{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:06:37Z","timestamp":1789074397769,"version":"build-2803163510"},"reference-count":182,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009156","name":"Nantong City Science and Technology Bureau","doi-asserted-by":"publisher","award":["JC2023044"],"award-info":[{"award-number":["JC2023044"]}],"id":[{"id":"10.13039\/501100009156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.ejphar.2026.179275","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:04:55Z","timestamp":1787238295000},"page":"179275","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Therapeutic targeting of G protein-coupled receptors in central nervous system disorders: from novel mechanisms to precision pharmacology"],"prefix":"10.1016","volume":"1033","author":[{"given":"Chicheng","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2887-1564","authenticated-orcid":false,"given":"Jinhuan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ejphar.2026.179275_bib1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1021\/acsptsci.0c00013","article-title":"mGluR5 contribution to neuropathology in alzheimer mice is disease stage-dependent","volume":"3","author":"Abd-Elrahman","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.ejphar.2026.179275_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13041-018-0364-9","article-title":"Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer's disease mouse models","volume":"11","author":"Abd-Elrahman","year":"2018","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ejphar.2026.179275_bib3","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8294","article-title":"The immunostimulatory activity of polysaccharides from Glycyrrhiza uralensis","volume":"8","author":"Aipire","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.ejphar.2026.179275_bib4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/mcne.2000.0834","article-title":"Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle","volume":"15","author":"Akaaboune","year":"2000","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179275_bib5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1756-6606-4-21","article-title":"Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness","volume":"4","author":"Albert","year":"2011","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ejphar.2026.179275_bib6","first-page":"98","article-title":"G protein-coupled receptors as therapeutic target","volume":"158","author":"Alc\u00e1ntara-Hern\u00e1ndez","year":"2022","journal-title":"Gac. Med. Mex."},{"key":"10.1016\/j.ejphar.2026.179275_bib7","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1038\/s41591-025-03833-1","article-title":"Shared and disease-specific pathways in frontotemporal dementia and Alzheimer's and Parkinson's diseases","volume":"31","author":"Ali","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2026.179275_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1411168","article-title":"Flavonoids against depression: a comprehensive review of literature","volume":"15","author":"Alizadeh","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-1-0716-0814-2_10","article-title":"Elucidating the role of lipid rafts on G protein-coupled receptor function in the mouse kidney: an in vivo approach","volume":"2187","author":"Asico","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ejphar.2026.179275_bib10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0301-0082(02)00079-5","article-title":"Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies","volume":"68","author":"Auld","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2026.179275_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020506","article-title":"G-Protein-Coupled receptors in CNS: a potential therapeutic target for intervention in neurodegenerative disorders and associated cognitive deficits","volume":"9","author":"Azam","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ejphar.2026.179275_bib12","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1006\/exnr.2000.7397","article-title":"On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis","volume":"163","author":"Bartus","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ejphar.2026.179275_bib13","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1523\/JNEUROSCI.5093-08.2009","article-title":"Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus","volume":"29","author":"Besser","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179275_bib14","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.biopsych.2005.11.003","article-title":"The role of CREB in depression and antidepressant treatment","volume":"59","author":"Blendy","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.179275_bib15","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","article-title":"Alzheimer's disease","volume":"368","author":"Blennow","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2026.179275_bib16","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/35067575","article-title":"Oligomerization of G-protein-coupled transmitter receptors","volume":"2","author":"Bouvier","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179275_bib17","doi-asserted-by":"crossref","first-page":"21453","DOI":"10.1074\/jbc.C200176200","article-title":"The immune modulator FTY720 targets sphingosine 1-phosphate receptors","volume":"277","author":"Brinkmann","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ejphar.2026.179275_bib18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/13607863.2018.1544213","article-title":"WHO's global action plan on the public health response to dementia: some challenges and opportunities","volume":"24","author":"Cahill","year":"2020","journal-title":"Aging Ment. Health"},{"key":"10.1016\/j.ejphar.2026.179275_bib19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0014-2999(01)01440-6","article-title":"SCH 57790, a selective muscarinic M(2) receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals","volume":"431","author":"Carey","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib20","article-title":"Detecting and measuring of GPCR signaling - comparison of human induced pluripotent stem cells and immortal cell lines","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ejphar.2026.179275_bib21","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.cellsig.2015.03.027","article-title":"Heterodimerization of human orexin receptor 1 and kappa opioid receptor promotes protein kinase A\/cAMP-response element binding protein signaling via a G\u03b1s-mediated mechanism","volume":"27","author":"Chen","year":"2015","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ejphar.2026.179275_bib22","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/s41586-023-06420-x","article-title":"Tail