{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:30:40Z","timestamp":1791196240360,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2022GXNSFBA035652"],"award-info":[{"award-number":["2022GXNSFBA035652"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["AD23026062"],"award-info":[{"award-number":["AD23026062"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2026GXNSFAA00640057"],"award-info":[{"award-number":["2026GXNSFAA00640057"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304582"],"award-info":[{"award-number":["82304582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260724"],"award-info":[{"award-number":["82260724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ejphar.2026.179007","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:08:55Z","timestamp":1779376135000},"page":"179007","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Connexin32 inhibits renal tubulointerstitial fibrosis in diabetic kidney disease by regulating NOX4\/MRTF-A positive feedback loop"],"prefix":"10.1016","volume":"1029","author":[{"given":"Dezhe","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqi","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiudong","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guitian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiquan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.179007_bib1","article-title":"Protein-bound uremic toxin clearance as biomarker of kidney tubular function in diabetic kidney disease","volume":"15","author":"Ahmed","year":"2025","journal-title":"Sci Rep-Uk"},{"key":"10.1016\/j.ejphar.2026.179007_bib3","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.4103\/1673-5374.390973","article-title":"NADPH oxidase 4 (NOX4) as a biomarker and therapeutic target in neurodegenerative diseases","volume":"19","author":"Boonpraman","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ejphar.2026.179007_bib4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mce.2017.07.014","article-title":"MRTF-A mediated FN and ICAM-1 expression in AGEs-induced rat glomerular mesangial cells via activating STAT5","volume":"460","author":"Chen","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ejphar.2026.179007_bib5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bcp.2017.12.002","article-title":"CK2\u03b1 promotes advanced glycation end products-induced expressions of fibronectin and intercellular adhesion molecule-1 via activating MRTF-A in glomerular mesangial cells","volume":"148","author":"Chen","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179007_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/bph.14853","article-title":"Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation","volume":"177","author":"Chen","year":"2020","journal-title":"Brit J Pharmacol"},{"key":"10.1016\/j.ejphar.2026.179007_bib7","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1038\/s41401-020-0475-6","article-title":"Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway","volume":"41","author":"Chen","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2026.179007_bib8","doi-asserted-by":"crossref","first-page":"17444","DOI":"10.1021\/acs.jafc.4c04183","article-title":"Diosgenin reduces acute kidney injury and ameliorates the progression to chronic kidney disease by modifying the NOX4\/p65 signaling pathways","volume":"72","author":"Chiang","year":"2024","journal-title":"J Agr Food Chem"},{"key":"10.1016\/j.ejphar.2026.179007_bib9","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41581-021-00393-8","article-title":"Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors","volume":"17","author":"DeFronzo","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ejphar.2026.179007_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.408","article-title":"A folate\/RGD-dual-functionalized mesoporous silica nanoparticles targeting GABA-p38 MAPK-MRTFs\/SRF signaling pathway in rheumatoid arthritis","volume":"11","author":"Deng","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.ejphar.2026.179007_bib11","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.7150\/ijbs.75891","article-title":"Erratum: Cx43 deficiency confers EMT-mediated tamoxifen resistance to breast cancer via c-Src\/PI3K\/Akt pathway: erratum","volume":"18","author":"DengPan","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ejphar.2026.179007_bib12","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ajpath.2012.10.009","article-title":"Characterization and role of SCAI during renal fibrosis and epithelial-to-mesenchymal transition","volume":"182","author":"Fintha","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ejphar.2026.179007_bib13","doi-asserted-by":"crossref","first-page":"103078","DOI":"10.1016\/j.redox.2024.103078","article-title":"DRD4 alleviates acute kidney injury by suppressing ISG15\/NOX4 axis-associated oxidative stress","volume":"70","author":"Gao","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2026.179007_bib14","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s00424-021-02608-0","article-title":"Connexin