{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:25:58Z","timestamp":1788279958944,"version":"build-2803163510"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860525"],"award-info":[{"award-number":["81860525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA0918802"],"award-info":[{"award-number":["2024YFA0918802"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ejphar.2026.179237","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T06:03:22Z","timestamp":1786773802000},"page":"179237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Topical recombinant human type III collagen for atopic dermatitis: Evaluation of efficacy and safety"],"prefix":"10.1016","volume":"1032","author":[{"given":"Jiayuan","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoping","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jikui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liurong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3790-1200","authenticated-orcid":false,"given":"Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9608-9079","authenticated-orcid":false,"given":"Ying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2469-9675","authenticated-orcid":false,"given":"Qinyuan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ejphar.2026.179237_bib1","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98006","article-title":"Lipid abnormalities in atopic skin are driven by type 2 cytokines","volume":"3","author":"Berdyshev","year":"2018","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.ejphar.2026.179237_bib2","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jid.2017.09.032","article-title":"Disruption of the epidermal barrier induces regulatory T cells via IL-33 in mice","volume":"138","author":"Bruhs","year":"2018","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.ejphar.2026.179237_bib3","doi-asserted-by":"crossref","first-page":"745.e1","DOI":"10.1016\/j.jaad.2025.05.1386","article-title":"Focused update: guidelines of care for the management of atopic dermatitis in adults","volume":"93","author":"Davis","year":"2025","journal-title":"J. Am. Acad. Dermatol."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179237_bib4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S2213-2600(25)00003-7","article-title":"Global, regional, and national burden of asthma and atopic dermatitis, 1990-2021, and projections to 2050: a systematic analysis of the global Burden of Disease Study 2021","volume":"13","year":"2025","journal-title":"Lancet Respir. Med."},{"issue":"9","key":"10.1016\/j.ejphar.2026.179237_bib6","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.3390\/ijms26094009","article-title":"Recent advances in the development and application of cell-loaded collagen scaffolds","volume":"26","author":"He","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.ejphar.2026.179237_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0292791","article-title":"Age-related changes in dermal collagen physical properties in human skin","volume":"18","author":"He","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.ejphar.2026.179237_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121849","article-title":"Regeneration of infarcted hearts by myocardial infarction-responsive injectable hydrogels with combined anti-apoptosis, anti-inflammatory and pro-angiogenesis properties","volume":"290","author":"Hu","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.ejphar.2026.179237_bib8","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s42825-025-00212-x","article-title":"Injectable hydrogels with tailored recombinant humanized collagen type I for the repair of damaged hearts by remodeling the myocardial microenvironment","volume":"7","author":"Hu","year":"2025","journal-title":"Collagen Leather"},{"issue":"4","key":"10.1016\/j.ejphar.2026.179237_bib9","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.bbrc.2018.12.018","article-title":"Characterization by high-resolution crystal structure analysis of a triple-helix region of human collagen type III with potent cell adhesion activity","volume":"508","author":"Hua","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179237_bib10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12865-022-00531-2","article-title":"Combined application of dinitrofluorobenzene and ovalbumin induced AD-like dermatitis with an increase in helper T-cell cytokines and a prolonged Th2 response","volume":"23","author":"Jiang","year":"2022","journal-title":"BMC Immunol."},{"issue":"3","key":"10.1016\/j.ejphar.2026.179237_bib11","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/kjm2.12163","article-title":"Subcutaneous injection of recombinant heat shock protein 70 ameliorates atopic dermatitis skin lesions in a mouse model","volume":"36","author":"Kao","year":"2020","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"6","key":"10.1016\/j.ejphar.2026.179237_bib12","doi-asserted-by":"crossref","first-page":"522","DOI":"10.5021\/ad.2021.33.6.522","article-title":"A clinical and biochemical evaluation of a temperature-controlled continuous non-invasive radiofrequency device for the treatment of melasma","volume":"33","author":"Kwon","year":"2021","journal-title":"Ann. Dermatol."},{"issue":"6","key":"10.1016\/j.ejphar.2026.179237_bib13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.5021\/ad.2021.33.6.497","article-title":"Consensus update for systemic treatment of atopic dermatitis","volume":"33","author":"Lee","year":"2021","journal-title":"Ann. Dermatol."},{"issue":"7","key":"10.1016\/j.ejphar.2026.179237_bib14","first-page":"788","article-title":"The global burden of atopic dermatitis in elderly populations: trends, disparities, and future projections","volume":"13","author":"Li","year":"2025","journal-title":"Healthcare (Basel, Switzerland)"},{"issue":"5","key":"10.1016\/j.ejphar.2026.179237_bib15","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1093\/jbcr\/irae040","article-title":"Recombinant human collagen type III improves hypertrophic scarring by regulating the ratio of type I\/III collagen","volume":"45","author":"Lin-Hui","year":"2024","journal-title":"J. Burn Care Res. : Official Pub. Am. Burn Assoc."