{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:04:54Z","timestamp":1791612294866,"version":"4.3.4"},"reference-count":129,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ejphar.2026.178986","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:56:32Z","timestamp":1778817392000},"page":"178986","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Nitric oxide signaling in Alzheimer's disease: A double-edged sword"],"prefix":"10.1016","volume":"1029","author":[{"given":"Rufaida","family":"Wasim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5546","key":"10.1016\/j.ejphar.2026.178986_bib1","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1126\/science.1066273","article-title":"Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation","volume":"294","author":"Antonova","year":"2001","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.ejphar.2026.178986_bib2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0092-8674(00)81797-3","article-title":"Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons","volume":"87","author":"Arancio","year":"1996","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178986_bib3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ccr.2010.10.029","article-title":"Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A","volume":"19","author":"Arozarena","year":"2011","journal-title":"Cancer Cell"},{"issue":"6","key":"10.1016\/j.ejphar.2026.178986_bib4","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1046\/j.1471-4159.2001.00205.x","article-title":"Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals","volume":"76","author":"Asanuma","year":"2001","journal-title":"J. Neurochem."},{"issue":"7321","key":"10.1016\/j.ejphar.2026.178986_bib5","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature09613","article-title":"Glial and neuronal control of brain blood flow","volume":"468","author":"Attwell","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.178986_bib6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/bc.bc_3_21","article-title":"The influence of renal ischemia-reperfusion injury on remote organs: the histological brain changes in male and female rats","volume":"7","author":"Azarkish","year":"2021","journal-title":"Brain Circ"},{"key":"10.1016\/j.ejphar.2026.178986_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3806157","article-title":"Getting to NO Alzheimer's disease: neuroprotection versus neurotoxicity mediated by nitric oxide","volume":"2016","author":"Balez","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"12","key":"10.1016\/j.ejphar.2026.178986_bib8","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.biopsych.2007.03.024","article-title":"Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia","volume":"62","author":"Bartzokis","year":"2007","journal-title":"Biol. Psychiatry"},{"issue":"12","key":"10.1016\/j.ejphar.2026.178986_bib9","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.biopsych.2012.07.010","article-title":"Multimodal magnetic resonance imaging assessment of white matter aging trajectories over the lifespan of healthy individuals","volume":"72","author":"Bartzokis","year":"2012","journal-title":"Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.ejphar.2026.178986_bib10","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0959-4388(94)90101-5","article-title":"Synaptic plasticity: LTP and LTD","volume":"4","author":"Bear","year":"1994","journal-title":"Curr. Opin. Neurobiol."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178986_bib18","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(91)90505-K","article-title":"Possible involvement of nitric oxide in long-term potentiation","volume":"199","author":"B\u00f6hme","year":"1991","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.ejphar.2026.178986_bib13","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1523\/JNEUROSCI.23-05-01941.2003","article-title":"On the role of nitric oxide in hippocampal long-term potentiation","volume":"23","author":"Bon","year":"2003","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178986_bib14","first-page":"47","article-title":"Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction","volume":"8","author":"Boolell","year":"1996","journal-title":"Int. J. Impot. Res."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178986_bib15","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0306-4522(95)00349-N","article-title":"Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase","volume":"69","author":"Boulton","year":"1995","journal-title":"Neuroscience"},{"issue":"22","key":"10.1016\/j.ejphar.2026.178986_bib16","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1212\/WNL.0b013e3181a18691","article-title":"Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort","volume":"72","author":"Breitner","year":"2009","journal-title":"Neurology"},{"issue":"2\u20133","key":"10.1016\/j.ejphar.2026.178986_bib17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-5793(94)01290-3","article-title":"Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase","volume":"356","author":"Brown","year":"1994","journal-title":"FEBS Lett."},{"issue":"5","key":"10.1016\/j.ejphar.2026.178986_bib20","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.acn.2003.08.008","article-title":"Relationship between plasticity, mild cognitive impairment and cognitive decline","volume":"19","author":"Calero","year":"2004","journal-title":"Arch. Clin. Neuropsychol."