{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:46:28Z","timestamp":1785804388707,"version":"3.56.0"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013798","name":"Jiangxi Science and Technology Normal University","doi-asserted-by":"publisher","award":["2023BSQD39"],"award-info":[{"award-number":["2023BSQD39"]}],"id":[{"id":"10.13039\/501100013798","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20242BAB25576"],"award-info":[{"award-number":["20242BAB25576"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304606"],"award-info":[{"award-number":["82304606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ejphar.2026.178596","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T16:44:16Z","timestamp":1769186656000},"page":"178596","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Remodeling of androgen metabolism network mediated by UGT2B: a new perspective on treatment resistance in prostate cancer"],"prefix":"10.1016","volume":"1015","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1760-4834","authenticated-orcid":false,"given":"YuanYuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhua","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.178596_bib1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41416-020-0887-6","article-title":"UGT2B17 modifies drug response in chronic lymphocytic leukaemia","volume":"123","author":"Allain","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejphar.2026.178596_bib2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/pros.20749","article-title":"Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes","volume":"68","author":"Bao","year":"2008","journal-title":"Prostate"},{"key":"10.1016\/j.ejphar.2026.178596_bib3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.beem.2008.01.001","article-title":"Inactivation of androgens by UDP-glucuronosyltransferases in the human prostate","volume":"22","author":"Barbier","year":"2008","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.ejphar.2026.178596_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2019.105506","article-title":"The role of adrenal derived androgens in castration resistant prostate cancer","volume":"197","author":"Barnard","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ejphar.2026.178596_bib5","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.18632\/oncotarget.6479","article-title":"Low \u03b22-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism","volume":"7","author":"Braadland","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.ejphar.2026.178596_bib6","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ejphar.2026.178596_bib7","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1124\/dmd.114.062935","article-title":"Induction of UDP-glucuronosyltransferase 2B15 gene expression by the major active metabolites of tamoxifen, 4-hydroxytamoxifen and endoxifen, in breast cancer cells","volume":"43","author":"Chanawong","year":"2015","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2026.178596_bib8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jsb.2018.11.001","article-title":"Structural dissection of sterol glycosyltransferase UGT51 from Saccharomyces cerevisiae for substrate specificity","volume":"204","author":"Chen","year":"2018","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.ejphar.2026.178596_bib9","first-page":"1855","article-title":"Bioinformatic analysis suggests that UGT2B15 activates the Hippo-YAP signaling pathway leading to the pathogenesis of gastric cancer","volume":"40","author":"Chen","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.ejphar.2026.178596_bib10","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/s41419-022-05084-1","article-title":"Second generation androgen receptor antagonists and challenges in prostate cancer treatment","volume":"13","author":"Chen","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2026.178596_bib11","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.apsb.2016.04.005","article-title":"17 \u03b2-Estradiol up-regulates UDP-glucuronosyltransferase 1A9 expression via estrogen receptor \u03b1","volume":"6","author":"Cho","year":"2016","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ejphar.2026.178596_bib12","doi-asserted-by":"crossref","first-page":"33466","DOI":"10.1074\/jbc.M703370200","article-title":"UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells","volume":"282","author":"Chouinard","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2026.178596_bib13","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.clpt.2005.02.006","article-title":"Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers","volume":"77","author":"Chung","year":"2005","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2026.178596_bib14","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1210\/jc.2003-030330","article-title":"Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor","volume":"89","author":"Clark","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2026.178596_bib15","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/oxfordjournals.humrep.a136732","article-title":"Mechanism of GnRH action in