{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:01:48Z","timestamp":1785888108835,"version":"3.56.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2308085Y44"],"award-info":[{"award-number":["2308085Y44"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371575"],"award-info":[{"award-number":["82371575"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272450"],"award-info":[{"award-number":["82272450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.ejphar.2026.178738","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:19:12Z","timestamp":1772781552000},"page":"178738","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Blockade of KCa3.1 ameliorates rheumatoid arthritis by suppressing macrophage M1 polarization via the NLRP3 inflammasome signaling pathway"],"prefix":"10.1016","volume":"1019","author":[{"given":"Jing","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8280-4827","authenticated-orcid":false,"given":"Yong-gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze-jun","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-cai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-jie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2629-0256","authenticated-orcid":false,"given":"Ren-peng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.178738_bib1","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/j.immuni.2022.11.009","article-title":"The pathogenesis of rheumatoid arthritis","volume":"55","author":"Alivernini","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.ejphar.2026.178738_bib2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1084\/jem.20172222","article-title":"Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity","volume":"215","author":"Boucher","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2026.178738_bib3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2026.178738_bib4","article-title":"The NLRP3 inflammasome as a pathogenic player showing therapeutic potential in rheumatoid arthritis and its comorbidities: a narrative review","volume":"25","author":"Chen","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.178738_bib5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1586\/14737159.8.2.179","article-title":"KCa3.1: target and marker for cancer, autoimmune disorder and vascular inflammation?","volume":"8","author":"Chou","year":"2008","journal-title":"Expert Rev. Mol. Diagn"},{"key":"10.1016\/j.ejphar.2026.178738_bib6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13075-015-0775-2","article-title":"Enhanced activity of NLRP3 inflammasome in peripheral blood cells of patients with active rheumatoid arthritis","volume":"17","author":"Choulaki","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ejphar.2026.178738_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.867260","article-title":"The role of M1\/M2 macrophage polarization in Rheumatoid Arthritis Synovitis","volume":"13","author":"Cutolo","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2026.178738_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102776","article-title":"Rheumatoid arthritis: Extra-articular manifestations and comorbidities","volume":"20","author":"Figus","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ejphar.2026.178738_bib9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni.1703","article-title":"The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis","volume":"10","author":"Franchi","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejphar.2026.178738_bib10","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/jcp.24924","article-title":"Functional role of the KCa3.1 potassium channel in synovial fibroblasts from rheumatoid arthritis patients","volume":"230","author":"Friebel","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2026.178738_bib11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1006\/geno.1998.5333","article-title":"Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia","volume":"51","author":"Ghanshani","year":"1998","journal-title":"Genomics"},{"key":"10.1016\/j.ejphar.2026.178738_bib12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/cei.13167","article-title":"NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis","volume":"194","author":"Guo","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ejphar.2026.178738_bib13","doi-asserted-by":"crossref","first-page":"9479","DOI":"10.1073\/pnas.0400733101","article-title":"Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages","volume":"101","author":"Hanley","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2026.178738_bib14","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature16959","article-title":"NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux","volume":"530","author":"He","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.178738_bib15","article-title":"LncRNAs and rheumatoid arthritis: from identifying mechanisms to clinical investigation","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2026.178738_bib16","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.celrep.2014.07.032","article-title":"Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease","volume":"8","author":"Kang","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2026.178738_bib17","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/annrheumdis-2013-203413","article-title":"Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain","volume":"74","author":"Kelly","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejphar.2026.178738_bib18","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41584-022-00790-8","article-title":"Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission","volume":"18","author":"Kurowska-Stolarska","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ejphar.2026.178738_bib19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nature11588","article-title":"The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP","volume":"492","author":"Lee","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.178738_bib20","doi-asserted-by":"crossref","first-page":"25817","DOI":"10.1074\/jbc.M608972200","article-title":"Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7","volume":"282","author":"Li","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2026.178738_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111933","article-title":"TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKCalpha-HuR axis in rheumatoid arthritis","volume":"132","author":"Lin","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2026.178738_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.997621","article-title":"Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis","volume":"13","author":"Lin","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2026.178738_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105365","article-title":"Activation and function of NLRP3 inflammasome in bone and joint-related diseases","volume":"23","author":"Murakami","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.178738_bib24","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1073\/pnas.1117765109","article-title":"Critical role for calcium mobilization in activation of the NLRP3 inflammasome","volume":"109","author":"Murakami","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2026.178738_bib25","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ejphar.2026.178738_bib26","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/art.41684","article-title":"Involvement of transient receptor potential Vanilloid channel 2 in the induction of lubricin and suppression of ectopic endochondral ossification in Mouse Articular