},{"issue":"7","key":"10.1016\/j.ejphar.2026.178986_bib21","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/stem.444","article-title":"Nitric oxide stimulates the proliferation of neural stem cells bypassing the epidermal growth factor receptor","volume":"28","author":"Carreira","year":"2010","journal-title":"Stem Cell."},{"issue":"7","key":"10.1016\/j.ejphar.2026.178986_bib22","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1089\/ars.2007.1959","article-title":"Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective","volume":"10","author":"Chen","year":"2008","journal-title":"Antioxid. Redox Signaling"},{"issue":"4","key":"10.1016\/j.ejphar.2026.178986_bib23","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1523\/JNEUROSCI.21-04-01179.2001","article-title":"\u03b2-Amyloid stimulation of microglia and monocytes results in TNF\u03b1-dependent expression of inducible nitric oxide synthase and neuronal apoptosis","volume":"21","author":"Combs","year":"2001","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178986_bib24","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bbr.2009.12.044","article-title":"The history of the cholinergic hypothesis","volume":"221","author":"Contestabile","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"12","key":"10.1016\/j.ejphar.2026.178986_bib25","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1634\/stemcells.2005-0640","article-title":"Nitric oxide exposure diverts neural stem cell fate from neurogenesis towards astrogliogenesis","volume":"24","author":"Covacu","year":"2006","journal-title":"Stem Cell."},{"issue":"8","key":"10.1016\/j.ejphar.2026.178986_bib26","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1111\/j.1476-5381.2011.01517.x","article-title":"Sildenafil restores cognitive function without affecting \u03b2-amyloid burden in a mouse model of Alzheimer's disease","volume":"164","author":"Cuadrado-Tejedor","year":"2011","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178986_bib27","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1037\/0033-2909.96.3.518","article-title":"Protein synthesis and memory: a review","volume":"96","author":"Davis","year":"1984","journal-title":"Psychol. Bull."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178986_bib28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/jamaneurol.2016.3232","article-title":"Association of amyloid pathology with myelin alteration in preclinical Alzheimer disease","volume":"74","author":"Dean","year":"2017","journal-title":"JAMA Neurol."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178986_bib29","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.2353\/ajpath.2010.100087","article-title":"Early oligodendrocyte\/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target","volume":"177","author":"Desai","year":"2010","journal-title":"Am. J. Pathol."},{"issue":"10","key":"10.1016\/j.ejphar.2026.178986_bib30","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1073\/pnas.91.10.4214","article-title":"Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity","volume":"91","author":"Dinerman","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178986_bib31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/cne.20840","article-title":"Decreased adult hippocampal neurogenesis in the PDAPP mouse model of Alzheimer's disease","volume":"495","author":"Donovan","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ejphar.2026.178986_bib32","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1177\/1039856218762308","article-title":"Alzheimer's disease: clinical update on epidemiology, pathophysiology and diagnosis","volume":"26","author":"Eratne","year":"2018","journal-title":"Australas. Psychiatry"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178986_bib34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0896-6273(00)00095-7","article-title":"Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON","volume":"28","author":"Fang","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2026.178986_bib33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2020.12.008","article-title":"The role of NO in COVID-19 and potential therapeutic strategies","volume":"163","author":"Fang","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2026.178986_bib36","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1023\/A:1020537506008","article-title":"Endothelium-derived relaxing factor: discovery, early studies, and identification as nitric oxide","volume":"19","author":"Furchgott","year":"1999","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.ejphar.2026.178986_bib35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine","volume":"288","author":"Furchgott","year":"1980","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.ejphar.2026.178986_bib37","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1523\/JNEUROSCI.19-10-03860.1999","article-title":"Different contributions of microtubule dynamics and transport to the growth of axons and collateral sprouts","volume":"19","author":"Gallo","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178986_bib38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12974-021-02369-8","article-title":"Microbial pathogens induce neurodegeneration in Alzheimer's disease mice: protection by microglial regulation","volume":"19","author":"Ganz","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"11","key":"10.1016\/j.ejphar.2026.178986_bib40","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1111\/j.1460-9568.2008.06285.x","article-title":"Concepts of neural nitric oxide-mediated