{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T14:02:02Z","timestamp":1772460122073,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20241914"],"award-info":[{"award-number":["BK20241914"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ejphar.2026.178604","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T16:58:25Z","timestamp":1769533105000},"page":"178604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Paeoniflorin alleviates urushiol-induced pruritus in mice by inhibiting Erk\/CCL2 pathway"],"prefix":"10.1016","volume":"1016","author":[{"given":"Huan","family":"You","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Tai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianmu","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefeng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongxiang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.178604_bib1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/pde.14450","article-title":"Erythema multiforme-like eruption associated with plant-induced allergic contact dermatitis in a pediatric patient: a case report","volume":"38","author":"Cattelan","year":"2021","journal-title":"Pediatr. Dermatol."},{"key":"10.1016\/j.ejphar.2026.178604_bib2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/cei.13575","article-title":"Keratinocytes: innate immune cells in atopic dermatitis","volume":"204","author":"Chieosilapatham","year":"2021","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ejphar.2026.178604_bib3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2147\/ITT.S260370","article-title":"Targeting IL-4 for the treatment of atopic dermatitis","volume":"9","author":"Chiricozzi","year":"2020","journal-title":"ImmunoTargets Ther."},{"key":"10.1016\/j.ejphar.2026.178604_bib4","article-title":"Protective role of CB1 receptors on keratinocytes in a mouse model of allergic contact dermatitis","volume":"20","author":"Cron","year":"2011","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.ejphar.2026.178604_bib5","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/all.12183","article-title":"Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors","volume":"68","author":"Gaffal","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.ejphar.2026.178604_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.4820","article-title":"Skin under Tnf influence: how regulatory T cells work against macrophages in psoriasis","volume":"241","author":"Gatzka","year":"2017","journal-title":"J. Pathol."},{"key":"10.1016\/j.ejphar.2026.178604_bib7","article-title":"Comparative Study on different skin Pruritus mouse models","volume":"8","author":"Guan","year":"2021","journal-title":"Front Med-Lausanne"},{"key":"10.1016\/j.ejphar.2026.178604_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fphar.2011.00010","article-title":"Anti-inflammatory and immunomodulatory effects of paeonia lactiflora pall., a traditional chinese herbal medicine","volume":"2","author":"He","year":"2011","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178604_bib9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","article-title":"IL-6 in inflammation, autoimmunity and cancer","volume":"33","author":"Hirano","year":"2021","journal-title":"Int. Immunol."},{"key":"10.1016\/j.ejphar.2026.178604_bib10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/cod.14685","article-title":"Kintsugi: a novel cause of urushiol-induced allergic contact dermatitis","volume":"92","author":"Hughes","year":"2024","journal-title":"Contact Dermat"},{"key":"10.1016\/j.ejphar.2026.178604_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.142067","article-title":"Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin","volume":"5","author":"Jiang","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.ejphar.2026.178604_bib12","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nri3150","article-title":"Early immune events in the induction of allergic contact dermatitis","volume":"12","author":"Kaplan","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2026.178604_bib13","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/brv.13043","article-title":"Unveiling the resistance of native weed communities: insights for managing invasive weed species in disturbed environments","volume":"99","author":"Khattak","year":"2024","journal-title":"Biol. Rev. Camb. Phil. Soc."},{"key":"10.1016\/j.ejphar.2026.178604_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005374","article-title":"TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation","volume":"5","author":"Kim","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejphar.2026.178604_bib15","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/BF01451007","article-title":"Study of pro-inflammatory (TNF-alpha, IL-1alpha, IL-6) and T-cell-derived (IL-2, IL-4) cytokines in plasma and synovial fluid of patients with juvenile chronic arthritis: correlations with clinical and laboratory parameters","volume":"17","author":"Kutukculer","year":"1998","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.ejphar.2026.178604_bib16","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/916497","article-title":"Cytokines and chemokines in irritant contact dermatitis","volume":"2013","author":"Lee","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2026.178604_bib17","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.fertnstert.2011.12.049","article-title":"Chemokine CCL2 enhances survival and invasiveness of endometrial stromal cells in an autocrine manner by activating Akt and MAPK\/Erk1\/2 signal pathway","volume":"97","author":"Li","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ejphar.2026.178604_bib18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/gutjnl-2015-310514","article-title":"Targeting of tumour-infiltrating macrophages via CCL2\/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma","volume":"66","author":"Li","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.ejphar.2026.178604_bib19","doi-asserted-by":"crossref","first-page":"E7572","DOI":"10.1073\/pnas.1606608113","article-title":"IL-33\/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy","volume":"113","author":"Liu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2026.178604_bib20","article-title":"Transcriptome profiling reveals Th2 bias and identifies endogenous itch mediators in poison ivy contact dermatitis","volume":"5","author":"Liu","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.ejphar.2026.178604_bib21","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124497","article-title":"Transcriptome profiling reveals Th2 bias and identifies endogenous itch mediators in poison ivy contact dermatitis","volume":"4","author":"Liu","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.ejphar.2026.178604_bib22","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4103\/0974-8520.105250","article-title":"Urushiol-induced contact dermatitis caused during Shodhana (purificatory measures) of Bhallataka (Semecarpus anacardium Linn.) fruit","volume":"33","author":"Llanchezhian","year":"2012","journal-title":"Ayu"},{"key":"10.1016\/j.ejphar.2026.178604_bib23","doi-asserted-by":"crossref","first-page":"9086","DOI":"10.1073\/pnas.0602392103","article-title":"Biomass and toxicity responses of poison ivy (Toxicodendron radicans) to elevated atmospheric CO2","volume":"103","author":"Mohan","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2026.178604_bib24","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/cei.13212","article-title":"Dietary soyasaponin attenuates 2,4-dinitrofluorobenzene-induced contact hypersensitivity via gut microbiota in