mRNA distribution in adult mouse kidneys","volume":"473","author":"Geis","year":"2021","journal-title":"Pfl\u00fcgers Archiv - European Journal of Physiology"},{"key":"10.1016\/j.ejphar.2026.179007_bib15","doi-asserted-by":"crossref","first-page":"107299","DOI":"10.1016\/j.nbd.2026.107299","article-title":"Patient-derived neural organoids reveal developmental impairments associated with a novel GJB1 mutation in X-linked Charcot-Marie-Tooth disease","volume":"220","author":"Guo","year":"2026","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2026.179007_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00125-014-3427-1","article-title":"Mind the gap: connexins and cell-cell communication in the diabetic kidney","volume":"58","author":"Hills","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.ejphar.2026.179007_bib17","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.3390\/ijms23052702","article-title":"NADPH oxidase 4 (NOX4) in cancer: linking redox signals to oncogenic metabolic adaptation","volume":"23","author":"Ildiko","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.179007_bib18","doi-asserted-by":"crossref","DOI":"10.1242\/dev.204681","article-title":"Myocardin-related transcription factor regulates actomyosin contractility and apical junction remodeling during vertebrate neural tube closure","volume":"152","author":"Itoh","year":"2025","journal-title":"Development"},{"key":"10.1016\/j.ejphar.2026.179007_bib19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41392-025-02527-x","article-title":"Hypoglycemia induces brain metabolic reprogramming and neurodegeneration via serum response factor and myocardin-related transcription factor-A","volume":"10","author":"Jang","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejphar.2026.179007_bib20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13287-024-03678-4","article-title":"Human umbilical cord\/placenta mesenchymal stem cell conditioned medium attenuates intestinal fibrosis in vivo and in vitro","volume":"15","author":"Jeong","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2026.179007_bib21","first-page":"1","article-title":"The mutual interplay of redox signaling and connexins","volume":"99","author":"Kai","year":"2021","journal-title":"Journal of molecular medicine (Berlin, Germany)"},{"key":"10.1016\/j.ejphar.2026.179007_bib23","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2119\/molmed.2016.00041","article-title":"RhoA\/ROCK signaling regulates TGF\u03b2-Induced epithelial-mesenchymal transition of lens epithelial cells through MRTF-A","volume":"22","author":"Korol","year":"2016","journal-title":"Molecular Medicine"},{"key":"10.1016\/j.ejphar.2026.179007_bib22","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.3390\/ijms27052152","article-title":"Connexin 43 and pannexin 1 in renal cell populations in diabetic kidney disease","volume":"27","author":"Kor\u010dulanin","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.179007_bib24","doi-asserted-by":"crossref","first-page":"7886","DOI":"10.1038\/s41467-022-35639-x","article-title":"Actin-microtubule cytoskeletal interplay mediated by MRTF-A\/SRF signaling promotes dilated cardiomyopathy caused by mutations","volume":"13","author":"Le Dour","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ejphar.2026.179007_bib25","article-title":"Redox-Sensitive regulation of Myocardin-Related transcription factor (MRTF-A) phosphorylation via Palladin in vascular smooth muscle cell differentiation marker gene expression","volume":"11","author":"Lee","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2026.179007_bib26","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1089\/ars.2022.0108","article-title":"Connexin32 promotes the activation of Foxo3a to ameliorate diabetic nephropathy inhibiting the polyubiquitination and degradation of Sirt1","volume":"39","author":"Li","year":"2023","journal-title":"Antioxid Redox Sign"},{"key":"10.1016\/j.ejphar.2026.179007_bib27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbrc.2022.03.111","article-title":"Glis2 inhibits the epithelial-mesenchymal transition and apoptosis of renal tubule cells by regulating the \u03b2-catenin signalling pathway in diabetic kidney disease","volume":"607","author":"Lifang","year":"2022","journal-title":"Biochem Bioph Res Co"},{"key":"10.1016\/j.ejphar.2026.179007_bib28","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.4103\/NRR.NRR-D-23-01265","article-title":"NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation","volume":"20","author":"Lin","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.ejphar.2026.179007_bib30","article-title":"Cinobufotalin inhibits proliferation, migration and invasion in hepatocellular carcinoma by triggering NOX4\/NLRP3\/GSDMD-dependent pyroptosis","volume":"14","author":"Liu","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.ejphar.2026.179007_bib29","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1016\/j.bbadis.2018.05.026","article-title":"Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production","volume":"1864","author":"Liu","year":"2018","journal-title":"Bba-Mol