{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:21:49Z","timestamp":1783146109042,"version":"3.54.6"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974530"],"award-info":[{"award-number":["81974530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007322","name":"Binzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.ejphar.2026.178928","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:55:44Z","timestamp":1777931744000},"page":"178928","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dihydromyricetin: A potential candidate for the treatment of cholestatic liver injury via inhibition of the NLRP3 inflammasome"],"prefix":"10.1016","volume":"1025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7458-5898","authenticated-orcid":false,"given":"Hao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6070-0234","authenticated-orcid":false,"given":"David","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Thu","family":"Hien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkin","family":"Musabaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim V.","family":"Shmanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhide","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.178928_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113308","article-title":"Dihydromyricetin protects against high glucose-induced endothelial dysfunction: role of HIF-1\u03b1\/ROR2\/NF-\u03baB","volume":"153","author":"Awad","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.ejphar.2026.178928_bib2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41575-019-0125-y","article-title":"Cholangiocyte pathobiology","volume":"16","author":"Banales","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"4","key":"10.1016\/j.ejphar.2026.178928_bib3","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1097\/HEP.0000000000001052","article-title":"Drug-induced cholestatic liver diseases","volume":"82","author":"Bjornsson","year":"2025","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.ejphar.2026.178928_bib4","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jhep.2013.03.033","article-title":"Decoding cell death signals in liver inflammation","volume":"59","author":"Brenner","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejphar.2026.178928_bib5","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.2147\/JIR.S430730","article-title":"The role of inflammation in cholestatic liver injury","volume":"16","author":"Chen","year":"2023","journal-title":"J. Inflamm. Res."},{"issue":"41","key":"10.1016\/j.ejphar.2026.178928_bib6","doi-asserted-by":"crossref","first-page":"6346","DOI":"10.3748\/wjg.v26.i41.6346","article-title":"Dihydromyricetin ameliorates chronic liver injury by reducing pyroptosis","volume":"26","author":"Cheng","year":"2020","journal-title":"World J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.ejphar.2026.178928_bib7","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41589-019-0277-7","article-title":"MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition","volume":"15","author":"Coll","year":"2019","journal-title":"Nat. Chem. Biol."},{"issue":"Pt 2","key":"10.1016\/j.ejphar.2026.178928_bib8","article-title":"Chitosan-modified dihydromyricetin liposomes promote the repair of liver injury in mice suffering from diabetes mellitus","volume":"273","author":"Ding","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejphar.2026.178928_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105767","article-title":"Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism","volume":"171","author":"Dong","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2026.178928_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2024.110084","article-title":"Modulation of keap-1\/Nrf2\/HO-1 and NF-\u0138b\/caspase-3 signaling pathways by dihydromyricetin ameliorates sodium valproate-induced liver injury","volume":"758","author":"Emad","year":"2024","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.ejphar.2026.178928_bib11","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/hep.31494","article-title":"Bidirectional role of NLRP3 during acute and chronic cholestatic liver injury","volume":"73","author":"Frissen","year":"2021","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178928_bib12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jhep.2020.07.041","article-title":"Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis","volume":"74","author":"Gaul","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejphar.2026.178928_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175325","article-title":"Molecular mechanism and therapeutic significance of dihydromyricetin in nonalcoholic fatty liver disease","volume":"935","author":"Gong","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.ejphar.2026.178928_bib14","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1002\/mnfr.201500316","article-title":"Curcumin suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock","volume":"59","author":"Gong","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"issue":"51","key":"10.1016\/j.ejphar.2026.178928_bib15","doi-asserted-by":"crossref","first-page":"83951","DOI":"10.18632\/oncotarget.13796","article-title":"Chenodeoxycholic acid activates NLRP3 inflammasome and contributes to cholestatic liver fibrosis","volume":"7","author":"Gong","year":"2016","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.ejphar.2026.178928_bib16","doi-asserted-by":"crossref","first-page":"10489","DOI":"10.3168\/jds.2024-26233","article-title":"Yogurt alleviates alcohol-induced hepatocyte pyroptosis and inflammation via autophagy\/P62\/Nrf2\/ROS\/NLRP3 pathway","volume":"108","author":"Guan","year":"2025","journal-title":"J. Dairy Sci."},{"issue":"4","key":"10.1016\/j.ejphar.2026.178928_bib17","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.immuni.2016.10.009","article-title":"Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome","volume":"45","author":"Guo","year":"2016","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.ejphar.2026.178928_bib18","first-page":"372","article-title":"Dihydromyricetin promotes autophagy and attenuates renal interstitial fibrosis by regulating miR-155-5p\/PTEN signaling in diabetic nephropathy","volume":"20","author":"Guo","year":"2020","journal-title":"Bosn. J. Basic Med. Sci."