{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T05:09:29Z","timestamp":1779426569997,"version":"3.53.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007156","name":"Innovation and Technology Commission - Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ejphar.2026.178713","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:19:20Z","timestamp":1772781560000},"page":"178713","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Chronic co-treatment with geniposide and shanzhiside methyl ester elicits antidepressant effects via PACAP signaling in stressed male mice"],"prefix":"10.1016","volume":"1019","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6298-2922","authenticated-orcid":false,"given":"Ping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-7184","authenticated-orcid":false,"given":"Zafar","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxiao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk-yu","family":"Yau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.178713_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115719","article-title":"Saffron essential oil ameliorates CUMS-induced depression-like behavior in mice via the MAPK-CREB1-BDNF signaling pathway","volume":"300","author":"Chen","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2026.178713_bib2","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1038\/s41380-025-03317-1","article-title":"Rapid antidepressant effect of single-bout exercise is mediated by adiponectin-induced APPL1 nucleus translocation in anterior cingulate cortex","volume":"30","author":"Cheng","year":"2025","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ejphar.2026.178713_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109194","article-title":"PSD-95 protects synapses from beta-amyloid","volume":"35","author":"Dore","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2026.178713_bib4","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.2147\/NDT.S114560","article-title":"Nine traditional Chinese herbal formulas for the treatment of depression: an ethnopharmacology, phytochemistry, and pharmacology review","volume":"12","author":"Feng","year":"2016","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"10.1016\/j.ejphar.2026.178713_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153980","article-title":"The therapeutic potential of traditional Chinese medicine in depression: targeting adult hippocampal neurogenesis","volume":"98","author":"Feng","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2026.178713_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/cns.12649","article-title":"Methamphetamine induces anhedonic-like behavior and impairs frontal cortical energetics in mice","volume":"23","author":"Fonseca","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.ejphar.2026.178713_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11020249","article-title":"Increasing adiponectin signaling by sub-chronic AdipoRon treatment elicits Antidepressant- and anxiolytic-like effects independent of changes in hippocampal plasticity","volume":"11","author":"Formolo","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2026.178713_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.995900","article-title":"Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy","volume":"13","author":"Gaszner","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ejphar.2026.178713_bib9","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/bcp.12845","article-title":"New perspectives on the involvement of mTOR in depression as well as in the action of antidepressant drugs","volume":"82","author":"Ignacio","year":"2016","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178713_bib10","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.biopsych.2018.10.004","article-title":"Hippocampal salt-inducible kinase 2 plays a role in depression via the CREB-Regulated transcription coactivator 1-cAMP response element binding-brain-derived neurotrophic factor pathway","volume":"85","author":"Jiang","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.178713_bib11","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.neuron.2020.05.015","article-title":"Targeting homeostatic synaptic plasticity for treatment of mood disorders","volume":"106","author":"Kavalali","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2026.178713_bib12","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.molmed.2023.02.003","article-title":"Bridging rapid and sustained antidepressant effects of ketamine","volume":"29","author":"Kim","year":"2023","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ejphar.2026.178713_bib13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.npep.2013.10.014","article-title":"Role of neuropeptides in anxiety, stress, and depression: from animals to humans","volume":"47","author":"Kormos","year":"2013","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejphar.2026.178713_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41386-023-01629-w","article-title":"Ketamine and rapid antidepressant action: new treatments and novel synaptic signaling mechanisms","volume":"49","author":"Krystal","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2026.178713_bib15","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2305772120","article-title":"Ketamine and the neurobiology of depression: toward next-generation rapid-acting antidepressant treatments","volume":"120","author":"Krystal","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2026.178713_bib16","article-title":"AdipoRon treatment induces a dose-dependent response in adult hippocampal neurogenesis","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.178713_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20075371","article-title":"Effects of voluntary wheel running exercise on chemotherapy-impaired cognitive and motor performance in mice","volume":"20","author":"Lee","year":"2023","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.ejphar.2026.178713_bib18","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1038\/s41596-018-0011-z","article-title":"Sucrose preference test for measurement of stress-induced anhedonia in mice","volume":"13","author":"Liu","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejphar.2026.178713_bib19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/bs.pmbts.2019.06.009","article-title":"Emerging evidence for the role of pituitary adenylate cyclase-activating peptide in neuropsychiatric disorders","volume":"167","author":"Lutfy","year":"2019","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10.1016\/j.ejphar.2026.178713_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12974-023-02693-1","article-title":"5-HT attenuates chronic stress-induced cognitive impairment in mice through intestinal flora disruption","volume":"20","author":"Ma","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2026.178713_bib21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1146\/annurev-clinpsy-072220-021440","article-title":"Major depression and its recurrences: life course matters","volume":"18","author":"Monroe","year":"2022","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.ejphar.2026.178713_bib22","doi-asserted-by":"crossref","first-page":"990","DOI":"10.2174\/138161211795589328","article-title":"The role of the PACAP signaling system in depression","volume":"17","author":"Pinhasov","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejphar.2026.178713_bib23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/0976500X231224528","article-title":"Chronic fluoxetine treatment reverses depressive-like behaviors in mice via enhancing neuroplasticity","volume":"14","author":"Qian","year":"2024","journal-title":"J. Pharmacol. Pharmacother."},{"issue":"Suppl. 1","key":"10.1016\/j.ejphar.2026.178713_bib24","article-title":"Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions","volume":"10","author":"Rasoanaivo","year":"2011","journal-title":"Malar. J."