transmission","volume":"27","author":"Garthwaite","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178986_bib39","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.ph.57.030195.003343","article-title":"Nitric oxide signaling in the central nervous system","volume":"57","author":"Garthwaite","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ejphar.2026.178986_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.716177","article-title":"Anti-inflammatory activity of a polypeptide fraction from Achyranthes bidentata in amyloid \u03b2 oligomers induced model of Alzheimer's disease","volume":"12","author":"Ge","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178986_bib42","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0959-4388(02)00326-4","article-title":"Retrograde neurotrophin signaling: Trk-ing along the axon","volume":"12","author":"Ginty","year":"2002","journal-title":"Curr. Opin. Neurobiol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178986_bib43","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1152\/japplphysiol.00966.2005","article-title":"Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease","volume":"100","author":"Girouard","year":"2006","journal-title":"J. Appl. Physiol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.178986_bib44","first-page":"21","article-title":"Evidence of neuronal oxidative damage in Alzheimer's disease","volume":"149","author":"Good","year":"1996","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.ejphar.2026.178986_bib45","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.neuron.2013.04.014","article-title":"Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta","volume":"78","author":"Griciuc","year":"2013","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178986_bib46","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/1534582303002001003","article-title":"How does the cerebral cortex work? Development, learning, attention, and 3-D vision by laminar circuits of visual cortex","volume":"2","author":"Grossberg","year":"2003","journal-title":"Behav. Cognit. Neurosci. Rev."},{"issue":"7","key":"10.1016\/j.ejphar.2026.178986_bib47","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/emmm.201200243","article-title":"Modification of \u03b3-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease","volume":"4","author":"Guix","year":"2012","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ejphar.2026.178986_bib48","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s12975-019-00767-y","article-title":"Short-term acute exercise preconditioning reduces neurovascular injury after stroke through induced eNOS activation","volume":"11","author":"Hafez","year":"2020","journal-title":"Transl. Stroke Res"},{"issue":"1","key":"10.1016\/j.ejphar.2026.178986_bib49","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0304-3940(93)90919-C","article-title":"Nitric oxide synthase inhibitors block long-term potentiation induced by weak but not strong tetanic stimulation at physiological brain temperatures in rat hippocampal slices","volume":"160","author":"Haley","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2026.178986_bib50","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3389\/fncel.2013.00190","article-title":"The role of nitric oxide in pre-synaptic plasticity and homeostasis","volume":"7","author":"Hardingham","year":"2013","journal-title":"Front. Cell. Neurosci."},{"issue":"6","key":"10.1016\/j.ejphar.2026.178986_bib51","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1046\/j.1471-4159.2002.01267.x","article-title":"Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease","volume":"83","author":"Haughey","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2026.178986_bib52","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1742-2094-2-22","article-title":"Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP [V717I] transgenic mice","volume":"2","author":"Heneka","year":"2005","journal-title":"J. Neuroinflammation"},{"issue":"33","key":"10.1016\/j.ejphar.2026.178986_bib53","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1523\/JNEUROSCI.0616-08.2008","article-title":"Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice","volume":"28","author":"Hickman","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178986_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.898955","article-title":"A review for the pharmacological effects of paeoniflorin in the nervous system","volume":"13","author":"Hong","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178986_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/eme07020","article-title":"Minocycline 200 mg or 400 mg versus placebo for mild Alzheimer's disease: the MADE phase II, three-arm RCT","volume":"7","author":"Howard","year":"2020","journal-title":"Efficacy Mech. Eval."