engagement of arrestin at the glucagon receptor","volume":"620","author":"Chen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.179275_bib23","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1007\/s13311-023-01415-y","article-title":"Effectiveness of ocrelizumab in primary progressive multiple sclerosis: a multicenter, retrospective, real-world study (OPPORTUNITY)","volume":"20","author":"Chisari","year":"2023","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejphar.2026.179275_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177417","article-title":"Navigating the complexities of neuronal signaling and targets in neurological disorders: from pathology to therapeutics","volume":"995","author":"Choudhary","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib25","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","article-title":"Global, regional, and national burden of Parkinson's disease, 1990-2016: a systematic analysis for the global burden of disease study 2016","volume":"17","author":"Collaborators","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2026.179275_bib26","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature10251","article-title":"Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis","volume":"476","author":"Consortium","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.179275_bib27","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1093\/brain\/awad064","article-title":"Impaired dopamine release in Parkinson's disease","volume":"146","author":"Cramb","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.ejphar.2026.179275_bib28","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0893-133X(01)00265-2","article-title":"The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus","volume":"25","author":"Dawson","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2026.179275_bib29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neuropharm.2017.07.010","article-title":"Antagonism of the 5-HT(6) receptor - preclinical rationale for the treatment of Alzheimer's disease","volume":"125","author":"de Jong","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2026.179275_bib30","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3233\/JPD-230372","article-title":"Effectiveness of continuous dopaminergic therapies in Parkinson's disease: a review of L-DOPA pharmacokinetics\/pharmacodynamics","volume":"14","author":"Demailly","year":"2024","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.ejphar.2026.179275_bib31","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12647","article-title":"A regenerative approach to the treatment of multiple sclerosis","volume":"502","author":"Deshmukh","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.179275_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051852","article-title":"The GPR17 Receptor-A promising goal for therapy and a potential marker of the neurodegenerative process in multiple sclerosis","volume":"21","author":"Dziedzic","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ejphar.2026.179275_bib33","series-title":"Essential Guide to Neurodegenerative Disorders","first-page":"269","article-title":"Chapter 17 - non-motor symptoms of Parkinson's disease","author":"El-Mansoury","year":"2025"},{"key":"10.1016\/j.ejphar.2026.179275_bib34","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2147\/JEP.S265282","article-title":"Pathophysiological mechanisms and experimental pharmacotherapy for L-Dopa-Induced dyskinesia","volume":"13","author":"Fabbrini","year":"2021","journal-title":"J. Exp. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2003.tb07458.x","article-title":"Description of Parkinson's disease as a clinical syndrome","volume":"991","author":"Fahn","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.ejphar.2026.179275_bib36","doi-asserted-by":"crossref","first-page":"558","DOI":"10.2174\/0113894501298344240507080149","article-title":"GPR56, an adhesion GPCR with multiple roles in human diseases, current status and future perspective","volume":"25","author":"Fan","year":"2024","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.ejphar.2026.179275_bib37","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1038\/s41591-025-03831-3","article-title":"Disruption of the cerebrospinal fluid-plasma protein balance in cognitive impairment and aging","volume":"31","author":"Farinas","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2026.179275_bib38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1877-1173(10)91002-8","article-title":"G protein-coupled receptor heteromers as new targets for drug development","volume":"91","author":"Ferr\u00e9","year":"2010","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.ejphar.2026.179275_bib39","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.biopsych.2014.07.019","article-title":"A role for Mitogen- and stress-activated kinase 1 in L-DOPA-Induced dyskinesia and \u0394FosB expression","volume":"79","author":"Feyder","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.179275_bib40","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.3390\/molecules27123680","article-title":"Drugs targeting the A3 adenosine receptor: human clinical study data","volume":"27","author":"Fishman","year":"2022","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.ejphar.2026.179275_bib41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3390\/biomedicines11020249","article-title":"Increasing adiponectin signaling by sub-chronic AdipoRon treatment elicits Antidepressant- and anxiolytic-like effects independent of changes in hippocampal plasticity","volume":"11","author":"Formolo","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.ejphar.2026.179275_bib42","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nrn.2017.136","article-title":"Regenerating CNS myelin - from mechanisms to experimental medicines","volume":"18","author":"Franklin","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179275_bib43","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1124\/mol.63.6.1256","article-title":"The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints","volume":"63","author":"Fredriksson","year":"2003","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib44","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.neuroimage.2008.05.009","article-title":"Correlation between serotonin synthesis and 5-HT1A receptor binding in the living human brain: a combined alpha-[11C]MT and [18F]MPPF positron emission tomography study","volume":"42","author":"Frey","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.ejphar.2026.179275_bib45","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s12640-010-9206-y","article-title":"Disruption of the CaMKII\/CREB signaling is associated with zinc deficiency-induced learning and memory impairments","volume":"19","author":"Gao","year":"2011","journal-title":"Neurotox. Res."