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178928_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s12276-022-00737-9","article-title":"Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis","volume":"54","author":"Han","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"12","key":"10.1016\/j.ejphar.2026.178928_bib20","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and regulation of NLRP3 inflammasome activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178928_bib21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s12944-024-02263-1","article-title":"Dihydromyricetin suppresses endothelial NLRP3 inflammasome activation and attenuates atherogenesis by promoting mitophagy","volume":"23","author":"Hu","year":"2024","journal-title":"Lipids Health Dis."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178928_bib22","first-page":"305","article-title":"Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome","volume":"119","author":"Imaeda","year":"2009","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2026.178928_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121663","article-title":"\u03b3-Mangostin abrogates AINT-induced cholestatic liver injury: impact on Nrf2\/NF-\u03baB\/NLRP3\/Caspase-1\/IL-1\u03b2\/GSDMD signalling","volume":"322","author":"Khayat","year":"2023","journal-title":"Life Sci."},{"issue":"10","key":"10.1016\/j.ejphar.2026.178928_bib24","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.ejphar.2026.178928_bib25","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1053\/j.gastro.2012.09.008","article-title":"Sterile inflammation in the liver","volume":"143","author":"Kubes","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ejphar.2026.178928_bib26","doi-asserted-by":"crossref","first-page":"15429","DOI":"10.2147\/JIR.S532042","article-title":"Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3\/caspase-1\/GSDMD pathway to activate LX2 cells","volume":"18","author":"Li","year":"2025","journal-title":"J. Inflamm. Res."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178928_bib27","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jhep.2021.02.035","article-title":"Limb expression 1-like (LIX1L) protein promotes cholestatic liver injury by regulating bile acid metabolism","volume":"75","author":"Li","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.ejphar.2026.178928_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154027","article-title":"Dihydromyricetin protects against Doxorubicin-induced cardiotoxicity through activation of AMPK\/mTOR pathway","volume":"99","author":"Li","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2026.178928_bib29","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.tifs.2019.07.038","article-title":"Dihydromyricetin: a review on identification and quantification methods, biological activities, chemical stability, metabolism and approaches to enhance its bioavailability","volume":"91","author":"Liu","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.ejphar.2026.178928_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156522","article-title":"Dihydromyricetin regulates the miR-155-5p\/SIRT1\/VDAC1 pathway to promote liver regeneration and improve alcohol-induced liver injury","volume":"139","author":"Ma","year":"2025","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.ejphar.2026.178928_bib31","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3390\/cells9040837","article-title":"Role and mechanisms of mitophagy in liver diseases","volume":"9","author":"Ma","year":"2020","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.ejphar.2026.178928_bib32","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1007\/s40265-016-0616-x","article-title":"Obeticholic acid: first global approval","volume":"76","author":"Markham","year":"2016","journal-title":"Drugs"},{"issue":"5","key":"10.1016\/j.ejphar.2026.178928_bib33","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1002\/hep.25801","article-title":"Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure","volume":"56","author":"Marques","year":"2012","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.ejphar.2026.178928_bib34","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178928_bib35","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10557-020-06968-0","article-title":"Dihydromyricetin prevents diabetic cardiomyopathy via miR-34a suppression by activating autophagy","volume":"34","author":"Ni","year":"2020","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178928_bib36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1089-3261(03)00135-1","article-title":"Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease","volume":"8","author":"Paumgartner","year":"2004","journal-title":"Clin. Liver Dis."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178928_bib37","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13567-022-01024-1","article-title":"Dihydromyricetin alleviates Escherichia coli lipopolysaccharide-induced hepatic injury in chickens by inhibiting the NLRP3 inflammasome","volume":"53","author":"Shi","year":"2022","journal-title":"Vet. Res."