{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:03:50Z","timestamp":1776776630678,"version":"3.51.2"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DE240101233"],"award-info":[{"award-number":["DE240101233"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001794","name":"University of Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1162597"],"award-info":[{"award-number":["APP1162597"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.ejphar.2026.178850","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:20:10Z","timestamp":1775604010000},"page":"178850","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The nanobody Nb.C1 potentiates human acid-sensing ion channel 1a and 1b"],"prefix":"10.1016","volume":"1022","author":[{"given":"Mimi","family":"Golder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0709-5589","authenticated-orcid":false,"given":"Neville J.","family":"Butcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6429-6022","authenticated-orcid":false,"given":"Jennifer D.","family":"Naughton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8926-0161","authenticated-orcid":false,"given":"Junyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1101-5705","authenticated-orcid":false,"given":"Theo","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3616-0279","authenticated-orcid":false,"given":"Lachlan D.","family":"Rash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2420-4262","authenticated-orcid":false,"given":"Mehdi","family":"Mobli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0235-2029","authenticated-orcid":false,"given":"Ben","family":"Cristofori-Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ejphar.2026.178850_bib1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1186\/s12951-024-02900-y","article-title":"Discovery of nanobodies: a comprehensive review of their applications and potential over the past five years","volume":"22","author":"Alexander","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"12","key":"10.1016\/j.ejphar.2026.178850_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051516","article-title":"High yield production and refolding of the double-knot toxin, an activator of TRPV1 channels","volume":"7","author":"Bae","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.ejphar.2026.178850_bib3","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202313519","article-title":"Mechanism of acid-sensing ion channel modulation by Hi1a","volume":"156","author":"Berger","year":"2024","journal-title":"J. Gen. Physiol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178850_bib4","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1038\/s42003-025-09090-9","article-title":"Molecular mechanisms and hotspots of pH sensing in ASIC1a revealed by computational and functional analysis","volume":"8","author":"Bignucolo","year":"2025","journal-title":"Commun. Biol."},{"issue":"7373","key":"10.1016\/j.ejphar.2026.178850_bib5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nature10607","article-title":"A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain","volume":"479","author":"Bohlen","year":"2011","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ejphar.2026.178850_bib6","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.cell.2010.03.052","article-title":"A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain","volume":"141","author":"Bohlen","year":"2010","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.ejphar.2026.178850_bib7","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41573-022-00542-z","article-title":"Advances in covalent drug discovery","volume":"21","author":"Boike","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2026.178850_bib8","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.3389\/fnins.2019.01247","article-title":"Involvement of acid-sensing ion channel 1b in the development of acid-induced chronic muscle pain","volume":"13","author":"Chang","year":"2019","journal-title":"Front. Neurosci."},{"issue":"14","key":"10.1016\/j.ejphar.2026.178850_bib9","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1073\/pnas.1614728114","article-title":"Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a","volume":"114","author":"Chassagnon","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"17","key":"10.1016\/j.ejphar.2026.178850_bib10","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1073\/pnas.95.17.10240","article-title":"A sensory neuron-specific, proton-gated ion channel","volume":"95","author":"Chen","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178850_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1085\/jgp.200509303","article-title":"The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity","volume":"126","author":"Chen","year":"2005","journal-title":"J. Gen. Physiol."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178850_bib12","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1085\/jgp.200509409","article-title":"Interaction of acid-sensing ion channel (ASIC) 1 with the tarantula toxin psalmotoxin 1 is state dependent","volume":"127","author":"Chen","year":"2006","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.ejphar.2026.178850_bib13","doi-asserted-by":"crossref","DOI":"10.2174\/011570159X381737250710050221","article-title":"Proton-sensitive receptors\/channels: therapeutic target for ischemic stroke, focusing on their roles and mechanisms","author":"Cheng","year":"2025","journal-title":"Curr. Neuropharmacol."},{"issue":"12","key":"10.1016\/j.ejphar.2026.178850_bib14","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1080\/17460441.2021.1948997","article-title":"Evolution of the drug-target residence time model","volume":"16","author":"Copeland","year":"2021","journal-title":"Expet Opin. Drug Discov."