},{"issue":"Pt 8","key":"10.1016\/j.ejphar.2026.179275_bib46","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/brain\/120.8.1461","article-title":"The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion","volume":"120","author":"Gay","year":"1997","journal-title":"Brain : J. Neurol."},{"key":"10.1016\/j.ejphar.2026.179275_bib47","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/(SICI)1098-2396(199607)23:3<164::AID-SYN5>3.0.CO;2-6","article-title":"Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats","volume":"23","author":"G\u00e9rard","year":"1996","journal-title":"Synapse"},{"key":"10.1016\/j.ejphar.2026.179275_bib48","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0006-8993(96)01224-3","article-title":"Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system","volume":"746","author":"G\u00e9rard","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2026.179275_bib49","first-page":"1","article-title":"Multiple sclerosis: pathogenesis, symptoms, diagnoses and cell-based therapy","volume":"19","author":"Ghasemi","year":"2017","journal-title":"Cell J"},{"key":"10.1016\/j.ejphar.2026.179275_bib50","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1242\/dmm.030205","article-title":"Neurodegenerative disease: models, mechanisms, and a new hope","volume":"10","author":"Gitler","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ejphar.2026.179275_bib51","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1142\/S0192415X24500824","article-title":"Paeoniflorin attenuates oxidative stress and inflammation in Parkinson's disease by activating the HSF1-NRF1 axis","volume":"52","author":"Gong","year":"2024","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.ejphar.2026.179275_bib52","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.neuron.2007.01.008","article-title":"Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior","volume":"53","author":"Gonz\u00e1lez-Maeso","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2026.179275_bib53","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nri2550","article-title":"Autoimmune T cell responses in the central nervous system","volume":"9","author":"Goverman","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ejphar.2026.179275_bib54","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.neurobiolaging.2012.05.005","article-title":"A\u03b2 leads to Ca2+ signaling alterations and transcriptional changes in glial cells","volume":"34","author":"Grolla","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ejphar.2026.179275_bib55","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.celrep.2017.06.023","article-title":"Silent allosteric modulation of mGluR5 maintains glutamate signaling while rescuing alzheimer's mouse phenotypes","volume":"20","author":"Haas","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2026.179275_bib56","first-page":"277","article-title":"Multiple sclerosis - remyelination failure as a cause of disease progression","volume":"27","author":"Hagemeier","year":"2012","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.ejphar.2026.179275_bib57","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.celrep.2016.04.077","article-title":"Chronic pharmacological mGluR5 inhibition prevents cognitive impairment and reduces pathogenesis in an alzheimer disease mouse model","volume":"15","author":"Hamilton","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.ejphar.2026.179275_bib58","first-page":"68s","article-title":"Antibodies and antisense oligonucleotide for probing the distribution and putative functions of central 5-HT6 receptors","volume":"21","author":"Hamon","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.ejphar.2026.179275_bib59","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrd.2017.178","article-title":"Trends in GPCR drug discovery: new agents, targets and indications","volume":"16","author":"Hauser","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2026.179275_bib60","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.3233\/JPD-212672","article-title":"Efficacy of istradefylline, an adenosine A2A receptor antagonist, as adjunctive therapy to levodopa in Parkinson's disease: a pooled analysis of 8 phase 2b\/3 trials","volume":"11","author":"Hauser","year":"2021","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.ejphar.2026.179275_bib61","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1056\/NEJMoa1601277","article-title":"Ocrelizumab versus interferon Beta-1a in relapsing multiple sclerosis","volume":"376","author":"Hauser","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2026.179275_bib62","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41592-021-01344-8","article-title":"Lineage recording in human cerebral organoids","volume":"19","author":"He","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ejphar.2026.179275_bib63","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1073\/pnas.1401819111","article-title":"Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia","volume":"111","author":"Heiman","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.ejphar.2026.179275_bib64","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1474-4422(15)00313-0","article-title":"The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research","volume":"15","author":"Hohlfeld","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ejphar.2026.179275_bib65","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1210\/en.2006-0933","article-title":"GPR39 signaling is stimulated by zinc ions but not by obestatin","volume":"148","author":"Holst","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.ejphar.2026.179275_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1015035","article-title":"Potential therapeutic effects and pharmacological evidence of sinomenine in central nervous system disorders","volume":"13","author":"Hong","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.898955","article-title":"A review for the pharmacological effects of paeoniflorin in the nervous system","volume":"13","author":"Hong","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib68","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41586-020-1953-1","article-title":"Structure of the neurotensin receptor 1 in complex with \u03b2-arrestin 1","volume":"579","author":"Huang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ejphar.2026.179275_bib69","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1038\/s41591-025-03834-0","article-title":"The global neurodegeneration proteomics consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging","volume":"31","author":"Imam","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2026.179275_bib70","article-title":"Dopamine agonists in Parkinson's disease: impact of D1-like or D2-like dopamine receptor subtype selectivity and avenues for future treatment","volume":"9","author":"Isaacson","year":"2023","journal-title":"Clin. Park Relat. Disord."