{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:44:50Z","timestamp":1776120290836,"version":"3.50.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["UBACyT20020190100180BA"],"award-info":[{"award-number":["UBACyT20020190100180BA"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010253","name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["PIP 11220220100587CO"],"award-info":[{"award-number":["PIP 11220220100587CO"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010253","name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020190100180BA"],"award-info":[{"award-number":["20020190100180BA"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010253","name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["09\/2021"],"award-info":[{"award-number":["09\/2021"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ejphar.2026.178801","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:53:44Z","timestamp":1774461224000},"page":"178801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Involvement of the cannabinoid system in stress-induced reinstatement to opioid use: a study in CB1 knockout mice of both sexes"],"prefix":"10.1016","volume":"1021","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3609-4486","authenticated-orcid":false,"given":"Jesus","family":"Villalobos Vasquez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia Silvana","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela Noem\u00ed","family":"Balerio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.ejphar.2026.178801_bib1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1080\/15622975.2022.2039408","article-title":"Endocannabinoids and addiction memory: relevance to methamphetamine\/morphine abuse","volume":"23","author":"Alizamini","year":"2022","journal-title":"World J. Biol. Psychiatr."},{"key":"10.1016\/j.ejphar.2026.178801_bib2","first-page":"1","article-title":"Cannabinoid CB1 receptor and mu-opioid receptor interaction: new insights from conditional knockout mice","author":"Alton","year":"2025","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.ejphar.2026.178801_bib3","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0091-3057(99)00168-9","article-title":"Gender differences in dopaminergic function in striatum and nucleus accumbens","volume":"64","author":"Becker","year":"1999","journal-title":"Pharmacol., Biochem. Behav."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.yfrne.2007.07.003","article-title":"Sex differences in drug abuse","volume":"29","author":"Becker","year":"2008","journal-title":"Front. Neuroendocrinol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2042-6410-3-14","article-title":"Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis","volume":"3","author":"Becker","year":"2012","journal-title":"Biol. Sex Differ."},{"issue":"7","key":"10.1016\/j.ejphar.2026.178801_bib6","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1177\/0269881120965952","article-title":"Cannabidiol prevents priming- and stress-induced reinstatement of the conditioned place preference induced by cocaine in mice","volume":"35","author":"Calpe-L\u00f3pez","year":"2021","journal-title":"J. Psychopharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41398-024-03001-y","article-title":"Estrogen receptor beta signaling enhances extinction memory recall for heroin-conditioned cues in a sex- and region-specific manner","volume":"14","author":"Carter","year":"2024","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0006-8993(93)91225-H","article-title":"Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies","volume":"610","author":"Castner","year":"1993","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178801_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1046\/j.1360-0443.2002.00014.x","article-title":"Applying extinction research and theory to cue-exposure addiction treatments","volume":"97","author":"Conklin","year":"2002","journal-title":"Addiction"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0166-4328(00)00311-9","article-title":"Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse","volume":"118","author":"Cossu","year":"2001","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2026.178801_bib11","series-title":"Neuropathology of Drug Addictions and Substance Misuse","first-page":"804","article-title":"Role of the endocannabinoid system and major cannabis constituents in the reconsolidation and extinction of rewarding drug-associated memories","author":"de Carvalho","year":"2016"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresrev.2006.05.003","article-title":"An endocannabinoid mechanism in relapse to drug seeking: a review of animal studies and clinical perspectives","volume":"53","author":"Fattore","year":"2007","journal-title":"Brain Res. Rev."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178801_bib13","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3390\/biomedicines10030588","article-title":"Molecular mechanisms underlying the retrieval and extinction of morphine withdrawal-associated memories in the basolateral amygdala and dentate gyrus","volume":"10","author":"Franco-Garc\u00eda","year":"2022","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.ejphar.2026.178801_bib14","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1124\/pharmrev.120.000191","article-title":"Animal models of drug relapse and craving after voluntary abstinence: a review","volume":"73","author":"Fredriksson","year":"2021","journal-title":"Pharmacol. Rev."},{"issue":"6","key":"10.1016\/j.ejphar.2026.178801_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12822","article-title":"Sex differences in oral oxycodone self-administration and stress-primed reinstatement in rats","volume":"25","author":"Fulenwider","year":"2020","journal-title":"Addict. Biol."