{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:54:32Z","timestamp":1791564872945,"version":"4.3.4"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2023 \/03485-7"],"award-info":[{"award-number":["2023 \/03485-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302348 \/2025-5"],"award-info":[{"award-number":["302348 \/2025-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008725","name":"Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2019\/35\/D\/NZ7\/01042"],"award-info":[{"award-number":["2019\/35\/D\/NZ7\/01042"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ejphar.2026.179265","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T08:43:19Z","timestamp":1787388199000},"page":"179265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Preclinical characterization of the efficacy and safety of histamine H3 receptor antagonist, LINS01022, as a novel analgesic for chronic neuropathic pain treatment"],"prefix":"10.1016","volume":"1034","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4733-7319","authenticated-orcid":false,"given":"Magdalena","family":"Maciuszek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1440-1932","authenticated-orcid":false,"given":"Magdalena","family":"Bia\u0142o\u0144","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Kr\u00f3lewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2990-3620","authenticated-orcid":false,"given":"Karolina","family":"Noworyta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia A.","family":"Fiocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5770-2589","authenticated-orcid":false,"given":"Flavia B.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0091-0066","authenticated-orcid":false,"given":"Katarzyna","family":"Starowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5269-2008","authenticated-orcid":false,"given":"Wesley L.","family":"Gouveia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8625-6351","authenticated-orcid":false,"given":"Lidia M.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9089-273X","authenticated-orcid":false,"given":"Jo\u00e3o Paulo S.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4366-6577","authenticated-orcid":false,"given":"Katarzyna","family":"Popiolek-Barczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"302","key":"10.1016\/j.ejphar.2026.179265_bib1","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/302832a0","article-title":"Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor","volume":"28","author":"Arrang","year":"1983","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.ejphar.2026.179265_bib2","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1474-4422(10)70143-5","article-title":"Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment","volume":"9","author":"Baron","year":"2010","journal-title":"Lancet Neurol."},{"issue":"16","key":"10.1016\/j.ejphar.2026.179265_bib3","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1212\/WNL.0b013e3181f884b1","article-title":"Histamine in the CNS: multiple functions and potential neurologic implications","volume":"75","author":"Benarroch","year":"2010","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179265_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.ejphar.2026.179265_bib5","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1113\/jphysiol.2006.120493","article-title":"Histaminergic and glycinergic modulation of GABA release in the vestibular nuclei of normal and labyrinthectomised rats","volume":"577","author":"Bergquist","year":"2006","journal-title":"J Physiol."},{"issue":"8","key":"10.1016\/j.ejphar.2026.179265_bib6","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1111\/j.1476-5381.1996.tb16086.x","article-title":"Inhibition of cortical acetylcholine release and cognitive performance by histamine H3 receptor activation in rats","volume":"119","author":"Blandina","year":"1996","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.ejphar.2026.179265_bib7","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.pain.2007.08.013","article-title":"Prevalence of chronic pain with neuropathic characteristics in the general population","volume":"136","author":"Bouhassira","year":"2008","journal-title":"Pain"},{"issue":"52","key":"10.1016\/j.ejphar.2026.179265_bib8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/BF01922417","article-title":"Involvement of H1 receptors in the central antinociceptive effect of histamine: pharmacological dissection by electrophysiological analysis","volume":"16","author":"Braga","year":"1996","journal-title":"Experientia"},{"issue":"4","key":"10.1016\/j.ejphar.2026.179265_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpain.2005.06.009","article-title":"Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment","volume":"10","author":"Breivik","year":"2006","journal-title":"Eur. J. Pain"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179265_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.pain.2006.09.039","article-title":"Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: potential antinociceptive targets","volume":"129","author":"Cannon","year":"2007","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.ejphar.2026.179265_bib10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0014-2999(03)01737-0","article-title":"Activation of spinal histamine H3 receptors inhibits mechanical nociception","volume":"470","author":"Cannon","year":"2003","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179265_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/ejp.1097","article-title":"Effects of S 38093, an antagonist\/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats","volume":"22","author":"Chaumette","year":"2018","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.ejphar.2026.179265_bib13","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/j.1476-5381.1992.tb13386.x","article-title":"Histamine H3 receptors modulate the release of [3H]-acetylcholine from slices of rat entorhinal cortex: evidence for the possible existence of H3 receptor subtypes","volume":"107","author":"Clapham","year":"1992","journal-title":"Br. J. Pharmacol."