},{"key":"10.1016\/j.ejphar.2026.179275_bib71","article-title":"Moving to a non-dopaminergic approach for the treatment of OFF fluctuations in Parkinson's disease","volume":"12","author":"Isaacson","year":"2025","journal-title":"Clin. Park Relat. Disord."},{"key":"10.1016\/j.ejphar.2026.179275_bib72","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/01.wnr.0000215779.76602.93","article-title":"GPR39 receptor expression in the mouse brain","volume":"17","author":"Jackson","year":"2006","journal-title":"Neuroreport"},{"key":"10.1016\/j.ejphar.2026.179275_bib73","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/ana.410390304","article-title":"Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The multiple sclerosis collaborative research group (MSCRG)","volume":"39","author":"Jacobs","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejphar.2026.179275_bib74","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.cell.2024.01.028","article-title":"Direct interrogation of context-dependent GPCR activity with a universal biosensor platform","volume":"187","author":"Janicot","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2026.179275_bib75","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.euroneuro.2011.05.001","article-title":"The socioeconomic consequences of multiple sclerosis: a controlled national study","volume":"22","author":"Jennum","year":"2012","journal-title":"Eur. Neuropsychopharmacol. : J. European College Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib76","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jalz.2014.01.001","article-title":"A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease","volume":"10","author":"Jessen","year":"2014","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.ejphar.2026.179275_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2019.101665","article-title":"Targeting the transferrin receptor for brain drug delivery","volume":"181","author":"Johnsen","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2026.179275_bib78","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/da.22403","article-title":"Orexin 1 and 2 receptor involvement IN CO2 -induced panic-associated behavior and autonomic responses","volume":"32","author":"Johnson","year":"2015","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.ejphar.2026.179275_bib79","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/mds.21225","article-title":"Valvular heart disease in Parkinson's disease patients treated with dopamine agonists: a reader-blinded monocenter echocardiography study","volume":"22","author":"Junghanns","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ejphar.2026.179275_bib80","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuroscience.2020.08.017","article-title":"Nucleus reuniens lesion and antidepressant treatment prevent hippocampal neurostructural alterations induced by chronic mild stress in Male rats","volume":"454","author":"Kafetzopoulos","year":"2021","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2026.179275_bib81","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0896-6273(03)00124-7","article-title":"APP processing and synaptic function","volume":"37","author":"Kamenetz","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2026.179275_bib82","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0140-6736(18)30475-6","article-title":"Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study","volume":"391","author":"Kappos","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2026.179275_bib83","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1056\/NEJMoa0909494","article-title":"A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis","volume":"362","author":"Kappos","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ejphar.2026.179275_bib84","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.179275_bib85","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13048-024-01479-0","article-title":"Unveiling G-protein coupled receptors as potential targets for ovarian cancer nanomedicines: from RNA sequencing data analysis to in vitro validation","volume":"17","author":"Khetan","year":"2024","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.ejphar.2026.179275_bib86","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1080\/13543784.2018.1483334","article-title":"The role of 5 HT6-receptor antagonists in Alzheimer's disease: an update","volume":"27","author":"Khoury","year":"2018","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.ejphar.2026.179275_bib87","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41531-017-0015-3","article-title":"Integrated molecular landscape of Parkinson's disease","volume":"3","author":"Klemann","year":"2017","journal-title":"npj Parkinson's Dis."},{"key":"10.1016\/j.ejphar.2026.179275_bib88","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ejphar.2026.179275_bib89","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1126\/science.1169096","article-title":"Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice","volume":"323","author":"Kuchibhotla","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2026.179275_bib90","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.3389\/fimmu.2018.03116","article-title":"Pathogenic mechanisms associated with different clinical courses of multiple sclerosis","volume":"9","author":"Lassmann","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ejphar.2026.179275_bib91","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1523\/JNEUROSCI.15-05-04077.1995","article-title":"Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation","volume":"15","author":"Levey","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179275_bib92","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1111\/cns.13970","article-title":"Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation","volume":"28","author":"Li","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.ejphar.2026.179275_bib93","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/glia.22502","article-title":"Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB","volume":"61","author":"Lim","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.ejphar.2026.179275_bib94","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1523\/JNEUROSCI.4051-15.2017","article-title":"LRRK2 G2019S induces