{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:51:10Z","timestamp":1787698270086,"version":"build-2784847793"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372412"],"award-info":[{"award-number":["82372412"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572767"],"award-info":[{"award-number":["82572767"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008109","name":"Wuxi Municipal Bureau on Science and Technology","doi-asserted-by":"publisher","award":["Y20232018"],"award-info":[{"award-number":["Y20232018"]}],"id":[{"id":"10.13039\/501100008109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ejphar.2026.178811","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:13:03Z","timestamp":1774627983000},"page":"178811","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Coixol attenuates osteoclastogenesis and ovariectomy-induced bone loss via the HIF-1\u03b1-mediated suppression of NF-\u03baB signaling"],"prefix":"10.1016","volume":"1021","author":[{"given":"Shu-Wen","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei-Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi -Xin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Dong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Bo","family":"Ti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Ting","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Qing","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Chen","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Lai","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9892-5074","authenticated-orcid":false,"given":"Jun-Xing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ejphar.2026.178811_bib1","doi-asserted-by":"crossref","first-page":"E338","DOI":"10.1073\/pnas.1515397113","article-title":"Inhibition of Hif1\u03b1 prevents both trauma-induced and genetic heterotopic ossification","volume":"113","author":"Agarwal","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178811_bib2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJMcp1513724","article-title":"Clinical practice. Postmenopausal osteoporosis","volume":"374","author":"Black","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2026.178811_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107901","article-title":"HIF-1\u03b1 activator DMOG inhibits alveolar bone resorption in murine periodontitis by regulating macrophage polarization","volume":"99","author":"Chen","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"22","key":"10.1016\/j.ejphar.2026.178811_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/cells11223552","article-title":"HIF-1\u03b1 regulates bone homeostasis and angiogenesis, participating in the occurrence of bone metabolic diseases","volume":"11","author":"Chen","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2026.178811_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101842","article-title":"Physiological functions of podosomes: from structure and function to therapy implications in osteoclast biology of bone resorption","volume":"85","author":"Chen","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"6","key":"10.1016\/j.ejphar.2026.178811_bib7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1089\/152581602321080529","article-title":"Angiogenesis and plasticity: role of erythropoietin in vascular systems","volume":"11","author":"Chong","year":"2002","journal-title":"J. Hematother. Stem Cell Res."},{"issue":"9","key":"10.1016\/j.ejphar.2026.178811_bib9","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4065\/83.9.1032","article-title":"Bisphosphonates: mechanism of action and role in clinical practice","volume":"83","author":"Drake","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ejphar.2026.178811_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114350","article-title":"Research on the effect of spleen-invigorating and anti-swelling active ingredients in crude and processed coix seed based on spectrum - Effects relationship combined with chemometrics","volume":"205","author":"Du","year":"2021","journal-title":"J. Pharmaceut. Biomed. Anal."},{"issue":"8","key":"10.1016\/j.ejphar.2026.178811_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12081635","article-title":"Mechanistic insights and therapeutic strategies in osteoporosis: a comprehensive review","volume":"12","author":"Elahmer","year":"2024","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.ejphar.2026.178811_bib12","doi-asserted-by":"crossref","first-page":"ITC17","DOI":"10.7326\/AITC201708010","article-title":"Osteoporosis","volume":"167","author":"Ensrud","year":"2017","journal-title":"Ann. Intern. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178811_bib13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1001\/jama.2020.2923","article-title":"Bisphosphonates for postmenopausal osteoporosis","volume":"325","author":"Ensrud","year":"2021","journal-title":"J. Am. Med. Assoc."