},{"issue":"8","key":"10.1016\/j.ejphar.2026.178850_bib15","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021581118","article-title":"Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: implications as an analgesic lead","volume":"118","author":"Cristofori-Armstrong","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2026.178850_bib16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neuropharm.2017.04.042","article-title":"Acid-sensing ion channel (ASIC) structure and function: insights from spider, snake and sea anemone venoms","volume":"127","author":"Cristofori-Armstrong","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2026.178850_bib17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.bcp.2019.03.004","article-title":"The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: importance of interactions at the channel subunit interface and potential for engineering selective analogues","volume":"163","author":"Cristofori-Armstrong","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178850_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/srep14763","article-title":"Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels","volume":"5","author":"Cristofori-Armstrong","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2026.178850_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-67068-x","article-title":"Ion channel inhibition by targeted recruitment of NEDD4-2 with divalent nanobodies","author":"Darko-Boateng","year":"2025","journal-title":"Nat. Commun."},{"issue":"63","key":"10.1016\/j.ejphar.2026.178850_bib20","doi-asserted-by":"crossref","first-page":"12548","DOI":"10.1039\/C5CC04657B","article-title":"Enhancing the efficiency of sortase-mediated ligations through nickel-peptide complex formation","volume":"51","author":"David Row","year":"2015","journal-title":"Chem. Commun."},{"issue":"7421","key":"10.1016\/j.ejphar.2026.178850_bib21","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nature11494","article-title":"Black mamba venom peptides target acid-sensing ion channels to abolish pain","volume":"490","author":"Diochot","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.178850_bib22","article-title":"Binding revisited-avidity in cellular function and signaling","volume":"7","author":"Erlendsson","year":"2020","journal-title":"Front. Mol. Biosci."},{"issue":"33","key":"10.1016\/j.ejphar.2026.178850_bib23","doi-asserted-by":"crossref","first-page":"25116","DOI":"10.1074\/jbc.M003643200","article-title":"Isolation of a tarantula toxin specific for a class of proton-gated na+ channels","volume":"275","author":"Escoubas","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.ejphar.2026.178850_bib24","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/nm1668","article-title":"Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system","volume":"13","author":"Friese","year":"2007","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178850_bib25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1113\/JP289258","article-title":"Acid-sensing ion channel 1a deficiency drives endocrine hypertension in male mice","volume":"604","author":"Garcia","year":"2026","journal-title":"J. Physiol."},{"issue":"50","key":"10.1016\/j.ejphar.2026.178850_bib26","doi-asserted-by":"crossref","first-page":"E11837","DOI":"10.1073\/pnas.1809662115","article-title":"TRPV1 pore turret dictates distinct DkTx and capsaicin gating","volume":"115","author":"Geron","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2026.178850_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neuropharm.2014.12.016","article-title":"Biophysical properties of acid-sensing ion channels (ASICs)","volume":"94","author":"Grunder","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2026.178850_bib28","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73384","article-title":"Conformational decoupling in acid-sensing ion channels uncovers mechanism and stoichiometry of PcTx1-mediated inhibition","volume":"11","author":"Heusser","year":"2022","journal-title":"eLife"},{"issue":"12","key":"10.1016\/j.ejphar.2026.178850_bib29","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.tips.2021.09.008","article-title":"Acid-sensing ion channels as potential therapeutic targets","volume":"42","author":"Heusser","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"issue":"53","key":"10.1016\/j.ejphar.2026.178850_bib30","doi-asserted-by":"crossref","first-page":"41852","DOI":"10.1074\/jbc.M110.171330","article-title":"Identification of a calcium permeable human acid-sensing ion channel 1 transcript variant","volume":"285","author":"Hoagland","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"7873","key":"10.1016\/j.ejphar.2026.178850_bib31","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.ejphar.2026.178850_bib32","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41573-024-00958-9","article-title":"Know your molecule: pharmacological characterization of drug candidates to enhance efficacy and reduce late-stage attrition","volume":"23","author":"Kenakin","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"issue":"10","key":"10.1016\/j.ejphar.2026.178850_bib33","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1111\/febs.70032","article-title":"Sea anemone Cys-ladder peptide Ms13-1 induces a pain response as a positive modulator of acid-sensing ion channel 1a","volume":"292","author":"Khasanov","year":"2025","journal-title":"FEBS J."},{"issue":"4","key":"10.1016\/j.ejphar.2026.178850_bib34","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s43440-025-00748-z","article-title":"Residence time in drug discovery: current insights and future perspectives","volume":"77","author":"Kordylewski","year":"2025","journal-title":"Pharmacol. Rep."},{"issue":"8022","key":"10.1016\/j.ejphar.2026.178850_bib35","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/s41586-024-07684-7","article-title":"Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury","volume":"631","author":"Lai","year":"2024","journal-title":"Nature"},{"issue":"33","key":"10.1016\/j.ejphar.2026.178850_bib36","doi-asserted-by":"crossref","first-page":"8430","DOI":"10.1073\/pnas.1806614115","article-title":"Acid-sensing ion channels emerged over 600 Mya and are conserved throughout the deuterostomes","volume":"115","author":"Lynagh","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2026.178850_bib37","article-title":"Nanobodies targeting ion channels: advancing therapeutics through precision and structural insights","author":"M","year":"2025","journal-title":"Chem. Commun."