Anxiety\/depression-like behavior before the onset of motor dysfunction with 5-HT(1A) receptor upregulation in mice","volume":"38","author":"Lim","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179275_bib95","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.pbb.2014.03.003","article-title":"The VGF-derived peptide TLQP62 produces antidepressant-like effects in mice via the BDNF\/TrkB\/CREB signaling pathway","volume":"120","author":"Lin","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.ejphar.2026.179275_bib96","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1124\/jpet.111.185660","article-title":"CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor","volume":"339","author":"Lindemann","year":"2011","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2026.179275_bib97","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/sj.bjp.0706335","article-title":"Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists","volume":"146","author":"Liu","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib98","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/md18060333","article-title":"Protective effect of fucoidan against MPP(+)-induced SH-SY5Y cells apoptosis by affecting the PI3K\/Akt pathway","volume":"18","author":"Liu","year":"2020","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.ejphar.2026.179275_bib99","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev.med.57.121304.131442","article-title":"Current pharmacotherapy for Alzheimer's disease","volume":"57","author":"Lle\u00f3","year":"2006","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.ejphar.2026.179275_bib100","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41573-025-01139-y","article-title":"GPCR drug discovery: new agents, targets and indications","volume":"24","author":"Lorente","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2026.179275_bib101","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1227157","article-title":"Pathological \u03b1-synuclein transmission initiates parkinson-like neurodegeneration in nontransgenic mice","volume":"338","author":"Luk","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ejphar.2026.179275_bib102","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1093\/brain\/awy151","article-title":"The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells","volume":"141","author":"Machado-Santos","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.ejphar.2026.179275_bib103","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0006-3223(96)00365-4","article-title":"Lower serum zinc in major depression is a sensitive marker of treatment resistance and of the immune\/inflammatory response in that illness","volume":"42","author":"Maes","year":"1997","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.179275_bib104","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/j.1460-9568.2006.05003.x","article-title":"Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release","volume":"24","author":"Marcos","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179275_bib105","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s13311-020-00836-3","article-title":"The leukotriene receptor antagonist montelukast reduces alpha-synuclein load and restores memory in an animal model of dementia with lewy bodies","volume":"17","author":"Marschallinger","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ejphar.2026.179275_bib106","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/ana.1010","article-title":"Adenosine A2A receptor activation reduces proinflammatory events and decreases cell death following intracerebral hemorrhage","volume":"49","author":"Mayne","year":"2001","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ejphar.2026.179275_bib107","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1600-0447.1990.tb03077.x","article-title":"Zinc in depressive disorder","volume":"82","author":"McLoughlin","year":"1990","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.ejphar.2026.179275_bib108","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuron.2012.03.009","article-title":"Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice","volume":"74","author":"Michalon","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2026.179275_bib109","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1152\/physrev.1998.78.1.189","article-title":"Dopamine receptors: from structure to function","volume":"78","author":"Missale","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ejphar.2026.179275_bib110","article-title":"GPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB\/BDNF down-regulation in the hippocampus","volume":"18","author":"M\u0142yniec","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib111","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbr.2012.10.020","article-title":"The role of the GPR39 receptor in zinc deficient-animal model of depression","volume":"238","author":"M\u0142yniec","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ejphar.2026.179275_bib112","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0006-8993(95)01273-7","article-title":"Involvement of GABA(B) receptor systems in action of antidepressants: baclofen but not bicuculline attenuates the effects of antidepressants on the forced swim test in rats","volume":"709","author":"Nakagawa","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.ejphar.2026.179275_bib113","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","article-title":"Neurobiology of depression","volume":"34","author":"Nestler","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.ejphar.2026.179275_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2025.107150","article-title":"Deep brain stimulation rescues the homeostasis disruption of circulating D- and L-amino acids level in men with Parkinson's disease","volume":"216","author":"Nuzzo","year":"2025","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2026.179275_bib115","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/S1471-1931(00)00030-6","article-title":"Continuous dopamine-receptor stimulation in early Parkinson's disease","volume":"23","author":"Olanow","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2026.179275_bib116","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.829966","article-title":"Indole-3-Carbinol selectively prevents chronic stress-induced depression-but not anxiety-like behaviors via suppressing pro-inflammatory cytokine production and oxido-nitrosative stress in the brain","volume":"13","author":"Pan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib117","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1038\/jcbfm.2012.126","article-title":"Drug transport across the blood-brain