gonadotrophs","volume":"3","author":"Clayton","year":"1988","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ejphar.2026.178596_bib16","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1124\/dmd.30.11.1257","article-title":"Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9","volume":"30","author":"Court","year":"2002","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2026.178596_bib17","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S0022-3565(24)29222-3","article-title":"Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms","volume":"299","author":"Court","year":"2001","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2026.178596_bib18","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1124\/jpet.104.067660","article-title":"UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver","volume":"310","author":"Court","year":"2004","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2026.178596_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002805","article-title":"A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation","volume":"8","author":"Coviello","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ejphar.2026.178596_bib20","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ajpath.2023.12.003","article-title":"Androgen receptore-interacting proteins in prostate cancer development and therapy resistance","volume":"194","author":"Culig","year":"2024","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2026.178596_bib21","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1021\/acs.jafc.7b03907","article-title":"Use of a promiscuous glycosyltransferase from bacillus subtilis 168 for the enzymatic synthesis of novel protopanaxatriol-type ginsenosides","volume":"66","author":"Dai","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.ejphar.2026.178596_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0032","article-title":"Transcriptional programs activated by exposure of human prostate cancer cells to androgen","volume":"3","author":"DePrimo","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.ejphar.2026.178596_bib23","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1210\/endrev\/bnab002","article-title":"Hormonal therapy for prostate cancer","volume":"42","author":"Desai","year":"2021","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2026.178596_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1530\/JME-20-0057","article-title":"The role of the androgen receptor as a driver and mitigator of cellular stress Interplay of developmental hippo-notch signaling pathways with the DNA damage response in prostate cancer","volume":"65","author":"Doultsinos","year":"2020","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.ejphar.2026.178596_bib25","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1124\/dmd.110.033696","article-title":"Dabigatran acylglucuronide, the major human metabolite of dabigatran: in vitro formation, stability, and pharmacological activity","volume":"38","author":"Ebner","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2026.178596_bib26","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1002\/tox.24118","article-title":"Unveiling hormone-stimulated gene mechanisms in prostate cancer: a prognostic model, immune infiltration analysis, and drug sensitivity study sex-specific outcomes in cancer therapy: the central role of hormones","volume":"39","author":"Fan","year":"2024","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.ejphar.2026.178596_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107779","article-title":"The intestinal functions of PXR and CAR","volume":"216","author":"Feng","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2026.178596_bib28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.mce.2011.09.032","article-title":"Activation of estrogen receptor \u03b1 by raloxifene through an activating protein-1-dependent tethering mechanism in human cervical epithelial cancer cells: a role for c-Jun N-terminal kinase","volume":"348","author":"Fogarty","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ejphar.2026.178596_bib29","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/bdd.405","article-title":"Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine","volume":"25","author":"Ghosal","year":"2004","journal-title":"Biopharm Drug Dispos."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178596_bib30","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13046-025-03299-6","article-title":"Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-\u03b21 signaling mechanism","volume":"44","author":"Gorodetska","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.ejphar.2026.178596_bib31","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0090-9556(25)07570-1","article-title":"Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates","volume":"22","author":"Green","year":"1994","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2026.178596_bib32","doi-asserted-by":"crossref","first-page":"6963","DOI":"10.1158\/0008-5472.CAN-13-1462","article-title":"Androgen glucuronidation: an unexpected target for androgen deprivation therapy, with prognosis and diagnostic implications","volume":"73","author":"Grosse","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2026.178596_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2024.1418975","article-title":"Exploring novel Apalutamide analogues as potential therapeutics for prostate cancer: design, molecular docking investigations and molecular dynamics simulation","volume":"12","author":"Gupta","year":"2024","journal-title":"Front. Chem."