},{"key":"10.1016\/j.ejphar.2026.178986_bib56","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/bc.BC_2_17","article-title":"Neuroprotective effects of tenuigenin on neurobehavior, oxidative stress, and tau hyperphosphorylation induced by intracerebroventricular streptozotocin in rats","volume":"4","author":"Huang","year":"2018","journal-title":"Brain Circ"},{"issue":"5","key":"10.1016\/j.ejphar.2026.178986_bib58","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrn1387","article-title":"Neurovascular regulation in the normal brain and in Alzheimer's disease","volume":"5","author":"Iadecola","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178986_bib59","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1016\/S0021-9258(19)89205-0","article-title":"Activation of soluble guanylate cyclase by NO-hemoproteins involves NO-heme exchange: comparison of heme-containing and heme-deficient enzyme forms","volume":"261","author":"Ignarro","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2026.178986_bib60","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/2394-8108.178541","article-title":"Inducible nitric oxide synthase (NOS-2) in subarachnoid hemorrhage: regulatory mechanisms and therapeutic implications","volume":"2","author":"Iqbal","year":"2016","journal-title":"Brain Circ"},{"issue":"2","key":"10.1016\/j.ejphar.2026.178986_bib61","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1152\/jn.1995.74.2.891","article-title":"Nitric oxide is used as an orthograde cotransmitter at identified histaminergic synapses","volume":"74","author":"Jacklet","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2026.178986_bib62","doi-asserted-by":"crossref","first-page":"248","DOI":"10.4103\/bc.bc_69_20","article-title":"Clinical application of nitric oxide in ischemia and reperfusion injury: a literature review","volume":"6","author":"Jiang","year":"2020","journal-title":"Brain Circ"},{"key":"10.1016\/j.ejphar.2026.178986_bib63","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/jnc.13632","article-title":"The amyloid cascade hypothesis: are we poised for success or failure?","volume":"139","author":"Karran","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2026.178986_bib64","first-page":"23","article-title":"Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine","volume":"3","author":"Katsuki","year":"1977","journal-title":"J. Cyclic. Nucl. Res."},{"key":"10.1016\/j.ejphar.2026.178986_bib65","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s10571-019-00767-4","article-title":"Inflammatory pathways following subarachnoid hemorrhage","volume":"40","author":"Khey","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.ejphar.2026.178986_bib66","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0002-9149(99)00114-9","article-title":"Cardiovascular effects of sildenafil citrate and recommendations for its use","volume":"84","author":"Kloner","year":"1999","journal-title":"Am. J. Cardiol."},{"issue":"5","key":"10.1016\/j.ejphar.2026.178986_bib67","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.neuron.2011.07.001","article-title":"Nitration of tyrosine 10 critically enhances amyloid \u03b2 aggregation and plaque formation","volume":"71","author":"Kummer","year":"2011","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.ejphar.2026.178986_bib68","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.canlet.2008.03.057","article-title":"Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives","volume":"269","author":"Kundu","year":"2008","journal-title":"Cancer Lett."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178986_bib69","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3109\/07853899509002591","article-title":"Nitric oxide in the peripheral nervous system","volume":"27","author":"Lefebvre","year":"1995","journal-title":"Ann. Med."},{"key":"10.1016\/j.ejphar.2026.178986_bib70","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1177\/0271678X20973787","article-title":"Role of endothelial nitric oxide synthase for early brain injury after subarachnoid hemorrhage in mice","volume":"41","author":"Lenz","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"4","key":"10.1016\/j.ejphar.2026.178986_bib71","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4103\/bc.bc_13_17","article-title":"A focus on CXCR4 in Alzheimer's disease","volume":"3","author":"Li","year":"2017","journal-title":"Brain Circ"},{"issue":"2","key":"10.1016\/j.ejphar.2026.178986_bib72","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nrd1958","article-title":"Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond","volume":"5","author":"Lipton","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2026.178986_bib74","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1177\/0271678X20983216","article-title":"Intrathecal and systemic alterations of L-arginine metabolism in patients after intracerebral hemorrhage","volume":"41","author":"Mader","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178986_bib77","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.meatsci.2007.09.008","article-title":"Effects of data expression, sample location, and oxygen partial pressure on initial nitric oxide metmyoglobin formation and metmyoglobin-reducing-activity measurement in beef muscle","volume":"79","author":"Mancini","year":"2008","journal-title":"Meat Sci."},{"issue":"11","key":"10.1016\/j.ejphar.2026.178986_bib78","doi-asserted-by":"crossref","first-page":"20607","DOI":"10.3390\/ijms151120607","article-title":"Molecular mechanisms underlying the effects of statins in the central nervous system","volume":"15","author":"McFarland","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.178986_bib82","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0896-6273(00)80073-2","article-title":"Inhibition of nitric oxide synthase impairs a distinct form of long-term memory in the honeybee, Apis mellifera","volume":"16","author":"M\u00fcller","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2026.178986_bib79","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1523\/JNEUROSCI.1574-03.2004","article-title":"Nitric oxide is a physiological inhibitor of neurogenesis in the adult mouse subventricular zone and olfactory