{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T13:04:58Z","timestamp":1769173498289,"version":"3.49.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-21-CE37-0019-01"],"award-info":[{"award-number":["ANR-21-CE37-0019-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ejphar.2026.178543","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T16:38:20Z","timestamp":1767976700000},"page":"178543","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Sex-linked loss of motivation to eat by morphine"],"prefix":"10.1016","volume":"1014","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3711-1999","authenticated-orcid":false,"given":"Giorgia","family":"Bresciani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9566-3808","authenticated-orcid":false,"given":"Alessandro","family":"Piccin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7286-6941","authenticated-orcid":false,"given":"Angelo","family":"Contarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.178543_bib1","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"10.1016\/j.ejphar.2026.178543_bib2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00213-021-06048-7","article-title":"Acute pain-related depression of operant responding maintained by social interaction or food in male and female rats","volume":"239","author":"Baldwin","year":"2022","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.ejphar.2026.178543_bib3","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1124\/pr.115.011163","article-title":"Sex differences in animal models: focus on addiction","volume":"68","author":"Becker","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2026.178543_bib4","doi-asserted-by":"crossref","first-page":"11396","DOI":"10.1523\/JNEUROSCI.1393-11.2011","article-title":"Augmented cocaine seeking in response to stress or CRF delivered into the ventral tegmental area following long-access self-administration is mediated by CRF receptor type 1 but not CRF receptor type 2","volume":"31","author":"Blacktop","year":"2011","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178543_bib5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00213-011-2266-8","article-title":"Prevention of social stress-escalated cocaine self-administration by CRF-R1 antagonist in the rat VTA","volume":"218","author":"Boyson","year":"2011","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.ejphar.2026.178543_bib6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0014-2999(93)90118-2","article-title":"Endogenous nitric oxide modulates morphine-induced changes in locomotion and food intake in mice","volume":"231","author":"Calignano","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178543_bib7","doi-asserted-by":"crossref","first-page":"11560","DOI":"10.1523\/JNEUROSCI.4763-12.2014","article-title":"Knockdown of CRF1 receptors in the ventral tegmental area attenuates cue- and acute food deprivation stress-induced cocaine seeking in mice","volume":"34","author":"Chen","year":"2014","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178543_bib8","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0063-23.2023","article-title":"Food restriction level and reinforcement schedule differentially influence behavior during acquisition and devaluation procedures in mice","volume":"10","author":"Chev\u00e9e","year":"2023","journal-title":"eNeuro"},{"key":"10.1016\/j.ejphar.2026.178543_bib9","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0091-3057(02)01039-0","article-title":"Gender differences in the intravenous self-administration of mu opiate agonists","volume":"74","author":"Cicero","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2026.178543_bib10","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1210\/endo.141.7.7653","article-title":"Dissociation of locomotor activation and suppression of food intake induced by CRF in CRFR1-deficient mice","volume":"141","author":"Contarino","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2026.178543_bib11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuropharm.2017.01.024","article-title":"CRF1 receptor-deficiency increases cocaine reward","volume":"117","author":"Contarino","year":"2017","journal-title":"Neuropharmacol."},{"key":"10.1016\/j.ejphar.2026.178543_bib12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1874467210666170302104053","article-title":"The CRF family of neuropeptides and their receptors - mediators of the central stress response","volume":"11","author":"Dedic","year":"2018","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178543_bib13","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1007\/s00213-015-3967-1","article-title":"Developmental emergence of an obsessive-compulsive phenotype and binge behavior in rats","volume":"232","author":"Freund","year":"2015","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.ejphar.2026.178543_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12822","article-title":"Sex differences in oral oxycodone self-administration and stress-primed reinstatement in rats","volume":"25","author":"Fulenwider","year":"2020","journal-title":"Addict. Biol."},{"key":"10.1016\/j.ejphar.2026.178543_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106034","article-title":"Role of CB2 cannabinoid receptor in the development of food addiction in male mice","volume":"179","author":"Garc\u00eda-Blanco","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2026.178543_bib16","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1038\/s41386-021-01035-0","article-title":"Enhanced heroin self-administration and distinct dopamine adaptations in female rats","volume":"46","author":"George","year":"2021","journal-title":"Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2026.178543_bib17","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00213-011-2433-y","article-title":"Dissociation of corticotropin-releasing factor receptor subtype involvement in sensitivity to locomotor effects of methamphetamine and cocaine","volume":"219","author":"Giardino","year":"2012","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ejphar.2026.178543_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neuroscience.2014.05.033","article-title":"Sex-dependent diversity in ventral tegmental dopaminergic neurons and developmental programing: a molecular, cellular and behavioral analysis","volume":"282","author":"Gillies","year":"2014","journal-title":"Neuroscience."