},{"key":"10.1016\/j.ejphar.2026.178596_bib34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.gene.2017.08.038","article-title":"Genetic variations in UGT2B28, UGT2B17, UGT2B15 genes and the risk of prostate cancer: a case-control study","volume":"634","author":"Habibi","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.ejphar.2026.178596_bib35","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.mce.2015.11.013","article-title":"Osteoblasts promote castration-resistant prostate cancer by altering intratumoral steroidogenesis","volume":"422","author":"Hagberg Thulin","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ejphar.2026.178596_bib36","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00005392-199707000-00004","article-title":"The relationship between prostatic intraepithelial neoplasia and prostate cancer: critical issues","volume":"158","author":"H\u00e4ggman","year":"1997","journal-title":"J. Urol."},{"key":"10.1016\/j.ejphar.2026.178596_bib37","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/pros.20024","article-title":"Prostate cancer and polymorphism D85Y in gene for dihydrotestosterone degrading enzyme UGT2B15: frequency of DD homozygotes increases with Gleason Score","volume":"59","author":"Hajdinjak","year":"2004","journal-title":"Prostate"},{"key":"10.1016\/j.ejphar.2026.178596_bib38","article-title":"Development and validation of the utLIFE-PC algorithm for noninvasive detection of prostate cancer in urine: a prospective, observational study","volume":"5","author":"Han","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.ejphar.2026.178596_bib39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.chemosphere.2008.09.053","article-title":"Human UDP-glucuronosyltransferase isoforms involved in bisphenol A glucuronidation","volume":"74","author":"Hanioka","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.ejphar.2026.178596_bib40","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1365-2125.2009.03519.x","article-title":"Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion","volume":"68","author":"He","year":"2009","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178596_bib41","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/pros.24049","article-title":"AKR1C3 mediates pan-AR antagonist resistance in castration-resistant prostate cancer","volume":"80","author":"Hertzog","year":"2020","journal-title":"Prostate"},{"key":"10.1016\/j.ejphar.2026.178596_bib42","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/pros.24049","article-title":"AKR1C3 mediates pan-AR antagonist resistance in castration-resistant prostate cancer","volume":"80","author":"Hertzog","year":"2020","journal-title":"Prostate"},{"key":"10.1016\/j.ejphar.2026.178596_bib43","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1124\/mol.109.057380","article-title":"Estrogen receptor alpha, fos-related antigen-2, and c-Jun coordinately regulate human UDP glucuronosyltransferase 2B15 and 2B17 expression in response to 17beta-estradiol in MCF-7 cells","volume":"76","author":"Hu","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178596_bib44","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/03602532.2022.2048846","article-title":"Regulation of human UDP-glycosyltransferase (UGT) genes by miRNAs","volume":"54","author":"Hu","year":"2022","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.ejphar.2026.178596_bib45","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1158\/0008-5472.CAN-15-3372","article-title":"Androgen and estrogen receptors in breast cancer coregulate human UDP-Glucuronosyltransferases 2B15 and 2B17","volume":"76","author":"Hu","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2026.178596_bib46","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1002\/ijc.35082","article-title":"Age-specific incidence trends of 32 cancers in China, 1983 to 2032: evidence from cancer Incidence in five continents","volume":"155","author":"Hu","year":"2024","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ejphar.2026.178596_bib47","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1098\/rsos.191121","article-title":"GuUGT, a glycosyltransferase from Glycyrrhiza uralensis, exhibits glycyrrhetinic acid 3- and 30-O-glycosylation","volume":"6","author":"Huang","year":"2019","journal-title":"R. Soc. Open Sci."},{"key":"10.1016\/j.ejphar.2026.178596_bib48","first-page":"232","article-title":"Studies on prostatic cancer. I. The effect of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate","volume":"22","author":"Huggins","year":"1972","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ejphar.2026.178596_bib49","article-title":"Androgen receptor transcriptional activity is required for heregulin-1beta-mediated nuclear localization of the HER3\/ErbB3 receptor tyrosine kinase","volume":"299","author":"Jathal","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2026.178596_bib50","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1042\/BJ20071136","article-title":"Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells","volume":"410","author":"Kaeding","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.ejphar.2026.178596_bib51","first-page":"9","article-title":"Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expression","volume":"5","author":"Kanaya","year":"2003","journal-title":"Asian J. Androl."