Basis Dis"},{"key":"10.1016\/j.ejphar.2026.179007_bib31","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s00018-026-06176-3","article-title":"Renal fibrosis is induced by hyperactive Wnt\/\u03b2-catenin pathway via microbial-mediated tryptophan metabolism-driven AhR signaling in rodents and humans","volume":"83","author":"Liu","year":"2026","journal-title":"Cell. Mol. Life Sci. : CMLS"},{"key":"10.1016\/j.ejphar.2026.179007_bib33","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1097\/JS9.0000000000002337","article-title":"Neutrophil membrane-engineered Panax ginseng root-derived exosomes loaded miRNA 182-5p targets NOX4\/Drp-1\/NLRP3 signal pathway to alleviate acute lung injury in sepsis: experimental studies (vol 110, pg 72, 2024)","volume":"111","author":"Ma","year":"2025","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.ejphar.2026.179007_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/IMNA-D-24-00018","article-title":"New insights into the use of traditional Chinese medicine for treating diabetic kidney disease by regulating DNA methylation","volume":"11","author":"Ma","year":"2024","journal-title":"Integr Med Nephrol Androl"},{"key":"10.1016\/j.ejphar.2026.179007_bib34","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1002\/jcp.29356","article-title":"MKL1 mediates TGF-\u03b2-induced CTGF transcription to promote renal fibrosis","volume":"235","author":"Mao","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2026.179007_bib35","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.2337\/dci23-0030","article-title":"Diabetic nephropathy: update on pillars of therapy slowing progression","volume":"46","author":"Naaman","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ejphar.2026.179007_bib36","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s13287-025-04393-4","article-title":"Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes","volume":"16","author":"O'Neill","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ejphar.2026.179007_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.15460","article-title":"Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity","volume":"5","author":"Panayiotou","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.ejphar.2026.179007_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101947","article-title":"NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases","volume":"41","author":"Park","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2026.179007_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177289","article-title":"Hirsutine mitigates ferroptosis in podocytes of diabetic kidney disease by downregulating the p53\/GPX4 signaling pathway","volume":"991","author":"Pei","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179007_bib40","article-title":"Early growth response factor 1 upregulates pro-fibrotic genes through activation of TGF-\u03b21\/Smad pathway via transcriptional regulation of PAR1 in high-glucose treated HK-2 cells","volume":"572","author":"Ping","year":"2023","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ejphar.2026.179007_bib41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12964-025-02335-4","article-title":"The gut-heart axis: a correlation between Paneth cells' dysfunction, microbiome dysbiosis, and cardiovascular diseases","volume":"23","author":"Rezabakhsh","year":"2025","journal-title":"Cell Commun. Signal. : CCS"},{"key":"10.1016\/j.ejphar.2026.179007_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1423279","article-title":"LncRNAs in oncogenic microenvironment: from threat to therapy","volume":"12","author":"Roy","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.ejphar.2026.179007_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106084","article-title":"Connexin32 ameliorates epithelial-to-mesenchymal-transition in diabetic renal tubular via inhibiting NOX4","volume":"176","author":"Sun","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2026.179007_bib44","first-page":"1","article-title":"Novel therapeutic target for diabetic kidney disease through downregulation of miRNA-192-5p and miRNA-21-5p by celastrol: implication of autophagy, oxidative stress, and fibrosis","volume":"398","author":"Tantawy","year":"2024","journal-title":"N. Schmied. Arch. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179007_bib45","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41581-024-00827-z","article-title":"Combination therapy for kidney disease in people with diabetes mellitus","volume":"20","author":"van Raalte","year":"2024","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.ejphar.2026.179007_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113965","article-title":"Therapeutic potential of pro-resolving mediators in diabetic kidney disease","volume":"178","author":"Vartak","year":"2021","journal-title":"Adv Drug Deliver Rev"},{"key":"10.1016\/j.ejphar.2026.179007_bib47","first-page":"1","article-title":"Mechanism of astragaloside IV in treatment of renal tubulointerstitial fibrosis","volume":"31","author":"Wang","year":"2024","journal-title":"Chin. J. Integr. Med."