},{"key":"10.1016\/j.ejphar.2026.178543_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13293-022-00412-8","article-title":"Sex differences in sucrose reinforcement in Long-evans rats","volume":"13","author":"Grimm","year":"2022","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.ejphar.2026.178543_bib20","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/jnr.24427","article-title":"Naloxone reversed cognitive impairments induced by repeated morphine under heavy perceptual load in the 5-choice serial reaction time task","volume":"97","author":"Guo","year":"2019","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ejphar.2026.178543_bib21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1124\/pr.55.1.3","article-title":"International Union of pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands","volume":"55","author":"Hauger","year":"2003","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2026.178543_bib22","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1124\/jpet.103.052092","article-title":"Corticotropin-releasing factor in brain: a role in activation, arousal, and affect regulation","volume":"311","author":"Heinrichs","year":"2004","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2026.178543_bib23","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1038\/npp.2013.147","article-title":"CRF-CRF1 receptor system in the central and basolateral nuclei of the amygdala differentially mediates excessive eating of palatable food","volume":"38","author":"Iemolo","year":"2013","journal-title":"Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol"},{"key":"10.1016\/j.ejphar.2026.178543_bib24","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/mp.2011.119","article-title":"CRF2 receptor-deficiency eliminates opiate withdrawal distress without impairing stress coping","volume":"17","author":"Ingallinesi","year":"2012","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ejphar.2026.178543_bib25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.drugalcdep.2017.07.006","article-title":"The importance of nutrition in aiding recovery from substance use disorders: a review","volume":"179","author":"Jeynes","year":"2017","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.ejphar.2026.178543_bib26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejphar.2007.12.010","article-title":"Morphine sex-dependently induced place conditioning in adult wistar rats","volume":"582","author":"Karami","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178543_bib27","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: reporting in vivo experiments: the ARRIVE guidelines","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178543_bib28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fnbeh.2020.00074","article-title":"Sex differences and the role of estradiol in mesolimbic reward circuits and vulnerability to cocaine and opiate addiction","volume":"14","author":"Kokane","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178543_bib29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuron.2008.06.012","article-title":"A role for brain stress systems in addiction","volume":"59","author":"Koob","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2026.178543_bib30","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bbr.2009.01.006","article-title":"Gender differences in delay-discounting under mild food restriction","volume":"200","author":"Koot","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2026.178543_bib31","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1007\/s00213-016-4368-9","article-title":"The effects of sex, estrous cycle, and social contact on cocaine and heroin self-administration in rats","volume":"233","author":"Lacy","year":"2016","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ejphar.2026.178543_bib32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.neuropharm.2013.03.019","article-title":"Reward and aversion in a heterogeneous midbrain dopamine system","volume":"76","author":"Lammel","year":"2014","journal-title":"Neuropharmacol."},{"key":"10.1016\/j.ejphar.2026.178543_bib33","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuropharm.2014.12.021","article-title":"Corticotropin-releasing factor 1 receptor mediates the activity of the reward system evoked by morphine-induced conditioned place preference","volume":"95","author":"Lasheras","year":"2015","journal-title":"Neuropharmacol."},{"key":"10.1016\/j.ejphar.2026.178543_bib34","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s00213-014-3838-1","article-title":"Enhanced motivation for food reward induced by stress and attenuation by corticotrophin-releasing factor receptor antagonism in rats: implications for overeating and obesity","volume":"232","author":"Liu","year":"2015","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.ejphar.2026.178543_bib35","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1046\/j.1471-4159.2003.01635.x","article-title":"Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypes","volume":"84","author":"Lu","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2026.178543_bib36","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0091-3057(95)02013-6","article-title":"Male\/female comparison of morphine effect on food intake--relation to anorexia nervosa","volume":"53","author":"Marrazzi","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2026.178543_bib37","article-title":"An operant conditioning model combined with a chemogenetic approach to Study the neurobiology of food addiction in mice","volume":"10","author":"Mart\u00edn-Garc\u00eda","year":"2020","journal-title":"Bio-Protoc."},{"key":"10.1016\/j.ejphar.2026.178543_bib38","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1360-0443.2011.03660.x","article-title":"Eating patterns among heroin users: a qualitative study with implications for nutritional interventions","volume":"107","author":"Neale","year":"2012","journal-title":"Addict. Abingdon Engl."