bulb","volume":"24","author":"Moreno-L\u00f3pez","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178986_bib81","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s12975-016-0466-6","article-title":"Role of cyclooxygenase-2 in relation to nitric oxide and endothelin-1 on pathogenesis of cerebral vasospasm after subarachnoid hemorrhage in rabbit","volume":"7","author":"Munakata","year":"2016","journal-title":"Transl. Stroke Res"},{"key":"10.1016\/j.ejphar.2026.178986_bib83","series-title":"Line Bisection as a Neural Marker of Approach Motivation","first-page":"979","author":"Nash","year":"2010"},{"key":"10.1016\/j.ejphar.2026.178986_bib84","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40478-018-0515-3","article-title":"White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes","volume":"6","author":"Nasrabady","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.ejphar.2026.178986_bib85","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1084\/jem.20051529","article-title":"Protection from Alzheimer-like disease in the mouse by genetic ablation of inducible nitric oxide synthase","volume":"202","author":"Nathan","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ejphar.2026.178986_bib86","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1083\/jcb.200805132","article-title":"PSD-95 promotes synaptogenesis and multiinnervated spine formation through nitric oxide signaling","volume":"183","author":"Nikonenko","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ejphar.2026.178986_bib87","doi-asserted-by":"crossref","first-page":"9735","DOI":"10.1073\/pnas.97.17.9735","article-title":"A\u03b21\u201340-related reduction in functional hyperemia in mouse neocortex during somatosensory activation","volume":"97","author":"Niwa","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejphar.2026.178986_bib88","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.tics.2012.04.005","article-title":"Memory aging and brain maintenance","volume":"16","author":"Nyberg","year":"2012","journal-title":"Trends Cognit. Sci."},{"key":"10.1016\/j.ejphar.2026.178986_bib90","doi-asserted-by":"crossref","first-page":"11285","DOI":"10.1073\/pnas.88.24.11285","article-title":"Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger","volume":"88","author":"O'Dell","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejphar.2026.178986_bib89","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s12975-021-00921-5","article-title":"Is cerebral amyloid-\u03b2 deposition related to post-stroke cognitive impairment?","volume":"12","author":"Ouyang","year":"2021","journal-title":"Transl. Stroke Res"},{"key":"10.1016\/j.ejphar.2026.178986_bib91","doi-asserted-by":"crossref","first-page":"9566","DOI":"10.1073\/pnas.1633579100","article-title":"Nitric oxide negatively regulates mammalian adult neurogenesis","volume":"100","author":"Packer","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejphar.2026.178986_bib92","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/j.bbadis.2018.11.007","article-title":"Functions and dysfunctions of nitric oxide in brain","volume":"1865","author":"Pic\u00f3n-Pag\u00e8s","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.ejphar.2026.178986_bib93","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1176\/appi.ajp.2011.11010009","article-title":"Association of cerebral emboli with accelerated cognitive deterioration in Alzheimer's disease and vascular dementia","volume":"169","author":"Purandare","year":"2012","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.178986_bib96","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1172\/JCI137040","article-title":"Tau is not necessary for amyloid-\u03b2\u2013induced synaptic and memory impairments","volume":"130","author":"Puzzo","year":"2020","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2026.178986_bib95","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.neurobiolaging.2013.09.002","article-title":"Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice","volume":"35","author":"Puzzo","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2026.178986_bib94","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1523\/JNEUROSCI.0864-09.2009","article-title":"Phosphodiesterase-5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model","volume":"29","author":"Puzzo","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178986_bib97","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/01.STR.0000060127.96986.F4","article-title":"Pulse pressure and risk of Alzheimer disease in persons aged 75 years and older: a community-based, longitudinal study","volume":"34","author":"Qiu","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.ejphar.2026.178986_bib98","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1073\/pnas.0307446101","article-title":"Nitric oxide, oxidants, and protein tyrosine nitration","volume":"101","author":"Radi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejphar.2026.178986_bib99","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1073\/pnas.1804932115","article-title":"Oxygen radicals, nitric oxide, and peroxynitrite: redox pathways in molecular medicine","volume":"115","author":"Radi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejphar.2026.178986_bib100","doi-asserted-by":"crossref","first-page":"10237","DOI":"10.1073\/pnas.172399499","article-title":"Appraising the brain's energy budget","volume":"99","author":"Raichle","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejphar.2026.178986_bib101","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.3390\/cells11121885","article-title":"Innate