},{"key":"10.1016\/j.ejphar.2026.178801_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92389-4","article-title":"CB1R activation in nucleus accumbens core promotes stress-induced reinstatement of cocaine seeking by elevating extracellular glutamate in a drug-paired context","volume":"11","author":"Guzman","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2026.178801_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2022.109428","article-title":"Estimated number of injection-involved drug overdose deaths, United States, 2000 \u2013 2018","volume":"234","author":"Hall","year":"2022","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.ejphar.2026.178801_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2024.173848","article-title":"Drug discrimination learning: interoceptive stimulus control of behavior and its implications for regulated and dysregulated drug intake","volume":"244","author":"Huang","year":"2024","journal-title":"Pharmacol., Biochem. Behav."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178801_bib19","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1037\/pha0000588","article-title":"The effect of stress on opioid addiction-related behaviors: a review of preclinical literature","volume":"31","author":"Kamens","year":"2023","journal-title":"Exp. Clin. Psychopharmacol"},{"key":"10.1016\/j.ejphar.2026.178801_bib20","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.physbeh.2015.06.005","article-title":"Intra-accumbal CB1 receptor blockade reduced extinction and reinstatement of morphine","volume":"149","author":"Khaleghzadeh-Ahangar","year":"2015","journal-title":"Physiol. Behav."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178801_bib21","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/phn.13526","article-title":"Recovery from heroin addiction: a qualitative study","volume":"42","author":"Krowka","year":"2025","journal-title":"Public Health Nurs."},{"issue":"5400","key":"10.1016\/j.ejphar.2026.178801_bib22","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1126\/science.283.5400.401","article-title":"Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice","volume":"283","author":"Ledent","year":"1999","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.ejphar.2026.178801_bib23","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1097\/00001756-200008030-00008","article-title":"Corticotropin-releasing factor receptor type I mediates stress-induced relapse to opiate dependence in rats","volume":"11","author":"Lu","year":"2000","journal-title":"Neuroreport"},{"issue":"6642","key":"10.1016\/j.ejphar.2026.178801_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/41567","article-title":"Absence of opiate rewarding effects in mice lacking dopamine D2 receptors","volume":"388","author":"Maldonado","year":"1997","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.ejphar.2026.178801_bib25","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.tins.2006.01.008","article-title":"Involvement of the endocannabinoid system in drug addiction","volume":"29","author":"Maldonado","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2026.178801_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.addicn.2022.100038","article-title":"Corticotropin releasing factor and drug seeking in substance use disorders: preclinical evidence and translational limitations","volume":"4","author":"Mantsch","year":"2022","journal-title":"Addict. Neurosci."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s40429-020-00350-8","article-title":"Anxiety and opioid use disorder: potential targets for treatment and prevention","volume":"8","author":"McHugh","year":"2021","journal-title":"Curr. Addict. Rep."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00213-015-4092-x","article-title":"CB1 receptor antagonism blocks stress-potentiated reinstatement of cocaine seeking in rats","volume":"233","author":"McReynolds","year":"2016","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-023-02666-1","article-title":"Drug memory reconsolidation: from molecular mechanisms to the clinical context","volume":"13","author":"Milton","year":"2023","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib30","first-page":"1","article-title":"What is addiction? History, terminology, and core concepts","volume":"106","author":"Olsen","year":"2022","journal-title":"Med. Clin."},{"key":"10.1016\/j.ejphar.2026.178801_bib31","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fpsyt.2014.00092","article-title":"Cannabinoid regulation of brain reward processing with an emphasis on the role of CB1 receptors: a step back into the future","volume":"5","author":"Panagis","year":"2014","journal-title":"Front. Psychiatr."},{"issue":"10","key":"10.1016\/j.ejphar.2026.178801_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/nrn4004","article-title":"Endocannabinoid signalling in reward and addiction","volume":"16","author":"Parsons","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.ejphar.2026.178801_bib33","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1460-9568.2005.03916.x","article-title":"Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling","volume":"21","author":"Patel","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178801_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108491","article-title":"Sex differences in vulnerability to addiction","volume":"187","author":"Quigley","year":"2021","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.ejphar.2026.178801_bib35","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00213-006-0345-z","article-title":"Social stress is as effective as physical stress in reinstating morphine-induced place preference in mice","volume":"185","author":"Ribeiro Do Couto","year":"2006","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0006-8993(02)02890-1","article-title":"Conditioned place preference to morphine in cannabinoid CB1 receptor knockout mice","volume":"945","author":"Rice","year":"2002","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178801_bib37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.pharmthera.2011.06.005","article-title":"Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors","volume":"132","author":"Serrano","year":"2011","journal-title":"Pharmacol. Therapeut."},{"issue":"4","key":"10.1016\/j.ejphar.2026.178801_bib38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF02895287","article-title":"Effect of stress on opioid-seeking behavior: evidence from studies with rats","volume":"18","author":"Shaham","year":"1996","journal-title":"Ann. Behav. Med.: Publ. Soc. Behav. Med."