},{"issue":"99","key":"10.1016\/j.ejphar.2026.178596_bib52","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1007\/s00204-025-04099-9","article-title":"An evaluation of the human relevance of the hepatocellular tumors observed in mice treated with synthetic fungicide, pyridachlometyl, based on mode of action","volume":"99","author":"Kawamoto","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.ejphar.2026.178596_bib53","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1007\/s00259-024-06698-7","article-title":"Comparison of discovery rates and prognostic utility of [(68)Ga]Ga-PSMA-11 PET\/CT and circulating tumor DNA in prostate cancer-a cross-sectional study","volume":"51","author":"Kluge","year":"2024","journal-title":"Eur. J. Nucl. Med. Mol. Imag."},{"key":"10.1016\/j.ejphar.2026.178596_bib54","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.tem.2010.01.002","article-title":"Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer","volume":"21","author":"Knudsen","year":"2010","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.ejphar.2026.178596_bib55","doi-asserted-by":"crossref","DOI":"10.1142\/S0219720019500033","article-title":"Bioinformatic identification of differentially expressed genes associated with prognosis of locally advanced lymph node-positive prostate cancer","volume":"17","author":"Kudryavtseva","year":"2019","journal-title":"J. Bioinf. Comput. Biol."},{"key":"10.1016\/j.ejphar.2026.178596_bib56","article-title":"Androgen receptor dynamics in prostate cancer: from disease progression to treatment resistance","volume":"15","author":"Li","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejphar.2026.178596_bib57","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s41416-025-02938-1","article-title":"The long noncoding RNA lncZBTB10 facilitates AR function via S-palmitoylation to promote prostate cancer progression and abiraterone resistance","volume":"7","author":"Lin","year":"2025","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ejphar.2026.178596_bib58","doi-asserted-by":"crossref","first-page":"5558","DOI":"10.1093\/hmg\/ddu268","article-title":"Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver","volume":"23","author":"Liu","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ejphar.2026.178596_bib59","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41419-025-07406-5","article-title":"Identification of mitochondrial carrier homolog 2 as an important therapeutic target of castration-resistant prostate cancer","volume":"16","author":"Liu","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2026.178596_bib60","first-page":"6155","article-title":"Huaier extract inhibits prostate cancer growth via targeting Ar\/Ar-V7 pathway","volume":"11","author":"Liu","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejphar.2026.178596_bib61","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/14737159.2019.1604223","article-title":"Metabolomic profiling for the identification of novel diagnostic markers and therapeutic targets in prostate cancer: an update","volume":"19","author":"Lucarelli","year":"2019","journal-title":"Expert Rev. Mol. Diagn"},{"key":"10.1016\/j.ejphar.2026.178596_bib62","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1530\/ERC-24-0274","article-title":"Systems-level liquid biopsy in advanced prostate cancer","volume":"32","author":"Lyman","year":"2025","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.ejphar.2026.178596_bib63","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00008571-199708000-00001","article-title":"The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence","volume":"7","author":"Mackenzie","year":"1997","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.ejphar.2026.178596_bib64","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1124\/mol.110.069336","article-title":"The novel UDP glycosyltransferase 3A2: cloning, catalytic properties, and tissue distribution","volume":"79","author":"Mackenzie","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178596_bib65","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10434-000-0777-3","article-title":"An allele-specific polymerase chain reaction method for the determination of the D85Y polymorphism in the human UDP-glucuronosyltransferase 2B15 gene in a case-control study of prostate cancer","volume":"7","author":"MacLeod","year":"2000","journal-title":"Ann. Surg Oncol."},{"key":"10.1016\/j.ejphar.2026.178596_bib66","first-page":"11","article-title":"Androgen deprivation therapy: indications, methods of utilization, side effects and their management","volume":"27","author":"Magee","year":"2020","journal-title":"Can. J. Urol."