immune cell death in neuroinflammation and Alzheimer's disease","volume":"11","author":"Rajesh","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2026.178986_bib102","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1146\/annurev-biochem-032620-104801","article-title":"Lipoproteins in the central nervous system: from biology to pathobiology","volume":"91","author":"Raulin","year":"2022","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ejphar.2026.178986_bib103","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuron.2009.06.021","article-title":"Activity-dependent regulation of synapses by retrograde messengers","volume":"63","author":"Regehr","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2026.178986_bib104","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1056\/NEJMoa013128","article-title":"Memantine in moderate-to-severe Alzheimer's disease","volume":"348","author":"Reisberg","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2026.178986_bib105","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1515\/revneuro-2017-0063","article-title":"Amyloid toxicity in Alzheimer's disease","volume":"29","author":"Reiss","year":"2018","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178986_bib106","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.nbd.2008.04.005","article-title":"A possible link between astrocyte activation and tau nitration in Alzheimer's disease","volume":"31","author":"Reyes","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2026.178986_bib107","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1152\/jn.1999.82.3.1569","article-title":"Induction of hippocampal LTD requires nitric-oxide-stimulated PKG activity and Ca2+ release from cyclic ADP-ribose-sensitive stores","volume":"82","author":"Reyes-Harde","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.ejphar.2026.178986_bib108","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.molcel.2005.12.006","article-title":"A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons","volume":"21","author":"Riccio","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ejphar.2026.178986_bib109","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002935","article-title":"Impaired adult neurogenesis in the dentate gyrus of a triple transgenic mouse model of Alzheimer's disease","volume":"3","author":"Rodr\u00edguez","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2026.178986_bib110","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1097\/WNR.0b013e32832be77d","article-title":"Impaired cell proliferation in the subventricular zone in an Alzheimer's disease model","volume":"20","author":"Rodr\u00edguez","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejphar.2026.178986_bib111","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jalz.2010.09.002","article-title":"Transcranial Doppler ultrasound blood flow velocity and pulsatility index as systemic indicators for Alzheimer's disease","volume":"7","author":"Roher","year":"2011","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.ejphar.2026.178986_bib112","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1126\/science.1207401","article-title":"Displacement above the hypocenter of the 2011 Tohoku-Oki earthquake","volume":"332","author":"Sato","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2026.178986_bib113","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1720572","article-title":"A requirement for the intercellular messenger nitric oxide in long-term potentiation","volume":"254","author":"Schuman","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2026.178986_bib114","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces A\u03b2 plaques in Alzheimer's disease","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.178986_bib115","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","article-title":"Amyloid-\u03b2 protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory","volume":"14","author":"Shankar","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2026.178986_bib116","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1742-7843.2004.pto950504.x","article-title":"Effect of Hibiscus rosa sinensis extract on hyperproliferation and oxidative damage caused by benzoyl peroxide and ultraviolet radiations in mouse skin","volume":"95","author":"Sharma","year":"2004","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.ejphar.2026.178986_bib117","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.biochem.68.1.821","article-title":"CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals","volume":"68","author":"Shaywitz","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ejphar.2026.178986_bib119","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trial","volume":"330","author":"Sims","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2026.178986_bib122","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1439-0442.2005.00755.x","article-title":"Characterization of the cytokine pattern of porcine bone marrow-derived cells treated with 1\u03b1,25(OH)2D3","volume":"52","author":"Sipos","year":"2005","journal-title":"J. Vet. Med. A Physiol. Pathol. Clin. Med."