},{"issue":"12","key":"10.1016\/j.ejphar.2026.178811_bib14","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1093\/abbs\/gmu103","article-title":"Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-\u03baB signaling pathway","volume":"46","author":"Feng","year":"2014","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178811_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s40279-013-0100-7","article-title":"Bone quality: the determinants of bone strength and fragility","volume":"44","author":"Fonseca","year":"2014","journal-title":"Sports Med."},{"issue":"13","key":"10.1016\/j.ejphar.2026.178811_bib46","doi-asserted-by":"crossref","DOI":"10.1177\/00220345251344946","article-title":"Synthetic Mimotopes of Salivary Peptides against SARS-CoV-2 In Vitro","volume":"104","author":"Garcia-J\u00fanior","year":"2025","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178811_bib3","article-title":"Emerging regulated cell death mechanisms in bone remodeling: decoding ferroptosis, cuproptosis, disulfidptosis, and PANoptosis as therapeutic targets for skeletal disorders","volume":"11","author":"Hai-Ting","year":"2025","journal-title":"Cell Death Discov"},{"issue":"2","key":"10.1016\/j.ejphar.2026.178811_bib16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41368-018-0015-0","article-title":"Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss","volume":"10","author":"Hirai","year":"2018","journal-title":"Int. J. Oral Sci."},{"issue":"1-2","key":"10.1016\/j.ejphar.2026.178811_bib17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ejphar.2007.11.013","article-title":"Berberine inhibits RANKL-induced osteoclast formation and survival through suppressing the NF-kappaB and Akt pathways","volume":"580","author":"Hu","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.ejphar.2026.178811_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25040894","article-title":"Coixol suppresses NF-\u03baB, MAPK pathways and NLRP3 inflammasome activation in lipopolysaccharide-induced RAW 264.7 cells","volume":"25","author":"Hu","year":"2020","journal-title":"Molecules"},{"issue":"22","key":"10.1016\/j.ejphar.2026.178811_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216175","article-title":"Role and regulation of transcription factors in osteoclastogenesis","volume":"24","author":"Jiang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.178811_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.phymed.2018.06.020","article-title":"Icariin abrogates osteoclast formation through the regulation of the RANKL-mediated TRAF6\/NF-\u03baB\/ERK signaling pathway in Raw264.7 cells","volume":"51","author":"Kim","year":"2018","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.ejphar.2026.178811_bib21","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1111\/bph.15024","article-title":"Overview of treatment approaches to osteoporosis","volume":"178","author":"Langdahl","year":"2021","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178811_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/emm.2004.1","article-title":"Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions","volume":"36","author":"Lee","year":"2004","journal-title":"Exp. Mol. Med."},{"issue":"9","key":"10.1016\/j.ejphar.2026.178811_bib23","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1074\/jbc.272.9.5375","article-title":"Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia","volume":"272","author":"Lee","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178811_bib24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1186\/s13018-025-05879-w","article-title":"Natural traditional Chinese medicine products: emerging therapeutic targets for the treatment of osteoporosis","volume":"20","author":"Liu","year":"2025","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.ejphar.2026.178811_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.601224","article-title":"Recent advances of osterix transcription factor in osteoblast differentiation and bone formation","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.ejphar.2026.178811_bib26","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s00198-017-3919-1","article-title":"Observations following discontinuation of long-term denosumab therapy","volume":"28","author":"McClung","year":"2017","journal-title":"Osteoporos. Int."},{"issue":"12","key":"10.1016\/j.ejphar.2026.178811_bib27","doi-asserted-by":"crossref","first-page":"593","DOI":"10.5306\/wjco.v14.i12.593","article-title":"Anti-tumor effect of coix seed based on the theory of medicinal and food homology","volume":"14","author":"Meng","year":"2023","journal-title":"World J. Clin. Oncol."},{"key":"10.1016\/j.ejphar.2026.178811_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/ptr.8503","article-title":"Salvianolic acid A mitigates osteoporotic bone loss by repressing reactive oxygen species via the Nrf2-HO-1 pathway","author":"Qiu","year":"2025","journal-title":"Phytother Res."