},{"issue":"10289","key":"10.1016\/j.ejphar.2026.179265_bib14","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1016\/S0140-6736(21)00393-7","article-title":"Chronic pain: an update on burden, best practices, and new advances","volume":"397","author":"Cohen","year":"2021","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.ejphar.2026.179265_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.2","article-title":"Neuropathic pain","volume":"3","author":"Colloca","year":"2017","journal-title":"Nat. Rev. Dis. Primer."},{"key":"10.1016\/j.ejphar.2026.179265_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115924","article-title":"Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands \u2013 functional characterization and modeling studies on H3 and H4 receptors","volume":"30","author":"Corr\u00eaa","year":"2021","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179265_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/cbdd.13387","article-title":"Pharmacological and SAR analysis of the LINS01 compounds at the human histamine H1, H2, and H3 receptors","volume":"93","author":"Corr\u00eaa","year":"2019","journal-title":"Chem. Biol. Drug Des."},{"issue":"2","key":"10.1016\/j.ejphar.2026.179265_bib16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/cbdd.12947","article-title":"1-[(2,3-Dihydro-1-benzofuran-2-yl) methyl]piperazines as novel anti-inflammatory compounds: synthesis and evaluation on H3R\/H4R","volume":"90","author":"Corr\u00eaa","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ejphar.2026.179265_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/bph.17441","article-title":"Guidance on the planning and reporting of experimental design and analysis","author":"Curtis","year":"2025","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179265_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.ejphar.2026.179265_bib20","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/cmdc.201600182","article-title":"A BOILED-egg to predict gastrointestinal absorption and brain penetration of small molecules","volume":"11","author":"Daina","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.ejphar.2026.179265_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.117850","article-title":"Histamine H3 receptor blockade alleviates neuropathic pain through the regulation of glial cells activation","volume":"183","author":"Degutis","year":"2025","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179265_bib23","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s11011-016-9840-z","article-title":"H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice","volume":"31","author":"Dudek","year":"2016","journal-title":"Metab. Brain Dis."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179265_bib25","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ejpain.2004.01.007","article-title":"Sex differences in opioid analgesia: clinical and experimental findings","volume":"8","author":"Fillingim","year":"2004","journal-title":"Eur. J. Pain"},{"issue":"5","key":"10.1016\/j.ejphar.2026.179265_bib26","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jpain.2008.12.001","article-title":"Sex, gender, and pain: a review of recent clinical and experimental findings","volume":"10","author":"Fillingim","year":"2009","journal-title":"J. Pain"},{"issue":"2","key":"10.1016\/j.ejphar.2026.179265_bib27","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","article-title":"Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis","volume":"14","author":"Finnerup","year":"2015","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.ejphar.2026.179265_bib28","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/jps.22796","article-title":"Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: application to dibenz[b,f]azepine-5-carboxamide derivatives","volume":"101","author":"Fortuna","year":"2012","journal-title":"J. Pharm. Sci."