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178801_bib39","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s002130050608","article-title":"CP-154,526, a selective, non-peptide antagonist of the corticotropin-releasing factor1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroin-trained rats","volume":"137","author":"Shaham","year":"1998","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib40","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1046\/j.1460-9568.2000.00899.x","article-title":"Clonidine blocks stress-induced reinstatement of heroin seeking in rats: an effect independent of locus coeruleus noradrenergic neurons","volume":"12","author":"Shaham","year":"2000","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00213-002-1224-x","article-title":"The reinstatement model of drug relapse: history, methodology and major findings","volume":"168","author":"Shaham","year":"2003","journal-title":"Psychopharmacology"},{"issue":"3","key":"10.1016\/j.ejphar.2026.178801_bib42","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/BF02246300","article-title":"Effects of restraint stress and intraventral tegmental area","volume":"119","author":"Shaham","year":"1995","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.ejphar.2026.178801_bib43","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0091-3057(95)00015-O","article-title":"Effects of restraint stress and intra-ventral tegmental area injections of morphine and methyl naltrexone on the discriminative stimulus effects of heroin in the rat","volume":"51","author":"Shaham","year":"1995","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.54.1.1","article-title":"Neurobiology of relapse to heroin and cocaine seeking: a review","volume":"54","author":"Shalev","year":"2002","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib45","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s002130100748","article-title":"Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats","volume":"156","author":"Shalev","year":"2001","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2026.178801_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104522","article-title":"Sex differences in opioid receptor mediated effects: role of androgens","volume":"134","author":"Sharp","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178801_bib47","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0006-8993(93)90107-X","article-title":"Effects of castration, estrogen replacement and estrus cycle on monoamine metabolism in the nucleus accumbens, measured by microdialysis","volume":"621","author":"Shimizu","year":"1993","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.ejphar.2026.178801_bib48","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1615\/CritRevNeurobiol.v12.i4.10","article-title":"The neurobiology of opiate reinforcement","volume":"12","author":"Shippenberg","year":"1998","journal-title":"Crit. Rev. Neurobiol."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178801_bib49","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF02246168","article-title":"The CCKB antagonist PD-134,308 facilitates rewarding effects of endogenous enkephalins but does not induce place preference in rats","volume":"123","author":"Valverde","year":"1996","journal-title":"Psychopharmacology"},{"issue":"4","key":"10.1016\/j.ejphar.2026.178801_bib50","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1152\/physrev.00014.2018","article-title":"The neuroscience of drug reward and addiction","volume":"99","author":"Volkow","year":"2019","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.ejphar.2026.178801_bib51","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/sj.npp.1300915","article-title":"Sex differences in neurochemical effects of dopaminergic drugs in rat striatum","volume":"31","author":"Walker","year":"2006","journal-title":"Neuropsychopharmacology: Off. Publ. Am. College Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178801_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(02)02980-3","article-title":"Effects of lesions of various brain areas on drug priming or footshock-induced reactivation of extinguished conditioned place preference","volume":"950","author":"Wang","year":"2002","journal-title":"Brain Res."},{"issue":"12","key":"10.1016\/j.ejphar.2026.178801_bib53","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1097\/00001756-200008210-00034","article-title":"Stress or drug priming induces reinstatement of extinguished conditioned place preference","volume":"11","author":"Wang","year":"2000","journal-title":"Neuroreport"},{"issue":"2","key":"10.1016\/j.ejphar.2026.178801_bib54","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-2999(01)01487-X","article-title":"Noradrenaline in the bed nucleus of the stria terminalis is critical for stress-induced reactivation of morphine-conditioned place preference in rats","volume":"432","author":"Wang","year":"2001","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178801_bib55","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0304-3940(94)90510-X","article-title":"Quantitative microdialysis determination of extracellular striatal dopamine concentration in male and female rats: effects of estrous cycle and gonadectomy","volume":"180","author":"Xiao","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2026.178801_bib56","article-title":"The effects of repeated morphine treatment on the endogenous cannabinoid system in the ventral tegmental area","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926002839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926002839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:49:33Z","timestamp":1776116973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926002839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":56,"alternative-id":["S0014299926002839"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178801","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of the cannabinoid system in stress-induced reinstatement to opioid use: a study in CB1 knockout mice of both sexes","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178801"}}