},{"issue":"12","key":"10.1016\/j.ejphar.2026.179237_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202400121","article-title":"A whole-course-repair System based on stimulus-responsive multifunctional hydrogels for myocardial tissue regeneration","volume":"8","author":"Liu","year":"2024","journal-title":"Small Methods"},{"issue":"3","key":"10.1016\/j.ejphar.2026.179237_bib17","first-page":"51","article-title":"An overview of atopic dermatitis disease burden, pathogenesis, and the current treatment landscape: recommendations for appropriate utilization of systemic therapies","volume":"18","author":"Martin","year":"2025","journal-title":"J. Clin. Aesthetic Dermatol."},{"issue":"9","key":"10.1016\/j.ejphar.2026.179237_bib18","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1039\/D3BM00091E","article-title":"Engineered collagen polymeric materials create noninflammatory regenerative microenvironments that avoid classical foreign body responses","volume":"11","author":"Morrison","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.ejphar.2026.179237_bib19","doi-asserted-by":"crossref","DOI":"10.1177\/03946320221111135","article-title":"Purpurin suppresses atopic dermatitis via TNF-\u03b1\/IFN-\u03b3-induced inflammation in HaCaT cells","volume":"36","author":"Oh","year":"2022","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179237_bib20","doi-asserted-by":"crossref","unstructured":"Saeki, H., et al. English version of clinical practice guidelines for the management of atopic dermatitis 2024. J. Dermatol., 52(2), e70\u2013e142. https:\/\/doi.org\/10.1111\/1346-8138.17544.","DOI":"10.1111\/1346-8138.17544"},{"issue":"2","key":"10.1016\/j.ejphar.2026.179237_bib21","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jid.2023.08.009","article-title":"ZNF750 regulates skin barrier function by driving cornified envelope and lipid processing pathways","volume":"144","author":"Schwartz","year":"2024","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.ejphar.2026.179237_bib22","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1111\/odi.14540","article-title":"Recombination humanized type III collagen promotes oral ulcer healing","volume":"30","author":"Shuai","year":"2024","journal-title":"Oral Dis."},{"issue":"8","key":"10.1016\/j.ejphar.2026.179237_bib23","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.3390\/ijms22084130","article-title":"Molecular mechanisms of atopic dermatitis pathogenesis","volume":"22","author":"Sroka-Tomaszewska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.179237_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/198789","article-title":"The infant skin barrier: can we preserve, protect, and enhance the barrier?","volume":"2012","author":"Telofski","year":"2012","journal-title":"Dermatol. Res. Practice"},{"issue":"6","key":"10.1016\/j.ejphar.2026.179237_bib25","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.jaad.2025.01.082","article-title":"Tape-strip profiling identifies unique immune and lipid dysregulation in patients with seborrheic dermatitis","volume":"92","author":"Ungar","year":"2025","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ejphar.2026.179237_bib26","first-page":"154","article-title":"The biological effect of recombinant humanized collagen on damaged skin induced by UV-photoaging: an in vivo study","volume":"11","author":"Wang","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.ejphar.2026.179237_bib27","article-title":"Characterization of recombinant humanized collagen type III and its influence on cell behavior and phenotype","volume":"284","author":"Wang","year":"2023","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.ejphar.2026.179237_bib28","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.3390\/ijms23116289","article-title":"Preparation of recombinant human Collagen III protein hydrogels with sustained release of extracellular vesicles for skin wound healing","volume":"23","author":"Xu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.179237_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1342176","article-title":"Interplay of cytokines in the pathophysiology of atopic dermatitis: insights from Murin models and human","volume":"11","author":"Yamamura","year":"2024","journal-title":"Front. Med."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179237_bib30","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/19768354.2025.2498928","article-title":"Comprehensive analysis of protective effects of Loranthus tanakae Franch. and Sav. on ovalbumin-induced atopic dermatitis in mice and TNF-\u03b1\/INF-\u03b3-stimulated HaCaT cells","volume":"29","author":"Yang","year":"2025","journal-title":"Anim. Cell Syst."},{"key":"10.1016\/j.ejphar.2026.179237_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbad033","article-title":"Recombinant humanized collagen remodels endometrial immune microenvironment of chronic endometritis through macrophage immunomodulation","volume":"10","author":"You","year":"2023","journal-title":"Regen. Biomater."},{"issue":"38","key":"10.1016\/j.ejphar.2026.179237_bib32","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100749118","article-title":"Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis","volume":"118","author":"Zhang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ejphar.2026.179237_bib33","article-title":"Effects of Huang-Lian-Jie-Du decoction on improving skin barrier function and modulating T helper cell differentiation in 1-chloro-2,4-dinitrobenzene-induced atopic dermatitis mice","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179237_bib34","article-title":"The role of various collagen types in tumor biology: a review","volume":"15","author":"Zhou","year":"2025","journal-title":"Front. Oncol."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926007193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926007193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:02:45Z","timestamp":1788278565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926007193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":34,"alternative-id":["S0014299926007193"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179237","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical recombinant human type III collagen for atopic dermatitis: Evaluation of efficacy and safety","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179237","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"179237"}}