{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:15:08Z","timestamp":1783638908430,"version":"3.55.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471518"],"award-info":[{"award-number":["82471518"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ejphar.2026.178605","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:28:04Z","timestamp":1770337684000},"page":"178605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["GHSR1A blockade by JMV2959 following memory retrieval disrupts reconsolidation and suppresses heroin-seeking behavior"],"prefix":"10.1016","volume":"1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9820-8069","authenticated-orcid":false,"given":"Qihua","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1070-8147","authenticated-orcid":false,"given":"Zhihao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.ejphar.2026.178605_bib1","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15113","article-title":"Expression of the growth hormone secretagogue receptor 1a (GHS-R1a) in the brain","volume":"9","author":"Airapetov","year":"2021","journal-title":"Physiological Reports"},{"key":"10.1016\/j.ejphar.2026.178605_bib2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.npep.2017.11.002","article-title":"Local injection of d-lys-3-GHRP-6 in the rat amygdala, dentate gyrus or ventral tegmental area impairs memory consolidation","volume":"67","author":"Beheshti","year":"2018","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejphar.2026.178605_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113270","article-title":"Differential expression levels of the hippocampal ghrelin and its receptor mRNA during memory consolidation","volume":"408","author":"Beheshti","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2026.178605_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2020.112969","article-title":"D-Lys-3-GHRP-6 impairs memory consolidation and downregulates the hippocampal serotonin HT1A, HT7 receptors and glutamate GluA1 subunit of AMPA receptors","volume":"223","author":"Beheshti","year":"2020","journal-title":"Physiol. Behav."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178605_bib5","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neulet.2012.04.009","article-title":"Ghrelin promotes reorganization of dendritic spines in cultured rat hippocampal slices","volume":"516","author":"Berrout","year":"2012","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178605_bib6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.nlm.2007.12.004","article-title":"Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation","volume":"90","author":"Blundell","year":"2008","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.ejphar.2026.178605_bib7","article-title":"Blockade of \u03b2-Adrenergic receptors by propranolol disrupts reconsolidation of drug memory and attenuates heroin seeking","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.ejphar.2026.178605_bib8","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.biopsych.2006.03.013","article-title":"Anisomycin, a protein synthesis inhibitor, disrupts traumatic memory consolidation and attenuates posttraumatic stress response in rats","volume":"60","author":"Cohen","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.178605_bib9","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.57335","article-title":"Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency","volume":"9","author":"Crouse","year":"2020","journal-title":"eLife"},{"issue":"3","key":"10.1016\/j.ejphar.2026.178605_bib10","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00213-019-05415-9","article-title":"A role for leptin and ghrelin in the augmentation of heroin seeking induced by chronic food restriction","volume":"237","author":"D'Cunha","year":"2020","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178605_bib11","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1038\/s41467-019-13162-w","article-title":"Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories","volume":"10","author":"Das","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2026.178605_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134367","article-title":"Role of mesolimbic ghrelin in the acquisition of cocaine reward","volume":"709","author":"Dunn","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2026.178605_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174039","article-title":"A ghrelin receptor antagonist reduces the ability of ghrelin, alcohol or amphetamine to induce a dopamine release in the ventral tegmental area and in nucleus accumbens shell in rats","volume":"899","author":"Edvardsson","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"12","key":"10.1016\/j.ejphar.2026.178605_bib14","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/j.euroneuro.2015.10.004","article-title":"A ghrelin receptor (GHS-R1A) antagonist attenuates the rewarding properties of morphine and increases opioid peptide levels in reward areas in mice","volume":"25","author":"Engel","year":"2015","journal-title":"Eur. Neuropsychopharmacol. : the Journal of the European College of Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.ejphar.2026.178605_bib15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00213-017-4793-4","article-title":"Psychedelics