},{"key":"10.1016\/j.ejphar.2026.178986_bib121","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S1474-4422(02)00102-3","article-title":"The role of nitric oxide in multiple sclerosis","volume":"1","author":"Smith","year":"2002","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2026.178986_bib123","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0304-3940(92)90413-2","article-title":"Sources and targets of nitric oxide in rat cerebellum","volume":"137","author":"Southam","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2026.178986_bib124","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/0028-3908(93)90021-T","article-title":"The nitric oxide-cyclic GMP signalling pathway in rat brain","volume":"32","author":"Southam","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2026.178986_bib125","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.bbi.2011.04.017","article-title":"Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease","volume":"25","author":"Swardfager","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.ejphar.2026.178986_bib126","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.881088","article-title":"N-methyl-D-aspartate receptors antagonist prevents secondary ischemic brain injury associated with lipopolysaccharide-induced sepsis-like state presumably via immunomodulatory actions","volume":"16","author":"Taheri","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178986_bib127","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/(SICI)1098-1136(199704)19:4<286::AID-GLIA2>3.0.CO;2-W","article-title":"Nitric oxide-mediated cGMP synthesis in oligodendrocytes in the developing rat brain","volume":"19","author":"Tanaka","year":"1997","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2026.178986_bib128","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2165\/11310810-000000000-00000","article-title":"Tumour necrosis factor modulation for treatment of Alzheimer's disease: rationale and current evidence","volume":"23","author":"Tobinick","year":"2009","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ejphar.2026.178986_bib129","first-page":"82","article-title":"Neuronal nitric oxide synthase expressing neurons: a journey from birth to neuronal circuits","volume":"6","author":"Tricoire","year":"2012","journal-title":"Front. Neural Circ."},{"key":"10.1016\/j.ejphar.2026.178986_bib130","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1001\/jama.289.2.210","article-title":"Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis","volume":"289","author":"Trinh","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2026.178986_bib131","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature04782","article-title":"S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration","volume":"441","author":"Uehara","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.178986_bib132","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.3390\/molecules26164897","article-title":"Green tea suppresses brain aging","volume":"26","author":"Unno","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ejphar.2026.178986_bib136","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.14506.1","article-title":"Current understanding of Alzheimer's disease diagnosis and treatment","volume":"7","author":"Weller","year":"2018","journal-title":"F1000Research"},{"key":"10.1016\/j.ejphar.2026.178986_bib137","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s12975-020-00847-4","article-title":"Cerebral small vessel disease influences hippocampal subfield atrophy in mild cognitive impairment","volume":"12","author":"Wong","year":"2021","journal-title":"Transl. Stroke Res"},{"key":"10.1016\/j.ejphar.2026.178986_bib138","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.22-10-j0001.2002","article-title":"Alzheimer's \u03b2-amyloid peptides compete for insulin binding to the insulin receptor","volume":"22","author":"Xie","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.178986_bib140","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.biomaterials.2013.09.063","article-title":"Dual-functional nanoparticles targeting amyloid plaques in the brains of Alzheimer's disease mice","volume":"35","author":"Zhang","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejphar.2026.178986_bib141","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0306-4522(01)00117-8","article-title":"Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia","volume":"105","author":"Zhang","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2026.178986_bib142","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12975-012-0217-2","article-title":"Inhaled nitric oxide protects males but not females from neonatal mouse hypoxia-ischemia brain injury","volume":"4","author":"Zhu","year":"2013","journal-title":"Transl. Stroke Res"},{"key":"10.1016\/j.ejphar.2026.178986_bib143","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1523\/JNEUROSCI.23-01-00223.2003","article-title":"Expression of inducible nitric oxide synthase after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus","volume":"23","author":"Zhu","year":"2003","journal-title":"J. Neurosci."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926004681?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926004681?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:13:14Z","timestamp":1784808794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926004681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":129,"alternative-id":["S0014299926004681"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178986","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide signaling in Alzheimer's disease: A double-edged sword","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178986","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178986"}}