{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:43:01Z","timestamp":1786236181867,"version":"build-2736575974"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ40935"],"award-info":[{"award-number":["2023JJ40935"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30832"],"award-info":[{"award-number":["2023JJ30832"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301756"],"award-info":[{"award-number":["82301756"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M733947"],"award-info":[{"award-number":["2023M733947"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M772383"],"award-info":[{"award-number":["2025M772383"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.ejphar.2026.179133","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:56:11Z","timestamp":1783626971000},"page":"179133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Bazedoxifene attenuates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome activation of macrophages in mice"],"prefix":"10.1016","volume":"1030","author":[{"given":"Hai-Yan","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Xi","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan-Shi-Yu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cha-Xiang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3930-6846","authenticated-orcid":false,"given":"Ren","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.179133_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104736","article-title":"Acute lung injury: the therapeutic role of Rho kinase inhibitors","volume":"155","author":"Abedi","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2026.179133_bib2","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/s41423-022-00922-w","article-title":"How location and cellular signaling combine to activate the NLRP3 inflammasome","volume":"19","author":"Akbal","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.ejphar.2026.179133_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2826.2011.02156.x","article-title":"Selective oestrogen receptor modulators decrease the inflammatory response of glial cells","volume":"24","author":"Arevalo","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ejphar.2026.179133_bib4","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1056\/NEJMp1706595","article-title":"Acute lung failure - our evolving understanding of ARDS","volume":"377","author":"Bernard","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2026.179133_bib5","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(22)01485-4","article-title":"Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes","volume":"400","author":"Bos","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2026.179133_bib6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial dynamics and its involvement in disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.ejphar.2026.179133_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189911","article-title":"Bazedoxifene and conjugated estrogen combination maintains metabolic homeostasis and benefits liver health","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2026.179133_bib8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41419-024-06473-4","article-title":"HECTD3 inhibits NLRP3 inflammasome assembly and activation by blocking NLRP3-NEK7 interaction","volume":"15","author":"Cheng","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ejphar.2026.179133_bib9","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/s12276-023-01019-8","article-title":"TXNIP: a key protein in the cellular stress response pathway and a potential therapeutic target","volume":"55","author":"Choi","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ejphar.2026.179133_bib10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tips.2022.04.003","article-title":"NLRP3 and pyroptosis blockers for treating inflammatory diseases","volume":"43","author":"Coll","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ejphar.2026.179133_bib11","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.2165\/11207420-000000000-00000","article-title":"Bazedoxifene: a review of its use in the treatment of postmenopausal osteoporosis","volume":"71","author":"Duggan","year":"2011","journal-title":"Drugs"},{"key":"10.1016\/j.ejphar.2026.179133_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2026.179133_bib13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","article-title":"The cell biology of mitochondrial membrane dynamics","volume":"21","author":"Giacomello","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2026.179133_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/cells11192953","article-title":"Macrophage-mediated inflammation in skin wound healing","volume":"11","author":"Hassanshahi","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2026.179133_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.addr.2019.12.001","article-title":"Drug delivery to macrophages: a review of targeting drugs and drug carriers to macrophages for inflammatory diseases","volume":"165\u2013166","author":"He","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ejphar.2026.179133_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112408","article-title":"Baicalein suppresses lipopolysaccharide-induced acute lung injury by regulating Drp1-dependent mitochondrial fission of macrophages","volume":"145","author":"Jiang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2026.179133_bib17","article-title":"IL-6\/STAT3 signaling promotes cardiac dysfunction by upregulating FUNDC1-Dependent mitochondria-associated endoplasmic reticulum membranes formation in sepsis mice","volume":"8","author":"Jiang","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ejphar.2026.179133_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31442","article-title":"MEOX1 triggers myofibroblast apoptosis resistance, contributing to pulmonary fibrosis in mice","author":"Jin","year":"2024","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2026.179133_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154545","article-title":"Xuanfei Baidu formula alleviates impaired mitochondrial dynamics and activated NLRP3 inflammasome by repressing