barrier","volume":"32","author":"Pardridge","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ejphar.2026.179275_bib118","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1212\/WNL.43.4.662","article-title":"Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS\/MRI study group and the IFNB multiple sclerosis study group","volume":"43","author":"Paty","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.ejphar.2026.179275_bib119","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0031-6997(24)01417-0","article-title":"Autoregulation of serotonin neurons: role in antidepressant drug action","volume":"51","author":"Pi\u00f1eyro","year":"1999","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.ejphar.2026.179275_bib120","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/mds.25945","article-title":"The prevalence of Parkinson's disease: a systematic review and meta-analysis","volume":"29","author":"Pringsheim","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ejphar.2026.179275_bib121","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1093\/brain\/awg224","article-title":"Cannabinoids inhibit neurodegeneration in models of multiple sclerosis","volume":"126","author":"Pryce","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.ejphar.2026.179275_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116395","article-title":"GPR56: a potential therapeutic target for neurological and psychiatric disorders","volume":"226","author":"Qi","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib123","article-title":"Current status of GABA receptor subtypes in analgesia","volume":"168","author":"Qian","year":"2023","journal-title":"Biomed. Pharmacotherapy = Biomedecine and pharmacotherapie"},{"key":"10.1016\/j.ejphar.2026.179275_bib124","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.theriogenology.2016.09.040","article-title":"GPR39 is region-specifically expressed in mouse oviduct correlating with the Zn(2+) distribution","volume":"88","author":"Qiao","year":"2017","journal-title":"Theriogenology"},{"key":"10.1016\/j.ejphar.2026.179275_bib125","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.jpsychires.2011.06.018","article-title":"Meta-analysis of randomized controlled trials to assess the effectiveness and safety of free and easy wanderer plus, a polyherbal preparation for depressive disorders","volume":"45","author":"Qin","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.ejphar.2026.179275_bib126","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12974-016-0739-8","article-title":"Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB\/STAT3 pathway after ischemic stroke in mice","volume":"13","author":"Qiu","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ejphar.2026.179275_bib127","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1523\/JNEUROSCI.15-02-01455.1995","article-title":"Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired","volume":"15","author":"Quirion","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179275_bib128","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/path.6381","article-title":"Characterisation of GPR17-expressing oligodendrocyte precursors in human ischaemic lesions and correlation with reactive glial responses","volume":"265","author":"Raffaele","year":"2025","journal-title":"J. Pathol."},{"key":"10.1016\/j.ejphar.2026.179275_bib129","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002316","article-title":"Risk of hospitalization with neurodegenerative disease after moderate-to-severe traumatic brain injury in the working-age population: a retrospective cohort study using the Finnish national health registries","volume":"14","author":"Raj","year":"2017","journal-title":"PLoS Med."},{"key":"10.1016\/j.ejphar.2026.179275_bib130","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1038\/sj.bjp.0702723","article-title":"The recombinant 5-HT1A receptor: g protein coupling and signalling pathways","volume":"127","author":"Raymond","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib131","doi-asserted-by":"crossref","DOI":"10.1177\/1756286420911296","article-title":"PF-06649751 efficacy and safety in early Parkinson's disease: a randomized, placebo-controlled trial","volume":"13","author":"Riesenberg","year":"2020","journal-title":"Therapeutic Adv. Neurol. Disorder."},{"key":"10.1016\/j.ejphar.2026.179275_bib132","doi-asserted-by":"crossref","first-page":"67s","DOI":"10.1097\/00004714-199006001-00013","article-title":"Clinical effects of the 5-HT1A partial agonists in depression: a composite analysis of buspirone in the treatment of depression","volume":"10","author":"Robinson","year":"1990","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib133","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1166\/jbn.2016.2215","article-title":"Lipid-core nanocapsules act as a drug shuttle through the blood brain barrier and reduce glioblastoma after intravenous or oral administration","volume":"12","author":"Rodrigues","year":"2016","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.ejphar.2026.179275_bib134","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.tins.2006.09.004","article-title":"Targeting adenosine A2A receptors in Parkinson's disease","volume":"29","author":"Schwarzschild","year":"2006","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ejphar.2026.179275_bib135","doi-asserted-by":"crossref","first-page":"10117","DOI":"10.1523\/JNEUROSCI.3581-04.2004","article-title":"M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity","volume":"24","author":"Seeger","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ejphar.2026.179275_bib136","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.euroneuro.2013.06.005","article-title":"Schizophrenia and dopamine receptors","volume":"23","author":"Seeman","year":"2013","journal-title":"Eur. Neuropsychopharmacol. : J. European College Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib137","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1038\/s41591-025-03835-z","article-title":"APOE \u03b54 carriers share immune-related proteomic changes across neurodegenerative diseases","volume":"31","author":"Shvetcov","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.ejphar.2026.179275_bib138","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.neuropharm.2004.08.010","article-title":"Magnesium-deficient diet alters depression- and anxiety-related behavior in mice--influence of desipramine and Hypericum perforatum extract","volume":"47","author":"Singewald","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2026.179275_bib139","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jad.2010.04.024","article-title":"Serum zinc level in depressed patients during zinc supplementation of imipramine