{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:10:00Z","timestamp":1792696200971,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ejphar.2026.178987","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T06:46:00Z","timestamp":1779518760000},"page":"178987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Design, synthesis, and inhibition of oxidative, amyloidogenic, and cholinergic dysfunction of saxagliptin-derived schiff bases against STZ-induced sporadic AD-like pathology"],"prefix":"10.1016","volume":"1028","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4323-4902","authenticated-orcid":false,"given":"Swagata","family":"Pattanaik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8805-8682","authenticated-orcid":false,"given":"Pratap Kumar","family":"Sahu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhir Kumar","family":"Paidesetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakti Ketan","family":"Prusty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kakarla","family":"Pakeeraiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preetesh Kumar","family":"Panda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Lopamudra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.178987_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2025.149650","article-title":"Plumbagin as a potential therapeutic agent for scopolamine-induced Alzheimer's disease: mechanistic insights into GSK-3\u03b2 inhibition","volume":"1859","author":"Ahsan","year":"2025","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2026.178987_bib2","article-title":"Attenuation of PI3K\/AKT signaling pathway by Ocimum gratissimum leaf flavonoid-rich extracts in streptozotocin-induced diabetic male rats","volume":"38","author":"Ajiboye","year":"2024","journal-title":"Biochem. Biophys. Rep."},{"issue":"7","key":"10.1016\/j.ejphar.2026.178987_bib3","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1007\/s00213-021-05826-7","article-title":"7, 8-Dihydroxyflavone improves cognitive functions in ICV-STZ rat model of sporadic Alzheimer's disease by reversing oxidative stress, mitochondrial dysfunction, and insulin resistance","volume":"238","author":"Akhtar","year":"2021","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.ejphar.2026.178987_bib4","article-title":"Deteriorated thiol-disulphide and oxidized-reduced glutathione status in blood in Alzheimer's disease","volume":"133","author":"Akunal","year":"2024","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.ejphar.2026.178987_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104792","article-title":"Design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for Alzheimer's disease","volume":"110","author":"Amin","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"8","key":"10.1016\/j.ejphar.2026.178987_bib6","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.cmet.2025.06.005","article-title":"Insulin signaling in microglia: a metabolic switch controlling neuroinflammation and amyloid pathology in Alzheimer's disease","volume":"37","author":"Barone","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.ejphar.2026.178987_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2025.108441","article-title":"Investigating the effect of acrylamide, penitrem A and 3-acetyldeoxynivalenol in SH-SY5Y human neuroblastoma cells: exploring the oxidative stress","author":"Bridgeman","year":"2025","journal-title":"Toxicon"},{"key":"10.1016\/j.ejphar.2026.178987_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119421","article-title":"Modulatory effects of caffeic acid on purinergic and cholinergic systems and oxi-inflammatory parameters of streptozotocin-induced diabetic rats","volume":"277","author":"Castro","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.ejphar.2026.178987_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.prenap.2024.100137","article-title":"Prophylactic administration of naringin prevents anticancer drug 5-fluorouracil-induced hepatorenal toxicity via suppressing lipid peroxidation and oxidative stress in rats","volume":"6","author":"Famurewa","year":"2025","journal-title":"Pharmacological Research-Natural Products"},{"key":"10.1016\/j.ejphar.2026.178987_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113375","article-title":"Bilateral intracerebroventricular injection of streptozotocin induces AD-like behavioral impairments and neuropathological features in mice: involved with the fundamental role of neuroinflammation","volume":"153","author":"Fan","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178987_bib11","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1007\/s12035-015-9132-3","article-title":"Intracerebroventricular streptozotocin injections as a model of Alzheimer's disease: in search of a relevant mechanism","volume":"53","author":"Grieb","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2026.178987_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.cct.2021.106549","article-title":"Current druggable targets for therapeutic control of Alzheimer's disease","volume":"109","author":"Gupta","year":"2021","journal-title":"Contemp. Clin. Trials"},{"issue":"8","key":"10.1016\/j.ejphar.2026.178987_bib13","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/inorganics11080320","article-title":"Metal complexes with schiff bases as antimicrobials and catalysts","volume":"11","author":"Iacopetta","year":"2023","journal-title":"Inorganics"},{"key":"10.1016\/j.ejphar.2026.178987_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110561","article-title":"Swertiamarin and quercetin combination ameliorates hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced type 2 diabetes mellitus in wistar rats","volume":"130","author":"Jaishree","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2026.178987_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.lddd.2025.100109","article-title":"Synthesis, characterization, and neuroprotective effect of taxifolin-conjugated gold nanoparticles against amyloid \u03b2eta induced Alzheimer's disease","author":"Kalyanam","year":"2025","journal-title":"Lett. Drug Des. Discovery"},{"key":"10.1016\/j.ejphar.2026.178987_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120538","article-title":"Intranasal metformin treatment ameliorates cognitive functions via insulin signaling pathway in ICV-STZ-induced mice model of Alzheimer's disease","volume":"299","author":"Kazkayasi","year":"2022","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.ejphar.2026.178987_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.sjbs.2023.103560","article-title":"Sterubin protects against chemically-induced Alzheimer's disease by reducing biomarkers of inflammation-IL-6\/IL-\u03b2\/TNF-\u03b1 and oxidative stress-SOD\/MDA in rats","volume":"30","author":"Kazmi","year":"2023","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.ejphar.2026.178987_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.neuropharm.2013.04.008","article-title":"Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease","volume":"72","author":"Kosaraju","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2026.178987_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.meomic.2025.100044","article-title":"Neuroprotective