and reconsolidation of traumatic and appetitive maladaptive memories: focus on cannabinoids and ketamine","volume":"235","author":"Fattore","year":"2018","journal-title":"Psychopharmacology"},{"issue":"12","key":"10.1016\/j.ejphar.2026.178605_bib16","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/ijnp\/pyad060","article-title":"The impact of heroin self-administration and environmental enrichment on ventral tegmental CRF1 receptor expression","volume":"26","author":"Galaj","year":"2023","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"10","key":"10.1016\/j.ejphar.2026.178605_bib17","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1007\/s00213-014-3817-6","article-title":"Ghrelin increases memory consolidation through hippocampal mechanisms dependent on glutamate release and NR2B-subunits of the NMDA receptor","volume":"232","author":"Ghersi","year":"2015","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2026.178605_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2024.107988","article-title":"Basolateral amygdala inputs to the nucleus accumbens shell modulate the consolidation of cued-response and inhibitory avoidance learning","volume":"215","author":"Glickman","year":"2024","journal-title":"Neurobiol. Learn. Mem."},{"issue":"9","key":"10.1016\/j.ejphar.2026.178605_bib19","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1111\/acer.12499","article-title":"The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL\/6J mice","volume":"38","author":"Gomez","year":"2014","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"19","key":"10.1016\/j.ejphar.2026.178605_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2023.06.023","article-title":"A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction","volume":"111","author":"Gunduz-Cinar","year":"2023","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.ejphar.2026.178605_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s12264-024-01294-z","article-title":"Memory reconsolidation updating in substance addiction: applications, mechanisms, and future prospects for clinical therapeutics","volume":"41","author":"Huang","year":"2025","journal-title":"Neurosci. Bull."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178605_bib23","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.neulet.2011.09.056","article-title":"SKF 83566 attenuates the effects of ghrelin on performance in the object location memory task","volume":"504","author":"Jacoby","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"12","key":"10.1016\/j.ejphar.2026.178605_bib24","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1007\/s00213-023-06454-z","article-title":"MK-801 and cognitive functions: investigating the behavioral effects of a non-competitive NMDA receptor antagonist","volume":"240","author":"Janus","year":"2023","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.ejphar.2026.178605_bib25","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neuint.2017.09.013","article-title":"Ghrelin receptor antagonism of morphine-induced conditioned place preference and behavioral and accumbens dopaminergic sensitization in rats","volume":"110","author":"Jerabek","year":"2017","journal-title":"Neurochem. Int."},{"issue":"2-3","key":"10.1016\/j.ejphar.2026.178605_bib26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.drugalcdep.2011.01.010","article-title":"Ghrelin receptor antagonism attenuates nicotine-induced locomotor stimulation, accumbal dopamine release and conditioned place preference in mice","volume":"117","author":"Jerlhag","year":"2011","journal-title":"Drug Alcohol Depend."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178605_bib27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1037\/bne0000349","article-title":"The basolateral amygdala-medial prefrontal cortex circuitry regulates behavioral flexibility during appetitive reversal learning","volume":"134","author":"Keefer","year":"2020","journal-title":"Behav. Neurosci."},{"issue":"0 0","key":"10.1016\/j.ejphar.2026.178605_bib28","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.neuropharm.2013.05.024","article-title":"Addiction as a stress surfeit disorder","volume":"76 Pt B","author":"Koob","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2026.178605_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fnmol.2019.00095","article-title":"Relevance of ERK1\/2 post-retrieval participation on memory processes: insights in their particular role on reconsolidation and persistence of memories","volume":"12","author":"Krawczyk","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178605_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2023.173528","article-title":"Ghrelin\/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats","volume":"224","author":"Lapka","year":"2023","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2026.178605_bib31","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.bbr.2018.08.009","article-title":"Reversal of morphine conditioned behavior by an anti-dopaminergic post-trial drug treatment during re-consolidation","volume":"359","author":"Leite Junior","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2026.178605_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.1020098","article-title":"Extracellular signal-regulated kinase in the basolateral amygdala is required for reconsolidation of heroin-associated memory","volume":"15","author":"Li","year":"2022","journal-title":"Front. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178605_bib33","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/s41386-022-01417-y","article-title":"Modulation of methamphetamine memory reconsolidation by neural projection from basolateral amygdala to nucleus accumbens","volume":"48","author":"Li","year":"2023","journal-title":"Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2026.178605_bib34","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3389\/fpsyt.2020.00322","article-title":"Memory retrieval-extinction combined with virtual reality reducing drug craving for methamphetamine: study protocol for a randomized controlled trial","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Psychiatr."},{"issue":"4","key":"10.1016\/j.ejphar.2026.178605_bib35","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41380-023-01942-2","article-title":"Preventing incubation of drug craving to treat drug relapse: from bench to bedside","volume":"28","author":"Liu","year":"2023","journal-title":"Mol. Psychiatr."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178605_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s002130100885","article-title":"Reactivation of morphine conditioned place preference by drug priming: role of environmental cues and sensitization","volume":"159","author":"Lu","year":"2002","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2026.178605_bib37","doi-asserted-by":"crossref","first-page":"7675","DOI":"10.1038\/ncomms8675","article-title":"A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking","volume":"6","author":"Luo","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2026.178605_bib38","doi-asserted-by":"crossref","first-page":"7675","DOI":"10.1038\/ncomms8675","article-title":"A novel UCS memory retrieval-extinction procedure to inhibit relapse to drug seeking","volume":"6","author":"Luo","year":"2015","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.ejphar.2026.178605_bib39","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.tins.2024.04.005","article-title":"Neuroimaging of opioid effects in humans across conditions of acute administration, chronic pain therapy, and opioid use disorder","volume":"47","author":"Martucci","year":"2024","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2026.178605_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2020.582147","article-title":"Drug-Induced conditioned place preference and its practical use in substance use disorder research","volume":"14","author":"McKendrick","year":"2020","journal-title":"Frontiers Behav. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178605_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1268366","article-title":"Ghrelin receptor antagonist JMV2959 blunts cocaine and oxycodone drug-seeking, but not self-administration, in male rats","volume":"14","author":"Merritt","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.ejphar.2026.178605_bib42","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.neuron.2005.08.006","article-title":"Molecular substrates for retrieval and reconsolidation of cocaine-associated contextual memory","volume":"47","author":"Miller","year":"2005","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178605_bib43","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41398-023-02666-1","article-title":"Drug memory reconsolidation: from molecular mechanisms to the clinical context","volume":"13","author":"Milton","year":"2023","journal-title":"Transl. Psychiatry"},{"issue":"6","key":"10.1016\/j.ejphar.2026.178605_bib44","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1210\/en.2005-1182","article-title":"Direct stimulation of ghrelin secretion by sympathetic nerves","volume":"147","author":"Mundinger","year":"2006","journal-title":"Endocrinology"},{"issue":"17","key":"10.1016\/j.ejphar.2026.178605_bib45","doi-asserted-by":"crossref","first-page":"6639","DOI":"10.1523\/JNEUROSCI.4364-14.2015","article-title":"Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine","volume":"35","author":"Navarro","year":"2015","journal-title":"J. Neurosci. : the Official Journal of the Society For Neuroscience"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178605_bib46","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s11033-024-09585-4","article-title":"A case control study investigating the methylation levels of GHRL and GHSR genes in alcohol use disorder","volume":"51","author":"\u00d6zkan-Kotilo\u011flu","year":"2024","journal-title":"Mol. Biol. Rep."},{"issue":"15","key":"10.1016\/j.ejphar.2026.178605_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abf0364","article-title":"Cues conditioned to withdrawal and negative reinforcement: neglected but key motivational elements driving opioid addiction","volume":"7","author":"Pantazis","year":"2021","journal-title":"Sci. Adv."