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.ejphar.2025.178503_bib64","article-title":"1146 sleep deprivation induces ageing-like changes in antigravity muscles of young adult male wistar rats","volume":"1991","author":"Sharma","year":"1981","journal-title":"Education"},{"key":"10.1016\/j.ejphar.2025.178503_bib65","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0960-0760(03)00360-1","article-title":"Sources of estrogen and their importance","volume":"86","author":"Simpson","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ejphar.2025.178503_bib66","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.phrs.2017.06.015","article-title":"Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice","volume":"123","author":"Singh","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2025.178503_bib67","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1039\/C9FO00881K","article-title":"Naringenin ameliorates diabetic neuropathic pain by modulation of oxidative-nitrosative stress, cytokines and MMP-9 levels","volume":"11","author":"Singh","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.ejphar.2025.178503_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75702-5","article-title":"Anti-inflammatory Bifidobacterium strains prevent dextran sodium sulfate induced colitis and associated gut microbial dysbiosis in mice","volume":"10","author":"Singh","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2025.178503_bib69","article-title":"Mitigation of MAFLD in high fat-high sucrose-fructose fed mice by a combination of genistein consumption and exercise training","volume":"2157\u20132172","author":"St Aubin","year":"2022","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"10.1016\/j.ejphar.2025.178503_bib70","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/01.RES.0000082334.17947.11","article-title":"Modulation of antioxidant enzyme expression and function by estrogen","volume":"93","author":"Strehlow","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178503_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.631552","article-title":"The role of gut microbial \u03b2-glucuronidase in estrogen reactivation and breast cancer","volume":"9","author":"Sui","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2025.178503_bib72","article-title":"The role of gut microbiota in intestinal disease: from an oxidative stress perspective","volume":"15","author":"Sun","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.ejphar.2025.178503_bib73","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3177\/jnsv.49.168","article-title":"Effects of soy oligosaccharides on plasma and cecal isoflavones, and cecal enzyme activities in mice","volume":"49","author":"Tamura","year":"2003","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.ejphar.2025.178503_bib74","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12964-024-01582-1","article-title":"High oestrogen receptor alpha expression correlates with adverse prognosis and promotes metastasis in colorectal cancer","volume":"22","author":"Topi","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.ejphar.2025.178503_bib75","series-title":"The Estrobolome: the Bidirectional Relationship Between Gut Microbes and Hormones","author":"Tracy Tranchitella","year":"2023"},{"key":"10.1016\/j.ejphar.2025.178503_bib76","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3892\/etm.2017.4469","article-title":"Dietary soy isoflavones alleviate dextran sulfate sodium-induced inflammation and oxidative stress in mice","volume":"14","author":"Wang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.ejphar.2025.178503_bib77","doi-asserted-by":"crossref","first-page":"4995","DOI":"10.1039\/D0FO03254A","article-title":"Supplementation with soy isoflavones alleviates depression-like behaviour via reshaping the gut microbiota structure","volume":"12","author":"Wang","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.ejphar.2025.178503_bib78","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/01.RES.0000188212.57180.55","article-title":"Progesterone antagonizes the vasoprotective effect of estrogen on antioxidant enzyme expression and function","volume":"97","author":"Wassmann","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2025.178503_bib79","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbi.2016.02.022","article-title":"NLRP3 inflammasome activation mediates estrogen deficiency-induced depression-and anxiety-like behavior and hippocampal inflammation in mice","volume":"56","author":"Xu","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2025.178503_bib80","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.702628","article-title":"Surgical menopause and estrogen therapy modulate the gut microbiota, obesity markers, and spatial memory in rats","volume":"11","author":"Zeibich","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ejphar.2025.178503_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153818","article-title":"Oleic acid alleviates LPS-induced acute kidney injury by restraining inflammation and oxidative stress via the Ras\/MAPKs\/PPAR-\u03b3 signaling pathway","volume":"94","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2025.178503_bib82","article-title":"Biochanin A attenuates ovariectomy-induced cognition deficit via antioxidant effects in female rats","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925012579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299925012579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T22:25:02Z","timestamp":1768947902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299925012579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":82,"alternative-id":["S0014299925012579"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178503","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Soy isoflavone ameliorates gut-brain axis dysfunction via ER-\u03b2 activation and \u03b2-glucuronidase modulation in estrogen-deficient rats","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2025.178503","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178503"}}