effects of Persea americana and Tabebuia rosea ethanolic extracts against aluminum chloride-induced Alzheimer's disease in rat model","author":"Onifade","year":"2025","journal-title":"Medicine in Omics"},{"key":"10.1016\/j.ejphar.2026.178987_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112730","article-title":"Therapeutic efficacy of Clompanus pubescens leaves fractions via downregulation of neuronal cholinesterases\/Na+-K+ ATPase\/IL-1 \u03b2, and improving the neurocognitive and antioxidants status of streptozotocin-induced diabetic rats","volume":"148","author":"Onikanni","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2026.178987_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114691","article-title":"Neuroprotective potential of tranilast in streptozotocin-induced sporadic Alzheimer's disease model targeting TXNIP-NLRP3 inflammasome pathway","volume":"156","author":"Padhy","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2026.178987_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.142313","article-title":"Antimicrobial assessment and computational investigation of newly designed and synthesized schiff base of chloroformylated chromene-sulfonamide derivatives against bacterial DNA gyrase","volume":"1339","author":"Pakeeraiah","year":"2025","journal-title":"J. Mol. Struct."},{"issue":"43","key":"10.1016\/j.ejphar.2026.178987_bib23","doi-asserted-by":"crossref","first-page":"31633","DOI":"10.1039\/D4RA05756B","article-title":"Multimodal antibacterial potency of newly designed and synthesized Schiff's\/Mannich based coumarin derivatives: potential inhibitors of bacterial DNA gyrase and biofilm production","volume":"14","author":"Pakeeraiah","year":"2024","journal-title":"RSC advances"},{"key":"10.1016\/j.ejphar.2026.178987_bib24","doi-asserted-by":"crossref","DOI":"10.1039\/D5MD00221D","article-title":"Design, synthesis and computational approach of vanillyl-imidazolonyl-sulfamethoxazole derivatives as potent antimicrobial candidates tackling microbial resistance","author":"Panda","year":"2025","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.ejphar.2026.178987_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102698","article-title":"Repurposing drugs: a promising therapeutic approach against alzheimer's disease","author":"Pattanaik","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.ejphar.2026.178987_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.140386","article-title":"Design and synthesis of phyto-Saxagliptin conjugates: targeting DPP IV, AChE, and \u03b2-amyloid in cognitive impairment","volume":"1322","author":"Pattanaik","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.ejphar.2026.178987_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149342","article-title":"Exploring DPP IV inhibitors for Alzheimer's disease: bridging diabetes and neurodegeneration","volume":"1848","author":"Pattanaik","year":"2025","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2026.178987_bib28","article-title":"Effect of selenium nanoparticles conjugated vildagliptin on cognitive dysfunction associated with diabetes mellitus","volume":"98","author":"Pradhan","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ejphar.2026.178987_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.115026","article-title":"Effect of vildagliptin conjugated monometallic nanoparticles and bimetallic nanocomposites on diabetes-induced cognitive deficit","volume":"383","author":"Pradhan","year":"2025","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2026.178987_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173522","article-title":"Alogliptin reversed hippocampal insulin resistance in an amyloid-beta fibrils induced animal model of Alzheimer's disease","volume":"889","author":"Rahman","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.178987_bib31","unstructured":"Rana, R., Sharma, A., Kumar, N., Mohanna, P., Khanna, A., & Bedi, P. M. S. Exploring the urate lowering properties of Erigeron Annuus Lin. And phytosterol contributions: in vitro assays and in silico approaches. And Phytosterol Contributions: in Vitro Assays and in Silico Approaches."},{"key":"10.1016\/j.ejphar.2026.178987_bib32","article-title":"Schiff base metformin-derivatives ameliorate aluminium chloride-induced alzheimer's disease-like pathology in rats","volume":"10","author":"Rath","year":"2026","journal-title":"J. Mol. Struct."},{"issue":"3","key":"10.1016\/j.ejphar.2026.178987_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.phyplu.2025.100806","article-title":"Therapeutic potential of Asplenium caudatum in aluminum Chloride-induced Alzheimer's diseases: an insight of integrative approaches","volume":"5","author":"Sajad","year":"2025","journal-title":"Phytomed. Plus"},{"key":"10.1016\/j.ejphar.2026.178987_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124218","article-title":"Brain-targeted Tet-1 peptide-PLGA nanoparticles for berberine delivery against STZ-induced Alzheimer's disease in a rat model: alleviation of hippocampal synaptic dysfunction, Tau pathology, and amyloidogenesis","volume":"658","author":"Saleh","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ejphar.2026.178987_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.148175","article-title":"Animal model of Alzheimer's disease induced by streptozotocin: new insights about cholinergic pathway","volume":"1799","author":"Silva","year":"2023","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2026.178987_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2023.137090","article-title":"Neuroprotective potential of honokiol in ICV-STZ induced neuroinflammation, A\u03b2 (1\u2212 4 2) and NF-kB expression in experimental model of rats","volume":"799","author":"Singh","year":"2023","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2026.178987_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.prenap.2025.100258","article-title":"Unveiling the multifaceted wound healing potential of Grewia asiatica leaf extracts in incision, excision, and cotton pellet models","author":"Upadhyay","year":"2025","journal-title":"Pharmacological Research-Natural Products"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926004693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926004693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T20:23:32Z","timestamp":1781036612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926004693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":37,"alternative-id":["S0014299926004693"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178987","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis, and inhibition of oxidative, amyloidogenic, and cholinergic dysfunction of saxagliptin-derived schiff bases against STZ-induced sporadic AD-like pathology","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.178987","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"178987"}}