},{"issue":"7575","key":"10.1016\/j.ejphar.2026.178928_bib38","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.ejphar.2026.178928_bib39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cyto.2015.01.007","article-title":"Estrogen alters baseline and inflammatory-induced cytokine levels independent from hypothalamic-pituitary-adrenal axis activity","volume":"72","author":"Shivers","year":"2015","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.ejphar.2026.178928_bib40","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/acer.14326","article-title":"Dihydromyricetin protects the liver via changes in lipid metabolism and enhanced ethanol metabolism","volume":"44","author":"Silva","year":"2020","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.ejphar.2026.178928_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102404","article-title":"Inhibition of NLRP3-mediated crosstalk between hepatocytes and liver macrophages by geniposidic acid alleviates cholestatic liver inflammatory injury","volume":"55","author":"Song","year":"2022","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.ejphar.2026.178928_bib42","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1039\/D1FO03971G","article-title":"Dihydromyricetin prevents obesity via regulating bile acid metabolism associated with the farnesoid X receptor in ob\/ob mice","volume":"13","author":"Song","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.ejphar.2026.178928_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113888","article-title":"Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1","volume":"175","author":"Sun","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"8","key":"10.1016\/j.ejphar.2026.178928_bib44","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1002\/jsfa.14126","article-title":"Dihydromyricetin ameliorates hyperuricemia through inhibiting uric acid reabsorption","volume":"105","author":"Sun","year":"2025","journal-title":"J. Sci. Food Agric."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178928_bib45","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jhep.2012.03.035","article-title":"Inflammasomes in liver diseases","volume":"57","author":"Szabo","year":"2012","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.ejphar.2026.178928_bib46","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.chembiol.2017.03.009","article-title":"Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages","volume":"24","author":"Taabazuing","year":"2017","journal-title":"Cell Chem. Biol."},{"issue":"6","key":"10.1016\/j.ejphar.2026.178928_bib47","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jhep.2017.02.026","article-title":"Targeting hepatic macrophages to treat liver diseases","volume":"66","author":"Tacke","year":"2017","journal-title":"J. Hepatol."},{"issue":"7","key":"10.1016\/j.ejphar.2026.178928_bib48","first-page":"842","article-title":"The role of miR-199b-3p in regulating Nrf2 pathway by dihydromyricetin to alleviate septic acute kidney injury","volume":"55","author":"Tian","year":"2021","journal-title":"Free Radic. Res."},{"issue":"7","key":"10.1016\/j.ejphar.2026.178928_bib49","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ejphar.2026.178928_bib50","doi-asserted-by":"crossref","DOI":"10.1038\/srep15224","article-title":"Estrogen accelerates the resolution of inflammation in macrophagic cells","volume":"5","author":"Villa","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2026.178928_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1691796","article-title":"Preclinical research of dihydromyricetin for fibrotic diseases","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178928_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112771","article-title":"Recent update on application of dihydromyricetin in metabolic related diseases","volume":"148","author":"Wang","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.ejphar.2026.178928_bib53","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1586\/17474124.2015.1060855","article-title":"Sterile inflammation in acute liver injury: myth or mystery?","volume":"9","author":"Woolbright","year":"2015","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178928_bib54","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/hep.26592","article-title":"NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice","volume":"59","author":"Wree","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.ejphar.2026.178928_bib55","article-title":"Dihydromyricetin improves myocardial functioning by influencing autophagy through SNHG17\/Mir-34a\/SIDT2 axis","volume":"17","author":"Xiao","year":"2024","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178928_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2023.116595","article-title":"Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis","volume":"473","author":"Xu","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178928_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125569","article-title":"Preparation, characterization and protective effect of chitosan - Tripolyphosphate encapsulated dihydromyricetin nanoparticles on acute kidney injury caused by cisplatin","volume":"245","author":"Yan","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.ejphar.2026.178928_bib58","doi-asserted-by":"crossref","first-page":"5911","DOI":"10.1111\/jcmm.15278","article-title":"Dihydromyricetin increases endothelial nitric oxide production and inhibits atherosclerosis through microRNA-21 in apolipoprotein E-deficient mice","volume":"24","author":"Yang","year":"2020","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178928_bib59","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s12967-024-05060-7","article-title":"Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK\/PGC-1\u03b1 and PPAR\u03b1-mediated autophagy pathway","volume":"22","author":"Yang","year":"2024","journal-title":"J. Transl. Med."},{"issue":"7329","key":"10.1016\/j.ejphar.2026.178928_bib60","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.ejphar.2026.178928_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167266","article-title":"Gpbar-1\/cAMP\/PKA signaling mitigates macrophage-mediated acute cholestatic liver injury via antagonizing NLRP3-ASC inflammasome","volume":"1870","author":"Zhuang","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926004103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926004103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:13:32Z","timestamp":1783145612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926004103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":61,"alternative-id":["S0014299926004103"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178928","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dihydromyricetin: A potential candidate for the treatment of cholestatic liver injury via inhibition of the NLRP3 inflammasome","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178928","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178928"}}