cartilage","volume":"73","author":"Nakamoto","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.ejphar.2026.178738_bib27","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1038\/s41467-023-38241-x","article-title":"Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis","volume":"14","author":"Obeidat","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2026.178738_bib28","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41423-021-00670-3","article-title":"An update on the regulatory mechanisms of NLRP3 inflammasome activation","volume":"18","author":"Paik","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.ejphar.2026.178738_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/846782","article-title":"Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease","volume":"2015","author":"Paramel","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2026.178738_bib30","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/sj.cdd.4402195","article-title":"Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration","volume":"14","author":"Petrilli","year":"2007","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2026.178738_bib31","first-page":"179","article-title":"Protective effect and mechanism of Bitong formula on rheumatoid arthritis rats: exploration based on NLRP3 inflammasome-mediated pyroptosis","volume":"42","author":"Qing","year":"2024","journal-title":"Chin Archiv. Trad. Chin Med."},{"key":"10.1016\/j.ejphar.2026.178738_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adf4699","article-title":"KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation","volume":"8","author":"Ran","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.ejphar.2026.178738_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107615","article-title":"Platelets fuel the inflammasome activation of innate immune cells","volume":"31","author":"Rolfes","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2026.178738_bib34","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1002\/eji.201545772","article-title":"Caspase-11 activates a canonical NLRP3 inflammasome by promoting K(+) efflux","volume":"45","author":"Ruhl","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.ejphar.2026.178738_bib35","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2221958120","article-title":"Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes","volume":"120","author":"Savadipour","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2026.178738_bib36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.immuni.2017.11.026","article-title":"Chanzyme TRPM7 mediates the Ca(2+) influx essential for lipopolysaccharide-induced toll-like receptor 4 endocytosis and macrophage activation","volume":"48","author":"Schappe","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.ejphar.2026.178738_bib37","first-page":"4561","article-title":"TRPM7 regulates proliferation and polarisation of macrophages","volume":"127","author":"Schilling","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ejphar.2026.178738_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2019.102397","article-title":"Macrophage M1\/M2 polarization and rheumatoid arthritis: a systematic review","volume":"18","author":"Tardito","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.ejphar.2026.178738_bib39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.imbio.2012.05.013","article-title":"The effects of Kv1.3 and IKCa1 potassium channel inhibition on calcium influx of human peripheral T lymphocytes in rheumatoid arthritis","volume":"218","author":"Toldi","year":"2013","journal-title":"Immunobiology"},{"key":"10.1016\/j.ejphar.2026.178738_bib40","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1172\/JCI30836","article-title":"The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans","volume":"118","author":"Toyama","year":"2008","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2026.178738_bib41","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/ard-2022-222708","article-title":"PU.1 promotes development of rheumatoid arthritis via repressing FLT3 in macrophages and fibroblast-like synoviocytes","volume":"82","author":"Tu","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ejphar.2026.178738_bib42","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/phar.1236","article-title":"Targeting potassium channels Kv1.3 and KC a 3.1: routes to selective immunomodulators in autoimmune disorder treatment?","volume":"33","author":"Wang","year":"2013","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.ejphar.2026.178738_bib43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.coi.2020.01.005","article-title":"TRPM2, linking oxidative stress and Ca(2+) permeation to NLRP3 inflammasome activation","volume":"62","author":"Wang","year":"2020","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.ejphar.2026.178738_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.856296","article-title":"Oleamide-Mediated polarization of M1 macrophages and IL-1beta production by regulating NLRP3-Inflammasome activation in primary human monocyte-derived macrophages","volume":"13","author":"Wisitpongpun","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2026.178738_bib45","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.2174\/092986707780831186","article-title":"Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications","volume":"14","author":"Wulff","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.ejphar.2026.178738_bib46","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/1471-2407-14-330","article-title":"Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner","volume":"14","author":"Xu","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ejphar.2026.178738_bib47","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tibs.2022.10.002","article-title":"The NLRP3 inflammasome: activation and regulation","volume":"48","author":"Xu","year":"2023","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ejphar.2026.178738_bib48","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/ATVBAHA.116.308461","article-title":"Role of KCa3.1 channels in macrophage polarization and its relevance in atherosclerotic plaque instability","volume":"37","author":"Xu","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ejphar.2026.178738_bib49","doi-asserted-by":"crossref","first-page":"719","DOI":"10.2147\/JIR.S297131","article-title":"KCa3.1 inhibition of macrophages suppresses inflammatory response leading to endothelial damage in a cell model of Kawasaki Disease","volume":"14","author":"Zheng","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.ejphar.2026.178738_bib50","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41584-024-01146-0","article-title":"Ion channels in osteoarthritis: emerging roles and potential targets","volume":"20","author":"Zhou","year":"2024","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ejphar.2026.178738_bib51","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.178738_bib52","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s00109-019-01814-9","article-title":"Critical regulation of atherosclerosis by the KCa3.1 channel and the retargeting of this therapeutic target in in-stent neoatherosclerosis","volume":"97","author":"Zhu","year":"2019","journal-title":"J. Mol. Med. (Berl.)"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926002207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926002207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T04:45:31Z","timestamp":1779425131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926002207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":52,"alternative-id":["S0014299926002207"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178738","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blockade of KCa3.1 ameliorates rheumatoid arthritis by suppressing macrophage M1 polarization via the NLRP3 inflammasome signaling pathway","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178738","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178738"}}