{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T20:58:23Z","timestamp":1781038703039,"version":"3.54.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ejphar.2026.179004","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:19:48Z","timestamp":1779319188000},"page":"179004","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Therapeutic effects of zanamivir against L-NAME-induced preeclampsia in mice and network pharmacology analysis"],"prefix":"10.1016","volume":"1028","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0601-3078","authenticated-orcid":false,"given":"Tao","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjifu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.179004_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/jama.2024.8931","article-title":"Trends in Preeclampsia risk factors in the US from 2010 to 2021","volume":"332","author":"Ayyash","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.ejphar.2026.179004_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/nu16213627","article-title":"Preeclampsia and future implications on growth and body composition in preterm infants","volume":"16","author":"Calek","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.ejphar.2026.179004_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1022770","article-title":"Circulating concentrations of glycocalyx degradation products in preeclampsia","volume":"13","author":"Carlberg","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejphar.2026.179004_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpobgyn.2023.102437","article-title":"Pharmacogenomics of Preeclampsia therapies: current evidence and future challenges for clinical implementation","volume":"92","author":"Chaemsaithong","year":"2024","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.ejphar.2026.179004_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","article-title":"Pre-eclampsia","volume":"9","author":"Dimitriadis","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ejphar.2026.179004_bib6","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202502214RR","article-title":"Targeting NF-kappaB signaling pathway by Cryptotanshinone prevents preeclampsia-like symptoms: involvement of placental angiogenesis and oxidative stress","volume":"39","author":"Gao","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.ejphar.2026.179004_bib7","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1007\/s43032-022-00894-2","article-title":"The efficacy mechanism of epigallocatechin gallate against pre-eclampsia based on network pharmacology and molecular docking","volume":"29","author":"Gao","year":"2022","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.ejphar.2026.179004_bib8","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1128\/AAC.00344-08","article-title":"Limited inhibitory effects of oseltamivir and zanamivir on human sialidases","volume":"52","author":"Hata","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ejphar.2026.179004_bib9","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jacc.2020.08.014","article-title":"Preeclampsia-Pathophysiology and clinical presentations: JACC state-of-the-art review","volume":"76","author":"Ives","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ejphar.2026.179004_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1126\/science.1232552","article-title":"Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity","volume":"340","author":"Kim","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2026.179004_bib11","first-page":"3141","article-title":"Inhibition of nitric oxide synthase lowers fatty acid oxidation in preeclampsia-like mice at early gestational stage","volume":"124","author":"Ma","year":"2011","journal-title":"Chin. Med. J. (Engl. Ed.)"},{"key":"10.1016\/j.ejphar.2026.179004_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preghy.2020.04.002","article-title":"Relative impact of pre-eclampsia on birth weight in a low resource setting: a prospective cohort study","volume":"21","author":"Nakimuli","year":"2020","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.ejphar.2026.179004_bib13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ncpneph0035","article-title":"Mechanisms of disease: pre-eclampsia","volume":"1","author":"Noris","year":"2005","journal-title":"Nat. Clin. Pract. Nephrol."},{"key":"10.1016\/j.ejphar.2026.179004_bib14","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbrc.2007.01.137","article-title":"The role of endothelial glycocalyx components in mechanotransduction of fluid shear stress","volume":"355","author":"Pahakis","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ejphar.2026.179004_bib15","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00424-007-0212-8","article-title":"The endothelial glycocalyx: composition, functions, and visualization","volume":"454","author":"Reitsma","year":"2007","journal-title":"Pfl\u00fcgers Archiv"},{"key":"10.1016\/j.ejphar.2026.179004_bib16","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1177\/1933719116648218","article-title":"Pravastatin effects on placental prosurvival molecular pathways in a mouse model of preeclampsia","volume":"23","author":"Saad","year":"2016","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.ejphar.2026.179004_bib17","article-title":"A network pharmacology study on mechanism of resveratrol in treating preeclampsia via regulation of AGE-RAGE and HIF-1 signalling pathways","volume":"13","author":"Shi","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ejphar.2026.179004_bib18","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1189\/jlb.1209776","article-title":"LPS-induced cytokine production in human dendritic cells is regulated by sialidase activity","volume":"88","author":"Stamatos","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.ejphar.2026.179004_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0276232","article-title":"Glycocalyx degradation and the endotheliopathy of viral infection","volume":"17","author":"Taghavi","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2026.179004_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/frph.2025.1706009","article-title":"Global prevalence of preeclampsia, eclampsia, and HELLP syndrome: a systematic review and meta-analysis","volume":"7","author":"Vera-Ponce","year":"2025","journal-title":"Front. Reprod. Health"},{"key":"10.1016\/j.ejphar.2026.179004_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.681632","article-title":"Current state of preeclampsia mouse models: approaches, relevance, and standardization","volume":"12","author":"Waker","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ejphar.2026.179004_bib22","article-title":"Factors influencing glycocalyx degradation: a narrative review","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2026.179004_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.010647","article-title":"Early onset preeclampsia is associated with glycocalyx degradation and reduced microvascular perfusion","volume":"8","author":"Weissgerber","year":"2019","journal-title":"J. Am. Heart Assoc."},{"issue":"2020","key":"10.1016\/j.ejphar.2026.179004_bib24","article-title":"Vascular endothelial cell injury: causes, molecular mechanisms, and treatments","volume":"6","author":"Xia","year":"2025","journal-title":"MedComm"},{"key":"10.1016\/j.ejphar.2026.179004_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao5610","article-title":"Recurrent infection progressively disables host protection against intestinal inflammation","volume":"358","author":"Yang","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2026.179004_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1251876","article-title":"Endothelial cell activation and glycocalyx shedding - potential as biomarkers in patients with lupus nephritis","volume":"14","author":"Yung","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2026.179004_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.70284","article-title":"Study on the pathogenesis of preeclampsia and the mechanism of aspirin prevention by metabolomics","volume":"40","author":"Yutao","year":"2026","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.ejphar.2026.179004_bib28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41371-021-00568-7","article-title":"The preventive effects of aspirin on preeclampsia based on network pharmacology and bioinformatics","volume":"36","author":"Zhang","year":"2022","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.ejphar.2026.179004_bib29","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/jum.14380","article-title":"Systemic evaluation of vascular dysfunction by high-resolution sonography in an n(omega) -Nitro-l-Arginine methyl ester hydrochloride-induced mouse model of preeclampsia-like symptoms","volume":"37","author":"Zhao","year":"2018","journal-title":"J. Ultrasound Med."},{"key":"10.1016\/j.ejphar.2026.179004_bib30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s12884-021-03650-7","article-title":"Vagus nerve stimulation ameliorates L-NAME-induced preeclampsia-like symptoms in rats through inhibition of the inflammatory response","volume":"21","author":"Zheng","year":"2021","journal-title":"BMC Pregnancy Childbirth"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926004863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926004863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T20:23:56Z","timestamp":1781036636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926004863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":30,"alternative-id":["S0014299926004863"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179004","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic effects of zanamivir against L-NAME-induced preeclampsia in mice and network pharmacology analysis","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"179004"}}