treatment","volume":"126","author":"Siwek","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.ejphar.2026.179275_bib140","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2025.1679013","article-title":"Therapeutic potential of Glycyrrhiza polysaccharides in pseudorabies virus infection: immune modulation, antioxidant activity, and gut microbiota restoration","volume":"12","author":"Song","year":"2025","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.ejphar.2026.179275_bib141","doi-asserted-by":"crossref","first-page":"eabi8593","DOI":"10.1126\/scitranslmed.abi8593","article-title":"Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q","volume":"14","author":"Spurrier","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ejphar.2026.179275_bib142","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00702-008-0179-4","article-title":"Risk of valvular heart disease associated with the use of dopamine agonists in Parkinson's disease: a systematic review","volume":"116","author":"Steiger","year":"2009","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.ejphar.2026.179275_bib143","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-080952","article-title":"Projections for prevalence of Parkinson's disease and its driving factors in 195 countries and territories to 2050: modelling study of Global Burden of Disease Study 2021","volume":"388","author":"Su","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.ejphar.2026.179275_bib144","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00455-015-9671-9","article-title":"Dysphagia in Parkinson's disease","volume":"31","author":"Suttrup","year":"2016","journal-title":"Dysphagia"},{"key":"10.1016\/j.ejphar.2026.179275_bib145","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.neubiorev.2013.03.018","article-title":"Potential roles of zinc in the pathophysiology and treatment of major depressive disorder","volume":"37","author":"Swardfager","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.ejphar.2026.179275_bib146","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.2174\/1570159X15666170510143821","article-title":"Levodopa in Parkinson's disease: current status and future developments","volume":"16","author":"Tambasco","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib147","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1111\/bph.16099","article-title":"Targeting G protein-coupled receptors for heart failure treatment","volume":"181","author":"Thai","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib148","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/S0140-6736(18)30481-1","article-title":"Multiple sclerosis","volume":"391","author":"Thompson","year":"2018","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.ejphar.2026.179275_bib149","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.70168","article-title":"Ergothioneine treatment ameliorates the pathological phenotypes of Parkinson's disease models","volume":"169","author":"Tng","year":"2025","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ejphar.2026.179275_bib150","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1192\/bjp.184.5.386","article-title":"Global burden of depressive disorders in the year 2000","volume":"184","author":"Ust\u00fcn","year":"2004","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.ejphar.2026.179275_bib151","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12883-018-1151-z","article-title":"Urological dysfunctions in patients with Parkinson's disease: clues from clinical and non-invasive urological assessment","volume":"18","author":"Valentino","year":"2018","journal-title":"BMC Neurol."},{"key":"10.1016\/j.ejphar.2026.179275_bib152","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/mdc3.13312","article-title":"The discovery of \u03b1-Synuclein in lewy pathology of Parkinson's Disease: the inspiration of a revolution","volume":"8","author":"Visanji","year":"2021","journal-title":"Mov. Disord. Clin. Pract."},{"key":"10.1016\/j.ejphar.2026.179275_bib153","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.4065\/80.8.1016","article-title":"Valvular heart disease in patients taking pergolide","volume":"80","author":"Waller","year":"2005","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ejphar.2026.179275_bib154","doi-asserted-by":"crossref","first-page":"7222","DOI":"10.1016\/j.cell.2025.10.022","article-title":"Pathway-selective 5-HT(1A)R agonist as a rapid antidepressant strategy","volume":"188","author":"Wang","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.ejphar.2026.179275_bib155","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13195-024-01385-z","article-title":"Metabotropic glutamate receptor 5 (mGluR5) is associated with neurodegeneration and amyloid deposition in Alzheimer's disease: a [(18)F]PSS232 PET\/MRI study","volume":"16","author":"Wang","year":"2024","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.ejphar.2026.179275_bib156","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neuroscience.2014.06.032","article-title":"Genipin is active via modulating monoaminergic transmission and levels of brain-derived neurotrophic factor (BDNF) in rat model of depression","volume":"275","author":"Wang","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2026.179275_bib157","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejphar.2007.08.045","article-title":"The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors","volume":"578","author":"Wang","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib158","first-page":"3575","article-title":"Treatment with Shuyu capsule increases 5-HT1AR level and activation of cAMP-PKA-CREB pathway in hippocampal neurons treated with serum from a rat model of depression","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ejphar.2026.179275_bib159","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107395","article-title":"GPCR-mediated natural products and compounds: potential therapeutic targets for the treatment of neurological diseases","volume":"208","author":"Wang","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ejphar.2026.179275_bib160","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jep.2011.08.079","article-title":"Meta-analysis of the clinical effectiveness of traditional Chinese medicine formula chaihu-shugan-san in depression","volume":"141","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib161","article-title":"Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: a mechanism review","volume":"133","author":"Wang","year":"2021","journal-title":"Biomed. Pharmacotherapy = Biomedecine and pharmacotherapie"},{"key":"10.1016\/j.ejphar.2026.179275_bib162","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0306-4522(94)00439-C","article-title":"Localization