},{"key":"10.1016\/j.ejphar.2026.178811_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1043975","article-title":"Receptor activator of nuclear factor-\u03baB ligand-mediated osteoclastogenesis signaling pathway and related therapeutic natural compounds","volume":"13","author":"Qu","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"17","key":"10.1016\/j.ejphar.2026.178811_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179191","article-title":"Hypoxia pathway proteins and their impact on the blood vasculature","volume":"22","author":"Rodriguez","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178811_bib31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gene.2005.10.011","article-title":"Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells","volume":"366","author":"Ryoo","year":"2006","journal-title":"Gene"},{"key":"10.1016\/j.ejphar.2026.178811_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110031","article-title":"Coixol ameliorates Toxoplasma gondii infection-induced lung injury by interfering with T. gondii HSP70\/TLR4\/NF-\u03baB signaling pathway","volume":"118","author":"Shen","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"14","key":"10.1016\/j.ejphar.2026.178811_bib33","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1016\/j.febslet.2009.06.047","article-title":"Regulatory mechanism of NFATc1 in RANKL-induced osteoclast activation","volume":"583","author":"Song","year":"2009","journal-title":"FEBS Lett."},{"issue":"6","key":"10.1016\/j.ejphar.2026.178811_bib34","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts","volume":"3","author":"Takayanagi","year":"2002","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.ejphar.2026.178811_bib44","article-title":"Comparative assessment of scoring functions on a diverse test set","volume":"49","author":"Tiejun","year":"2009","journal-title":"J Chem Inf Model"},{"issue":"3","key":"10.1016\/j.ejphar.2026.178811_bib35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1358\/mf.2005.27.3.890875","article-title":"Genistein inhibited hypoxia-inducible factor-1alpha expression induced by hypoxia and cobalt chloride in human retinal pigment epithelium cells","volume":"27","author":"Wang","year":"2005","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"issue":"22","key":"10.1016\/j.ejphar.2026.178811_bib36","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.21037\/atm-22-4603","article-title":"Hypoxia-inducible factor 1\u03b1 enhances RANKL-induced osteoclast differentiation by upregulating the MAPK pathway","volume":"10","author":"Wang","year":"2022","journal-title":"Ann. Transl. Med."},{"issue":"9","key":"10.1016\/j.ejphar.2026.178811_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24098029","article-title":"The role of HIF-1\u03b1 in bone regeneration: a new direction and challenge in bone tissue engineering","volume":"24","author":"You","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.ejphar.2026.178811_bib38","first-page":"4313","article-title":"Quercetin rescued TNF-alpha-induced impairments in bone marrow-derived mesenchymal stem cell osteogenesis and improved osteoporosis in rats","volume":"10","author":"Yuan","year":"2018","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178811_bib39","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1186\/s12885-023-11069-w","article-title":"Glioma angiogenesis is boosted by ELK3 activating the HIF-1 \u03b1\/VEGF-A signaling axis","volume":"23","author":"Yueyang","year":"2023","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178811_bib45","article-title":"Chromone-embedded peptidomimetics and furopyrimidines as highly potent SARS-CoV-2 infection inhibitors: docking and MD simulation study","volume":"16","author":"Zahra","year":"2023","journal-title":"BMC Res Notes"},{"issue":"15","key":"10.1016\/j.ejphar.2026.178811_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27154808","article-title":"Actional mechanisms of active ingredients in functional food adlay for human health","volume":"27","author":"Zeng","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178811_bib8","article-title":"Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis","volume":"13","author":"Zhenyu","year":"2025","journal-title":"Bone Res."},{"key":"10.1016\/j.ejphar.2026.178811_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118694","article-title":"Coixol mitigates Toxoplasma gondii infection-induced liver injury by inhibiting the Toxoplasma gondii HSP70\/TLR4\/NF-\u03baB signaling pathway in hepatic macrophages","volume":"335","author":"Zhou","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.ejphar.2026.178811_bib42","doi-asserted-by":"crossref","first-page":"21182","DOI":"10.1002\/jcp.28721","article-title":"HIF-1\u03b1 facilitates osteocyte-mediated osteoclastogenesis by activating JAK2\/STAT3 pathway in vitro","volume":"234","author":"Zhu","year":"2019","journal-title":"J. Cell. Physiol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926002931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926002931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:36:39Z","timestamp":1778708199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926002931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":45,"alternative-id":["S0014299926002931"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178811","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Coixol attenuates osteoclastogenesis and ovariectomy-induced bone loss via the HIF-1\u03b1-mediated suppression of NF-\u03baB signaling","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178811","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178811"}}