},{"key":"10.1016\/j.ejphar.2026.178596_bib67","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adq3802","article-title":"Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers","volume":"11","author":"Mao","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ejphar.2026.178596_bib68","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jsbmb.2015.09.021","article-title":"Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer","volume":"155","author":"Margaillan","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ejphar.2026.178596_bib69","doi-asserted-by":"crossref","first-page":"792","DOI":"10.5812\/numonthly.9430","article-title":"Molecular pathways in prostate cancer","volume":"5","author":"Mazaris","year":"2013","journal-title":"Nephrourol. Mon."},{"key":"10.1016\/j.ejphar.2026.178596_bib70","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1152\/physrev.00058.2017","article-title":"The UDP-glycosyltransferase (UGT) superfamily: new members, new functions, and novel paradigms","volume":"99","author":"Meech","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2026.178596_bib71","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.pharmthera.2012.01.009","article-title":"The glycosidation of xenobiotics and endogenous compounds: versatility and redundancy in the UDP glycosyltransferase superfamily","volume":"134","author":"Meech","year":"2012","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2026.178596_bib72","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1124\/mol.114.093823","article-title":"A novel function for UDP glycosyltransferase 8: galactosidation of bile acids","volume":"87","author":"Meech","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178596_bib73","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1158\/0008-5472.CAN-08-0249","article-title":"Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth","volume":"68","author":"Montgomery","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2026.178596_bib74","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1021\/acschembio.0c00069","article-title":"Reversal of apalutamide and darolutamide Aldo-Keto reductase 1C3-mediated resistance by a small molecule inhibitor","volume":"15","author":"Morsy","year":"2020","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.ejphar.2026.178596_bib75","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1021\/tx050317i","article-title":"Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity","volume":"19","author":"Mutlib","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.ejphar.2026.178596_bib76","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1124\/dmd.107.015909","article-title":"Stereoselective glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin by human UDP-glucuronosyltransferase (UGT) 1A1, UGT1A9, and UGT2B15: effects of UGT-UGT interactions","volume":"35","author":"Nakajima","year":"2007","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2026.178596_bib77","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1124\/dmd.108.021428","article-title":"Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines","volume":"36","author":"Nakamura","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.ejphar.2026.178596_bib78","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2133\/dmpk.DMPK-13-RG-004","article-title":"UDP-glucuronosyltransferase 2B15 (UGT2B15) is the major enzyme responsible for sipoglitazar glucuronidation in humans: retrospective identification of the UGT isoform by in vitro analysis and the effect of UGT2B15*2 mutation","volume":"28","author":"Nishihara","year":"2013","journal-title":"Drug Metabol. Pharmacokinet."},{"key":"10.1016\/j.ejphar.2026.178596_bib79","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1016\/S0006-2952(02)00994-2","article-title":"Reverse geometrical selectivity in glucuronidation and sulfation of cis- and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases","volume":"63","author":"Nishiyama","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178596_bib80","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/pharmaceutics10010006","article-title":"Regulation of hepatic UGT2B15 by methylation in adults of asian descent","volume":"10","author":"Oeser","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ejphar.2026.178596_bib81","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cdp.2006.04.004","article-title":"Association of the polymorphisms of genes involved in androgen metabolism and signaling pathways with familial prostate cancer risk in a Japanese population","volume":"30","author":"Okugi","year":"2006","journal-title":"Cancer Detect. Prev."},{"key":"10.1016\/j.ejphar.2026.178596_bib82","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.bcp.2020.114402","article-title":"The N6-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression","volume":"189","author":"Ondo","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178596_bib83","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.arcmed.2023.102889","article-title":"Exploring the interplay between vitamin B(12)-related biomarkers, DNA methylation, and gene-nutrition interaction in esophageal precancerous lesions","volume":"54","author":"Pan","year":"2023","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.ejphar.2026.178596_bib84","doi-asserted-by":"crossref","first-page":"E428","DOI":"10.1210\/jc.2011-2064","article-title":"Differential expression