},{"issue":"40","key":"10.1016\/j.ejphar.2026.178850_bib38","article-title":"A novel antigen design strategy to isolate single-domain antibodies that target human Nav1.7 and reduce pain in animal models","volume":"11","author":"Martina","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178850_bib39","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s41467-023-36579-w","article-title":"A bivalent remipede toxin promotes calcium release via ryanodine receptor activation","volume":"14","author":"Maxwell","year":"2023","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.ejphar.2026.178850_bib40","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","article-title":"ColabFold: making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178850_bib41","doi-asserted-by":"crossref","first-page":"7556","DOI":"10.1038\/s41467-022-35025-7","article-title":"Selective posttranslational inhibition of Ca(V)beta(1)-associated voltage-dependent calcium channels with a functionalized nanobody","volume":"13","author":"Morgenstern","year":"2022","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.ejphar.2026.178850_bib42","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41573-022-00501-8","article-title":"Avidity in antibody effector functions and biotherapeutic drug design","volume":"21","author":"Oostindie","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178850_bib43","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nprot.2014.039","article-title":"A general protocol for the generation of nanobodies for structural biology","volume":"9","author":"Pardon","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ejphar.2026.178850_bib44","article-title":"Acid-sensing ion channels: structure, function, pharmacology and clinical significance","author":"Rash","year":"2025","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178850_bib45","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1113\/JP278707","article-title":"Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors","volume":"599","author":"Rook","year":"2021","journal-title":"J. Physiol."},{"key":"10.1016\/j.ejphar.2026.178850_bib46","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-1-4939-6887-9_10","article-title":"A strategy for production of correctly folded disulfide-rich peptides in the periplasm of E. coli","volume":"1586","author":"Saez","year":"2017","journal-title":"Methods Mol. Biol."},{"issue":"5","key":"10.1016\/j.ejphar.2026.178850_bib47","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1124\/mol.111.072207","article-title":"A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a","volume":"80","author":"Saez","year":"2011","journal-title":"Mol. Pharmacol."},{"issue":"7116","key":"10.1016\/j.ejphar.2026.178850_bib48","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nature05285","article-title":"Spider toxins activate the capsaicin receptor to produce inflammatory pain","volume":"444","author":"Siemens","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.178850_bib49","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.coi.2018.02.003","article-title":"Modulating ion channel function with antibodies and nanobodies","volume":"52","author":"Stortelers","year":"2018","journal-title":"Curr. Opin. Immunol."},{"issue":"8","key":"10.1016\/j.ejphar.2026.178850_bib50","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1111\/bph.12106","article-title":"Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands","volume":"168","author":"Vauquelin","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178850_bib51","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00424-006-0183-1","article-title":"Optimized expression vector for ion channel studies in xenopus oocytes and mammalian cells using alfalfa mosaic virus","volume":"454","author":"Venkatachalan","year":"2007","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"10","key":"10.1016\/j.ejphar.2026.178850_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14100709","article-title":"Mechanisms of action of the peptide toxins targeting human and rodent acid-sensing ion channels and relevance to their in vivo analgesic effects","volume":"14","author":"Verkest","year":"2022","journal-title":"Toxins"},{"key":"10.1016\/j.ejphar.2026.178850_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.02.005","article-title":"A molecular view of the function and pharmacology of acid-sensing ion channels","volume":"154","author":"Vullo","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"6621","key":"10.1016\/j.ejphar.2026.178850_bib54","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/386173a0","article-title":"A proton-gated cation channel involved in acid-sensing","volume":"386","author":"Waldmann","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.178850_bib55","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.67115","article-title":"Structure and analysis of nanobody binding to the human ASIC1a ion channel","volume":"10","author":"Wu","year":"2021","journal-title":"eLife"},{"issue":"6","key":"10.1016\/j.ejphar.2026.178850_bib56","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2004.08.026","article-title":"Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels","volume":"118","author":"Xiong","year":"2004","journal-title":"Cell"},{"issue":"20","key":"10.1016\/j.ejphar.2026.178850_bib57","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1016\/j.cell.2021.08.012","article-title":"Structural snapshots of TRPV1 reveal mechanism of polymodal functionality","volume":"184","author":"Zhang","year":"2021","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.ejphar.2026.178850_bib58","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nn.2132","article-title":"Seizure termination by acidosis depends on ASIC1a","volume":"11","author":"Ziemann","year":"2008","journal-title":"Nat. Neurosci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926003328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926003328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:13:55Z","timestamp":1776773635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926003328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":58,"alternative-id":["S0014299926003328"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178850","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The nanobody Nb.C1 potentiates human acid-sensing ion channel 1a and 1b","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178850","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"178850"}}