},{"key":"10.1016\/j.ejphar.2026.178543_bib39","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/FBP.0000000000000119","article-title":"Distinct interactions of cannabidiol and morphine in three nociceptive behavioral models in mice","volume":"26","author":"Neelakantan","year":"2015","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178543_bib40","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.neuron.2007.01.022","article-title":"Disruption of the CRF\/CRF1 receptor stress system exacerbates the somatic signs of opiate withdrawal","volume":"53","author":"Papaleo","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2026.178543_bib41","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00213-009-1558-8","article-title":"Acute effects of morphine on distinct forms of impulsive behavior in rats","volume":"205","author":"Pattij","year":"2009","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.ejphar.2026.178543_bib42","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.pbb.2007.03.012","article-title":"Impulsivity (delay discounting) for food and cocaine in male and female rats selectively bred for high and low saccharin intake","volume":"86","author":"Perry","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178543_bib43","article-title":"Disruption of the CRF1 receptor eliminates morphine-induced sociability deficits and firing of oxytocinergic neurons in male mice","volume":"13","author":"Piccin","year":"2025","journal-title":"eLife"},{"key":"10.1016\/j.ejphar.2026.178543_bib44","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1007\/s00213-022-06131-7","article-title":"Morphine reduces the interest for natural rewards","volume":"239","author":"Piccin","year":"2022","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.ejphar.2026.178543_bib45","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0091-3057(01)00777-8","article-title":"Influence of estrogen in the acquisition of intravenously self-administered heroin in female rats","volume":"72","author":"Roth","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2026.178543_bib46","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/neuro.08.013.2009","article-title":"Dopamine, behavioral economics, and effort","volume":"3","author":"Salamone","year":"2009","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178543_bib47","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00433813","article-title":"Differential effects of morphine on food and water intake in food deprived and freely-feeding rats","volume":"72","author":"Sanger","year":"1980","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.ejphar.2026.178543_bib48","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0376-8716(94)01088-3","article-title":"Nutritional assessment of drug addicts","volume":"38","author":"Santolaria-Fern\u00e1ndez","year":"1995","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.ejphar.2026.178543_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113329","article-title":"The effects of strain and estrous cycle on heroin- and sugar-maintained responding in female rats","volume":"409","author":"Schmidt","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2026.178543_bib50","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.physbeh.2017.03.042","article-title":"Preliminary evidence of sex differences in behavioral and neural responses to palatable food reward in rats","volume":"176","author":"Sinclair","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.ejphar.2026.178543_bib51","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1038\/sj.npp.1300720","article-title":"Motivational effects of cannabinoids and opioids on food reinforcement depend on simultaneous activation of cannabinoid and opioid systems","volume":"30","author":"Solinas","year":"2005","journal-title":"Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2026.178543_bib52","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbr.2018.11.023","article-title":"Sex differences in hedonic and homeostatic aspects of palatable food motivation","volume":"359","author":"Tapia","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2026.178543_bib53","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neuropharm.2019.03.019","article-title":"Male and female mice develop escalation of heroin intake and dependence following extended access","volume":"151","author":"Towers","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2026.178543_bib54","series-title":"World Drug Report 2024","year":"2024"},{"key":"10.1016\/j.ejphar.2026.178543_bib55","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/1096-9861(20001211)428:2<191::AID-CNE1>3.0.CO;2-U","article-title":"Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse","volume":"428","author":"Van Pett","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ejphar.2026.178543_bib56","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrn.2017.130","article-title":"The dopamine motive system: implications for drug and food addiction","volume":"18","author":"Volkow","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178543_bib57","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1210\/endo.137.12.8940412","article-title":"In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation","volume":"137","author":"Webster","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2026.178543_bib58","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1124\/jpet.118.255844","article-title":"The effects of morphine, baclofen, and buspirone alone and in combination on schedule-controlled responding and hot plate antinociception in rats","volume":"370","author":"Wilkerson","year":"2019","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2026.178543_bib59","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1111\/bph.14531","article-title":"Oestradiol influences on dopamine release from the nucleus accumbens shell: sex differences and the role of selective oestradiol receptor subtypes","volume":"176","author":"Yoest","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178543_bib60","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.yhbeh.2018.04.002","article-title":"Rapid effects of ovarian hormones in dorsal striatum and nucleus accumbens","volume":"104","author":"Yoest","year":"2018","journal-title":"Horm. Behav."},{"key":"10.1016\/j.ejphar.2026.178543_bib61","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.drudis.2010.02.011","article-title":"Progress in corticotropin-releasing factor-1 antagonist development","volume":"15","author":"Zorrilla","year":"2010","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ejphar.2026.178543_bib62","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0006-8993(02)03189-X","article-title":"Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat","volume":"952","author":"Zorrilla","year":"2002","journal-title":"Brain Res."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926000257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926000257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T20:59:18Z","timestamp":1769115558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926000257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":62,"alternative-id":["S0014299926000257"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178543","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-linked loss of motivation to eat by morphine","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178543","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178543"}}