{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:48:22Z","timestamp":1786654102050,"version":"build-2736575974"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371519"],"award-info":[{"award-number":["82371519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071519"],"award-info":[{"award-number":["82071519"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.ejphar.2026.179170","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:32:17Z","timestamp":1784763137000},"page":"179170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The pan-salt-inducible kinase inhibitor YKL-06-061 exerts antidepressant-like effects via hippocampal CRTC1\u2013CREB\u2013BDNF pathway activation in chronic stress models"],"prefix":"10.1016","volume":"1031","author":[{"given":"Feng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Jie","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Lun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-Yang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Yan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.179170_bib1","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.2174\/138161209788168047","article-title":"New antidepressant drugs: beyond monoaminergic mechanisms","volume":"15","author":"Alamo","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ejphar.2026.179170_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrm3072","article-title":"CREB and the CRTC co-activators: sensors for hormonal and metabolic signals","volume":"12","author":"Altarejos","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ejphar.2026.179170_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuropharm.2015.10.034","article-title":"BDNF - a key transducer of antidepressant effects","volume":"102","author":"Bjorkholm","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2026.179170_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.115325","article-title":"Depression diagnosis: EEG-based cognitive biomarkers and machine learning","volume":"478","author":"Boby","year":"2025","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2026.179170_bib5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-981-33-6044-0_10","article-title":"Neurogenesis and neuroplasticity in major depression: its therapeutic implication","volume":"1305","author":"Bourin","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ejphar.2026.179170_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/hup.178","article-title":"How valuable are animal models in defining antidepressant activity?","volume":"16","author":"Bourin","year":"2001","journal-title":"Hum. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biopsych.2021.05.008","article-title":"Brain-Derived neurotrophic factor signaling in depression and antidepressant action","volume":"90","author":"Castren","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.179170_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2024.173820","article-title":"Hippocampal SorCS2 overexpression represses chronic stress-induced depressive-like behaviors by promoting the BDNF-TrkB system","volume":"242","author":"Chen","year":"2024","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2026.179170_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115097","article-title":"Hippocampal F3\/Contactin plays a role in chronic stress-induced depressive-like effects and the antidepressant actions of vortioxetine in mice","volume":"202","author":"Chen","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.pnpbp.2012.05.018","article-title":"Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex","volume":"39","author":"Chiba","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.179170_bib11","first-page":"651","article-title":"Current understanding of the neurobiology of major depressive disorder","volume":"56","author":"Chirita","year":"2015","journal-title":"Rom. J. Morphol. Embryol."},{"key":"10.1016\/j.ejphar.2026.179170_bib12","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0140-6736(17)32802-7","article-title":"Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis","volume":"391","author":"Cipriani","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2026.179170_bib13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41392-024-01738-y","article-title":"Major depressive disorder: hypothesis, mechanism, prevention and treatment","volume":"9","author":"Cui","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejphar.2026.179170_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bcp.2015.03.011","article-title":"Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs","volume":"95","author":"Dale","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ajp.2017.01.025","article-title":"The neurobiology of depression: an integrated view","volume":"27","author":"Dean","year":"2017","journal-title":"Asian J. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.179170_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2021.110351","article-title":"Shared metabolic and neuroimmune mechanisms underlying type 2 diabetes Mellitus and major depressive disorder","volume":"111","author":"Duarte-Silva","year":"2021","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.179170_bib17","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1126\/science.1222939","article-title":"Synaptic dysfunction in depression: potential therapeutic targets","volume":"338","author":"Duman","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2026.179170_bib18","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1523\/JNEUROSCI.0367-19.2019","article-title":"CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons","volume":"40","author":"Esvald","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179170_bib19","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1007\/s12035-015-9152-z","article-title":"Revisiting the serotonin hypothesis: implications for major depressive disorders","volume":"53","author":"Fakhoury","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ejphar.2026.179170_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11020249","article-title":"Increasing adiponectin signaling by sub-chronic AdipoRon treatment elicits Antidepressant- and anxiolytic-like effects independent of changes in hippocampal plasticity","volume":"11","author":"Formolo","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2026.179170_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135994","article-title":"Xanthoceraside administration produces significant antidepressant effects in mice through activation of the hippocampal BDNF signaling pathway","volume":"757","author":"Guan","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2026.179170_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105932","article-title":"Hippocampal miR-206-3p participates in the pathogenesis of depression via regulating the expression of