{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:36:38Z","timestamp":1792078598307,"version":"4.4.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002642","name":"Korea University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1A2B2009442"],"award-info":[{"award-number":["NRF-2017R1A2B2009442"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ejphar.2026.178564","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:24:28Z","timestamp":1768609468000},"page":"178564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["STING inhibition by H-151 is associated with amelioration of psoriasis severity via modulation of pathogenic T helper cell subsets"],"prefix":"10.1016","volume":"1015","author":[{"given":"Yerim","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yebin","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiho","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0384-4407","authenticated-orcid":false,"given":"Tae Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.178564_bib26","unstructured":"American Veterinary Medical Association, 2020. AVMA Guidelines for the Euthanasia of Animals: 2020 Edition. https:\/\/www.avma.org\/KB\/Policies\/Documents\/euthanasia.pdf (accessed 17 January 2026)."},{"key":"10.1016\/j.ejphar.2026.178564_bib1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1001\/jamadermatol.2014.3593","article-title":"Economic burden of psoriasis in the United States: a systematic review","volume":"151","author":"Brezinski","year":"2015","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.ejphar.2026.178564_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.743180","article-title":"The global, regional, and national burden of psoriasis: results and insights from the Global Burden of Disease 2019 study","volume":"8","author":"Damiani","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.ejphar.2026.178564_bib3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.humimm.2016.12.010","article-title":"Th9 cells and IL-9 in autoimmune disorders: pathogenesis and therapeutic potentials","volume":"78","author":"Deng","year":"2017","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.ejphar.2026.178564_bib4","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.molimm.2023.10.002","article-title":"Comparison and subsets analysis of peripheral CD4(+) T cells in patients with psoriasis and psoriatic arthritis","volume":"163","author":"Gao","year":"2023","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.ejphar.2026.178564_bib5","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2026.178564_bib6","article-title":"Serious adverse events associated with systemic treatments for psoriasis: a network meta\u2010analysis of observational studies and randomized controlled trials","author":"Guelimi","year":"2024","journal-title":"Cochrane Database Syst. Rev. CD015263"},{"key":"10.1016\/j.ejphar.2026.178564_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.788940","article-title":"The role of helper T cells in psoriasis","volume":"12","author":"Hu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2026.178564_bib8","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.3390\/ijms22052719","article-title":"The role of tumor necrosis factor alpha (TNF-\u03b1) in autoimmune disease and current TNF-\u03b1 inhibitors in therapeutics","volume":"22","author":"Jang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.178564_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1005115","article-title":"The imbalance between type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris","volume":"13","author":"Kim","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2026.178564_bib10","article-title":"Challenges and future trends in the treatment of psoriasis","volume":"24","author":"Lee","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.178564_bib11","article-title":"Therapeutic development by targeting the cGAS-STING pathway in autoimmune disease and cancer","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178564_bib12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12964-023-01381-0","article-title":"Triggers for the onset and recurrence of psoriasis: a review and update","volume":"22","author":"Liu","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.ejphar.2026.178564_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/cei.12198","article-title":"Possible pathogenic role of T helper type 9 cells and interleukin (IL)-9 in atopic dermatitis","volume":"175","author":"Ma","year":"2013","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ejphar.2026.178564_bib14","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41576-019-0151-1","article-title":"DNA sensing by the cGAS\u2013STING pathway in health and disease","volume":"20","author":"Motwani","year":"2019","journal-title":"Nat. Rev. Genet."},{"issue":"Suppl. 2","key":"10.1016\/j.ejphar.2026.178564_bib15","doi-asserted-by":"crossref","first-page":"ii111","DOI":"10.1136\/annrheumdis-2012-202576","article-title":"Janus kinase inhibitors in autoimmune diseases","volume":"72","author":"O'Shea","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejphar.2026.178564_bib16","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1111\/bph.15673","article-title":"The STING antagonist H-151 ameliorates psoriasis via suppression of STING\/NF-\u03baB-mediated inflammation","volume":"178","author":"Pan","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178564_bib17","article-title":"National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study","volume":"369","author":"Parisi","year":"2020","journal-title":"Br. Med. J."},{"key":"10.1016\/j.ejphar.2026.178564_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2020.108397","article-title":"Comorbidities associated with psoriatic arthritis: review and update","volume":"214","author":"Perez-Chada","year":"2020","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.ejphar.2026.178564_bib19","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s12016-024-08991-7","article-title":"The immunology of psoriasis\u2014current concepts in pathogenesis","volume":"66","author":"Sieminska","year":"2024","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.ejphar.2026.178564_bib20","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1111\/jcmm.17236","article-title":"Activation of the STING\u2013IRF3 pathway involved in psoriasis with diabetes mellitus","volume":"26","author":"Xiaohong","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2026.178564_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2024.103351","article-title":"AIM2 deficiency in CD4(+) T cells promotes psoriasis-like inflammation by regulating Th17-Treg axis via AIM2-IKZF2 pathway","volume":"150","author":"Xin","year":"2025","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.ejphar.2026.178564_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jid.2021.08.430","article-title":"Cytosolic DNA\u2012mediated STING-dependent inflammation contributes to the progression of psoriasis","volume":"142","author":"Yu","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejphar.2026.178564_bib23","article-title":"A nanoinhibitor targeting cGAS\u2013STING pathway to reverse the homeostatic imbalance of inflammation in psoriasis","volume":"63","author":"Zhang","year":"2024","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/j.ejphar.2026.178564_bib24","article-title":"Discovery of STING antagonists targeting cGAS\u2013STING pathway to alleviate IMQ-induced psoriasis-like dermatitis","author":"Zhang","year":"2025","journal-title":"Eur. J. Pharmaceut. Sci."},{"key":"10.1016\/j.ejphar.2026.178564_bib25","article-title":"Aloperine ameliorates IMQ-induced psoriasis by attenuating Th17 differentiation and facilitating their conversion to Treg","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926000464?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926000464?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:56:19Z","timestamp":1778655379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926000464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":26,"alternative-id":["S0014299926000464"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178564","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"STING inhibition by H-151 is associated with amelioration of psoriasis severity via modulation of pathogenic T helper cell subsets","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178564","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178564"}}