},{"issue":"39","key":"10.1016\/j.ejphar.2026.179265_bib29","doi-asserted-by":"crossref","first-page":"9574","DOI":"10.1523\/JNEUROSCI.0580-17.2017","article-title":"Hypothalamic tuberomammillary nucleus neurons: electrophysiological diversity and essential role in arousal stability","volume":"37","author":"Fujita","year":"2017","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.ejphar.2026.179265_bib30","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.neuropharm.2006.08.001","article-title":"Pre-synaptic histamine H3 receptors regulate glutamate, but not GABA release in rat thalamus","volume":"52","author":"Gardu\u00f1o-Torres","year":"2007","journal-title":"Neuropharmacology"},{"issue":"8","key":"10.1016\/j.ejphar.2026.179265_bib31","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1097\/j.pain.0000000000002215","article-title":"Sex differences in neuroimmune and glial mechanisms of pain","volume":"162","author":"Gregus","year":"2021","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179265_bib32","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1124\/jpet.110.171264","article-title":"H3 receptors and pain modulation: peripheral, spinal, and brain interactions","volume":"336","author":"Hough","year":"2011","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2026.179265_bib33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.brainres.2010.07.083","article-title":"Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems","volume":"1354","author":"Hsieh","year":"2010","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.ejphar.2026.179265_bib34","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s40272-023-00575-w","article-title":"Pitolisant: pediatric first approval","volume":"25","author":"Keam","year":"2023","journal-title":"Pediatr. Drugs"},{"key":"10.1016\/j.ejphar.2026.179265_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150879","article-title":"Anxiolytic- and antidepressive-like effects of harmaline in mice are mediated via histamine H3 receptor blockade","volume":"736","author":"Khakpai","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179265_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.855","article-title":"Pitolisant, a wake\u2010promoting agent devoid of psychostimulant properties: preclinical comparison with amphetamine, modafinil, and solriamfetol","volume":"9","author":"Krief","year":"2021","journal-title":"Pharmacol. Res. Perspect."},{"issue":"3","key":"10.1016\/j.ejphar.2026.179265_bib37","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0091-3057(95)02051-9","article-title":"Investigation into the role of histamine receptors in rodent antinociception","volume":"53","author":"Lamberti","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"8","key":"10.1016\/j.ejphar.2026.179265_bib38","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.bcp.2007.01.023","article-title":"Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649","volume":"73","author":"Ligneau","year":"2007","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179265_bib39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.pain.2007.11.006","article-title":"Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain","volume":"138","author":"Medhurst","year":"2008","journal-title":"Pain"},{"issue":"8","key":"10.1016\/j.ejphar.2026.179265_bib40","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/S0028-3908(01)00144-7","article-title":"Histamine H3 receptor activation inhibits glutamate release from rat striatal synaptosomes","volume":"41","author":"Molina-Hern\u00e1ndez","year":"2001","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.ejphar.2026.179265_bib41","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/bph.14696","article-title":"Histamine, histamine receptors, and neuropathic pain relief","volume":"177","author":"Obara","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179265_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116527","article-title":"Therapeutic potential of LINS01 histamine H3 receptor antagonists as antineoplastic agents for triple negative breast cancer","volume":"174","author":"Ospital","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ejphar.2026.179265_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1159753","article-title":"Bulbospinal nociceptive ON and OFF cells related neural circuits and transmitters","volume":"14","author":"Peng","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.ejphar.2026.179265_bib44","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3390\/ph17030389","article-title":"Cytotoxic and antiproliferative activity of LASSBio-2208 and the attempts to determine its drug metabolism and pharmacokinetics in vitro profile","volume":"17","author":"Pillpe-Meza","year":"2024","journal-title":"Pharmaceuticals"},{"issue":"12","key":"10.1016\/j.ejphar.2026.179265_bib45","article-title":"Antinociceptive effects of novel histamine H 3 R and H 4 R receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse","author":"Popiolek-Barczyk","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.ejphar.2026.179265_bib46","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/BF00182737","article-title":"Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex","volume":"337","author":"Schlicker","year":"1988","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"6","key":"10.1016\/j.ejphar.2026.179265_bib47","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/BF00717738","article-title":"Inhibition of noradrenaline release in the rat brain cortex via presynaptic H3 receptors","volume":"340","author":"Schlicker","year":"1989","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179265_bib48","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/138955713804484695","article-title":"Histamine H3 receptor function and ligands: recent developments","volume":"13","author":"Singh","year":"2013","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.ejphar.2026.179265_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112230","article-title":"Differential contribution of H3R antagonism by LINS01 compounds on memory, anxiety-like behaviour and spontaneous locomotor activity in healthy rats","volume":"377","author":"Soliani","year":"2020","journal-title":"Behav. Brain Res."