{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:06:33Z","timestamp":1789074393896,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ejphar.2026.179268","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T23:00:26Z","timestamp":1787266826000},"page":"179268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["ERR\u03b1 ameliorates osteoarthritis by inhibiting chondrocyte pyroptosis via targeting NF-\u03baBp65"],"prefix":"10.1016","volume":"1033","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-1082","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-hang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongjun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ejphar.2026.179268_bib1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s10787-025-02102-4","article-title":"Diosgenin-mediated NF-\u03baB and MAPK pathway modulation for osteoarthritis treatment: molecular mechanisms, bioavailability enhancement, and therapeutic applications","volume":"34","author":"Adarkar","year":"2026","journal-title":"Inflammopharmacology"},{"issue":"6","key":"10.1016\/j.ejphar.2026.179268_bib3","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.18632\/aging.102937","article-title":"Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis","volume":"12","author":"Bao","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.ejphar.2026.179268_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jbmr.1836","article-title":"An energetic orphan in an endocrine tissue: a revised perspective of the function of estrogen receptor-related receptor alpha in bone and cartilage","volume":"28","author":"Bonnelye","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejphar.2026.179268_bib5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jbmr.1836","article-title":"An energetic orphan in an endocrine tissue: a revised perspective of the function of estrogen receptor-related receptor alpha in bone and cartilage","volume":"28","author":"Bonnelye","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ejphar.2026.179268_bib6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"issue":"6","key":"10.1016\/j.ejphar.2026.179268_bib7","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.berh.2011.11.010","article-title":"Emerging frontiers in cartilage and chondrocyte biology","volume":"25","author":"Fosang","year":"2011","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.ejphar.2026.179268_bib8","doi-asserted-by":"crossref","unstructured":"Gerwin N, Bendele A M , Glasson S, & Carlson C S. The OARSI histopathology initiative \u2013 recommendations for histological assessments of osteoarthritis in the rat. Osteoarthr. Cartil., 18(Suppl. 3), S24\u2013S34. 10.1016\/j.joca.2010.05.030.","DOI":"10.1016\/j.joca.2010.05.030"},{"key":"10.1016\/j.ejphar.2026.179268_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109983","article-title":"Inhibition of NEMO alleviates arthritis by blocking the M1 macrophage polarization","volume":"117","author":"Han","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"15","key":"10.1016\/j.ejphar.2026.179268_bib10","article-title":"Fisetin and resveratrol exhibit senotherapeutic effects and suppress cellular senescence in osteoarthritic cartilage-derived chondrogenic progenitor cells","volume":"997","author":"Jacob","year":"2025","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.ejphar.2026.179268_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1939-165X.2012.00418.x","article-title":"Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research","volume":"41","author":"Kilkenny","year":"2012","journal-title":"Vet. Clin. Pathol."},{"issue":"1015","key":"10.1016\/j.ejphar.2026.179268_bib12","article-title":"PEGylated cerium oxide nanoparticles alleviate osteoarthritis progression by inhibiting chondrocyte ferroptosis and maintaining cartilage homeostasis","volume":"15","author":"Li","year":"2026","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179268_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ejphar.2026.179268_bib14","series-title":"The National Academies Collection: Reports Funded by National Institutes of Health in Guide for the Care and Use of Laboratory Animals","year":"2011"},{"key":"10.1016\/j.ejphar.2026.179268_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rdc.2012.10.004","article-title":"Epidemiology of osteoarthritis","volume":"39","author":"Neogi","year":"2013","journal-title":"Rheum Dis Clin North Am."},{"issue":"12","key":"10.1016\/j.ejphar.2026.179268_bib16","article-title":"Role of HIF-1\u03b1\/ERR\u03b1 in enhancing cancer cell metabolism and promoting resistance of endometrial cancer cells to pyroptosis","volume":"21","author":"Su","year":"2022","journal-title":"Front. Oncol."},{"issue":"Pt B","key":"10.1016\/j.ejphar.2026.179268_bib17","article-title":"Notoginsenoside R1 suppresses inflammatory response and the pyroptosis of nucleus pulposus cells via inactivating NF-\u03baB\/NLRP3 pathways","volume":"101","author":"Tang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ejphar.2026.179268_bib18","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1007\/s00018-019-03129-x","article-title":"Insights into the activation mechanism of human estrogen-related receptor gamma by environmental endocrine disruptors","volume":"76","author":"Thouennon","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"issue":"12","key":"10.1016\/j.ejphar.2026.179268_bib19","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.joca.2007.05.005","article-title":"International Cartilage Repair Society (ICRS) and Oswestry macroscopic cartilage evaluation scores validated for use in Autologous Chondrocyte Implantation (ACI) and microfracture","volume":"15","author":"van den Borne","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ejphar.2026.179268_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110261","article-title":"Stevioside protects primary articular chondrocytes against IL-1\u03b2-induced inflammation and catabolism by targeting integrin","volume":"119","author":"Wan","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.ejphar.2026.179268_bib22","doi-asserted-by":"crossref","first-page":"191","DOI":"10.32604\/biocell.2023.045349","article-title":"Estrogen-related receptor alpha: a novel perspective on skeletal,muscular, and vascular systems","volume":"48","author":"Wang","year":"2024","journal-title":"Biocell"},{"issue":"1","key":"10.1016\/j.ejphar.2026.179268_bib21","doi-asserted-by":"crossref","DOI":"10.1186\/ar4133","article-title":"MMP13 is a critical target gene during the progression of osteoarthritis","volume":"15","author":"Wang","year":"2013","journal-title":"Arthritis Res. Ther."},{"issue":"1007","key":"10.1016\/j.ejphar.2026.179268_bib23","article-title":"PDGF-BB inhibits F-actin formation and chondrocyte dedifferentiation in osteoarthritis via oxygen-dependent HIF-1\u03b1\/SCIN regulation and RhoA\/ROCK signaling inhibition","volume":"15","author":"Wang","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179268_bib24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.omtm.2018.02.006","article-title":"Isoliquiritigenin inhibits IL-1\u03b2-induced production of matrix metalloproteinase in articular chondrocytes","volume":"9","author":"Zhang","year":"2018","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.ejphar.2026.179268_bib25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbrc.2021.03.055","article-title":"CY-09 attenuates the progression of osteoarthritis via inhibiting NLRP3 inflammasome-mediated pyroptosis","volume":"553","author":"Zhang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"14","key":"10.1016\/j.ejphar.2026.179268_bib26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbrc.2021.03.055","article-title":"CY-09 attenuates the progression of osteoarthritis via inhibiting NLRP3 inflammasome-mediated pyroptosis","volume":"553","author":"Zhang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926007508?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926007508?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:07:12Z","timestamp":1789070832000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926007508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":25,"alternative-id":["S0014299926007508"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179268","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ERR\u03b1 ameliorates osteoarthritis by inhibiting chondrocyte pyroptosis via targeting NF-\u03baBp65","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179268","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"179268"}}