of the androgen-conjugating UGT2B15 and UGT2B17 enzymes in prostate tumor cells during cancer progression","volume":"97","author":"P\u00e2quet","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ejphar.2026.178596_bib85","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2415308122","article-title":"Comparative transcriptomics reveals a mixed basal, club, and hillock epithelial cell identity in castration-resistant prostate cancer","volume":"122","author":"Pitzen","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ejphar.2026.178596_bib86","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.euo.2025.02.017","article-title":"Association of prior PARP inhibitor exposure with clinical outcomes after (177)Lu-PMSA-617 in men with castration-resistant prostate cancer and mutations in DNA homologous recombination repair genes","volume":"8","author":"Raychaudhuri","year":"2025","journal-title":"Eur. Urol. Oncol."},{"key":"10.1016\/j.ejphar.2026.178596_bib87","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41388-024-03230-x","article-title":"CRIPTO's multifaceted role in driving aggressive prostate cancer unveiled by in vivo, organoid, and patient data","volume":"44","author":"Rodrigues Sousa","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.ejphar.2026.178596_bib88","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.ijpharm.2025.125463","article-title":"siRNA-based therapeutics in hormone-driven cancers: advancements and benefits over conventional treatments","volume":"674","author":"Saha","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejphar.2026.178596_bib89","article-title":"Clinical and imaging predictors of false-positive and false-negative results in prostate multiparametric MRI using PI-RADS version 2. Radiol imaging","volume":"7","author":"Salka","year":"2025","journal-title":"Cancer"},{"key":"10.1016\/j.ejphar.2026.178596_bib90","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0047-6374(95)01593-O","article-title":"Ageing and prostate: age-related changes in androgen receptors of epithelial cells from benign hypertrophic glands compared with cancer","volume":"82","author":"S\u00e1nchez-Visconti","year":"1995","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.ejphar.2026.178596_bib91","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pharmthera.2013.07.003","article-title":"Androgen receptors in hormone-dependent and castration-resistant prostate cancer","volume":"140","author":"Shafi","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2026.178596_bib92","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/15592294.2020.1795601","article-title":"Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells","volume":"16","author":"Shafiee-Kermani","year":"2021","journal-title":"Epigenetics"},{"key":"10.1016\/j.ejphar.2026.178596_bib93","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41585-020-0354-4","article-title":"Depression and prostate cancer: implications for urologists and oncologists","volume":"17","author":"Sharpley","year":"2020","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.ejphar.2026.178596_bib94","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ejphar.2026.178596_bib95","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00345-002-0313-0","article-title":"High-grade prostatic intraepithelial neoplasia and prostate cancer risk reduction","volume":"21","author":"Steiner","year":"2003","journal-title":"World J. Urol."},{"key":"10.1016\/j.ejphar.2026.178596_bib96","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fendo.2013.00075","article-title":"Implication of human UGT2B7, 2B15, and 2B17 in 19-Norandrosterone metabolism","volume":"4","author":"Strahm","year":"2013","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ejphar.2026.178596_bib97","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00228-012-1382-7","article-title":"The effect of genetic polymorphisms in UGT2B15 on the pharmacokinetic profile of sipoglitazar, a novel anti-diabetic agent","volume":"69","author":"Stringer","year":"2013","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178596_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107907","article-title":"CAR: discovery and development by the pharmacogenetics laboratory at NIEHS, NIH","volume":"219","author":"Sueyoshi","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2026.178596_bib99","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1006\/jmbi.1999.3374","article-title":"Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4","volume":"295","author":"Turgeon","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ejphar.2026.178596_bib100","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1158\/1535-7163.MCT-17-1023","article-title":"AKR1C3 Inhibitor KV-37 exhibits antineoplastic effects and potentiates enzalutamide in combination therapy in prostate adenocarcinoma cells","volume":"17","author":"Verma","year":"2018","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.ejphar.2026.178596_bib101","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s00120-024-02511-3","article-title":"Aggressive variant prostate cancer and transdifferentiated neuroendocrine prostate cancer: from diagnosis to therapy","volume":"64","author":"von