mice","volume":"195","author":"Nagano","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ejphar.2026.178604_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113624","article-title":"Identification and hepatoprotective activity of total glycosides of paeony with high content of paeoniflorin extracted from Paeonia lactiflora Pall","volume":"173","author":"Peng","year":"2023","journal-title":"Food Chem. Toxicol. : an international journal published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.ejphar.2026.178604_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.708186","article-title":"Macrophages: the good, the bad, and the gluttony","volume":"12","author":"Ross","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2026.178604_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108364","article-title":"Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate\/SUCNR1-HIF-1alpha\/NLPR3 pathway","volume":"101","author":"Ruan","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2026.178604_bib28","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1007\/s10753-019-01086-y","article-title":"Interference of skin scratching attenuates accumulation of neutrophils in Murine allergic Contact dermatitis model","volume":"42","author":"Sakai","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2026.178604_bib29","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.intimp.2015.02.031","article-title":"Oral administration of paeoniflorin attenuates allergic contact dermatitis by inhibiting dendritic cell migration and Th1 and Th17 differentiation in a mouse model","volume":"25","author":"Shi","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2026.178604_bib30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.intimp.2014.02.001","article-title":"Paeoniflorin inhibits the maturation and immunostimulatory function of allergen-induced murine dendritic cells","volume":"19","author":"Shi","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2026.178604_bib31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jid.2021.07.182","article-title":"CCL2\u2012CCR2 signaling in the skin drives surfactant-induced irritant contact dermatitis through IL-1beta\u2012Mediated neutrophil accumulation","volume":"142","author":"Shibuya","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ejphar.2026.178604_bib32","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.intimp.2014.12.032","article-title":"Paeoniflorin inhibits skin lesions in imiquimod-induced psoriasis-like mice by downregulating inflammation","volume":"24","author":"Sun","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2026.178604_bib33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0021-5198(19)30623-7","article-title":"Paeoniflorin, a major constituent of peony root, reverses muscarinic M1-receptor antagonist-induced suppression of long-term potentiation in the rat hippocampal slice","volume":"83","author":"Tabata","year":"2000","journal-title":"Jpn. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178604_bib34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jdermsci.2025.08.004","article-title":"Dermal fibroblast subsets and their roles in inflammatory and autoimmune skin diseases","volume":"120","author":"Takahashi","year":"2025","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.ejphar.2026.178604_bib35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1440-1711.2005.01310.x","article-title":"IFN-gamma and TNF-alpha are involved in urushiol-induced contact hypersensitivity in mice","volume":"83","author":"Wakabayashi","year":"2005","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.ejphar.2026.178604_bib36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1248\/bpb.b19-00689","article-title":"Metformin suppresses LPS-Induced inflammatory responses in macrophage and ameliorates allergic contact dermatitis in mice via autophagy","volume":"43","author":"Wang","year":"2020","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ejphar.2026.178604_bib37","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s10753-018-0740-8","article-title":"Involvement of the negative feedback of IL-33 signaling in the anti-inflammatory effect of electro-acupuncture on allergic contact dermatitis via targeting MicroRNA-155 in mast cells","volume":"41","author":"Wang","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2026.178604_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1124\/pr.111.005074","article-title":"CC chemokine receptors and chronic inflammation--therapeutic opportunities and pharmacological challenges","volume":"65","author":"White","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2026.178604_bib39","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","article-title":"The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch","volume":"155","author":"Wilson","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2026.178604_bib40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jaci.2019.06.016","article-title":"Pruritus in allergy and immunology","volume":"144","author":"Yang","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ejphar.2026.178604_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.imlet.2024.106902","article-title":"Aloe-emodin relieves allergic contact dermatitis pruritus by inhibiting mast cell degranulation","volume":"270","author":"Yang","year":"2024","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.ejphar.2026.178604_bib42","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41586-024-07098-5","article-title":"IL-10 constrains sphingolipid metabolism to limit inflammation","volume":"627","author":"York","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.178604_bib43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2009.12.007","article-title":"Effects and mechanisms of aloperine on 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB\/c mice","volume":"629","author":"Yuan","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178604_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073467","article-title":"Role of ERK pathway in the pathogenesis of atopic dermatitis and its potential as a therapeutic target","volume":"23","author":"Zeze","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.178604_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107452","article-title":"Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony","volume":"207","author":"Zhang","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2026.178604_bib46","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12974-019-1476-6","article-title":"Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain","volume":"16","author":"Zhou","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2026.178604_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109824","article-title":"Responses of the proteome in testis of mice exposed chronically to environmentally relevant concentrations of Microcystin-LR","volume":"187","author":"Zhou","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926000865?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926000865?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:07:06Z","timestamp":1772456826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926000865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":47,"alternative-id":["S0014299926000865"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178604","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paeoniflorin alleviates urushiol-induced pruritus in mice by inhibiting Erk\/CCL2 pathway","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178604","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178604"}}