},{"key":"10.1016\/j.ejphar.2026.178713_bib25","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jep.2017.03.042","article-title":"Rapid antidepressant effects of Yueju: a new look at the function and mechanism of an old herbal medicine","volume":"203","author":"Ren","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2026.178713_bib26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jep.2016.04.023","article-title":"Two standardized fractions of Gardenia jasminoides ellis with rapid antidepressant effects are differentially associated with BDNF up-regulation in the hippocampus","volume":"187","author":"Ren","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2026.178713_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2023.102350","article-title":"Hippocampal pituitary adenylate cyclase\u2013activating polypeptide mediates rapid antidepressant-like effects of Yueju pill","volume":"101","author":"Ren","year":"2023","journal-title":"Neuropeptides"},{"key":"10.1016\/j.ejphar.2026.178713_bib28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1017\/S0033291719001727","article-title":"New\/emerging psychoactive substances and associated psychopathological consequences","volume":"51","author":"Schifano","year":"2021","journal-title":"Psychol. Med."},{"key":"10.1016\/j.ejphar.2026.178713_bib29","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/s41398-022-02290-5","article-title":"ERK\/mTOR signaling may underlying the antidepressant actions of rapastinel in mice","volume":"12","author":"Shen","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.178713_bib30","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.neuroscience.2004.10.009","article-title":"A role for adult neurogenesis in spatial long-term memory","volume":"130","author":"Snyder","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2026.178713_bib31","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1038\/s41380-024-02476-x","article-title":"NAc-DBS corrects depression-like behaviors in CUMS mouse model via disinhibition of DA neurons in the VTA","volume":"29","author":"Song","year":"2024","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ejphar.2026.178713_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/srep13573","article-title":"Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice","volume":"5","author":"Tang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2026.178713_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/srep13573","article-title":"Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice","volume":"5","author":"Tang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2026.178713_bib34","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1038\/s41467-019-11641-8","article-title":"Activating newborn neurons suppresses depression and anxiety-like behaviors","volume":"10","author":"Tunc-Ozcan","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2026.178713_bib35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1124\/pr.109.001370","article-title":"Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery","volume":"61","author":"Vaudry","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2026.178713_bib36","article-title":"Chronic treatment of mixture of two iridoids proportional to prescriptional dose of Yueju improves hippocampal PACAP-related neuroinflammation and neuroplasticity signaling in the LPS-induced depression model","volume":"338","author":"Wu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2026.178713_bib37","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1142\/S0192415X21500531","article-title":"Neuroplasticity: a key player in the antidepressant action of Chinese herbal medicine","volume":"49","author":"Xia","year":"2021","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.ejphar.2026.178713_bib38","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s10571-015-0316-1","article-title":"Instant and lasting down-regulation of NR1 expression in the hippocampus is associated temporally with antidepressant activity after acute yueju","volume":"36","author":"Xia","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2026.178713_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/srep26331","article-title":"PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine","volume":"6","author":"Xue","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2026.178713_bib40","first-page":"1","article-title":"Yueju pill rapidly induces antidepressant-like effects and acutely enhances BDNF expression in mouse brain","volume":"2013","author":"Xue","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.ejphar.2026.178713_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2019.00470","article-title":"Effects of maternal voluntary wheel running during pregnancy on adult hippocampal neurogenesis, temporal order memory, and depression-like behavior in adult female and Male offspring","volume":"13","author":"Yau","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178713_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024263","article-title":"Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats","volume":"6","author":"Yau","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2026.178713_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156927","article-title":"Exploring the neuroplasticity hypothesis in depression: the role of traditional Chinese herbal medicine","volume":"143","author":"Zeng","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2026.178713_bib44","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.3727\/096368912X655181","article-title":"Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats","volume":"21","author":"Zhang","year":"2012","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ejphar.2026.178713_bib45","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1111\/bph.15847","article-title":"Synergistic effects of two naturally occurring iridoids in eliciting a rapid antidepressant action by up\u2010regulating hippocampal PACAP signalling","volume":"179","author":"Zhang","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178713_bib46","first-page":"1","article-title":"Rapid antidepressant activity of ethanol extract ofGardenia jasminoidesEllis is associated with upregulation of BDNF expression in the hippocampus","volume":"2015","author":"Zhang","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.ejphar.2026.178713_bib47","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40779-024-00548-1","article-title":"Hippocampal PACAP signaling activation triggers a rapid antidepressant response","volume":"11","author":"Zhang","year":"2024","journal-title":"Milit. Med. Res."},{"key":"10.1016\/j.ejphar.2026.178713_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115085","article-title":"Dexmedetomidine attenuates sleep deprivation-induced inhibition of hippocampal neurogenesis via VEGF-VEGFR2 signaling and inhibits neuroinflammation","volume":"165","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2026.178713_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.712445","article-title":"Early enhancement of neuroplasticity index, the ratio of serum brain-derived neurotrophic factor level to HAMD-24 Score, in predicting the long-term antidepressant efficacy","volume":"15","author":"Zhang","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178713_bib50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neulet.2018.04.010","article-title":"Geniposide improves repeated restraint stress-induced depression-like behavior in mice by ameliorating neuronal apoptosis via regulating GLP-1R\/AKT signaling pathway","volume":"676","author":"Zhao","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2026.178713_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116272","article-title":"Traditional Chinese medicine decoctions and Chinese patent medicines for the treatment of depression: efficacies and mechanisms","volume":"307","author":"Zhuang","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2026.178713_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/9160515","article-title":"Neural plasticity associated with hippocampal PKA-CREB and NMDA signaling is involved in the antidepressant effect of repeated low dose of yueju pill on chronic mouse model of learned helplessness","volume":"2017","author":"Zou","year":"2017","journal-title":"Neural Plast."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926001950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926001950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:48:14Z","timestamp":1779425294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926001950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":52,"alternative-id":["S0014299926001950"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178713","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic co-treatment with geniposide and shanzhiside methyl ester elicits antidepressant effects via PACAP signaling in stressed male mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178713","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178713"}}