BDNF","volume":"174","author":"Guan","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2026.179170_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1037\/a0038550","article-title":"A brief history of the development of antidepressant drugs: from monoamines to glutamate","volume":"23","author":"Hillhouse","year":"2015","journal-title":"Exp. Clin. Psychopharmacol"},{"key":"10.1016\/j.ejphar.2026.179170_bib24","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1176\/foc.8.4.foc488","article-title":"Advances in the management of treatment-resistant depression","volume":"8","author":"Holtzheimer","year":"2010","journal-title":"Focus"},{"key":"10.1016\/j.ejphar.2026.179170_bib25","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s40263-016-0376-x","article-title":"Brivaracetam: a review in partial-onset (Focal) seizures in patients with epilepsy","volume":"30","author":"Hoy","year":"2016","journal-title":"CNS Drugs"},{"key":"10.1016\/j.ejphar.2026.179170_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153412","article-title":"Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe(-\/-)mice: role of SIRT1","volume":"81","author":"Hua","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ejphar.2026.179170_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106123","article-title":"Oroxylin A inhibits carcinogen-induced skin tumorigenesis through inhibition of inflammation by regulating SHCBP1 in mice","volume":"80","author":"Huang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuropharm.2019.05.013","article-title":"The protective effects of Ghrelin\/GHSR on hippocampal neurogenesis in CUMS mice","volume":"155","author":"Huang","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2026.179170_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109437","article-title":"The salt-inducible kinases inhibitor HG-9-91-01 exhibits antidepressant-like actions in mice exposed to chronic unpredictable mild stress","volume":"227","author":"Huang","year":"2023","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2026.179170_bib30","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.biopsych.2018.10.004","article-title":"Hippocampal salt-inducible kinase 2 plays a role in depression via the CREB-regulated transcription coactivator 1-cAMP response element binding-brain-derived neurotrophic factor pathway","volume":"85","author":"Jiang","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.179170_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/bph.13668","article-title":"Antidepressant-like effects of fenofibrate in mice via the hippocampal brain-derived neurotrophic factor signalling pathway","volume":"174","author":"Jiang","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib32","article-title":"Ferrostatin-1 ameliorates liver dysfunction via reducing iron in thioacetamide-induced acute liver injury in mice","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ph16081152","article-title":"Gypenoside-14 reduces depression via downregulation of the nuclear factor kappa B (NF-kB) signaling pathway on the lipopolysaccharide (LPS)-induced depression model","volume":"16","author":"Jiang","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ejphar.2026.179170_bib34","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: reporting in vivo experiments: the ARRIVE guidelines","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib35","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.179170_bib36","first-page":"3","article-title":"The increasing burden of depression","volume":"7","author":"Lepine","year":"2011","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"10.1016\/j.ejphar.2026.179170_bib37","first-page":"1322","article-title":"Botulinum neurotoxin A ameliorates depressive-like behavior in a reserpine-induced Parkinson's disease mouse model via suppressing hippocampal microglial engulfment and neuroinflammation","volume":"44","author":"Li","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ejphar.2026.179170_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.113038","article-title":"Antidepressant-like activity of L-701324 in mice: a behavioral and neurobiological characterization","volume":"399","author":"Liu","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2026.179170_bib39","article-title":"The selective SIK2 inhibitor ARN-3236 produces strong antidepressant-like efficacy in mice via the hippocampal CRTC1-CREB-BDNF pathway","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib40","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1001\/jamapsychiatry.2013.1985","article-title":"The experience of symptoms of depression in men vs women: analysis of the national comorbidity survey replication","volume":"70","author":"Martin","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.ejphar.2026.179170_bib41","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1111\/bph.12955","article-title":"Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP","volume":"172","author":"McGrath","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib42","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuroscience.2015.05.053","article-title":"Pathogenesis of depression: insights from human and rodent studies","volume":"321","author":"Menard","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2026.179170_bib43","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1750-1326-6-85","article-title":"Adult hippocampal neurogenesis and its role in Alzheimer's disease","volume":"6","author":"Mu","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ejphar.2026.179170_bib44","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.celrep.2017.05.042","article-title":"A UV-Independent topical small-molecule approach for melanin production in human skin","volume":"19","author":"Mujahid","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2026.179170_bib45","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fnmol.2015.00046","article-title":"A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis","volume":"8","author":"Ortega-Martinez","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179170_bib46","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21031170","article-title":"BDNF as a promising therapeutic agent in Parkinson's Disease","volume":"21","author":"Palasz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.179170_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.3305","article-title":"Blocking salt-inducible kinases with YKL-06-061 prevents PTZ-induced seizures in mice","volume":"13","author":"Peng","year":"2023","journal-title":"Brain Behav"},{"key":"10.1016\/j.ejphar.2026.179170_bib48","first-page":"37","article-title":"Serotonin norepinephrine reuptake inhibitors: a pharmacological comparison","volume":"11","author":"Sansone","year":"2014","journal-title":"Innov Clin Neurosci"},{"key":"10.1016\/j.ejphar.2026.179170_bib49","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.neuron.2010.12.004","article-title":"SIK2 is a