},{"issue":"5667","key":"10.1016\/j.ejphar.2026.178605_bib48","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1126\/science.1089459","article-title":"Rapid rewiring of arcuate nucleus feeding circuits by leptin","volume":"304","author":"Pinto","year":"2004","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.ejphar.2026.178605_bib49","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.biopsych.2020.07.022","article-title":"The basolateral amygdala to Nucleus accumbens core circuit mediates the conditioned reinforcing effects of cocaine-paired cues on cocaine seeking","volume":"89","author":"Puaud","year":"2021","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178605_bib50","first-page":"518","article-title":"Differential functional selectivity and downstream signaling bias of ghrelin receptor antagonists and inverse agonists","volume":"33","author":"Ramirez","year":"2019","journal-title":"FASEB (Fed. Am. Soc. Exp. Biol.) J."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178605_bib51","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2174\/1874473707666140205200532","article-title":"Role of ghrelin in drug abuse and reward-relevant behaviors: a burgeoning field and gaps in the literature","volume":"6","author":"Revitsky","year":"2013","journal-title":"Curr. Drug Abuse Rev."},{"key":"10.1016\/j.ejphar.2026.178605_bib52","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.brainresbull.2017.09.003","article-title":"Molecular and synaptic mechanisms regulating drug-associated memories: towards a bidirectional treatment strategy","volume":"141","author":"Rich","year":"2018","journal-title":"Brain Res. Bull."},{"issue":"7","key":"10.1016\/j.ejphar.2026.178605_bib53","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1523\/JNEUROSCI.21-07-02518.2001","article-title":"Basolateral amygdala-nucleus accumbens interactions in mediating glucocorticoid enhancement of memory consolidation","volume":"21","author":"Roozendaal","year":"2001","journal-title":"J. Neurosci. : the Official Journal of the Society For Neuroscience"},{"issue":"45","key":"10.1016\/j.ejphar.2026.178605_bib54","doi-asserted-by":"crossref","first-page":"11582","DOI":"10.1523\/JNEUROSCI.2049-06.2006","article-title":"Blocking memory reconsolidation reverses memory-associated changes in glutamate receptor expression","volume":"26","author":"Rose","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178605_bib55","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuroscience.2017.03.019","article-title":"Selective post-training time window for memory consolidation interference of cannabidiol into the prefrontal cortex: reduced dopaminergic modulation and immediate gene expression in limbic circuits","volume":"350","author":"Rossignoli","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2026.178605_bib56","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuroscience.2020.01.027","article-title":"Ghrelin induces place preference for social interaction in the larger peer of a Male rat pair","volume":"447","author":"Sch\u00e9le","year":"2020","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.ejphar.2026.178605_bib57","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.biopsych.2011.10.028","article-title":"Neural signature of reconsolidation impairments by propranolol in humans","volume":"71","author":"Schwabe","year":"2012","journal-title":"Biol. Psychiatry"},{"issue":"9","key":"10.1016\/j.ejphar.2026.178605_bib58","doi-asserted-by":"crossref","first-page":"543","DOI":"10.5498\/wjp.v11.i9.543","article-title":"Recent advances in the treatment of opioid use disorders-focus on long-acting buprenorphine formulations","volume":"11","author":"Soyka","year":"2021","journal-title":"World J. Psychiatr."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178605_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020761","article-title":"The role of Ghrelin\/GHS-R1A signaling in nonalcohol drug addictions","volume":"23","author":"Sustkova-Fiserova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.ejphar.2026.178605_bib60","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12845","article-title":"Ghrelin receptor antagonism of fentanyl-induced conditioned place preference, intravenous self-administration, and dopamine release in the nucleus accumbens in rats","volume":"25","author":"Sustkova-Fiserova","year":"2020","journal-title":"Addict. Biol."},{"issue":"4","key":"10.1016\/j.ejphar.2026.178605_bib61","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nrn2090","article-title":"Molecular mechanisms of memory reconsolidation","volume":"8","author":"Tronson","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178605_bib62","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.nlm.2018.02.009","article-title":"Learning and memory is modulated by cannabidiol when administered during trace fear-conditioning","volume":"149","author":"Uhernik","year":"2018","journal-title":"Neurobiol. Learn. Mem."},{"issue":"7","key":"10.1016\/j.ejphar.2026.178605_bib63","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/jamapsychiatry.2022.1240","article-title":"Association of drug cues and craving with drug use and relapse: a systematic review and meta-analysis","volume":"79","author":"Vafaie","year":"2022","journal-title":"JAMA Psychiatry"},{"issue":"6","key":"10.1016\/j.ejphar.2026.178605_bib64","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/adb.12114","article-title":"The role of ghrelin in drug and natural reward","volume":"18","author":"Vengeliene","year":"2013","journal-title":"Addict. Biol."