},{"issue":"June","key":"10.1016\/j.ejphar.2026.179265_bib51","first-page":"1","article-title":"Different immune cells mediate mechanical pain hypersensitivity in male and female mice","volume":"18","author":"Sorge","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179265_bib50","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cophys.2018.05.006","article-title":"Sex differences in pain responses","volume":"6","author":"Sorge","year":"2018","journal-title":"Curr. Opin. Physiol."},{"issue":"15","key":"10.1016\/j.ejphar.2026.179265_bib52","doi-asserted-by":"crossref","first-page":"8035","DOI":"10.3390\/ijms25158035","article-title":"AR71, histamine H3 receptor ligand\u2014in vitro and in vivo evaluation (Anti-Inflammatory activity, metabolic stability, toxicity, and analgesic action)","volume":"25","author":"Stasiak","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.ejphar.2026.179265_bib53","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jmedchem.3c00430","article-title":"Dual piperidine-based histamine H3 and Sigma-1 receptor ligands in the treatment of nociceptive and neuropathic pain","volume":"66","author":"Szczepa\u0144ska","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ejphar.2026.179265_bib54","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0304-3959(94)90182-1","article-title":"Histamine-induced modulation of nociceptive responses","volume":"58","author":"Thoburn","year":"1994","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.ejphar.2026.179265_bib55","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/bph.12149","article-title":"Preclinical evaluation of the abuse potential of pitolisant, a histamine H3 receptor inverse agonist\/antagonist compared with modafinil","volume":"169","author":"Uguen","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2026.179265_bib56","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.pain.2013.10.027","article-title":"Higher pain perception and lack of recovery from neuropathic pain in females : a behavioural , immunohistochemical , and proteomic investigation on sex-related differences in mice","volume":"155","author":"Vacca","year":"2014","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.ejphar.2026.179265_bib57","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.pain.2013.11.013","article-title":"Neuropathic pain in the general population: a systematic review of epidemiological studies","volume":"155","author":"van Hecke","year":"2014","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.ejphar.2026.179265_bib58","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.70142","article-title":"Histamine dynamics during ingestive behavior measured by the novel biosensor <scp>HisLightG<\/scp>","volume":"169","author":"Volcko","year":"2025","journal-title":"J. Neurochem."},{"issue":"10100","key":"10.1016\/j.ejphar.2026.179265_bib59","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016: a systematic analysis for the global burden of disease study 2016","volume":"390","author":"Vos","year":"2017","journal-title":"Lancet"},{"issue":"772","key":"10.1016\/j.ejphar.2026.179265_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2015.12.039","article-title":"Spinal histamine in attenuation of mechanical hypersensitivity in the spinal nerve ligation-induced model of experimental neuropathy","volume":"5","author":"Wei","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179265_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.650793","article-title":"Behaviors related to psychiatric disorders and pain perception in C57BL\/6J mice during different phases of estrous cycle","volume":"15","author":"Zhao","year":"2021","journal-title":"Front. Neurosci."},{"issue":"3","key":"10.1016\/j.ejphar.2026.179265_bib62","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0304-3959(90)91147-B","article-title":"Characterization of descending inhibition and facilitation from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat","volume":"42","author":"Zhuo","year":"1990","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.ejphar.2026.179265_bib63","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179265_bib64","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41398-025-03358-8","article-title":"Pitolisant alleviates brain network dysfunction and cognitive deficits in a mouse model of Alzheimer's disease","volume":"15","author":"Zou","year":"2025","journal-title":"Transl. Psychiatry"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926007478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926007478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:19:04Z","timestamp":1791562744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926007478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":63,"alternative-id":["S0014299926007478"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179265","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preclinical characterization of the efficacy and safety of histamine H3 receptor antagonist, LINS01022, as a novel analgesic for chronic neuropathic pain treatment","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"179265"}}