NF-\u03baB and MAPK pathways in LPS-induced ALI and inflammation models","volume":"108","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2026.179133_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113821","article-title":"Unraveling the priming phase of NLRP3 inflammasome activation: molecular insights and clinical relevance","volume":"146","author":"Liao","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2026.179133_bib21","article-title":"Advances in the use of exosomes for the treatment of ALI\/ARDS","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2026.179133_bib22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s11658-020-00205-0","article-title":"Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis","volume":"25","author":"Liu","year":"2020","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.ejphar.2026.179133_bib23","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s10753-021-01581-1","article-title":"Emodin attenuates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-dependent pyroptosis signaling pathway in vitro and in vivo","volume":"45","author":"Liu","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.ejphar.2026.179133_bib24","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1042\/CS20210879","article-title":"Pathogenesis of pneumonia and acute lung injury","volume":"136","author":"Long","year":"2022","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.ejphar.2026.179133_bib25","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1136\/thoraxjnl-2020-216296","article-title":"Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease","volume":"77","author":"Lugg","year":"2022","journal-title":"Thorax"},{"key":"10.1016\/j.ejphar.2026.179133_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173822","article-title":"Bazedoxifene exhibits anti-inflammation and anti-atherosclerotic effects via inhibition of IL-6\/IL-6R\/STAT3 signaling","volume":"893","author":"Luo","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179133_bib27","doi-asserted-by":"crossref","first-page":"9910","DOI":"10.1002\/jcp.29806","article-title":"Epoxyeicosatrienoic acids inhibit the activation of NLRP3 inflammasome in murine macrophages","volume":"235","author":"Luo","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ejphar.2026.179133_bib28","doi-asserted-by":"crossref","DOI":"10.1172\/JCI170501","article-title":"Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting","volume":"133","author":"Malainou","year":"2023","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.ejphar.2026.179133_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116476","article-title":"Reduced FNDC5-AMPK signaling in diabetic atrium increases the susceptibility of atrial fibrillation by impairing mitochondrial dynamics and activating NLRP3 inflammasome","volume":"229","author":"Meng","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179133_bib30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tox.2017.07.019","article-title":"Mitochondrial fusion, fission, and mitochondrial toxicity","volume":"391","author":"Meyer","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2026.179133_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpsurg.2020.100777","article-title":"Acute lung injury","volume":"57","author":"Mowery","year":"2020","journal-title":"Curr. Probl. Surg."},{"key":"10.1016\/j.ejphar.2026.179133_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/antiox14111276","article-title":"cGAS-STING-NF-\u03baB axis mediates rotenone-induced NLRP3 inflammasome activation through mitochondrial DNA release","volume":"14","author":"Mun","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.ejphar.2026.179133_bib33","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.immuni.2013.05.016","article-title":"K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter","volume":"38","author":"Mu\u00f1oz-Planillo","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.ejphar.2026.179133_bib34","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00124-20","article-title":"Bazedoxifene suppresses intracellular Mycobacterium tuberculosis growth by enhancing autophagy","volume":"5","author":"Ouyang","year":"2020","journal-title":"mSphere"},{"key":"10.1016\/j.ejphar.2026.179133_bib35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/d41586-021-00979-z","article-title":"A molecular connection hints at how a genetic risk factor drives Crohn's disease","volume":"593","author":"Plevy","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.179133_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107594","article-title":"New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology","volume":"213","author":"Rosdah","year":"2020","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2026.179133_bib37","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.7150\/ijbs.99456","article-title":"Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice","volume":"20","author":"Sha","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ejphar.2026.179133_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101954","article-title":"Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a\/HO-1 signaling pathway","volume":"41","author":"Shi","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.ejphar.2026.179133_bib39","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1111\/jcmm.15147","article-title":"Inhibition of Interleukin-6\/glycoprotein 130 signalling by Bazedoxifene ameliorates cardiac remodelling in pressure overload mice","volume":"24","author":"Shi","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.ejphar.2026.179133_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110751","article-title":"Bezafibrate attenuates acute lung injury by preserving mitochondrial dynamics equilibrium in pulmonary epithelial cells","volume":"123","author":"Song","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2026.179133_bib41","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1136\/thoraxjnl-2015-208032","article-title":"Alveolar macrophage-derived microvesicles mediate acute lung injury","volume":"71","author":"Soni","year":"2016","journal-title":"Thorax"},{"key":"10.1016\/j.ejphar.2026.179133_bib42","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1097\/SHK.0000000000002206","article-title":"Promoting mitochondrial dynamic equilibrium attenuates sepsis-induced acute lung injury by inhibiting proinflammatory polarization of alveolar macrophages","volume":"60","author":"Sun","year":"2023","journal-title":"Shock"},{"key":"10.1016\/j.ejphar.2026.179133_bib43","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2026.179133_bib44","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial dynamics: overview of molecular mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem."},{"key":"10.1016\/j.ejphar.2026.179133_bib45","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1161\/CIRCRESAHA.123.322512","article-title":"Distinct roles of DRP1 in conventional and alternative mitophagy in obesity cardiomyopathy","volume":"133","author":"Tong","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.ejphar.2026.179133_bib46","first-page":"1388","article-title":"[Acetaldehyde dehydrogenase 2 ameliorates lung endothelial barrier and balances mitochondrial dynamics in mice with acute lung injury]","volume":"43","author":"Wang","year":"2023","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.ejphar.2026.179133_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106083","article-title":"Xuanfei Baidu decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1\/IL17A pathway","volume":"176","author":"Wang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2026.179133_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.946832","article-title":"Macrophage autophagy in macrophage polarization, chronic inflammation and organ fibrosis","volume":"13","author":"Wen","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2026.179133_bib49","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s42255-024-00978-0","article-title":"Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation","volume":"6","author":"Xia","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.ejphar.2026.179133_bib50","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1038\/s41418-022-00947-8","article-title":"Ubiquitination of NLRP3 by gp78\/Insig-1 restrains NLRP3 inflammasome activation","volume":"29","author":"Xu","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ejphar.2026.179133_bib51","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.7150\/thno.43108","article-title":"A COX-2\/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.ejphar.2026.179133_bib52","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.7150\/ijbs.91543","article-title":"mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice","volume":"20","author":"Yang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ejphar.2026.179133_bib53","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1080\/14656566.2019.1615882","article-title":"Bazedoxifene for the treatment of osteoporosis","volume":"20","author":"Yavropoulou","year":"2019","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.ejphar.2026.179133_bib54","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1097\/PCC.0000000000003161","article-title":"Definition, incidence, and epidemiology of pediatric acute respiratory distress syndrome: from the second pediatric acute lung injury consensus conference","volume":"24","author":"Yehya","year":"2023","journal-title":"Pediatr. Crit. Care Med."},{"key":"10.1016\/j.ejphar.2026.179133_bib55","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1186\/s12964-024-01946-7","article-title":"Cadmium exposure triggers alveolar epithelial cell pyroptosis by inducing mitochondrial oxidative stress and activating the cGAS-STING pathway","volume":"22","author":"Zhang","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.ejphar.2026.179133_bib56","doi-asserted-by":"crossref","DOI":"10.1155\/mi\/3675276","article-title":"Mdivi-1 attenuates sepsis-associated acute lung injury by inhibiting M1 alveolar macrophage polarization and pyroptosis","volume":"2025","author":"Zhang","year":"2025","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ejphar.2026.179133_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175681","article-title":"Bazedoxifene attenuates intestinal injury in sepsis by suppressing the NF-\u03baB\/NLRP3 signaling pathways","volume":"947","author":"Zhang","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179133_bib58","doi-asserted-by":"crossref","first-page":"242","DOI":"10.7150\/ijbs.77304","article-title":"TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury","volume":"19","author":"Zhong","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ejphar.2026.179133_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135351","article-title":"Kr\u00fcppel-like transcription factor 14 alleviates alveolar epithelial cell senescence by inhibiting endoplasmic reticulum stress in pulmonary fibrosis","volume":"280","author":"Zhong","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ejphar.2026.179133_bib60","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12967-023-04027-4","article-title":"TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury","volume":"21","author":"Zhong","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ejphar.2026.179133_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109596","article-title":"Vasoactive intestinal peptide suppresses the NLRP3 inflammasome activation in lipopolysaccharide-induced acute lung injury mice and macrophages","volume":"121","author":"Zhou","year":"2020","journal-title":"Biomed. Pharmacother."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926006151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926006151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:26:46Z","timestamp":1786235206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926006151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":61,"alternative-id":["S0014299926006151"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179133","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bazedoxifene attenuates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome activation of macrophages in mice","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"179133"}}