},{"key":"10.1016\/j.ejphar.2026.179007_bib49","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.freeradbiomed.2025.09.057","article-title":"MiRNA-27a-5p alleviates diabetic vascular injury via modulating autophagy by targeting NOX4","volume":"241","author":"Wang","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2026.179007_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41401-025-01598-4","article-title":"Acteoside-containing caffeic acid is bioactive functional group of antifibrotic effect by suppressing inflammation via inhibiting AHR nuclear translocation in chronic kidney disease","volume":"46","author":"Wang","year":"2025","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2026.179007_bib48","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1002\/ptr.8324","article-title":"Geniposidic acid attenuates chronic tubulointerstitial nephropathy through regulation of the NF-\u0199B\/Nrf2 pathway via Aryl Hydrocarbon receptor signaling","volume":"38","author":"Wang","year":"2024","journal-title":"Phytother Res. : PTR"},{"key":"10.1016\/j.ejphar.2026.179007_bib51","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.yexcr.2017.08.023","article-title":"MRTF-A-miR-206-WDR1 form feedback loop to regulate breast cancer cell migration","volume":"359","author":"Xiang","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ejphar.2026.179007_bib52","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1111\/cas.14994","article-title":"Connexin32 activates necroptosis through src\u2010mediated inhibition of caspase 8 in hepatocellular carcinoma","volume":"112","author":"Xiang","year":"2021","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ejphar.2026.179007_bib53","article-title":"USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells","volume":"188","author":"Xiao-hong","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179007_bib54","article-title":"Discovery of PRDM16-Mediated TRPA1 induction as the mechanism for low tubulo-interstitial fibrosis in diabetic kidney disease","volume":"11","author":"Xu","year":"2024","journal-title":"Adv Sci"},{"key":"10.1016\/j.ejphar.2026.179007_bib56","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1111\/odi.14611","article-title":"MRTF\u2010A\/SRF signaling suppresses invasion of oral squamous cell carcinoma","volume":"30","author":"Yang","year":"2023","journal-title":"Oral Dis."},{"key":"10.1016\/j.ejphar.2026.179007_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105333","article-title":"CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes","volume":"163","author":"Yang","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2026.179007_bib57","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1161\/CIRCULATIONAHA.118.035377","article-title":"Megakaryocytic leukemia 1 bridges epigenetic activation of NADPH oxidase in macrophages to cardiac ischemia-reperfusion injury","volume":"138","author":"Yu","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.ejphar.2026.179007_bib58","article-title":"Myocardin-related transcription factor contributes to renal fibrosis through the regulation of extracellular microenvironment surrounding fibroblasts","volume":"37","author":"Yuta","year":"2023","journal-title":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.ejphar.2026.179007_bib59","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.freeradbiomed.2017.12.031","article-title":"Interaction between p22 phox and Nox4 in the endoplasmic reticulum suggests a unique mechanism of NADPH oxidase complex formation","volume":"116","author":"Zana","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ejphar.2026.179007_bib60","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1177\/09603271211002886","article-title":"Therapeutic effects of myocardin-related transcription factor A (MRTF-A) knockout on experimental mice with nonalcoholic steatohepatitis induced by high-fat diet","volume":"40","author":"Zhang","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.ejphar.2026.179007_bib61","doi-asserted-by":"crossref","first-page":"11990","DOI":"10.1039\/D4FO03564J","article-title":"Quercetin prevents the USP22-Snail1 signaling pathway to ameliorate diabetic tubulointerstitial fibrosis","volume":"15","author":"Zhao","year":"2024","journal-title":"Food Funct."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926004899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926004899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:12:08Z","timestamp":1784808728000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926004899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":60,"alternative-id":["S0014299926004899"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179007","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Connexin32 inhibits renal tubulointerstitial fibrosis in diabetic kidney disease by regulating NOX4\/MRTF-A positive feedback loop","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"179007"}}