of serotonin subtype 6 receptor messenger RNA in the rat brain by in situ hybridization histochemistry","volume":"64","author":"Ward","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.ejphar.2026.179275_bib163","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1124\/jpet.111.182063","article-title":"Pharmacological characterization of LY593093, an M1 muscarinic acetylcholine receptor-selective partial orthosteric agonist","volume":"338","author":"Watt","year":"2011","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.ejphar.2026.179275_bib164","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1146\/annurev-biochem-060614-033910","article-title":"The molecular basis of G protein-coupled receptor activation","volume":"87","author":"Weis","year":"2018","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.ejphar.2026.179275_bib165","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105700","article-title":"Immune responses in the Parkinson's disease brain","volume":"168","author":"Weiss","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ejphar.2026.179275_bib166","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrd2379","article-title":"Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development","volume":"6","author":"Wess","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ejphar.2026.179275_bib167","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0050052","article-title":"FMRP mediates mGluR5-dependent translation of amyloid precursor protein","volume":"5","author":"Westmark","year":"2007","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ejphar.2026.179275_bib168","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1517\/13543784.2015.1102884","article-title":"Investigational drugs targeting 5-HT6 receptors for the treatment of Alzheimer's disease","volume":"24","author":"Wicke","year":"2015","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.ejphar.2026.179275_bib169","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/cpdd.1039","article-title":"Safety, tolerability, and pharmacokinetics of mevidalen (LY3154207), a centrally acting dopamine D1 receptor-positive allosteric modulator, in patients with parkinson disease","volume":"11","author":"Wilbraham","year":"2022","journal-title":"Clin. Pharmacol. Drug Dev."},{"key":"10.1016\/j.ejphar.2026.179275_bib170","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/cei.12226","article-title":"Multiple sclerosis treatment and infectious issues: update 2013","volume":"175","author":"Winkelmann","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ejphar.2026.179275_bib171","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.euroneuro.2011.07.018","article-title":"The size and burden of mental disorders and other disorders of the brain in Europe 2010","volume":"21","author":"Wittchen","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib172","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41392-023-01427-2","article-title":"G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders","volume":"8","author":"Wong","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.ejphar.2026.179275_bib173","article-title":"Antidepressant-like activity of oroxylin A in mice models of depression: a behavioral and neurobiological characterization","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib174","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1124\/mol.116.107854","article-title":"GABA(B)R-induced EGFR transactivation promotes migration of human prostate cancer cells","volume":"92","author":"Xia","year":"2017","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.ejphar.2026.179275_bib175","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.pharmthera.2004.10.007","article-title":"Therapeutic potential of adenosine A(2A) receptor antagonists in Parkinson's disease","volume":"105","author":"Xu","year":"2005","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.ejphar.2026.179275_bib176","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2012.02.002","article-title":"Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease","volume":"97","author":"Xu","year":"2012","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.ejphar.2026.179275_bib177","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110616","article-title":"Striatal GluN2A gene suppression reduces L-DOPA-induced abnormal involuntary movements in parkinsonian rats","volume":"279","author":"Yabumoto","year":"2025","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.ejphar.2026.179275_bib178","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05449","article-title":"A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity","volume":"4","author":"Yao","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.ejphar.2026.179275_bib179","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/10799890701506147","article-title":"Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum","volume":"27","author":"Yasuda","year":"2007","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.ejphar.2026.179275_bib180","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41598-017-16790-8","article-title":"Parkinson disease with constipation: clinical features and relevant factors","volume":"8","author":"Yu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ejphar.2026.179275_bib181","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/S0140-6736(03)14738-1","article-title":"Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): Multicentre randomised placebo-controlled trial","volume":"362","author":"Zajicek","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.ejphar.2026.179275_bib182","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41398-022-01886-1","article-title":"Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo","volume":"12","author":"Zhang","year":"2022","journal-title":"Transl. Psychiatry"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926007570?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0014299926007570?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T20:08:35Z","timestamp":1789070915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0014299926007570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":182,"alternative-id":["S0014299926007570"],"URL":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179275","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic targeting of G protein-coupled receptors in central nervous system disorders: from novel mechanisms to precision pharmacology","name":"articletitle","label":"Article Title"},{"value":"European Journal of Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ejphar.2026.179275","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"179275"}}