Amsberg","year":"2025","journal-title":"Urologie"},{"key":"10.1016\/j.ejphar.2026.178596_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2019.01.001","article-title":"A 3-(4-nitronaphthen-1-yl) amino-benzoate analog as a bifunctional AKR1C3 inhibitor and AR antagonist: head to head comparison with other advanced AKR1C3 targeted therapeutics","volume":"192","author":"Wangtrakuldee","year":"2019","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ejphar.2026.178596_bib103","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/2664370","article-title":"High expression of ten eleven translocation 1 is associated with poor prognosis in hepatocellular carcinoma","volume":"2023","author":"Wen","year":"2023","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2026.178596_bib104","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1124\/jpet.115.226118","article-title":"Regulation of human UGT2B15 and UGT2B17 by miR-376c in prostate cancer cell lines","volume":"354","author":"Wijayakumara","year":"2015","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2026.178596_bib105","first-page":"577","article-title":"Steroid 5 alpha-reductase 2 deficiency","volume":"14","author":"Wilson","year":"1993","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ejphar.2026.178596_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115312","article-title":"CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer","volume":"44","author":"Xiang","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2026.178596_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111246","article-title":"Inhibition of human UDP-glucuronosyltransferase (UGT) enzymes by darolutamide: prediction of in vivo drug-drug interactions","volume":"403","author":"Xiao","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.ejphar.2026.178596_bib108","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10147-024-02676-z","article-title":"Characterization of PSA dynamics and oncological outcomes in patients with metastatic hormone-sensitive prostate cancer treated with androgen receptor signaling inhibitors","volume":"30","author":"Yamada","year":"2025","journal-title":"Int. J. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2026.178596_bib109","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.phymed.2021.153726","article-title":"Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC\/NF-\u03baB signaling pathway","volume":"92","author":"Yuan","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2026.178596_bib110","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.urolonc.2008.03.021","article-title":"Mechanisms mediating androgen receptor reactivation after castration","volume":"27","author":"Yuan","year":"2009","journal-title":"Urol. Oncol."},{"key":"10.1016\/j.ejphar.2026.178596_bib111","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.phrs.2022.106188","article-title":"Oridonin alleviates hyperbilirubinemia through activating LXR\u03b1-UGT1A1 axis","volume":"178","author":"Zhan","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2026.178596_bib112","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s12672-016-0250-9","article-title":"Classical and non-classical roles for pre-receptor control of DHT metabolism in prostate cancer progression","volume":"7","author":"Zhang","year":"2016","journal-title":"Horm Cancer"},{"key":"10.1016\/j.ejphar.2026.178596_bib113","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1158\/0008-5472.CAN-23-2796","article-title":"JMJD6 rewires ATF4-dependent glutathione metabolism to confer ferroptosis resistance in SPOP-mutated prostate cancer","volume":"85","author":"Zhang","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.ejphar.2026.178596_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113753","article-title":"Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15","volume":"172","author":"Zhang","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178596_bib115","doi-asserted-by":"crossref","first-page":"17829","DOI":"10.1074\/jbc.RA118.004846","article-title":"Loss of dihydrotestosterone-inactivation activity promotes prostate cancer castration resistance detectable by functional imaging","volume":"293","author":"Zhu","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2026.178596_bib116","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s12672-016-0268-z","article-title":"Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential","volume":"7","author":"Zimmer","year":"2016","journal-title":"Horm Cancer"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926000786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926000786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:02:28Z","timestamp":1770696148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926000786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":116,"alternative-id":["S0014299926000786"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178596","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Remodeling of androgen metabolism network mediated by UGT2B: a new perspective on treatment resistance in prostate cancer","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178596","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178596"}}