key regulator for neuronal survival after ischemia via TORC1-CREB","volume":"69","author":"Sasaki","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2026.179170_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113463","article-title":"Hypoxic ADSC-derived exosomes enhance wound healing in diabetic mice via delivery of circ-Snhg11 and induction of M2-like macrophage polarization","volume":"153","author":"Shi","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2026.179170_bib51","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1111\/bph.14346","article-title":"Hippocampal PPARalpha is a novel therapeutic target for depression and mediates the antidepressant actions of fluoxetine in mice","volume":"175","author":"Song","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib52","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mcn.2008.02.005","article-title":"BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth","volume":"38","author":"Spencer","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179170_bib53","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.3389\/fphar.2019.01522","article-title":"Inhibitory effects of columbianadin on nociceptive behaviors in a neuropathic pain model, and on voltage-gated calcium currents in dorsal root ganglion neurons in mice","volume":"10","author":"Su","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib54","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1111\/j.1742-4658.2007.05889.x","article-title":"TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain","volume":"274","author":"Takemori","year":"2007","journal-title":"FEBS J."},{"key":"10.1016\/j.ejphar.2026.179170_bib55","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jsbmb.2007.09.006","article-title":"Regulation of CREB-mediated gene expression by salt inducible kinase","volume":"108","author":"Takemori","year":"2008","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.ejphar.2026.179170_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2021.114885","article-title":"Virus-mediated decrease of LKB1 activity in the mPFC diminishes stress-induced depressive-like behaviors in mice","volume":"197","author":"Tang","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib57","article-title":"Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis","author":"Wang","year":"2022","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ejphar.2026.179170_bib58","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1038\/s41380-022-01881-4","article-title":"Salt-inducible kinase 1-CREB-regulated transcription coactivator 1 signalling in the paraventricular nucleus of the hypothalamus plays a role in depression by regulating the hypothalamic-pituitary-adrenal axis","volume":"29","author":"Wang","year":"2024","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.ejphar.2026.179170_bib59","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1124\/jpet.120.000092","article-title":"Potent therapy and transcriptional profile of combined erythropoietin-derived peptide cyclic helix B surface peptide and Caspase-3 siRNA against Kidney Ischemia\/Reperfusion Injury in mice","volume":"375","author":"Wu","year":"2020","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2026.179170_bib60","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.1111\/bph.17324","article-title":"Serotonergic transmission plays differentiated roles in the rapid and sustained antidepressant-like effects of ketamine","volume":"181","author":"Yin","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113927","article-title":"Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin","volume":"175","author":"Zeng","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib62","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1111\/bph.15847","article-title":"Synergistic effects of two naturally occurring iridoids in eliciting a rapid antidepressant action by up-regulating hippocampal PACAP signalling","volume":"179","author":"Zhang","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib63","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/ijnp\/pyz032","article-title":"Andrographolide exerts significant antidepressant-like effects involving the hippocampal BDNF System in mice","volume":"22","author":"Zhang","year":"2019","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib64","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brainres.2010.09.095","article-title":"Chronic antidepressant administration alleviates frontal and hippocampal BDNF deficits in CUMS rat","volume":"1366","author":"Zhang","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2026.179170_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105977","article-title":"Autophagy induction by rapamycin ameliorates experimental colitis and improves intestinal epithelial barrier function in IL-10 knockout mice","volume":"81","author":"Zhao","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2026.179170_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135535","article-title":"Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression","volume":"742","author":"Zhao","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ejphar.2026.179170_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152489","article-title":"Inhibition of ferroptosis attenuates busulfan-induced oligospermia in mice","volume":"440","author":"Zhao","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.ejphar.2026.179170_bib68","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.20m13699","article-title":"The prevalence and national burden of treatment-resistant depression and major depressive disorder in the United States","volume":"82","author":"Zhdanava","year":"2021","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.179170_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2024.173916","article-title":"Fluoxetine treatment reverses chronic stress-induced promotion on Fk506-binding protein 5 expression and multiple effects on glucocorticoid receptor phosphorylation in the paraventricular nucleus of mice","volume":"246","author":"Zhu","year":"2025","journal-title":"Pharmacol. Biochem. Behav."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926006527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926006527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:19:20Z","timestamp":1786652360000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926006527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":69,"alternative-id":["S0014299926006527"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179170","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The pan-salt-inducible kinase inhibitor YKL-06-061 exerts antidepressant-like effects via hippocampal CRTC1\u2013CREB\u2013BDNF pathway activation in chronic stress models","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179170","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"179170"}}