},{"issue":"11","key":"10.1016\/j.ejphar.2026.178605_bib65","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.biopsych.2010.12.016","article-title":"Effects of cue-exposure treatment on neural cue reactivity in alcohol dependence: a randomized trial","volume":"69","author":"Vollst\u00e4dt-Klein","year":"2011","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.ejphar.2026.178605_bib66","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1523\/JNEUROSCI.4716-04.2005","article-title":"Consolidation and reconsolidation of incentive learning in the amygdala","volume":"25","author":"Wang","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178605_bib67","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.80926","article-title":"Amygdala-cortical collaboration in reward learning and decision making","volume":"11","author":"Wassum","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.ejphar.2026.178605_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.932939","article-title":"Inhibition of Glycogen synthase kinase 3\u03b2 activity in the basolateral amygdala disrupts reconsolidation and Attenuates Heroin relapse","volume":"15","author":"Xie","year":"2022","journal-title":"Front. Mol. Neurosci."},{"issue":"6078","key":"10.1016\/j.ejphar.2026.178605_bib69","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1126\/science.1215070","article-title":"A memory retrieval-extinction procedure to prevent drug craving and relapse","volume":"336","author":"Xue","year":"2012","journal-title":"Science (New York, N.Y.)"},{"issue":"6078","key":"10.1016\/j.ejphar.2026.178605_bib70","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1126\/science.1215070","article-title":"A memory retrieval-extinction procedure to prevent drug craving and relapse","volume":"336","author":"Xue","year":"2012","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178605_bib71","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.55165","article-title":"Neural variability and cognitive control in individuals with opioid use disorder","volume":"8","author":"Ye","year":"2025","journal-title":"JAMA Netw. Open"},{"issue":"8","key":"10.1016\/j.ejphar.2026.178605_bib72","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/s41386-021-01249-2","article-title":"Involvement of the ghrelin system in the maintenance and reinstatement of cocaine-motivated behaviors: a role of adrenergic action at peripheral \u03b21 receptors","volume":"47","author":"You","year":"2022","journal-title":"Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178605_bib73","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1186\/s12888-025-06904-2","article-title":"Effect of inhibition of reactivated alcohol-associated memories with propranolol on alcohol craving","volume":"25","author":"Yu","year":"2025","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.ejphar.2026.178605_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104283","article-title":"The effect of a methadone-initiated memory reconsolidation updating procedure in opioid use disorder: a translational study","volume":"85","author":"Yue","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ejphar.2026.178605_bib75","article-title":"Disrupting reconsolidation by systemic inhibition of mTOR kinase via Rapamycin reduces cocaine-seeking behavior","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178605_bib76","article-title":"Disrupting reconsolidation by PKA inhibitor in BLA reduces heroin-seeking behavior","volume":"16","author":"Zhang","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178605_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.718615","article-title":"Growth hormone secretagogue receptor 1A antagonist JMV2959 effectively prevents morphine memory reconsolidation and relapse","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"36","key":"10.1016\/j.ejphar.2026.178605_bib78","doi-asserted-by":"crossref","first-page":"15868","DOI":"10.1073\/pnas.1011116107","article-title":"Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice","volume":"107","author":"Zhao","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2026.178605_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2021.110496","article-title":"Differential involvement of nucleus tractus solitarius projections and locus coeruleus projections to the basolateral amygdala in morphine-associated memory destabilization","volume":"115","author":"Zheng","year":"2022","journal-title":"Progress In Neuro-psychopharmacology & Biological Psychiatry"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926000877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926000877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:34:51Z","timestamp":1783636491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926000877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":78,"alternative-id":["S0014299926000877"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178605","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GHSR1A blockade by JMV2959 following memory retrieval disrupts reconsolidation and suppresses heroin-seeking behavior","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178605","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"178605"}}